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Home Other Building Blocks Y-33075

Y-33075

CAS No.:
199433-58-4
Catalog Number:
AG002C47
Molecular Formula:
C16H16N4O
Molecular Weight:
280.3244
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
98%
1 week
United States
$515
- +
50mg
98%
1 week
United States
$1707
- +
Product Description
Catalog Number:
AG002C47
Chemical Name:
Y-33075
CAS Number:
199433-58-4
Molecular Formula:
C16H16N4O
Molecular Weight:
280.3244
MDL Number:
MFCD16038858
IUPAC Name:
4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide
InChI:
InChI=1S/C16H16N4O/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15/h2-10H,17H2,1H3,(H2,18,19,20,21)/t10-/m1/s1
InChI Key:
JTVBXQAYBIJXRP-SNVBAGLBSA-N
SMILES:
O=C(c1ccc(cc1)[C@H](N)C)Nc1ccnc2c1cc[nH]2
UNII:
00ALI1GAY2
Properties
Complexity:
367  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
280.132g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
280.331g/mol
Monoisotopic Mass:
280.132g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
83.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.4  
Literature
Title Journal
Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Current eye research 20111001
Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries. Japanese journal of ophthalmology 20110701
Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells. Molecular vision 20110101
Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma. Bioorganic & medicinal chemistry letters 20100601
Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. Journal of medicinal chemistry 20091112
Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601
[Optic nerve regeneration in adult mammals]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20080601
A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Experimental neurology 20070501
Properties