NF-κB pathway contributes to cadmium-induced apoptosis of porcine granulosa cells.

Biological trace element research 20130601

Role of 15-hydroxyeicosatetraenoic acid in hemozoin-induced lysozyme release from human adherent monocytes.

BioFactors (Oxford, England) 20130101

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide.

Anti-cancer drugs 20121001

Parthenolide inhibits the LPS-induced secretion of IL-6 and TNF-α and NF-κB nuclear translocation in BV-2 microglia.

Phytotherapy research : PTR 20120901

Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells.

Basic & clinical pharmacology & toxicology 20120901

TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.

Biochimica et biophysica acta 20120901

Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma.

Molecular medicine reports 20120901

Biomimetic semisynthesis of arglabin from parthenolide.

The Journal of organic chemistry 20120817

Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model.

Experimental & molecular medicine 20120731

TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation.

Kidney international 20120601

Culture supernatants of breast cancer cell line MDA-MB-231 treated with parthenolide inhibit the proliferation, migration, and lumen formation capacity of human umbilical vein endothelial cells.

Chinese medical journal 20120601

Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis.

Cancer letters 20120501

Patch testing with constituents of Compositae mixes.

Contact dermatitis 20120501

Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities.

Inflammation 20120401

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

Leukemia 20120401

Targeting radioresistant osteosarcoma cells with parthenolide.

Journal of cellular biochemistry 20120401

9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity.

Planta medica 20120201

Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo.

Journal of biochemical and molecular toxicology 20120101

Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.

Chemical biology & drug design 20120101

Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates dextran sulfate sodium-induced colitis in mice.

International immunopharmacology 20120101

HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes.

Antiviral therapy 20120101

Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina.

The International journal of developmental biology 20120101

Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer androgen-independent cell lines.

International journal of molecular medicine 20111201

Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats.

Cytokine 20111201

Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments.

Journal of medicinal chemistry 20111124

Effects of nuclear factor-κB inhibitors on colon anastomotic healing in rats.

The Journal of surgical research 20111101

Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.).

Phytochemistry 20111001

Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells.

International journal of oncology 20111001

Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro.

Molecules (Basel, Switzerland) 20110809

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma.

The Journal of biological chemistry 20110805

Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal of medicinal chemistry 20110714

Molecular pathways of spontaneous and TNF-{alpha}-mediated neutrophil apoptosis under intermittent hypoxia.

American journal of respiratory cell and molecular biology 20110701

CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors.

Cytokine 20110701

Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.

Journal of cellular physiology 20110601

The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.

Leukemia & lymphoma 20110601

Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.

Biochimica et biophysica acta 20110601

A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.

International journal of cancer 20110515

The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.

Thrombosis research 20110501

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity.

Journal of molecular and cellular cardiology 20110401

Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.

Hypertension (Dallas, Tex. : 1979) 20110401

Parthenolide inhibits TRIF-dependent signaling pathway of Toll-like receptors in RAW264.7 macrophages.

Molecules and cells 20110331

Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells.

Hypertension (Dallas, Tex. : 1979) 20110301

Suppression of intracellular calcium levels and inhibition of degranulation in RBL-2H3 mast cells by the sesquiterpene lactone parthenolide.

Planta medica 20110201

NFκB inhibitors induce cell death in glioblastomas.

Biochemical pharmacology 20110201

Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue.

Journal of lipid research 20110201

Screening for Compositae sensitization with pure allergens: implications of molecular structure, strength of reaction, and time of testing.

Contact dermatitis 20110201

In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: an approach to their mechanisms of action.

Phytotherapy research : PTR 20110201

Parthenolide, an NF-κB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer.

Cancer genomics & proteomics 20110101

The NFĸB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.

Blood 20101223

Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells.

Experimental & molecular medicine 20101130

Paclitaxel efficacy is increased by parthenolide via nuclear factor-kappaB pathways in in vitro and in vivo human non-small cell lung cancer models.

