Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

Molecular cell 20120713

Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.

Mutagenesis 20120701

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.

Bioorganic & medicinal chemistry 20120615

A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.

European journal of human genetics : EJHG 20120601

Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine.

DNA repair 20120601

Management of glioblastoma in the elderly.

Clinical advances in hematology & oncology : H&O 20120601

Malignant progression in O6-methylguanine-DNA methyltransferase-deficient esophageal cancer cells is associated with Ezrin protein.

DNA and cell biology 20120501

DNA glycosylases: in DNA repair and beyond.

Chromosoma 20120201

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas.

NeuroImage 20120116

Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats.

Carcinogenesis 20120101

Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction.

Analytical and bioanalytical chemistry 20120101

Temozolomide: mechanisms of action, repair and resistance.

Current molecular pharmacology 20120101

Why do results conflict regarding the prognostic value of the methylation status in colon cancers? The role of the preservation method.

BMC cancer 20120101

MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR.

Journal of translational medicine 20120101

MutS homologue hMSH5: role in cisplatin-induced DNA damage response.

Molecular cancer 20120101

Detection of 1p19q deletion by real-time comparative quantitative PCR.

Biomarker insights 20120101

Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.

International journal of molecular sciences 20120101

Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.

PloS one 20120101

Methylation-mediated molecular dysregulation in clinical oral malignancy.

Journal of oncology 20120101

Strategies to improve the killing of tumors using temozolomide: targeting the DNA repair protein MGMT.

Current medicinal chemistry 20120101

Inhibition of ENNG-induced pyloric stomach and small intestinal carcinogenesis in mice by high temperature- and pressure-treated garlic.

Asian Pacific journal of cancer prevention : APJCP 20120101

The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.

PloS one 20120101

Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

Cancer prevention research (Philadelphia, Pa.) 20111101

Aberrant DNA methylation and prostate cancer.

Current genomics 20111101

Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?

International journal of environmental research and public health 20111001

Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine.

Journal of molecular biology 20110923

Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours.

British journal of cancer 20110906

Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair.

Physical biology 20110801

Role of DNA methylation in head and neck cancer.

Clinical epigenetics 20110801

Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine.

Carcinogenesis 20110701

Synergistic cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine and absence of poly(ADP-ribose) glycohydrolase involves chromatin decondensation.

International journal of oncology 20110701

Quantitative analysis of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas.

Journal of neuro-oncology 20110601

O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.

Brain tumor pathology 20110401

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

Cell death & disease 20110401

Role of alkyltransferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus.

Mutagenesis 20110301

MGMT is a molecular determinant for potency of the DNA-EGFR-combi-molecule ZRS1.

Molecular cancer research : MCR 20110301

O6-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications.

Journal of neuro-oncology 20110201

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

Journal of neuro-oncology 20110201

Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas.

The American journal of surgical pathology 20110201

[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110201

Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.

Clinical cancer research : an official journal of the American Association for Cancer Research 20110115

Development and validation of a new, sensitive immunochemical assay for O⁶-methylguanine in DNA and its application in a population study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110101

Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

PloS one 20110101

Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.

Journal of biomedicine & biotechnology 20110101

O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction.

BMC cancer 20110101

Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis.

International journal of environmental research and public health 20110101

NNK-Induced Lung Tumors: A Review of Animal Model.

Journal of oncology 20110101

Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy.

Journal of translational medicine 20110101

Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence.

Infectious diseases in obstetrics and gynecology 20110101

The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.

Molecular cancer 20110101

Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates.

PloS one 20110101

Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.

PloS one 20110101

Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells.

PloS one 20110101

Submicroscopic interstitial deletion of chromosome 11q22.3 in a girl with mild mental retardation and facial dysmorphism: Case report.

Molecular cytogenetics 20110101

Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.

Molecular cancer 20110101

Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.

PloS one 20110101

Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.

PloS one 20110101

The role of tobacco-derived carcinogens in pancreas cancer.

ISRN oncology 20110101

Innovative Therapies against Human Glioblastoma Multiforme.

ISRN oncology 20110101

Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity.

PloS one 20110101

Direct detection and sequencing of damaged DNA bases.

Genome integrity 20110101

The prognostic impact of O6-methylguanine DNA methyltransferase and epidermal growth factor receptor expressions on primary gliosarcoma: a clinicopathologic and immunohistochemical study of seven cases at a single institution.

