Home Other Building Blocks 2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, hydrochloride (1:1)

2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, hydrochloride (1:1)

CAS No.:
199864-86-3
Catalog Number:
AG002CEC
Molecular Formula:
C17H17ClFN3
Molecular Weight:
317.7884
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$140
- +
10mg
99%
1 week
United States
$190
- +
50mg
99%
1 week
United States
$590
- +
Product Description
Catalog Number:
AG002CEC
Chemical Name:
2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, hydrochloride (1:1)
CAS Number:
199864-86-3
Molecular Formula:
C17H17ClFN3
Molecular Weight:
317.7884
MDL Number:
MFCD11112196
IUPAC Name:
4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine;hydrochloride
InChI:
InChI=1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
InChI Key:
MKJPYBJBPRFMHL-UHFFFAOYSA-N
SMILES:
Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C.Cl
Properties
Complexity:
349  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
317.11g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
317.792g/mol
Monoisotopic Mass:
317.11g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
51.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100501
A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201
Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. British journal of pharmacology 20090901
Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach. Biological & pharmaceutical bulletin 20070301
Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. European journal of pharmacology 20040101
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nature medicine 20021001
MT-500 (POZEN). Current opinion in investigational drugs (London, England : 2000) 20010301
RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. British journal of pharmacology 19990701
Properties