Current cancer drug targets 20101101

Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101

Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells.

The Journal of pharmacology and experimental therapeutics 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11).

International journal of oncology 20101101

MTA1 coregulator regulates LPS response via MyD88-dependent signaling.

The Journal of biological chemistry 20101022

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.

British journal of haematology 20101001

Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons.

American journal of physiology. Cell physiology 20100901

Patch test reactivity to feverfew-containing creams in feverfew-allergic patients.

Contact dermatitis 20100901

Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.

Microbes and infection 20100801

In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease: a feasibility study.

Inflammatory bowel diseases 20100701

Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.

Natural product research 20100701

Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells.

British journal of pharmacology 20100701

Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells.

European journal of pharmacology 20100610

BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100601

Ghrelin decreases microvascular leak during inflammation.

The Journal of trauma 20100501

Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3.

Journal of leukocyte biology 20100501

Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.

Journal of neuroimmunology 20100415

A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.

Cancer research 20100401

Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells.

Chemico-biological interactions 20100330

Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.

The Journal of biological chemistry 20100326

[Molecular mechanisms of parthenolide's action: Old drug with a new face].

Postepy higieny i medycyny doswiadczalnej (Online) 20100316

Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator.

The Journal of biological chemistry 20100305

Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis.

Planta medica 20100201

Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro.

Melanoma research 20100201

IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.

Immunology letters 20100104

Inhibition of NF-kappaB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells.

International journal of molecular medicine 20100101

[Effect of parthenolide on leukemia K562 cells and its leukemia stem cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.

Molecular cancer 20100101

Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro.

Journal of experimental & clinical cancer research : CR 20100101

[Parthenolide inhibits neuroinflammation and promotes neurogenesis in the ischemic striatum following transient middle cerebral artery occlusion in the adult rat brain].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20091101

Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).

Bioorganic & medicinal chemistry letters 20090801

Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.

Expert opinion on investigational drugs 20090801

NF-kappaB regulates androgen receptor expression and prostate cancer growth.

The American journal of pathology 20090801

Effect of parthenolide on proliferation and apoptosis in gastric cancer cell line SGC7901.

Journal of digestive diseases 20090801

Screening biomaterials for stimulation of nitric oxide-mediated inflammation.

Journal of biomedical materials research. Part A 20090701

CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

Journal of the American Society of Nephrology : JASN 20090701

Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo.

Molecular cancer research : MCR 20090701

Parthenolide inhibits proliferation of vascular smooth muscle cells through induction of G0/G1 phase cell cycle arrest.

Journal of Zhejiang University. Science. B 20090701

Tanacetum vulgare: antiherpes virus activity of crude extract and the purified compound parthenolide.

Phytotherapy research : PTR 20090601

Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach.

The Prostate 20090601

Nuclear factor-[kappa]B inhibition provides additional protection against ischaemia/reperfusion injury in delayed sevoflurane preconditioning.

European journal of anaesthesiology 20090601

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

The Journal of pharmacology and experimental therapeutics 20090501

IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells.

Molecular endocrinology (Baltimore, Md.) 20090501

Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation.

The Journal of urology 20090501

A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.

Pancreas 20090501

Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis.

Parasitology research 20090401

Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives.

Bioorganic & medicinal chemistry letters 20090401

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

British journal of pharmacology 20090401

Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells.

Radiation research 20090401

JP-8 induces immune suppression via a reactive oxygen species NF-kappabeta-dependent mechanism.

Toxicological sciences : an official journal of the Society of Toxicology 20090301

Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.

Molecular cancer therapeutics 20090301

Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium).

Inflammopharmacology 20090201

Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-kappaB and mitochondrial cytochrome c cascade.

Journal of cellular and molecular medicine 20090101

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

BMC systems biology 20090101

Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

PloS one 20090101

Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells.

Chinese medical journal 20081220

Depressant-like effects of parthenolide in a rodent behavioural antidepressant test battery.