Indian journal of pathology & microbiology 20110101

[Induction of repair enzyme O6-methylguanine-DNA methyltransferase gene expression under the influence of cytokine EMAP II in human cells in vitro].

TSitologiia i genetika 20110101

Prevention of human papillomavirus-related malignancies of the female genital tract.

Infectious diseases in obstetrics and gynecology 20110101

A rapid, simple DNA mismatch repair substrate construction method.

Frontiers in oncology 20110101

Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.

The Journal of biological chemistry 20101224

Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.

The Journal of biological chemistry 20101224

Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

Carcinogenesis 20101201

O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment.

Neurosurgery 20101201

Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.

Biochemical pharmacology 20101101

Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.

Molecular pharmacology 20101101

Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.

Gut 20101101

Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.

British journal of cancer 20101026

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.

Human mutation 20101001

Clinical significance of molecular biomarkers in glioblastoma.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100901

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide.

British journal of cancer 20100629

Epigenetic aberrations and therapeutic implications in gliomas.

Cancer science 20100601

Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20100601

[The expression of O6-methylguanine DNA methyltransferase and p53 in non-small cell lung cancer and the association with the prognosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20100601

CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection.

Gastroenterology 20100501

Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.

The Journal of biological chemistry 20100430

RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine.

DNA repair 20100404

Recent advances in combined modality therapy.

The oncologist 20100401

O(6)-methylguanine in DNA: bad penny?

Cell cycle (Georgetown, Tex.) 20100201

Interaction of murine dnmt3a with DNA containing o6-methylguanine.

Biochemistry. Biokhimiia 20100201

Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).

Cancer biology & therapy 20100101

Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles.

Cell cycle (Georgetown, Tex.) 20100101

Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20100101

MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1.

PloS one 20100101

O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients.

Neuro-oncology 20100101

Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference.

BMC cancer 20100101

Activated CD4+ T cells enhance radiation effect through the cooperation of interferon-gamma and TNF-alpha.

BMC cancer 20100101

Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

BMC cancer 20100101

Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.

Breast cancer research : BCR 20100101

Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation.

BMC cancer 20100101

Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

PloS one 20100101

DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences.

Journal of nucleic acids 20100101

Temozolomide in malignant glioma.

OncoTargets and therapy 20100101

Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by Human and Yeast DNA Polymerase η.

Journal of nucleic acids 20100101

Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.

Journal of nucleic acids 20100101

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation.

Molecular cancer 20100101

Combining modularity, conservation, and interactions of proteins significantly increases precision and coverage of protein function prediction.

BMC genomics 20100101

Role of bevacizumab therapy in the management of glioblastoma.

Cancer management and research 20100101

Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.

Asian Pacific journal of cancer prevention : APJCP 20100101

Different threshold levels for 2-amino-3,8 dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4 (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.

Molecular medicine reports 20100101

O6-methylguanine repair by O6-alkylguanine-DNA alkyltransferase.

The journal of physical chemistry. B 20091224

Is inactivation of O6-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?

Leukemia & lymphoma 20091201

A quantum chemical study of repair of O6-methylguanine to guanine by tyrosine: evaluation of the winged helix-turn-helix model.

Journal of molecular modeling 20091101

Gas-phase thermochemical properties of the damaged base O(6)-methylguanine versus adenine and guanine.

The Journal of organic chemistry 20091002

The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

Molecular pharmacology 20091001

Repair of O6-methylguanine to guanine by cysteine in the absence and presence of histidine and by cysteine thiolate anion: a quantum chemical study.

Physical chemistry chemical physics : PCCP 20091001

Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.

Radiation research 20091001

Epigenetic cross-talk between DNA methylation and histone modifications in human cancers.

Yonsei medical journal 20090831

Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides.

The Journal of biological chemistry 20090821

Correlation of chromosomes 1p and 19q status and expressions of O6-methylguanine DNA methyltransferase (MGMT), p53 and Ki-67 in diffuse gliomas of World Health Organization (WHO) grades II and III: a clinicopathological study.

Neuropathology and applied neurobiology 20090801

Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy.

British journal of cancer 20090707

MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.

Annals of oncology : official journal of the European Society for Medical Oncology 20090701

Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression.

Oncology reports 20090701

Flipping of alkylated DNA damage bridges base and nucleotide excision repair.

