Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.

Cellular and molecular neurobiology 20121001

Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.

The Journal of pharmacology and experimental therapeutics 20121001

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.

Neuroscience 20120918

Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats.

European journal of pharmacology 20120915

Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome.

American journal of physiology. Endocrinology and metabolism 20120915

Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.

Naunyn-Schmiedeberg's archives of pharmacology 20120901

Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.

European journal of pharmacology 20120815

Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.

European journal of applied physiology 20120801

Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension.

Recent patents on cardiovascular drug discovery 20120801

[Effect of Fasudil on the phenotype conversion of LPS-stimulated BV-2 microglia].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801

Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.

Biochemical and biophysical research communications 20120727

ROCK1 feedback regulation of the upstream small GTPase RhoA.

Cellular signalling 20120701

Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon.

Arthritis care & research 20120601

Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.

Toxicology letters 20120601

The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.

Cancer chemotherapy and pharmacology 20120601

Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.

The American journal of pathology 20120601

Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway.

Stem cells and development 20120501

Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration.

Oncology reports 20120501

Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.

Lupus 20120501

Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.

Atherosclerosis 20120501

The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120401

Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.

Journal of cellular physiology 20120301

[Progress in pharmacotherapy of pulmonary arterial hypertension in children].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301

Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.

European journal of clinical pharmacology 20120201

Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.

Stroke 20120201

Effects of fasudil in patients with high-altitude pulmonary hypertension.

The European respiratory journal 20120201

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride.

Neuroscience 20120103

Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.

Neuroradiology 20120101

Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver.

Journal of hepatology 20120101

Cardioprotective effect of a combination of Rho-kinase inhibitor and p38 MAPK inhibitor on cardiovascular remodeling and oxidative stress in Dahl rats.

Journal of atherosclerosis and thrombosis 20120101

[Fasudil improves erectile function of hypertensive rats].

Zhonghua nan ke xue = National journal of andrology 20120101

Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.

Cancer biology & therapy 20120101

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.

BMC medicine 20120101

High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.

Cardiovascular diabetology 20120101

Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.

Swiss medical weekly 20120101

ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion.

Cardiovascular diabetology 20120101

Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.

International journal of molecular sciences 20120101

Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.

PloS one 20120101

Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.

Molecular and cellular biochemistry 20111201

Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.

American journal of physiology. Lung cellular and molecular physiology 20111201

Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.

The Journal of clinical endocrinology and metabolism 20111201

Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.

The Journal of surgical research 20111201

Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201

Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage.

Genetics and molecular research : GMR 20111129

Preventive effects of fasudil on adriamycin-induced cardiomyopathy: possible involvement of inhibition of RhoA/ROCK pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

American journal of physiology. Lung cellular and molecular physiology 20111101

Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.

Plastic and reconstructive surgery 20111101

[Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition].

Nippon Ganka Gakkai zasshi 20111101

[Fasudil(Rho-kinase inhibitor)].

Nihon rinsho. Japanese journal of clinical medicine 20111101

The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

Journal of neuroimmunology 20111028

Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.

Journal of neurosurgery 20111001

Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats.

Clinical and experimental pharmacology & physiology 20111001

Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.

Arteriosclerosis, thrombosis, and vascular biology 20111001

Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.

Chinese medical journal 20111001

Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901

The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.

International journal of molecular medicine 20110901

[Rho-kinase inhibitors].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901

Rho kinase as a therapeutic target in cardiovascular disease.

Future cardiology 20110901

Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats.

Die Pharmazie 20110901

Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.

Biochemical and biophysical research communications 20110812

Agonist-induced periodic vasomotion in rat isolated pulmonary artery.

Fundamental & clinical pharmacology 20110801

Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.

The Journal of thoracic and cardiovascular surgery 20110801

Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.

International journal of molecular medicine 20110801

Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts.

Arteriosclerosis, thrombosis, and vascular biology 20110801

Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.

Journal of the neurological sciences 20110715

Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.

American journal of physiology. Cell physiology 20110701

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.

Journal of cellular biochemistry 20110701

Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.

The Journal of pharmacology and experimental therapeutics 20110701

Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.

