Home Sulfos 2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-

2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-

CAS No.:
202409-33-4
Catalog Number:
AG002878
Molecular Formula:
C18H15ClN2O2S
Molecular Weight:
358.8419
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
98%(HPLC)
In Stock USA
United States
$168
- +
1g
98%(HPLC)
In Stock USA
United States
$393
- +
5g
98%(HPLC)
In Stock USA
United States
$1139
- +
Product Description
Catalog Number:
AG002878
Chemical Name:
2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-
CAS Number:
202409-33-4
Molecular Formula:
C18H15ClN2O2S
Molecular Weight:
358.8419
MDL Number:
MFCD06797512
IUPAC Name:
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
InChI:
InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
InChI Key:
MNJVRJDLRVPLFE-UHFFFAOYSA-N
SMILES:
Clc1cnc(c(c1)c1ccc(cc1)S(=O)(=O)C)c1ccc(nc1)C
UNII:
WRX4NFY03R
Properties
Complexity:
514  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
358.054g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
358.84g/mol
Monoisotopic Mass:
358.054g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
68.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3  
Literature
Title Journal
Downregulation of NF-κB and PCNA in the regulatory pathways of apoptosis by cyclooxygenase-2 inhibitors in experimental lung cancer. Molecular and cellular biochemistry 20121001
Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120901
Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review. The Journal of rheumatology. Supplement 20120901
Pain pharmacotherapy in patients with inflammatory arthritis and concurrent cardiovascular or renal disease: a Cochrane systematic review. The Journal of rheumatology. Supplement 20120901
Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib. European heart journal 20120801
Acupuncture as an adjunctive therapy to pharmacological treatment in patients with chronic pain due to osteoarthritis of the knee: a 3-armed, randomized, placebo-controlled trial. Pain 20120801
Perioperative use of etoricoxib reduces pain and opioid side-effects after total abdominal hysterectomy: a double-blind, randomized, placebo-controlled phase III study. Current medical research and opinion 20120801
Preoperative administration of etoricoxib in patients undergoing hip replacement causes inhibition of inflammatory mediators and pain relief. European journal of pain (London, England) 20120701
Chemopreventive effects of NSAIDs as inhibitors of cyclooxygenase-2 and inducers of apoptosis in experimental lung carcinogenesis. Molecular and cellular biochemistry 20120701
Pharmacokinetics and cardiovascular effect of etoricoxib in the absence or presence of St. John's Wort in rats. Arzneimittel-Forschung 20120701
Pioglitazone, etoricoxib, interferon-α, and metronomic capecitabine for metastatic renal cell carcinoma: final results of a prospective phase II trial. Medical oncology (Northwood, London, England) 20120601
A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatology international 20120601
[Effective pain management after hallux valgus correction]. Pflege Zeitschrift 20120601
Prescription of and adherence to non-steroidal anti-inflammatory drugs and gastroprotective agents in at-risk gastrointestinal patients. The American journal of gastroenterology 20120501
Single dose oral etoricoxib for acute postoperative pain in adults. The Cochrane database of systematic reviews 20120418
Prophylactic etoricoxib is effective in preventing 'first of Ramadan' headache: a placebo-controlled double-blind and randomized trial of prophylactic etoricoxib for ritual fasting headache. Headache 20120401
Glycosylation of human cyclooxygenase-2 (COX-2) decreases the efficacy of certain COX-2 inhibitors. Pharmacological research 20120401
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry 20120308
Panniculitis with arthralgia in patients with melanoma treated with selective BRAF inhibitors and its management. Archives of dermatology 20120301
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. The Cochrane database of systematic reviews 20120215
Detection of a minor amorphous phase in crystalline etoricoxib by dynamic mechanical analysis: comparison with Raman spectroscopy and modulated differential scanning calorimetry. Journal of pharmaceutical sciences 20120201
Fixed drug eruption caused by etoricoxib with tolerance to celecoxib and parecoxib. Contact dermatitis 20120201
Determination of free and total warfarin concentrations in plasma using UPLC MS/MS and its application to a patient samples. Biomedical chromatography : BMC 20120101
Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats. Journal of molecular neuroscience : MN 20120101
Sensitivity of single-domain versus multiple-domain outcome measures to identify responders in chronic low-back pain: pooled analysis of 2 placebo-controlled trials of etoricoxib. The Clinical journal of pain 20120101
Analgesic effect of etoricoxib (Arcoxia®) 120 mg during retinal laser photocoagulation. European journal of ophthalmology 20120101
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells. Pharmacological research 20120101
