Home Other Building Blocks 6-Methoxy-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole

6-Methoxy-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole

CAS No.:
20315-68-8
Catalog Number:
AG0028PB
Molecular Formula:
C12H14N2O
Molecular Weight:
202.2524
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
95%
In Stock USA
United States
$188
- +
500mg
95%
In Stock USA
United States
$313
- +
1g
95%
In Stock USA
United States
$438
- +
5g
95%
In Stock USA
United States
$998
- +
Product Description
Catalog Number:
AG0028PB
Chemical Name:
6-Methoxy-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole
CAS Number:
20315-68-8
Molecular Formula:
C12H14N2O
Molecular Weight:
202.2524
MDL Number:
MFCD00012071
IUPAC Name:
6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
InChI:
InChI=1S/C12H14N2O/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11/h2-3,6,13-14H,4-5,7H2,1H3
InChI Key:
QYMDEOQLJUUNOF-UHFFFAOYSA-N
SMILES:
COc1ccc2c(c1)c1CCNCc1[nH]2
Properties
Complexity:
234  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
202.111g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
202.257g/mol
Monoisotopic Mass:
202.111g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
37A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  
Literature
Title Journal
Prospective acetylcholinesterase inhibitory activity of indole and its analogs. Bioorganic & medicinal chemistry letters 20120415
Effects of spider venom toxin PWTX-I (6-Hydroxytrypargine) on the central nervous system of rats. Toxins 20110201
In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline. Journal of pineal research 20100801
Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage. International journal of molecular sciences 20100101
Pinoline may be used as a probe for CYP2D6 activity. Drug metabolism and disposition: the biological fate of chemicals 20090301
Pinoline and N-acetylserotonin reduce glutamate-induced lipid peroxidation in retinal homogenates. Neuroscience letters 20070202
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters 20061115
Protective effect of melatonin and pinoline on nitric oxide-induced lipid and protein peroxidation in rat brain homogenates. Neuroscience letters 20060911
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Antioxidant activity of melatonin and a pinoline derivative on linoleate model system. Journal of pineal research 20050801
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Effects of vitamin E and pinoline on retinal lipid peroxidation. Clinical & experimental optometry 20040501
Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorganic & medicinal chemistry letters 20040223
Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorganic & medicinal chemistry letters 20040223
Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorganic & medicinal chemistry letters 20031215
Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. European journal of pharmacology 20031215
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 20030601
Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20030101
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Properties