The Journal of pharmacology and experimental therapeutics 20110701

Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.

Mycopathologia 20110701

[The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium].

Zhonghua nei ke za zhi 20110701

Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.

Medical oncology (Northwood, London, England) 20110601

The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.

British journal of pharmacology 20110601

Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.

Cellular & molecular biology letters 20110601

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts.

Clinical and experimental pharmacology & physiology 20110601

[Anti-hepatofibrosis effect of fasudil hydrochloride on Schistosoma japonicum-infected mice].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110601

ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.

Microvascular research 20110501

Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid.

International journal of cardiology 20110414

Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.

Journal of applied physiology (Bethesda, Md. : 1985) 20110401

Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.

Cellular and molecular neurobiology 20110301

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Bioorganic & medicinal chemistry letters 20110215

Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats.

The journal of sexual medicine 20110201

Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.

Kidney international 20110201

Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase.

Brain research bulletin 20110201

HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.

Cancer science 20110201

Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.

Science signaling 20110125

Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.

Investigative ophthalmology & visual science 20110105

Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.

Life sciences 20110103

Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil.

Pediatric pulmonology 20110101

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.

Toxicology and applied pharmacology 20110101

Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.

Atherosclerosis 20110101

Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.

Urologia internationalis 20110101

Rho kinase inhibition in diabetic nephropathy.

Current opinion in nephrology and hypertension 20110101

Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.

Cellular immunology 20110101

Advances in treatment of cerebral vasospasm: an update.

Acta neurochirurgica. Supplement 20110101

Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.

Acta neurochirurgica. Supplement 20110101

Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases.

Acta neurochirurgica. Supplement 20110101

Continuous intravertebral artery injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

Neurology India 20110101

Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

Neurology India 20110101

Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats.

International journal of molecular sciences 20110101

Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101

Vasodilatation produced by fasudil mesylate in vivo and in vitro.

Vascular pharmacology 20110101

Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.

Renal failure 20110101

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

PloS one 20110101

Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.

Renal failure 20110101

Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.

Neurologia medico-chirurgica 20110101

Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.

Biological & pharmaceutical bulletin 20110101

Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

American journal of physiology. Heart and circulatory physiology 20101201

Urotensin II alters vascular reactivity in animals subjected to volume overload.

Peptides 20101101

Identification of small molecules enhancing autophagic function from drug network analysis.

Autophagy 20101101

[Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target].

Nippon Ganka Gakkai zasshi 20101101

[Effect of notch signaling on differentiation of rat marrow mesenchymal stem cells into neurons induced by fasudil hydrochloride].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20101101

Characterization of Fasudil in preclinical models of pain.

The journal of pain : official journal of the American Pain Society 20101001

Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.

The European respiratory journal 20101001

Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery.

Journal of ethnopharmacology 20100915

Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.

The Journal of pharmacology and experimental therapeutics 20100901

Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Hypertension research : official journal of the Japanese Society of Hypertension 20100901

Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.

Journal of neurochemistry 20100901

Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.

Canadian journal of physiology and pharmacology 20100901

NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.

American journal of physiology. Heart and circulatory physiology 20100801

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.

Brain research 20100716

Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.

Journal of applied physiology (Bethesda, Md. : 1985) 20100701

Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20100605

Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.

Neuropathology : official journal of the Japanese Society of Neuropathology 20100601

Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor.

Journal of neuroscience research 20100601

Modulation of cerebral malaria by fasudil and other immune-modifying compounds.

Experimental parasitology 20100601

Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.

Cancer biology & therapy 20100601

Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.

Current opinion in critical care 20100401

Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.

Bone 20100401

Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.

British journal of pharmacology 20100401

Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.

Medical science monitor : international medical journal of experimental and clinical research 20100401

Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.

The Thoracic and cardiovascular surgeon 20100401

Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.

Stem cell reviews 20100301

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.

Heart and vessels 20100301

Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.

Regulatory peptides 20100225

Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts.

Neuroscience letters 20100205

Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.

Pediatric research 20100201

Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice.

Molecular and cellular neurosciences 20100201

The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100201

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.

Journal of vascular surgery 20100201

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.