Differential role of cyclooxygenase isozymes on neuronal density in hippocampus CA1 region of intracerebroventricular streptozotocin treated rat brain. Journal of chemical neuroanatomy 20120101
Short stay and less pain after ambulatory anterior cruciate ligament (ACL) repair: COX-2 inhibitor versus glucocorticoid versus both combined. Acta anaesthesiologica Scandinavica 20120101
A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials. Current medical research and opinion 20120101
Effects of combination therapy with celecoxib and doxycycline on neointimal hyperplasia and inflammatory biomarkers in coronary artery disease patients treated with bare metal stents. Yonsei medical journal 20120101
Factors implicated in radiation therapy failure and radiosensitization of prostate cancer. Prostate cancer 20120101
Do nonsteroidal anti-inflammatory drugs affect bone healing? A critical analysis. TheScientificWorldJournal 20120101
Reactive arthritis after the intravesical instillation of BCG. Reumatologia clinica 20120101
Adoption of new drugs by physicians: a survival analysis. BMC health services research 20120101
Case report: safety and efficacy of tocilizumab in a patient with rheumatoid arthritis and chronic hepatitis C. Case reports in medicine 20120101
Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison. The open rheumatology journal 20120101
Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20120101
Gingival squamous cell carcinoma: A diagnostic impediment. Journal of Indian Society of Periodontology 20120101
Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers. TheScientificWorldJournal 20120101
Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791. PloS one 20120101
Upregulation of intrinsic apoptotic pathway in NSAIDs mediated chemoprevention of experimental lung carcinogenesis. Pharmacological reports : PR 20120101
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis). The Cochrane database of systematic reviews 20111109
Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. Allergy 20111101
Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity. The Cochrane database of systematic reviews 20111005
Patch testing in fixed drug eruptions--a 20-year review. Contact dermatitis 20111001
CONSORT recommendations in abstracts of randomised, controlled trials on migraine and headache. The journal of headache and pain 20111001
Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials. Alimentary pharmacology & therapeutics 20111001
Further assessment of the clinically effective dose range of etoricoxib: a randomized, double-blinded, placebo-controlled trial in rheumatoid arthritis. Current medical research and opinion 20111001
Protective effect of Etoricoxib against middle cerebral artery occlusion induced transient focal cerebral ischemia in rats. European journal of pharmacology 20110930
The use of etoricoxib and celecoxib for pain prevention after periodontal surgery: a double-masked, parallel-group, placebo-controlled, randomized clinical trial. Journal of periodontology 20110901
Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies. Arthritis care & research 20110901
Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS medicine 20110901
Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat. The Indian journal of medical research 20110901
6-Methyl-nicotinic acid. Acta crystallographica. Section E, Structure reports online 20110901
Defects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors. British journal of pharmacology 20110701
A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways. Journal of leukocyte biology 20110701
Individualized cost-effectiveness analysis. PLoS medicine 20110701
Etoricoxib-induced fixed drug eruption with positive lesional patch tests. Cutaneous and ocular toxicology 20110601
Certolizumab pegol plus methotrexate provides broad relief from the burden of rheumatoid arthritis: analysis of patient-reported outcomes from the RAPID 2 trial. Annals of the rheumatic diseases 20110601
Evaluation of NT-proBNP and high sensitivity C-reactive protein for predicting cardiovascular risk in patients with arthritis taking longterm nonsteroidal antiinflammatory drugs. The Journal of rheumatology 20110601
2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Annals of the rheumatic diseases 20110601
The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel. Annals of the rheumatic diseases 20110501
Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction. Pain 20110501
Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder. Cancer chemotherapy and pharmacology 20110401
Inhibitory effect of selective cyclooxygenase-2 inhibitor etoricoxib on human organic anion transporter 3 (hOAT3). Drug metabolism letters 20110401
Acetylsalicylate reduces endothelial and platelet-derived microparticles in patients with coronary artery disease. Canadian journal of physiology and pharmacology 20110401
Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses. Molecular therapy : the journal of the American Society of Gene Therapy 20110301
Predictors of response to cyclo-oxygenase-2 inhibitors in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib, and placebo. Pain medicine (Malden, Mass.) 20110301
