4-Thiazolidinecarboxylic acid, 2-oxo-
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The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione. | Toxicology letters 20170315 |
Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. | PloS one 20140101 |
Plant growth stimulation in Prunus species plantlets by BTH or OTC treatments under in vitro conditions. | Journal of plant physiology 20120715 |
The influence of glutathione on redox regulation by antioxidant proteins and apoptosis in macrophages exposed to 2-hydroxyethyl methacrylate (HEMA). | Biomaterials 20120701 |
Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats. | BMB reports 20120601 |
The greening of pesticide-environment interactions: some personal observations. | Environmental health perspectives 20120401 |
Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120301 |
L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF). | International journal of molecular sciences 20120101 |
Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats. | Alcoholism, clinical and experimental research 20111001 |
L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma. | The journal of physiological sciences : JPS 20110901 |
Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells. | Investigative ophthalmology & visual science 20110701 |
Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine. | American journal of respiratory cell and molecular biology 20110501 |
In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity. | Archives of toxicology 20110501 |
Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy. | Neurochemical research 20110301 |
Role of glutathione in immunity and inflammation in the lung. | International journal of general medicine 20110101 |
Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels. | International endodontic journal 20101201 |
Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels. | International endodontic journal 20100501 |
Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents. | Anticancer research 20100401 |
Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level. | Plant biology (Stuttgart, Germany) 20100101 |
Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. | PloS one 20100101 |
Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence. | Alcohol and alcoholism (Oxford, Oxfordshire) 20100101 |
Glutathione modulation reverses the growth-promoting effect of growth factors, improving the 5-fluorouracil antitumour response in WiDr colon cancer cells. | Anticancer research 20091001 |
The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF). | Iranian biomedical journal 20091001 |
Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid. | Toxicology 20090919 |
Application of key events analysis to chemical carcinogens and noncarcinogens. | Critical reviews in food science and nutrition 20090901 |
Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats. | Alcoholism, clinical and experimental research 20090801 |
Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis. | International journal of molecular medicine 20090801 |
L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro. | Journal of applied physiology (Bethesda, Md. : 1985) 20090701 |
Normal saline induces oxidative stress in peritoneal mesothelial cells. | Journal of pediatric surgery 20081001 |
Increased metal tolerance in Salix by nicotinamide and nicotinic acid. | Plant physiology and biochemistry : PPB 20080701 |
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. | American journal of physiology. Heart and circulatory physiology 20080601 |
A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome. | Critical care medicine 20080301 |
Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation. | Pflugers Archiv : European journal of physiology 20080101 |
Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress. | Canadian journal of microbiology 20080101 |
Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats. | Muscle & nerve 20071201 |
Toxicological assessment of indium nitrate on aquatic organisms and investigation of the effects on the PLHC-1 fish cell line. | The Science of the total environment 20071115 |
Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels. | Journal of biomedical materials research. Part B, Applied biomaterials 20071101 |
Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F. | Free radical biology & medicine 20071015 |
The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats. | Fundamental & clinical pharmacology 20071001 |
Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation. | Alcohol (Fayetteville, N.Y.) 20070801 |
Ecotoxicological effects of the antioxidant additive propyl gallate in five aquatic systems. | Water research 20070601 |
Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro. | Journal of endodontics 20070401 |
Synchrotron FTIR microspectroscopic analysis of the effects of anti-inflammatory therapeutics on wound healing in laminectomized rats. | Analytical and bioanalytical chemistry 20070301 |
Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose. | Free radical biology & medicine 20070301 |
Induction of heme oxygenase-1 expression by root canal sealers in human gingival fibroblasts is augmented by oxidative stress. | Journal of biomedical materials research. Part B, Applied biomaterials 20070201 |
Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants. | Archives of virology 20070101 |
Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma. | Cancer immunology, immunotherapy : CII 20060801 |
Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801 |
An antioxidant modulates expression of receptor activator of NF-kappaB in asthma. | Experimental & molecular medicine 20060630 |
Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. | Acta pharmacologica Sinica 20060401 |
Antioxidants as novel agents for asthma. | Mini reviews in medicinal chemistry 20060201 |
A zebrafish assay for identifying neuroprotectants in vivo. | Neurotoxicology and teratology 20060101 |
Redox-mediated bypass of restriction point via skipping of G1pm. | Theoretical biology & medical modelling 20060101 |
Effects of glutathione supplementation during peritoneal dialysis. | Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20060101 |
A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma. | Molecular pharmacology 20051101 |
The use of zebrafish for assessing ototoxic and otoprotective agents. | Hearing research 20051001 |
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. | Brain research. Molecular brain research 20050613 |
Correlation of in vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels. | Journal of cellular biochemistry 20050601 |
Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. | Journal of periodontal research 20050401 |
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201 |
L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041201 |
Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels. | Oral diseases 20041101 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease. | Neuroscience letters 20040617 |
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery. | Biological & pharmaceutical bulletin 20040301 |
Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid. | Biological & pharmaceutical bulletin 20040101 |
[Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts]. | Tsitologiia 20040101 |
Intracellular mediators of granulysin-induced cell death. | Journal of immunology (Baltimore, Md. : 1950) 20030901 |
L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency. | Free radical biology & medicine 20030601 |
Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules. | Metabolism: clinical and experimental 20030601 |
Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions. | World journal of surgery 20030401 |
The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis. | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20030301 |
Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels. | Journal of periodontal research 20030201 |
Relationship between intracellular glutathione level and the mode of cell death induced by pingyangmycin. | Oral oncology 20030101 |
[Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines]. | Tsitologiia 20030101 |
Glucose-induced changes in the phenotype of human peritoneal mesothelial cells: effect of L-2-oxothiazolidine carboxylic acid. | American journal of nephrology 20030101 |
[The correlation of tolerance to cerebral ischemia and body temperature with glutathione concentration]. | Biomeditsinskaia khimiia 20030101 |
In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR. | Magnetic resonance in medicine 20020901 |
Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro. | Journal of periodontal research 20020801 |
Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization. | The Journal of biological chemistry 20020215 |
L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases. | Melanoma research 20020201 |
In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice. | Archives of biochemistry and biophysics 20020115 |
Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. | Arteriosclerosis, thrombosis, and vascular biology 20020101 |
L-2-oxothiazolidine-4-carboxylate: an agent that modulates lipopolysaccharide-induced peritonitis in rats. | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20020101 |
Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status. | Redox report : communications in free radical research 20020101 |
[Glutathione in therapy]. | Postepy higieny i medycyny doswiadczalnej 20020101 |
Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice. | Journal of biochemical and molecular toxicology 20020101 |
Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. | Respiratory research 20020101 |
(L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1. | BJU international 20011201 |
Chronic ethanol ingestion potentiates TNF-alpha-mediated oxidative stress and apoptosis in rat type II cells. | American journal of physiology. Lung cellular and molecular physiology 20010801 |
Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101 |
Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases. | Melanoma research 20000401 |
Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives. | Journal of medicinal chemistry 19991118 |
Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus. | Biochemical pharmacology 19990515 |
Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats. | The Journal of urology 19970501 |
L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes. | Clinical and diagnostic laboratory immunology 19970501 |
Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy. | Experimental nephrology 19960101 |
L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain. | Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19950201 |
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication. | AIDS research and human retroviruses 19940801 |
Role of oxygen free radicals in cocaine-induced vascular disruption in mice. | Teratology 19940301 |