Brain research bulletin 20100115

The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100101

Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.

Arthritis and rheumatism 20100101

Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.

Neurologia medico-chirurgica 20100101

Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.

Endocrine journal 20100101

HA1077 enhances the cytokeratin expression of mesenchymal stem cells.

Journal of burn care & research : official publication of the American Burn Association 20100101

The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.

Experimental diabetes research 20100101

Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.

Journal of Alzheimer's disease : JAD 20100101

Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632.

Journal of biochemical and molecular toxicology 20100101

Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.

PloS one 20100101

Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.

PloS one 20100101

Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients.

Atherosclerosis 20091201

Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.

International journal of urology : official journal of the Japanese Urological Association 20091201

Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201

Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat.

Canadian journal of physiology and pharmacology 20091201

A Rho-kinase inhibitor, fasudil, attenuates progressive glomerulosclerosis induced by daunorubicin in rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20091201

Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.

Neurochemistry international 20091101

Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.

Brain, behavior, and immunity 20091101

Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice.

Atherosclerosis 20091101

Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.

Prostaglandins & other lipid mediators 20091101

Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.

American journal of physiology. Heart and circulatory physiology 20091101

Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation.

Brain research 20091027

Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.

Journal of viral hepatitis 20091001

Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm.

Cardiovascular & hematological agents in medicinal chemistry 20091001

[Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090901

[Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro].

Sheng li xue bao : [Acta physiologica Sinica] 20090825

Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.

Canadian journal of physiology and pharmacology 20090801

Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.

International journal of molecular medicine 20090701

Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.

The Journal of pharmacology and experimental therapeutics 20090501

Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.

American journal of physiology. Renal physiology 20090501

Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.

American journal of physiology. Heart and circulatory physiology 20090501

Vascular dysfunction in septic shock--any ROCKing news?

Critical care medicine 20090501

Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease.

Pediatric cardiology 20090401

Rho GTPases in hepatocellular carcinoma.

Biochimica et biophysica acta 20090401

Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.

Cellular and molecular neurobiology 20090301

Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.

Clinica chimica acta; international journal of clinical chemistry 20090301

Increased leukocyte ROCK activity in patients after acute ischemic stroke.

Brain research 20090227

Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.

Circulation journal : official journal of the Japanese Circulation Society 20090201

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.

Brain : a journal of neurology 20090201

Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.

Archives of pharmacal research 20090201

Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.

Ai zheng = Aizheng = Chinese journal of cancer 20090201

Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.

Biochemical pharmacology 20090115

Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.

European journal of pharmacology 20090114

Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.

Diabetes 20090101

Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.

American journal of physiology. Endocrinology and metabolism 20090101

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.

Pharmacology 20090101

In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.

Neonatology 20090101

The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.

Current eye research 20090101

Signaling through Rho GTPase pathway as viable drug target.

Current medicinal chemistry 20090101

Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway.

Surgery today 20090101

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.

Cardiovascular diabetology 20090101

RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.

Journal of cardiac surgery 20090101

Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.

Current topics in medicinal chemistry 20090101

A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation.

The Journal of thoracic and cardiovascular surgery 20081201

A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation.

Journal of computer-aided molecular design 20081101

Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.

American journal of physiology. Lung cellular and molecular physiology 20081101

Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.

Arthritis and rheumatism 20081101

Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.

European journal of pharmacology 20081010

Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.

The Journal of pharmacology and experimental therapeutics 20081001

Fasudil inhibits the myogenic response in the fetal pulmonary circulation.

American journal of physiology. Heart and circulatory physiology 20081001

[Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].

No shinkei geka. Neurological surgery 20081001

Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.

Molecular and cellular endocrinology 20080910

G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

Cardiovascular research 20080901

Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.

British journal of pharmacology 20080901

Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.

Journal of hypertension 20080901

Chronic stable angina pectoris.

Disease-a-month : DM 20080901

Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.

Cardiovascular drugs and therapy 20080801

Activated RHOA and peripheral axon regeneration.

Experimental neurology 20080801

Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.

The British journal of surgery 20080801

Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.

Anesthesia and analgesia 20080601

Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.