Corticosteroids or cyclooxygenase 2-selective inhibitor medication for the management of pain and swelling after third-molar surgery. The Journal of craniofacial surgery 20110301
ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Annals of the rheumatic diseases 20110201
Fixed drug eruption caused by etoricoxib--2 cases confirmed by patch testing. Contact dermatitis 20110201
The headache of the day of awe--no more? Headache 20110201
Development of multiple myeloma in a case of longstanding ankylosing spondylitis: more than a coincidence? International journal of rheumatic diseases 20110201
Effects of preemptive analgesia in laparoscopic cholecystectomy: a double-blind randomized controlled trial. Surgical endoscopy 20110101
A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20110101
Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. The Clinical journal of pain 20110101
Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ (Clinical research ed.) 20110101
NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies. PloS one 20110101
Common secondary causes of resistant hypertension and rational for treatment. International journal of hypertension 20110101
Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study. Arthritis research & therapy 20110101
Heme oxygenase/carbon monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib, a selective COX-2 inhibitor. Pharmacological reports : PR 20110101
Osteoarthritis subpopulations and implications for clinical trial design. Arthritis research & therapy 20110101
Development and pharmacological evaluation of cyclodextrin complexes of etoricoxib. Acta poloniae pharmaceutica 20110101
Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis. BMC medicine 20110101
Etoricoxibium picrate. Acta crystallographica. Section E, Structure reports online 20110101
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice. Neuro endocrinology letters 20110101
Prostacyclin: an inflammatory paradox. Frontiers in pharmacology 20110101
Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients. Journal of pharmacology & pharmacotherapeutics 20110101
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC complementary and alternative medicine 20110101
Definition of nonresponse to analgesic treatment of arthritic pain: an analytical literature review of the smallest detectable difference, the minimal detectable change, and the minimal clinically important difference on the pain visual analog scale. International journal of inflammation 20110101
Longitudinal numbers-needed-to-treat (NNT) for achieving various levels of analgesic response and improvement with etoricoxib, naproxen, and placebo in ankylosing spondylitis. BMC musculoskeletal disorders 20110101
Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway. International journal of rheumatology 20110101
Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents. Scientia pharmaceutica 20110101
Taste masked microspheres of ofloxacin: formulation and evaluation of orodispersible tablets. Scientia pharmaceutica 20110101
Preparation and Characterization of Metformin Hydrochloride - Compritol 888 ATO Solid Dispersion. Journal of young pharmacists : JYP 20110101
Single dose oral analgesics for acute postoperative pain in adults. The Cochrane database of systematic reviews 20110101
Meta-analysis of efficacy and safety of intravenous ferric carboxymaltose (Ferinject) from clinical trial reports and published trial data. BMC blood disorders 20110101
Dissolution behavior of β-cyclodextrin molecular inclusion complexes of aceclofenac. Journal of pharmacy & bioallied sciences 20110101
Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing. Nutrition & metabolism 20110101
NSAID-sensitive antihistamine-induced urticaria/angioedema. Journal of investigational allergology & clinical immunology 20110101
Non-steroidal anti-inflammatory drug (NSAID) related inhibition of aldosterone glucuronidation and arterial dysfunction in patients with rheumatoid arthritis: a cross-sectional clinical study. BMJ open 20110101
Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous ADR reporting. PloS one 20110101
Inhibition of HERG potassium channels by celecoxib and its mechanism. PloS one 20110101
Altered membrane lipid dynamics and chemoprevention by non-steroidal anti inflammatory drugs during colon carcinogenesis. Nutricion hospitalaria 20110101
Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review. ISRN pharmacology 20110101
Hepatic mitochondrial dysfunction in Friedreich ataxia. BMC neurology 20110101
Paracetamol and the placebo effect in osteoarthritis trials: a missing link? Pain research and treatment 20110101
Simultaneous estimation of etoricoxib and thiocolchicoside by RP-HPLC method in combined dosage forms. Acta poloniae pharmaceutica 20110101
Comparison of published orthopaedic trauma trials following registration in Clinicaltrials.gov. BMC musculoskeletal disorders 20110101
Pharmacokinetic and bioequivalence study of etoricoxib tablet in healthy Bangladeshi volunteers. Arzneimittel-Forschung 20110101
Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacognosy reviews 20110101
Solubility and dissolution enhancement of etoricoxib by solid dispersion technique using sugar carriers. ISRN pharmaceutics 20110101