Nature 20090611

Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.

Cancer science 20090601

Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Drug metabolism and disposition: the biological fate of chemicals 20090601

Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090301

A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.

Oncogene 20090226

Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells.

Biochemical and biophysical research communications 20090206

The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.

Neuro-oncology 20090201

Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20090201

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.

DNA repair 20090101

Epidemiology of brain tumors.

Methods in molecular biology (Clifton, N.J.) 20090101

O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors.

PloS one 20090101

Molecular neuropathology of gliomas.

International journal of molecular sciences 20090101

Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation.

BMC cancer 20090101

Temozolomide and cisplatin in relapsed/refractory acute leukemia.

Journal of hematology & oncology 20090101

Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains.

BMC microbiology 20090101

Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum.

Asian Pacific journal of cancer prevention : APJCP 20090101

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.

Cancer research 20081201

IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression.

Molecular cancer therapeutics 20081201

Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.

Mutagenesis 20080901

Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.

PLoS genetics 20080901

Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes.

Clinical interventions in aging 20080901

An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein.

Journal of biochemistry 20080801

Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.

Molecular pharmacology 20080801

Different initial steps of apoptosis induced by two types of antineoplastic drugs.

Biochemical pharmacology 20080801

Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells.

Carcinogenesis 20080601

A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.

Analytical biochemistry 20080601

Inhibition of the 5' to 3' exonuclease activity of hEXO1 by 8-oxoguanine.

Environmental and molecular mutagenesis 20080601

Effect of O6-methylguanine on the stability of G-quadruplex DNA.

Journal of the American Chemical Society 20080528

Mechanisms of chemoresistance to alkylating agents in malignant glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research 20080515

Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

[Methylnitrosourea as challenge mutagen in assessment of the DNA mismatch repair (MMR) activity: association with some types of cancer].

Genetika 20080501

Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency.

Mutation research 20080402

Ras regulation of DNA-methylation and cancer.

Experimental cell research 20080401

Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions.

Histopathology 20080401

Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction.

Mutation research 20080227

Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri.

Neurology 20080219

Mismatch repair proteins collaborate with methyltransferases in the repair of O(6)-methylguanine.

DNA repair 20080201

Molecular diagnostic testing in malignant gliomas: a practical update on predictive markers.

Journal of neuropathology and experimental neurology 20080101

K-ras mutations in sinonasal cancers in relation to wood dust exposure.

BMC cancer 20080101

Acetylation regulates WRN catalytic activities and affects base excision DNA repair.

PloS one 20080101

B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.

PloS one 20080101

Promoter methylation inhibits BRD7 expression in human nasopharyngeal carcinoma cells.

BMC cancer 20080101

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.

BMC genomics 20080101

High-fidelity correction of genomic uracil by human mismatch repair activities.

BMC molecular biology 20080101

Cell death upon epigenetic genome methylation: a novel function of methyl-specific deoxyribonucleases.

Genome biology 20080101

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway.

Journal of experimental & clinical cancer research : CR 20080101

Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine.

DNA repair 20071201

Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells.

International journal of cancer 20071115

From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

Cellular and molecular life sciences : CMLS 20071001

Nelarabine: a novel purine antimetabolite antineoplastic agent.

Clinical therapeutics 20070901

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

Cancer research 20070815

Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair.

Cell death and differentiation 20070801

MGMT: a personal perspective.

DNA repair 20070801

Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B cell lymphoma.

Annals of hematology 20070801

Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.

Cancer research 20070715

The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.

Bioorganic & medicinal chemistry 20070515

Methylation of O6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival.

Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

Silencing of O6-methylguanine DNA methyltransferase in the absence of promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa.

Oncology reports 20070401

Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.

American journal of clinical pathology 20070301

Dose response relationship in anti-stress gene regulatory networks.

PLoS computational biology 20070301

Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by 'wobble' pairing between O6-methylguanine and cytosine, but accurate bypass is preferred.

The Journal of biological chemistry 20070112

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

Oncogene 20070111

A distinct epigenetic signature at targets of a leukemia protein.

BMC genomics 20070101

Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.

PloS one 20070101

Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.

PloS one 20070101

The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.

Nucleosides, nucleotides & nucleic acids 20070101

Prostate cancer epigenetics: a review on gene regulation.

Gene regulation and systems biology 20070101

Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk.

