Home Nitros 1,1-Dioxide-6-nitro-benzo[b]thiophene

1,1-Dioxide-6-nitro-benzo[b]thiophene

CAS No.:
19983-44-9
Catalog Number:
AG002CE6
Molecular Formula:
C8H5NO4S
Molecular Weight:
211.1946
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
96%
In Stock USA
United States
$75
- +
1g
96%
In Stock USA
United States
$150
- +
5g
96%
In Stock USA
United States
$450
- +
10g
96%
In Stock USA
United States
$750
- +
Product Description
Catalog Number:
AG002CE6
Chemical Name:
1,1-Dioxide-6-nitro-benzo[b]thiophene
CAS Number:
19983-44-9
Molecular Formula:
C8H5NO4S
Molecular Weight:
211.1946
MDL Number:
MFCD00173799
IUPAC Name:
6-nitro-1-benzothiophene 1,1-dioxide
InChI:
InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI Key:
ZRRGOUHITGRLBA-UHFFFAOYSA-N
SMILES:
[O-][N+](=O)c1ccc2c(c1)S(=O)(=O)C=C2
Properties
Complexity:
375  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
210.994g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
211.191g/mol
Monoisotopic Mass:
210.994g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
88.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.7  
Literature
Title Journal
The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells. Toxicology in vitro : an international journal published in association with BIBRA 20171201
Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Toxicology and applied pharmacology 20171101
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. Neoplasia (New York, N.Y.) 20150701
Noncanonical STAT3 activation regulates excess TGF-β1 and collagen I expression in muscle of stricturing Crohn's disease. Journal of immunology (Baltimore, Md. : 1950) 20150401
Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling. The FEBS journal 20150301
Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. The Journal of biological chemistry 20140502
Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation. Cancer letters 20140501
JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic. Cell cycle (Georgetown, Tex.) 20130101
Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level. Histochemistry and cell biology 20121201
Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. The Journal of nutritional biochemistry 20121101
HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer biology & therapy 20120701
JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. Toxicological sciences : an official journal of the Society of Toxicology 20120601
STAT3 does not regulate acute liver injury after ischemia/reperfusion. The Journal of surgical research 20111201
STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer research 20111201
Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion. Circulation research 20111111
XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis : an international journal on programmed cell death 20110501
STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy? International journal of cancer 20110215
Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation - the rat isolated working heart. British journal of pharmacology 20110201
Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic research in cardiology 20101101
Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. European journal of immunology 20100901
Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma). Biology of the cell 20090923
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Molecular immunology 20090501
Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. Journal of molecular endocrinology 20090401
Regulating RISK: a role for JAK-STAT signaling in postconditioning? American journal of physiology. Heart and circulatory physiology 20081001
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chemistry & biology 20061101
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Properties