Formulation and evaluation of olanzapine matrix pellets for controlled release. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101
Modular therapy approach in metastatic castration-refractory prostate cancer. World journal of urology 20101201
Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures? Journal of evaluation in clinical practice 20101201
Numbers-needed-to-treat analyses--do timing, dropouts, and outcome matter? Pooled analysis of two randomized, placebo-controlled chronic low back pain trials. Pain 20101201
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology 20101201
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1. Bioorganic & medicinal chemistry letters 20101201
Long-term tolerability of etoricoxib in different types of NSAID-intolerant subjects. European annals of allergy and clinical immunology 20101201
Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet. International journal of emergency medicine 20101201
Coxibs: a significant therapeutic opportunity. Acta bio-medica : Atenei Parmensis 20101201
Enthalpy relaxation studies of two structurally related amorphous drugs and their binary dispersions. Drug development and industrial pharmacy 20101101
Risk factors for NSAID-associated upper GI clinical events in a long-term prospective study of 34 701 arthritis patients. Alimentary pharmacology & therapeutics 20101101
Compression of the superficial branch of the radial nerve by calcinosis cutis causing neuropathic pain. The Journal of hand surgery, European volume 20101101
Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury. International journal of clinical practice 20101001
Etoricoxib-induced toxic epidermal necrolysis: successful treatment with infliximab. The Journal of dermatology 20101001
Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells. British journal of cancer 20100928
Prophylactic etoricoxib is effective in preventing Yom Kippur headache: a placebo-controlled double-blind and randomized trial of prophylaxis for ritual fasting headache. Headache 20100901
The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100901
Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytotherapy research : PTR 20100901
Leprosy: a precipitating factor for complex regional pain syndrome. Minerva anestesiologica 20100901
Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs). Archives of biochemistry and biophysics 20100815
Preemptive dexamethasone and etoricoxib for pain and discomfort prevention after periodontal surgery: a double-masked, crossover, controlled clinical trial. Journal of periodontology 20100801
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality? Current hypertension reports 20100801
Pain management after elective hallux valgus surgery: a prospective randomized double-blind study comparing etoricoxib and tramadol. Anesthesia and analgesia 20100801
Approval of etoricoxib is unacceptable! Authorised and reimbursed in France, despite an unfavourable risk-benefit balance. Prescrire international 20100801
Chemopreventive role of etoricoxib (MK-0663) in experimental colon cancer: induction of mitochondrial proapoptotic factors. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20100701
Incidence and possible risk factors for clinical upper gastrointestinal events in patients taking selective cyclooxygenase-2 inhibitors: A prospective, observational, cohort study in Taiwan. Clinical therapeutics 20100701
Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy. Anti-cancer agents in medicinal chemistry 20100701
Acute gouty arthritis in a patient after total knee arthroplasty. Wiener klinische Wochenschrift 20100601
Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models. Fundamental & clinical pharmacology 20100601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20100601
Phosphorodiamidate-directed metalation of N-heterocycles using Mg- and Zn-TMP bases. Organic letters 20100507
Pain control in first-trimester surgical abortion: a systematic review of randomized controlled trials. Contraception 20100501
Patient benefit-risk in arthritis--a rheumatologist's perspective. Rheumatology (Oxford, England) 20100501
A review of the gastrointestinal safety data--a gastroenterologist's perspective. Rheumatology (Oxford, England) 20100501
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20100501
Etoricoxib improves pain, function and quality of life: results of a real-world effectiveness trial. International journal of rheumatic diseases 20100501
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. The Journal of pharmacy and pharmacology 20100501
Observation of oscillatory behavior during the dissolution of a pharmaceutical compound and evidence for the existence of an inverse Ostwald rule. Physical chemistry chemical physics : PCCP 20100421
Formulation and evaluation of mouth dissolving tablets of the Etoricoxib. Pakistan journal of pharmaceutical sciences 20100401
Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. British journal of cancer 20100216
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. Blood 20100204
Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice. Annals of the rheumatic diseases 20100201
Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study. Naunyn-Schmiedeberg's archives of pharmacology 20100201
Taste masking of Etoricoxib by using ion-exchange resin. Pharmaceutical development and technology 20100101
Water displacement leg volumetry in clinical studies--a discussion of error sources. BMC medical research methodology 20100101
Bullous fixed drug eruption to etoricoxib--further evidence of intraepidermal CD8+ T cell involvement. European journal of dermatology : EJD 20100101
Management of hyperuricemia in gout: focus on febuxostat. Clinical interventions in aging 20100101
Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data. Pediatric rheumatology online journal 20100101
Effect of etoricoxib, a cyclooxygenase-2 selective inhibitor on aberrant crypt formation and apoptosis in 1,2 dimethyl hydrazine induced colon carcinogenesis in rat model. Nutricion hospitalaria 20100101
Cost effectiveness of etoricoxib versus celecoxib and non-selective NSAIDS in the treatment of ankylosing spondylitis. PharmacoEconomics 20100101
Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature. Dermatology (Basel, Switzerland) 20100101
The effect of prednisolone on reduction of complaints after impacted third molar removal. Stomatologija 20100101
[The assessment of oral NSAID use in patients with rheumatoid arthritis in Hungary--a cross sectional non interventional study]. Acta pharmaceutica Hungarica 20100101
Etoricoxib--preemptive and postoperative analgesia (EPPA) in patients with laparotomy or thoracotomy--design and protocols. Trials 20100101
Role and rationale for the use of milnacipran in the management of fibromyalgia. Neuropsychiatric disease and treatment 20100101
Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion. PloS one 20100101
Preparation and evaluation of transdermal plasters containing norfloxacin: a novel treatment for burn wound healing. Eplasty 20100101
Pregabalin in fibromyalgia--responder analysis from individual patient data. BMC musculoskeletal disorders 20100101
RNAi-based strategies for cyclooxygenase-2 inhibition in cancer. Journal of biomedicine & biotechnology 20100101
High-performance thin-layer chromatographic determination of etoricoxib and thiocolchicoside in combined tablet dosage form. Journal of AOAC International 20100101
Comparison of a minimally invasive posterior approach and the standard posterior approach for total hip arthroplasty A prospective and comparative study. Journal of orthopaedic surgery and research 20100101
Evaluation of chemopreventive response of two cycloxygenase-2 inhibitors, etoricoxib and diclofenac in rat colon cancer using FTIR and NMR spectroscopic techniques. Nutricion hospitalaria 20100101
[Comparative evaluation of the safety and efficacy of etoricoxib and diclofenac on the upper gastrointestinal tract in patients with osteoarthrosis and rheumatoid arthritis (the multinational etoricoxib and diclofenac arthritis long-term (MEDAL) study program)]. Terapevticheskii arkhiv 20100101
Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3. Drug metabolism and pharmacokinetics 20100101
Comparing etoricoxib and celecoxib for preemptive analgesia for acute postoperative pain in patients undergoing arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial. BMC musculoskeletal disorders 20100101
Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. International journal of medical sciences 20100101
Masking the unpleasant taste of etoricoxib by crosslinked acrylic polymer based ion-exchange resin complexation. Polimery w medycynie 20100101
Musculoskeletal pain: prescription of NSAID and weak opioid by primary health care physicians in Sweden 2004-2008 - a retrospective patient record review. Journal of pain research 20100101
Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch. Journal of pain research 20100101
Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis. Asian Pacific journal of cancer prevention : APJCP 20100101
Formulation and evaluation of extended-release solid dispersion of metformin hydrochloride. Journal of young pharmacists : JYP 20100101
Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. Journal of applied oral science : revista FOB 20100101
Is it antiphospholipid syndrome? International journal of rheumatology 20100101
Risk of Upper Gastrointestinal Bleeding in a Cohort of New Users of Low-Dose ASA for Secondary Prevention of Cardiovascular Outcomes. Frontiers in pharmacology 20100101
Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment of acute pain from ankle fracture. Proceedings of the Western Pharmacology Society 20100101
Clinical efficacy of Rasona Pinda in the management of Amavata (rheumatoid arthritis). Ayu 20100101
Do COX-2 inhibitors raise blood pressure more than nonselective NSAIDs and placebo? An updated meta-analysis. Journal of hypertension 20091201
A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective cox-2 inhibitors as an example. PLoS medicine 20091201
Gastrointestinal and cardiovascular risk of non-selective NSAIDs and COX-2 inhibitors in elderly patients with knee osteoarthritis. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20091201
COX-2 inhibitors in patients with sensitivity to nonselective NSAIDs. The New England journal of medicine 20091126
