Home Carboxys phosphoric acid ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

phosphoric acid ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

CAS No.:
204255-11-8
Catalog Number:
AG0029D4
Molecular Formula:
C16H31N2O8P
Molecular Weight:
410.3997
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$75
- +
5g
98%
In Stock USA
United States
$294
- +
10g
98%
In Stock USA
United States
$475
- +
Product Description
Catalog Number:
AG0029D4
Chemical Name:
phosphoric acid ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
CAS Number:
204255-11-8
Molecular Formula:
C16H31N2O8P
Molecular Weight:
410.3997
MDL Number:
MFCD08059548
IUPAC Name:
ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;phosphoric acid
InChI:
InChI=1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1
InChI Key:
PGZUMBJQJWIWGJ-ONAKXNSWSA-N
SMILES:
OP(=O)(O)O.CCOC(=O)C1=C[C@H]([C@@H]([C@H](C1)N)NC(=O)C)OC(CC)CC
UNII:
4A3O49NGEZ
Properties
Complexity:
468  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
410.182g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
410.404g/mol
Monoisotopic Mass:
410.182g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
168A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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A case of asthma-complicated influenza myocarditis. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110601
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Study of specific oligosaccharide structures related with swine flu (H1N1) and avian flu, and tamiflu as their remedy. Journal of microbiology and biotechnology 20110501
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Neuraminidase-inhibitor resistance testing for pandemic influenza A (H1N1) 2009 in Ontario, Canada. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20110301
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An influenza outbreak among pilgrims sleeping at a school without purpose built overnight accommodation facilities. Communicable diseases intelligence quarterly report 20110301
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Influenza A (H1N1) virus-induced hepatocellular injury in a kidney transplant patient. Transplant infectious disease : an official journal of the Transplantation Society 20110201
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Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20110201
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Pandemic pharmaceutical dosing effects on wastewater treatment: no adaptation of activated sludge bacteria to degrade the antiviral drug oseltamivir (Tamiflu®) and loss of nutrient removal performance. FEMS microbiology letters 20110201
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Detection of an oseltamivir-resistant pandemic influenza A/H1N1 virus in the United Arab Emirates. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101
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Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method. Biomedical chromatography : BMC 20090801
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Investigation of steric and functionality limits in the enzymatic dihydroxylation of benzoate esters. Versatile intermediates for the synthesis of pseudo-sugars, amino cyclitols, and bicyclic ring systems. Organic & biomolecular chemistry 20090621
Patient-oriented pandemic influenza research. Lancet (London, England) 20090620
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Detection limit used for early warning in public health surveillance. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090601
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Rapid spread of drug-resistant influenza A viruses in the Basque Country, northern Spain, 2000-1 to 2008-9. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20090521
A short and practical synthesis of oseltamivir phosphate (Tamiflu) from (-)-shikimic acid. The Journal of organic chemistry 20090515
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A Bayesian model for evaluating influenza antiviral efficacy in household studies with asymptomatic infections. Biostatistics (Oxford, England) 20090401
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Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1. Antiviral research 20090401
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Adherence with oseltamivir chemoprophylaxis among workers exposed to poultry during avian influenza outbreaks in southern Israel. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20090301
Evolution of drug resistance in multiple distinct lineages of H5N1 avian influenza. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20090301
On the structure-based design of novel inhibitors of H5N1 influenza A virus neuraminidase (NA). Biophysical chemistry 20090301
Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems. Chemosphere 20090301
Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir. ChemMedChem 20090301
Cost-effectiveness of treating influenzalike illness with oseltamivir in the United States. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090301
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Antiviral resistance in influenza viruses circulating in Central and South America based on the detection of established genetic markers. Influenza and other respiratory viruses 20090301
Use of oseltamivir after influenza infection is associated with reduced incidence of recurrent adverse cardiovascular outcomes among military health system beneficiaries with prior cardiovascular diseases. Circulation. Cardiovascular quality and outcomes 20090301
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Use of oseltamivir in 12 European countries between 2002 and 2007--lack of association with the appearance of oseltamivir-resistant influenza A(H1N1) viruses. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20090205
Update on oseltamivir-resistant pandemic A (H1N1) 2009 influenza virus: January 2010. Releve epidemiologique hebdomadaire 20090205
Influenza outbreak management on a locked behavioral health unit. American journal of infection control 20090201
Aurintricarboxylic acid inhibits influenza virus neuraminidase. Antiviral research 20090201
Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants. Drug metabolism and disposition: the biological fate of chemicals 20090201
Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug metabolism and disposition: the biological fate of chemicals 20090201
Probing molecular level interaction of oseltamivir with H5N1-NA and model membranes by molecular docking, multinuclear NMR and DSC methods. Biochimica et biophysica acta 20090201
Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral microbiology and immunology 20090201
Neuropsychiatric concerns related to influenza treatment. The Nurse practitioner 20090201
Emergence of oseltamivir-resistant influenza A/H3N2 virus with altered hemagglutination pattern in a hematopoietic stem cell transplant recipient. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20090201
Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007-08. Emerging infectious diseases 20090201
Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation. Health technology assessment (Winchester, England) 20090201
Molecular characterization and phylogenetic analysis of H3N2 human influenza A viruses in Cheongju, South Korea. Journal of microbiology (Seoul, Korea) 20090201
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Effects of Clinacanthus siamensis leaf extract on influenza virus infection. Microbiology and immunology 20090201
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More resistance to oseltamivir (Tamiflu). The Medical letter on drugs and therapeutics 20090126
Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochemical pharmacology 20090115
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A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type reaction. Angewandte Chemie (International ed. in English) 20090101
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High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three 'one-pot' operations. Angewandte Chemie (International ed. in English) 20090101
Isolation of oseltamivir-resistant influenza A/H1N1 virus of different origins in Yokohama City, Japan, during the 2007-2008 influenza season. Japanese journal of infectious diseases 20090101
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