The Journal of pharmacy and pharmacology 20081201

Cytotoxic effects of catechol to neuroblastoma N2a cells.

General physiology and biophysics 20081201

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

Rheumatology (Oxford, England) 20081101

Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.

Clinical advances in hematology & oncology : H&O 20081101

NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.

Breast cancer research and treatment 20081001

Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells.

Molecular pharmacology 20080801

Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro.

Inflammation 20080801

Antileukemic activity of aminoparthenolide analogs.

Bioorganic & medicinal chemistry letters 20080715

A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes.

Journal of controlled release : official journal of the Controlled Release Society 20080702

Inhibition of Nod2 signaling and target gene expression by curcumin.

Molecular pharmacology 20080701

Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.

Blood 20080615

Inhibitory effects of parthenolide on antigen-induced microtubule formation and degranulation in mast cells.

International immunopharmacology 20080601

Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.

Journal of applied toxicology : JAT 20080501

Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and p53- and hsp72-independent apoptosis induction via the nuclear factor-kappaB signal pathway.

International journal of molecular medicine 20080501

Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.

Biochemical and biophysical research communications 20080418

Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells.

Cancer chemotherapy and pharmacology 20080401

Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.

Pharmacology, biochemistry, and behavior 20080401

Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.

European journal of pharmacology 20080331

[Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes].

Zhonghua yi xue za zhi 20080318

Antimyeloma effects of a sesquiterpene lactone parthenolide.

Clinical cancer research : an official journal of the American Association for Cancer Research 20080315

Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms.

Experimental parasitology 20080301

Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression.

Archives of dermatological research 20080201

Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB.

Journal of pharmacological sciences 20080201

The lipophilic hapten parthenolide induces interferon-gamma and interleukin-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro.

The British journal of dermatology 20080101

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.

Genome biology 20080101

Implications of the involvement of the endoplasmic reticulum stress pathway in drug-induced apoptosis.

Anticancer research 20080101

Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20080101

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

Folia histochemica et cytobiologica 20080101

An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

Blood 20071215

Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair.

Radiation research 20071201

The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.

Molecular cancer therapeutics 20070901

Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.

Cancer letters 20070828

Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS.

Journal of cellular physiology 20070801

Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury.

American journal of physiology. Renal physiology 20070701

Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated.

Chemistry & biology 20070701

Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.

International journal of cancer 20070615

Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.

American journal of respiratory cell and molecular biology 20070601

Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9.

Cell research 20070601

Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo.

Molecular cancer therapeutics 20070601

The solution and solid state stability and excipient compatibility of parthenolide in feverfew.

AAPS PharmSciTech 20070601

Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice.

Archives of biochemistry and biophysics 20070515

Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.

Life sciences 20070403

Parthenolide inhibits tubulin carboxypeptidase activity.

Cancer research 20070401

Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts.

Immunology letters 20070315

Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes.

Biochimica et biophysica acta 20070301

Compositae dermatitis from airborne parthenolide.

The British journal of dermatology 20070301

The leukemic stem cell.

Best practice & research. Clinical haematology 20070301

Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes.

Free radical biology & medicine 20070215

Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.

Journal of immunology (Baltimore, Md. : 1950) 20070215

TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells.

Cellular & molecular immunology 20070201

Parthenolide reduces cisplatin-induced renal damage.

Toxicology 20070125

Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research 20070101

Quantitative estimation of parthenolide in Tanacetum parthenium (L.) Schultz-Bip. cultivated in Egypt.

Journal of AOAC International 20070101

Understanding interactions between and among apoptosis inducing pathways in tumor cells.

In vivo (Athens, Greece) 20070101

Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells.

Pharmacological reports : PR 20070101

Antiapoptotic proteins as targets for bioactive compounds.

Polish journal of veterinary sciences 20070101

Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity.

Apoptosis : an international journal on programmed cell death 20061201

Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.

Cytokine 20061101

Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model.