Molecular cancer therapeutics 20080601

Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.

Neurologia medico-chirurgica 20080601

Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats.

Journal of the renin-angiotensin-aldosterone system : JRAAS 20080601

Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.

American journal of physiology. Lung cellular and molecular physiology 20080401

Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20080401

Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia.

The Journal of infectious diseases 20080401

Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.

Brain research 20080327

Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.

Diabetes 20080301

Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.

Hepatology (Baltimore, Md.) 20080301

Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.

American journal of physiology. Gastrointestinal and liver physiology 20080301

Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.

The American journal of pathology 20080301

Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina.

Coronary artery disease 20080301

Rho kinase inhibition: a new approach for treating diabetic nephropathy?

Diabetes 20080301

Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.

Journal of cardiovascular pharmacology 20080301

Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.

Brain research 20080208

[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].

No shinkei geka. Neurological surgery 20080201

Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.

Journal of cardiovascular pharmacology 20080201

Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.

Journal of cardiovascular pharmacology 20080101

Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.

Japanese journal of ophthalmology 20080101

In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis.

Methods in enzymology 20080101

Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.

Prostaglandins, leukotrienes, and essential fatty acids 20080101

Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.

American journal of physiology. Lung cellular and molecular physiology 20071101

Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.

Journal of neurochemistry 20071001

Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.

American journal of physiology. Gastrointestinal and liver physiology 20071001

Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.

Hypertension (Dallas, Tex. : 1979) 20071001

[Advances in the study of Rho kinase and its inhibitors].

Yao xue xue bao = Acta pharmaceutica Sinica 20071001

[Exercise-induced vasospastic angina].

Nihon rinsho. Japanese journal of clinical medicine 20070928

Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.

Life sciences 20070922

Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.

British journal of pharmacology 20070901

Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.

Spine 20070901

Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.

European journal of pharmacology 20070827

Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.

Journal of neuroscience research 20070815

Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.

Biochemical pharmacology 20070815

The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

Leukemia 20070801

A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.

Surgical neurology 20070801

Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.

Nature reviews. Drug discovery 20070801

Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats.

Journal of cardiovascular pharmacology 20070801

Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.

Journal of cardiovascular pharmacology 20070801

[Effects of fasudil on neuropathic pain-like state in mice].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070801

The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

European journal of pharmacology 20070730

Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide.

American journal of physiology. Heart and circulatory physiology 20070701

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.

Brain research 20070618

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

American journal of physiology. Heart and circulatory physiology 20070601

The RISK of ROCK.

American journal of physiology. Heart and circulatory physiology 20070601

Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601

Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.

Journal of hypertension 20070501

Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.

Molecular cancer therapeutics 20070501

Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.

Circulation 20070403

Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.

American journal of physiology. Heart and circulatory physiology 20070401

Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.

The Tohoku journal of experimental medicine 20070401

Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

Circulation research 20070330

RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.

The Journal of biological chemistry 20070316

Progress of the study of rho-kinase and future perspective of the inhibitor.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301

A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.

The Journal of endocrinology 20070301

Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.

Journal of cardiovascular pharmacology 20070301

Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.

Journal of the American College of Cardiology 20070213

The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system.

Plastic and reconstructive surgery 20070201

Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.

Journal of cardiovascular pharmacology 20070201

Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

Brain research 20070112

Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.

Chinese medical journal 20070105

Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.

Pharmacological research 20070101

Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.

Diabetes 20070101

Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract.

Journal of clinical pharmacology 20070101

Fasudil: a potential addition to the anti-arthritis weaponry.

Medical hypotheses 20070101

Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.

The Journal of veterinary medical science 20070101

RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.

Neurourology and urodynamics 20070101

Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.

Japanese journal of ophthalmology 20070101

Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.

Circulation research 20061208

Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway.

Cardiovascular research 20061201

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.

Journal of cardiovascular pharmacology 20061201

[Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20061201

Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.

American journal of physiology. Lung cellular and molecular physiology 20061101

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.

Journal of neuroimmunology 20061101

Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model.

The journal of sexual medicine 20061101

[Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061101

ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.

Circulation research 20061013

Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury.