Carcinogenesis 20061101

Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061010

DNA stability in the gas versus solution phases: a systematic study of thirty-one duplexes with varying length, sequence, and charge level.

Journal of the American Society for Mass Spectrometry 20061001

A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.

Cancer gene therapy 20060901

DNA damage-induced cell death by apoptosis.

Trends in molecular medicine 20060901

Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts.

The Journal of biological chemistry 20060811

Role of temozolomide in pediatric brain tumors.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20060701

Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk.

Pharmacogenetics and genomics 20060701

DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.

Clinical lung cancer 20060701

High frequency and strong prognostic relevance of O6-methylguanine DNA methyltransferase silencing in diffuse large B-cell lymphomas from the Middle East.

Human pathology 20060601

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.

Molecular cell 20060519

The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.

Organic & biomolecular chemistry 20060507

In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells.

Molecular therapy : the journal of the American Society of Gene Therapy 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.

Cancer 20060415

Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403

DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors.

The Journal of pharmacology and experimental therapeutics 20060201

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

Journal of neurochemistry 20060201

Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.

The Journal of molecular diagnostics : JMD 20060201

Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity.

The journal of medical investigation : JMI 20060201

Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.

Journal of the National Cancer Institute 20060104

[Comparison of geno- and cytotoxicity of methylnitrosourea on MMR-proficient and MMR-deficient human tumor cell lines].

Tsitologiia 20060101

Promoter hypermethylation of DNA repair gene MGMT in laryngeal squamous cell carcinoma.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

Molecular cancer 20060101

Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220

Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis.

Cancer letters 20050908

Epigenetic silencing of the MGMT gene in cancer.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20050801

Nelarabine: a nucleoside analog with efficacy in T-cell and other leukemias.

The Annals of pharmacotherapy 20050601

Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis.

Biochemistry 20050510

[Effect of beta-carotene supplementation on DNA oxidative and alkylation damage in rats].

Wei sheng yan jiu = Journal of hygiene research 20050501

Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.

Cancer research 20050415

Genetic pathways to glioblastomas.

Neuropathology : official journal of the Japanese Society of Neuropathology 20050301

Lack of EGF receptor contributes to drug sensitivity of human germline cells.

British journal of cancer 20050131

Inhibition by allyl sulfides and crushed garlic of O6-methylguanine formation in liver DNA of dimethylnitrosamine-treated rats.

Nutrition and cancer 20050101

Electrochemical detection of lesions in DNA.

Bioconjugate chemistry 20050101

PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells.

Nucleic acids research 20050101

Epigenetics of cervical cancer. An overview and therapeutic perspectives.

Molecular cancer 20050101

Intra- and intercellular variations in the repair efficiency of O6-methylguanine, and their contribution to kinetic complexity.

Mutation research 20041221

The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo.

The Journal of pharmacology and experimental therapeutics 20041201

Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041201

Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.

Oncogene 20040805

Proofreading activity of Pfu thermostable DNA polymerase on a 6-O-methylguanine-containing template monitored by ESI-FTICR mass spectrometry.

Chembiochem : a European journal of chemical biology 20040705

DNA damage and repair measured in different genomic regions using the comet assay with fluorescent in situ hybridization.

Mutagenesis 20040701

Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins.

Bioorganic & medicinal chemistry letters 20040607

The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.

DNA repair 20040603

Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.

Current opinion in investigational drugs (London, England : 2000) 20040601

Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients.

Oncogene 20040513

Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations.

DNA repair 20040401

Detection of O6-carboxymethyl-2'-deoxyguanosine in DNA following reaction of nitric oxide with glycine and in human blood DNA using a quantitative immunoslot blot assay.

Chemical research in toxicology 20040301

The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.

Chemical research in toxicology 20040301

[Promoter hypermethylation of DNA repair gene O6-methylguanine DNA methyltransferase in laryngeal squamous cell carcinoma].

Zhonghua er bi yan hou ke za zhi 20040301

Guanine 6-O-methylation pattern within the dioxin responsive element of the CYP1A1 enhancer shows two critical guanines for AhR/ARNT binding.

Chemistry & biodiversity 20040301

Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

Journal of medicinal chemistry 20040129

Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Biochemistry 20040120

Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

Oncogene 20040115

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

Oncogene 20040108

Promoter methylation status of multiple genes in brain metastases of solid tumors.