Prescription rates of protective co-therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines. Alimentary pharmacology & therapeutics 20091001
Examination of the effect of increasing doses of etoricoxib on oral methotrexate pharmacokinetics in patients with rheumatoid arthritis. Journal of clinical pharmacology 20091001
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20091001
MRI and clinical findings in patients with ankylosing spondylitis eligible for anti-tumour necrosis factor therapy after a short course of etoricoxib. Annals of the rheumatic diseases 20090901
Women's health and gender-based clinical trials on etoricoxib: methodological gender bias. Journal of public health (Oxford, England) 20090901
Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib and placebo. Rheumatology (Oxford, England) 20090901
Study on mechanism for amorphous drug stabilization using gelucire 50/13. Chemical & pharmaceutical bulletin 20090901
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters 20090801
Etoricoxib: a review of its use in the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gouty arthritis. Drugs 20090730
The effect of etoricoxib on the pharmacokinetics of oral contraceptives in healthy participants. Journal of clinical pharmacology 20090701
Serum urate during acute gout. The Journal of rheumatology 20090601
Baseline factors associated with congestive heart failure in patients receiving etoricoxib or diclofenac: multivariate analysis of the MEDAL program. European journal of heart failure 20090601
Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090501
Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin-cAMP pathway. British journal of pharmacology 20090501
Single dose oral etoricoxib for acute postoperative pain in adults. The Cochrane database of systematic reviews 20090415
Pain control in first trimester surgical abortion. The Cochrane database of systematic reviews 20090415
Determination of two COX-2 inhibitors in serum and synovial fluid of patients with inflammatory arthritis by ultra performance liquid chromatography-inductively coupled plasma mass spectroscopy and quadrupole time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis 20090405
Cardiovascular safety and gastrointestinal tolerability of etoricoxib vs diclofenac in a randomized controlled clinical trial (The MEDAL study). Rheumatology (Oxford, England) 20090401
Factors associated with blood pressure changes in patients receiving diclofenac or etoricoxib: results from the MEDAL study. Journal of hypertension 20090401
Non-steroidal anti-inflammatory drug use does not appear to be associated with increased cardiovascular mortality in patients with inflammatory polyarthritis: results from a primary care based inception cohort of patients. Annals of the rheumatic diseases 20090301
Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation. Cardiovascular research 20090201
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial. The American journal of gastroenterology 20090201
Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib. European journal of clinical pharmacology 20090101
Effect of PVP K30 and/or L-arginine on stability constant of etoricoxib-HPbetaCD inclusion complex: preparation and characterization of etoricoxib-HPbetaCD binary system. Drug development and industrial pharmacy 20090101
Frequency of ill-founded off-label prescribing in Dutch general practice. Pharmacoepidemiology and drug safety 20090101
Complexation of cox-2 inhibitors with bovine serum albumin: interaction mechanism. Pharmaceutical development and technology 20090101
Management of rheumatoid arthritis: summary of NICE guidance. BMJ (Clinical research ed.) 20090101
Competition between COX-2 inhibitors and some other drugs for binding sites on human serum albumin. Drug metabolism and drug interactions 20090101
The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101
The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. Journal of orthopaedic surgery and research 20090101
Cardiovascular and hematologic effects produced by chronic treatment with etoricoxib in normotensive rats. Acta cirurgica brasileira 20090101
Physicochemical investigation of the solid dispersion systems of etoricoxib with poloxamer 188. Pharmaceutical development and technology 20090101
Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis. BMJ (Clinical research ed.) 20090101
Gout. Novel therapies for treatment of gout and hyperuricemia. Arthritis research & therapy 20090101
Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis. Arthritis research & therapy 20090101
Effect of non-steroidal anti-inflammatory drug etoricoxib on the hematological parameters and enzymes of colon and kidney. Nutricion hospitalaria 20090101
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Chemopreventive effect of nonsteroidal anti-inflammatory drugs on 9,10-dimethylbenz[a]anthracene-induced lung carcinogenesis in mice. Oncology research 20090101
Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors. Clinical drug investigation 20090101
Celecoxib in arthritis: relative risk management profile and implications for patients. Therapeutics and clinical risk management 20090101