Journal of the peripheral nervous system : JPNS 20060901

[Role of the Rho/Rho-kinase pathway in the development of hypertensive glomerulosclerosis: renoprotective effect of Rho-kinase inhibitor in hypertensive glomerulosclerosis and its molecular mechanism].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.

Molecular cancer therapeutics 20060901

Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.

Neurologia medico-chirurgica 20060901

Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901

Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.

Experimental neurology 20060801

Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.

Journal of the American Society of Nephrology : JASN 20060801

In vivo X-ray angiography in the mouse brain using synchrotron radiation.

Stroke 20060701

Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats.

Hypertension (Dallas, Tex. : 1979) 20060601

Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.

Journal of vascular surgery 20060601

[Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].

Zhonghua yi xue za zhi 20060516

Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.

Journal of leukocyte biology 20060501

Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.

Autonomic & autacoid pharmacology 20060401

Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris.

Circulation journal : official journal of the Japanese Circulation Society 20060401

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

Journal of applied physiology (Bethesda, Md. : 1985) 20060301

Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.

Biological & pharmaceutical bulletin 20060301

Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.

Structure (London, England : 1993) 20060301

Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.

American journal of physiology. Lung cellular and molecular physiology 20060201

Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension.

Circulation journal : official journal of the Japanese Circulation Society 20060201

Involvement of Rho-kinase in experimental vascular endothelial dysfunction.

Molecular and cellular biochemistry 20060201

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.

The Journal of biological chemistry 20060106

Rho-kinase as a molecular target for insulin resistance and hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101

Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.

Journal of pharmacological sciences 20060101

Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis.

Journal of pharmacological sciences 20060101

Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.

Protein and peptide letters 20060101

Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats.

Pharmacology 20060101

Effect of fasudil on macrovascular disorder-induced endothelial dysfunction.

Canadian journal of physiology and pharmacology 20060101

Development of specific Rho-kinase inhibitors and their clinical application.

Biochimica et biophysica acta 20051230

Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.

European journal of pharmacology 20051219

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.

British journal of pharmacology 20051201

Smoking, endothelial function, and Rho-kinase in humans.

Arteriosclerosis, thrombosis, and vascular biology 20051201

Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial.

Journal of the neurological sciences 20051115

Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial.

Journal of the American College of Cardiology 20051115

Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.

American journal of physiology. Heart and circulatory physiology 20051101

Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.

British journal of pharmacology 20051101

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

Stroke 20051001

[Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study].

No to shinkei = Brain and nerve 20050901

Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells.

Liver international : official journal of the International Association for the Study of the Liver 20050801

Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.

Arteriosclerosis, thrombosis, and vascular biology 20050701

Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.

American journal of physiology. Heart and circulatory physiology 20050601

Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.

American journal of physiology. Heart and circulatory physiology 20050601

Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.

Circulation 20050531

Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.

Circulation 20050503

Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.

European journal of pharmacology 20050411

Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice.

European journal of pharmacology 20050411

Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.

Hypertension (Dallas, Tex. : 1979) 20050401

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

American journal of respiratory and critical care medicine 20050301

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.

Heart (British Cardiac Society) 20050301

Small guanine nucleotide-binding protein Rho and myocardial function.

Acta pharmacologica Sinica 20050301

Rho-kinase and myosin II activities are required for cell type and environment specific migration.

Genes to cells : devoted to molecular & cellular mechanisms 20050201

[Intra-arterial administration of fasudil hydrochloride: duration of action].

No shinkei geka. Neurological surgery 20050201

[The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil].

Zhonghua xin xue guan bing za zhi 20050101

Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta.

Naunyn-Schmiedeberg's archives of pharmacology 20041101

Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.

British journal of pharmacology 20041001

[Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].

Journal of cardiology 20041001

Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.

European journal of pharmacology 20040913

Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats.

Journal of hypertension 20040901

Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.

Journal of cardiovascular pharmacology 20040901

Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.

Brain research 20040820

[Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

Circulation 20040511

Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401

Rho kinase inhibition initiates apoptosis in human airway epithelial cells.

American journal of respiratory cell and molecular biology 20040301

Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.