International journal of molecular medicine 20040101

O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.

Bioconjugate chemistry 20040101

Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.

Cytogenetic and genome research 20040101

DNA damage processing and aberration formation in plants.

Cytogenetic and genome research 20040101

Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities.

Molecular cancer 20040101

BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20040101

The syntheses of tricyclic analogues of O6-methylguanine.

Organic & biomolecular chemistry 20031207

The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the 'bypass' DNA polymerase eta and the replicative DNA polymerase alpha.

Chemical research in toxicology 20031201

O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics.

Chemical research in toxicology 20031101

Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus.

The Biochemical journal 20031015

The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells.

Cancer research 20030915

Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family.

Emerging infectious diseases 20030701

In vivo protection of hematopoietic cells from alkylator-mediated DNA damage.

Current hematology reports 20030701

Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Chemical research in toxicology 20030601

K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts.

Chemical research in toxicology 20030401

DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system.

Journal of chemotherapy (Florence, Italy) 20030401

Mutation analysis of K-ras and beta-catenin genes related to O6-methylguanin-DNA methyltransferase and mismatch repair protein status in human gallbladder carcinoma.

International journal of molecular medicine 20030101

Evaluation of O6-methylguanine DNA methyltransferase activity in patients with gastric cancer.

Oncology research 20030101

Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells.

Chemical research in toxicology 20030101

Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. natalensis.

Asian Pacific journal of cancer prevention : APJCP 20030101

Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase.

The International journal of biological markers 20030101

Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse.

Nutrition and cancer 20030101

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine.

Mutagenesis 20021101

O6-benzylguanine-mediated enhancement of chemotherapy.

Molecular cancer therapeutics 20020901

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.

Journal of medicinal chemistry 20020801

DNA repair in resistance to alkylating anticancer drugs.

International journal of clinical pharmacology and therapeutics 20020801

Pharmacological strategies to increase the antitumor activity of methylating agents.

Current medicinal chemistry 20020701

DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.

Mutation research 20020320

Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats.

The journal of medical investigation : JMI 20020201

Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine.

Biochemistry 20020122

Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.

Biochemistry 20020122

Monitoring for DNA damage of humans occupationally exposed to methyl bromide.

Anticancer research 20020101

Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity.

Journal of experimental therapeutics & oncology 20020101

Glutathione S-transferase and O6-methylguanine DNA methyl transferase activities in patients with thyroid papillary carcinoma.

Cancer investigation 20020101

Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.

Cancer research 20011201

Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers.

Annals of surgical oncology 20011201

The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.

Chemico-biological interactions 20011128

Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.

Mutation research 20011101

Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.

Mutation research 20010822

Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

Cancer research 20010815

Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA.

Mutation research 20010808

High-performance liquid chromatographic method with electrochemical detection for the analysis of O6-methylguanine.

Journal of chromatography. B, Biomedical sciences and applications 20010805

Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

Cancer research 20010801

Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA.

The Journal of pharmacology and experimental therapeutics 20010701

Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.

Chemical research in toxicology 20010701

The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.

The Journal of biological chemistry 20010629

Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.

Mutation research 20010602

[Repair of alkylated DNA and consequences of its failure].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010601

Micellar electrokinetic capillary chromatography quantification of cytosine arabinoside and its metabolite, uracil arabinoside, in human serum.

Journal of chromatography. B, Biomedical sciences and applications 20010415

Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro.

Mutation research 20010404

Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

Cancer chemotherapy and pharmacology 20010401

Health span and life span in transgenic mice with modulated DNA repair.

Annals of the New York Academy of Sciences 20010401

Role of cytochrome P450 in DNA damage produced by treatment of colon cells with 1,2-dimethylhydrazine.

International journal of oncology 20010301

Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries.

Carcinogenesis 20010301

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

Cancer research 20010301

Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon.

The journal of medical investigation : JMI 20010201

Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

Cancer research 20010101

DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.

Progress in nucleic acid research and molecular biology 20010101

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.

Progress in nucleic acid research and molecular biology 20010101

O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer.

Nutrition and cancer 20010101

Novel DNA repair alkyltransferase from Caenorhabditis elegans.

Environmental and molecular mutagenesis 20010101

DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.

Mutation research 20000401

Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.

Mutation research 20000214

Chromium(III) decreases the fidelity of human DNA polymerase beta.

Biochemistry 19980630