[Comparison of the analgesic effect between 90 mg etoricoxib and dipyrone after exeresis of primary pterygium with conjunctival autograft]. Arquivos brasileiros de oftalmologia 20090101
Long-term tolerability of etoricoxib in patients with previous reactions to non-steroidal anti-inflammatory drugs. International journal of immunopathology and pharmacology 20090101
Long-Term Alendronate Use Not without Consequences? International journal of rheumatology 20090101
Chemoprevention of 1,2-dimethylhydrazine-induced colon carcinogenesis by a non-steroidal anti-inflammatory drug, etoricoxib, in rats: inhibition of nuclear factor kappaB. Asian Pacific journal of cancer prevention : APJCP 20090101
Na(+)-stimulated Na+/H+ exchange and an unfavorable Ca2+ homeostasis initiate the cycloxygenase-2 inhibitors-induced apoptotic signals in colonic epithelial cells during the early stage of colon carcinogenesis. Oncology research 20090101
Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors. Drug, healthcare and patient safety 20090101
[Overdose of etoricoxib: 840mg]. Reumatologia clinica 20090101
[Primary hypertrophic osteoarthropathy (pachydermoperiostosis). Report of two familial cases and literature review]. Reumatologia clinica 20090101
Evaluation of the pharmacokinetics of digoxin in healthy subjects receiving etoricoxib. British journal of clinical pharmacology 20081201
Antiinflammatory effects of etoricoxib alone and combined with NSAIDs in LPS-induced reactive arthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20081201
Systems biology: a therapeutic target for tumor therapy. Cancer microenvironment : official journal of the International Cancer Microenvironment Society 20081201
Responder analysis and correlation of outcome measures: pooled results from two identical studies comparing etoricoxib, celecoxib, and placebo in osteoarthritis. Osteoarthritis and cartilage 20081101
Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac. Gastroenterology 20081101
Celecoxib inhibits 5-lipoxygenase. Biochemical pharmacology 20081001
Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081001
Comparison of etoricoxib vs. ketorolac in postoperative pain relief. Acta anaesthesiologica Scandinavica 20081001
Risk management profile of etoricoxib: an example of personalized medicine. Therapeutics and clinical risk management 20081001
Neuropharmacology. Indian journal of pharmacology 20081001
Clinical pharmacology. Indian journal of pharmacology 20081001
Prospective randomized, double-blinded, placebo-controlled trial of preoperative etoricoxib for pain relief in uterine fractional curettage under paracervical block. European journal of obstetrics, gynecology, and reproductive biology 20080901
Adjunctive benefits of systemic etoricoxib in non-surgical treatment of aggressive periodontitis: short-term evaluation. Journal of periodontology 20080901
Thermodynamic behavior of glassy state of structurally related compounds. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801
Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology. Trends in pharmacological sciences 20080801
Asthmatic reaction induced by Etoricoxib in a patient with aspirin-sensitive asthma. Allergy 20080801
In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic & clinical pharmacology & toxicology 20080801
The anti-proliferative potency of celecoxib is not a class effect of coxibs. Biochemical pharmacology 20080715
The effect of etoricoxib premedication on postoperative analgesia requirement in orthopedic and trauma patients. Saudi medical journal 20080701
Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects. Journal of clinical pharmacology 20080601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20080601
Cardiovascular co-morbidity in rheumatic diseases. Vascular health and risk management 20080601
Etoricoxib and intermittent androgen deprivation therapy in patients with biochemical progression after radical prostatectomy. Urology 20080501
The efficacy of etoricoxib vs mefenamic acid in the treatment of primary dysmenorrhoea: a randomised comparative trial. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20080501
Trypanosoma cruzi: the role of PGE2 in immune response during the acute phase of experimental infection. Experimental parasitology 20080401
Safe adalimumab therapy for rheumatoid arthritis in a patient with pre-existing multiple myeloma. Nature clinical practice. Rheumatology 20080401
Evaluation of the changes in hemostatic parameters induced by etoricoxib in rat model. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080401
Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. Health technology assessment (Winchester, England) 20080401
Efficacy and tolerability of lumiracoxib, a highly selective cyclo-oxygenase-2 (COX2) inhibitor, in the management of pain and osteoarthritis. Therapeutics and clinical risk management 20080401
Etoricoxib, paracetamol, and dextropropoxyphene for postoperative pain management: a questionnaire survey of consumption of take-home medication after elective hallux valgus surgery. Foot & ankle specialist 20080401
Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II). Annals of the rheumatic diseases 20080301