The Prostate 20061001

Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

Planta medica 20061001

Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology 20060801

[Proliferation inhibiting and apoptosis inducing effects of parthenolide on human multiple myeloma cells].

Zhonghua yi xue za zhi 20060725

Estrogen dependent growth inhibitory effects of tamoxifen but not genistein in solid tumors derived from estrogen receptor positive (ER+) primary breast carcinoma MCF7: single agent and novel combined treatment approaches.

Bulletin du cancer 20060701

Quantification of parthenolide in Tanacetum species by LC-UV/LC-MS and microscopic comparison of Mexican/US feverfew samples.

Die Pharmazie 20060701

Artemisolide from Artemisia asiatica: nuclear factor-kappaB (NF-kappaB) inhibitor suppressing prostaglandin E2 and nitric oxide production in macrophages.

Archives of pharmacal research 20060701

The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro.

Leukemia 20060601

Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.

Molecular cancer research : MCR 20060601

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation.

Cancer research 20060501

Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB.

American journal of physiology. Regulatory, integrative and comparative physiology 20060401

Contact allergy to herbal teas derived from Asteraceae plants.

Contact dermatitis 20060401

Parthenolide has limited effects on nuclear factor-kappa beta increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice.

Cytokine 20060321

Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

Journal of cellular biochemistry 20060201

CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27.

Experimental dermatology 20060201

Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo.

The Journal of endocrinology 20060201

Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.

Endocrinology 20060101

Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines.

Journal of medicinal food 20060101

Probing protein function with small molecules.

Ernst Schering Research Foundation workshop 20060101

Inhibition of DMXAA-induced tumor necrosis factor production in murine splenocyte cultures by NF-kappaB inhibitors.

Oncology research 20060101

Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways.

Carcinogenesis 20051201

Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolide.

The Journal of pharmacology and experimental therapeutics 20051101

Processing of a sesquiterpene lactone by Papilio glaucus caterpillars.

Journal of chemical ecology 20051101

Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.

Biochimica et biophysica acta 20050915

Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.

The Journal of investigative dermatology 20050901

Feverfew: weeding out the root of leukaemia.

Expert opinion on biological therapy 20050901

[Effects of parthenolide on the activity and expression of urokinase type plasminogen activator in PGCL3 cells].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050901

Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.

Cephalalgia : an international journal of headache 20050801

Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids.

The Journal of nutritional biochemistry 20050801

Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis.

Cancer research 20050715

Intracellular redox state regulation by parthenolide.

Biochemical and biophysical research communications 20050701

NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis.

Cell biology international 20050701

Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.

The Journal of rheumatology 20050701

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

Blood 20050601

The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer.

Molecular cancer therapeutics 20050601

Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly.

Journal of plant physiology 20050501

Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy.

The Journal of biological chemistry 20050429

Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.

Cell death and differentiation 20050401

Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.

Cancer research 20050401

Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

Molecular cancer therapeutics 20050401

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

Journal of biochemistry and molecular biology 20050331

Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050301

NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis.

Journal of immunology (Baltimore, Md. : 1950) 20050201

A potent apoptosis-inducing activity of a sesquiterpene lactone, arucanolide, in HL60 cells: a crucial role of apoptosis-inducing factor.

Journal of pharmacological sciences 20050201

The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.

Molecular cancer therapeutics 20050101

Sabarubicin- (MEN 10755) and paclitaxel show different kinetics in nuclear factor-kappaB (NF-kB) activation: effect of parthenolide on their cytotoxicity.

Anticancer research 20050101

Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis.

Oncogene 20041118

Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.

Carcinogenesis 20041101

Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20041101

Microtubule-interfering activity of parthenolide.

Chemico-biological interactions 20041015

Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot.

Pharmacology, biochemistry, and behavior 20041001

Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.

Oncogene 20040923

Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1.

Acta pharmacologica Sinica 20040901

Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

Cancer letters 20040810

Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.