American journal of physiology. Heart and circulatory physiology 20040301

[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].

Nihon rinsho. Japanese journal of clinical medicine 20040301

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.

Circulation research 20040220

[Rho-kinase inhibitor].

Nihon rinsho. Japanese journal of clinical medicine 20040201

Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.

Circulation research 20040109

Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.

Arteriosclerosis, thrombosis, and vascular biology 20040101

Differential effects of Rho-kinase inhibition on artery wall mass and remodeling.

Journal of vascular surgery 20040101

The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis.

Drug news & perspectives 20040101

Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.

Cell biochemistry and biophysics 20040101

Rho kinase inhibitors block activation of pancreatic stellate cells.

British journal of pharmacology 20031201

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.

Kidney international 20031201

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

Structure (London, England : 1993) 20031201

Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.

British journal of pharmacology 20031001

Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.

The Journal of biological chemistry 20030822

Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.

European journal of pharmacology 20030711

Astrocyte stellation induced by Rho kinase inhibitors in culture.

Brain research. Developmental brain research 20030612

Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.

Kidney international 20030601

P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.

Journal of immunology (Baltimore, Md. : 1950) 20030601

Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans.

Hypertension (Dallas, Tex. : 1979) 20030501

Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.

Circulation research 20030418

Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.

Biochemical and biophysical research communications 20030411

Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil.

Journal of enzyme inhibition and medicinal chemistry 20030401

Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.

The Journal of physiology 20030315

Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae.

The Journal of physiology 20030201

A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

Brain research 20030103

Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.

Journal of the American College of Cardiology 20030101

Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone.

Journal of vascular research 20030101

RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.

British journal of pharmacology 20021201

[Basic and clinical studies on coronary vasospasm].

Masui. The Japanese journal of anesthesiology 20021201

Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.

European journal of pharmacology 20021129

Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats.

Life sciences 20021122

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.

Journal of cardiovascular pharmacology 20021101

The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein.

American journal of physiology. Heart and circulatory physiology 20021001

Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho.

Circulation research 20020906

Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.

Prostaglandins & other lipid mediators 20020901

[Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension].

Fukuoka igaku zasshi = Hukuoka acta medica 20020801

Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.

Biochimica et biophysica acta 20020612

Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.

The Biochemical journal 20020601

Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story?

Circulation 20020402

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.

Circulation 20020402

Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.

Life sciences 20020322

Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.

Journal of cardiovascular pharmacology 20020301

Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

International journal of pharmaceutics 20020131

The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway.

Pharmacology & therapeutics 20020101

Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.

British journal of pharmacology 20011201

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.

Hypertension (Dallas, Tex. : 1979) 20011201

Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils.

Mediators of inflammation 20011201

Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20011101

Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats.

European journal of pharmacology 20010907

Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.

British journal of pharmacology 20010901

Antiischemic properties of fasudil in experimental models of vasospastic angina.

Japanese journal of pharmacology 20010901

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.

Life sciences 20010810

Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.

Archives of ophthalmology (Chicago, Ill. : 1960) 20010801

Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.

Journal of cellular physiology 20010701

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.

Cardiovascular research 20010701

Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701

Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

Experimental cell research 20010610

Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage.

Neurosurgery 20010401

Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.

FEBS letters 20010330

Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.

Neurologia medico-chirurgica 20010301

Rho-associated kinase phosphorylates MARCKS in human neuronal cells.

Biochemical and biophysical research communications 20010126

Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.

Journal of muscle research and cell motility 20010101

Effect of Fasudil HCl, a protein kinase inhibitor, on cerebral vasospasm.

Acta neurochirurgica. Supplement 20010101

Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.

Acta neurochirurgica. Supplement 20010101

A novel drug delivery system as prophylaxis for cerebral vasospasm.

Acta neurochirurgica. Supplement 20010101

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

The Biochemical journal 20001001

Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.

AIDS research and human retroviruses 19980301

Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877.

Stroke 19940601

[Treatment of cerebral vasospasm by a protein kinase inhibitor AT 877].

No to shinkei = Brain and nerve 19930901

Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.

British journal of pharmacology 19891201