Carcinogenesis 20040801

Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.

Investigational new drugs 20040801

Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential.

Life sciences 20040702

NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen.

Annals of oncology : official journal of the European Society for Medical Oncology 20040601

The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release.

European journal of immunology 20040601

Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells.

Cancer letters 20040528

Modulation of inhibitor kappaB kinase/ nuclear factor kappaB signaling during critical illness: a double-edged sword.

Critical care medicine 20040501

Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells.

Cardiovascular research 20040401

Effect of C-reactive protein on chemokine expression in human aortic endothelial cells.

Journal of molecular and cellular cardiology 20040301

NF-kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability.

Stroke 20040201

Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest.

Anticancer research 20040101

Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death.

Redox report : communications in free radical research 20040101

Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20031201

Transport of parthenolide across human intestinal cells (Caco-2).

Planta medica 20031101

Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031001

Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.

FEBS letters 20030925

Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis.

Critical care medicine 20030901

Nuclear factor-kappaB: is it a therapeutic target for the adjuvant treatment of sepsis?

Critical care medicine 20030901

NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: difficulties in identification of dead cells in such cultures.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030801

Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis.

Stroke 20030701

[Sbudies on the effect of parthenolide on the proliferation of rat vascular smooth muscle cells and the mechanism].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701

Parthenolide and its photochemically synthesized 1(10)Z isomer: chemical reactivity and structure-activity relationship studies in human leucocyte chemotaxis.

Bioorganic & medicinal chemistry 20030403

Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1.

Journal of immunology (Baltimore, Md. : 1950) 20030215

Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. Shock 17(2):127-134, 2002.

Shock (Augusta, Ga.) 20030201

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.

The Journal of biological chemistry 20030131

Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation.

Advances in enzyme regulation 20030101

Cell cycle effects and caspase-dependent and independent death of HL-60 and Jurkat cells treated with the inhibitor of NF-kappaB parthenolide.

Cell cycle (Georgetown, Tex.) 20030101

Characterization of the molecular events following impairment of NF-kappaB-driven transcription in neurons.

Brain research. Molecular brain research 20021230

The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.

European journal of immunology 20021201

The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells.

Cell death and differentiation 20021101

Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells.

Journal of neuroimmunology 20021101

GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.

The Journal of biological chemistry 20021011

Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide.

The Journal of biological chemistry 20021011

Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis.

The American journal of pathology 20021001

Variations in parthenolide content and daily dose of feverfew products.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020815

The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway.

The Journal of allergy and clinical immunology 20020801

Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13.

Biochemistry 20020618

Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.

Molecular pharmacology 20020501

Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.

Biochemical and biophysical research communications 20020412

Nuclear factor-kappaB as a molecular target for migraine therapy.

Annals of neurology 20020401

Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activity.

British journal of pharmacology 20020301

Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury.

Shock (Augusta, Ga.) 20020201

Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells.

Anticancer research 20020101

GC determination of parthenolide in feverfew products.

Die Pharmazie 20011201

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.

The Journal of biological chemistry 20011026

Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector.

Gene therapy 20010901

6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.

Biochemical pharmacology 20010815

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.

Chemistry & biology 20010801

Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: involvement of nuclear factor-kappaB.

Immunology letters 20010702

Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts.

Cellular immunology 20010501

Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.

Oncogene 20010419

A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation.

Planta medica 20010301

Voltammetric determination of parthenolide in spiked human plasma and urine.

Phytochemical analysis : PCA 20010101

A new sesquiterpene lactone from Tsoongiodendron odorum Chun.

Journal of Asian natural products research 20010101

Augmentation of apoptosis responses in p53-deficient L1210 cells by compounds directed at blocking NFkappaB activation.

Anticancer research 20010101

Antimycobacterial evaluation of germacranolides.

Phytochemistry 19980901

Anti-inflammatory effects of South American Tanacetum vulgare.

The Journal of pharmacy and pharmacology 19980901