Clinical use and pharmacological properties of selective COX-2 inhibitors. European journal of clinical pharmacology 20080301
Correlation of measures of pain, function, and overall response: results pooled from two identical studies of etoricoxib in chronic low back pain. Spine 20080301
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20080301
Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis. Respiratory medicine 20080201
Preclinical pharmacology profile of CS-706, a novel cyclooxygenase-2 selective inhibitor, with potent antinociceptive and anti-inflammatory effects. European journal of pharmacology 20080106
Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. Journal of cancer research and clinical oncology 20080101
Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans. Clinical biochemistry 20080101
Validation of a capillary zone electrophoresis method for the comparative determination of etoricoxib in pharmaceutical formulations. Journal of separation science 20080101
Etoricoxib for pain management during thyroid surgery--a prospective, placebo-controlled study. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20080101
Primary stabbing headache can be responsive to etoricoxib, a selective COX-2 inhibitor. European journal of neurology 20080101
Etoricoxib-induced erythema-multiforme-like eruption. Dermatology (Basel, Switzerland) 20080101
Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes. Arthritis research & therapy 20080101
Etoricoxib-induced acute generalized exanthematous pustulosis. Acta dermato-venereologica 20080101
Long-term retention on treatment with lumiracoxib 100 mg once or twice daily compared with celecoxib 200 mg once daily: a randomised controlled trial in patients with osteoarthritis. BMC musculoskeletal disorders 20080101
Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores. Arthritis research & therapy 20080101
Efficacy of etoricoxib for pain relief during endometrial biopsy; a double blind randomized controlled trial. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080101
Prevention of post operative pain after abdominal hysterectomy by single dose etoricoxib. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080101
The cardiovascular risks of etoricoxib (Arcoxia). Annals of Saudi medicine 20080101
Effect of nonsteroidal anti-inflammatory drugs and the procarcinogen 1,2-dimethylhydrazine on the antioxidant defense system. International journal of toxicology 20080101
Effects of etoricoxib on the pharmacokinetics of phenytoin. Pharmacological reports : PR 20080101
Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports. Arthritis research & therapy 20080101
Use and misuse of the p-value. Bulletin of the NYU hospital for joint diseases 20080101
Superiority, equivalence, and non-inferiority trials. Bulletin of the NYU hospital for joint diseases 20080101
Antioxidative effects of nonsteroidal anti-inflammatory drugs during the initiation stages of experimental colon carcinogenesis in rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20080101
Safety of etoricoxib in patients with reactions to NSAIDs. Journal of investigational allergology & clinical immunology 20080101
Design, development, and optimization of orally disintegrating tablets of etoricoxib using vacuum-drying approach. PDA journal of pharmaceutical science and technology 20080101
A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis research & therapy 20080101
A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. BMC musculoskeletal disorders 20080101
Sevoflurane requirement during elective ankle day surgery: the effects of etirocoxib premedication, a prospective randomised study. Journal of orthopaedic surgery and research 20080101
Life satisfaction in patients with long-term non-malignant pain - relating LiSat-11 to the Multidimensional Pain Inventory (MPI). Health and quality of life outcomes 20080101
Concomitant use of gastroprotective drugs among elderly NSAID/COX-2 selective inhibitor users: a nationwide register-based study. Clinical drug investigation 20080101
Clinical pharmacokinetic and pharmacodynamic profile of etoricoxib. Clinical pharmacokinetics 20080101
New horizons and perspectives in the treatment of osteoarthritis. Arthritis research & therapy 20080101
Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis. Arthritis research & therapy 20080101
A rare cause of a common symptom, Anakinra is effective in the urticaria of Schnitzler Syndrome: a case report. Cases journal 20080101
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. BMC musculoskeletal disorders 20080101
Cyclooxygenase-2 inhibition by etoricoxib modulates plasma membrane fluidity in rat colon. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20080101
Selective immediate hypersensitivity to etoricoxib. Journal of investigational allergology & clinical immunology 20080101
[Cardiovascular risk of cyclooxygenase selective inhibitors]. Revista medica del Instituto Mexicano del Seguro Social 20080101
Effect of non-steroidal anti-inflammatory drugs and the pro-carcinogen 1,2 dimethylhydrazine on the rat intestinal membrane structure and function. Nutricion hospitalaria 20080101
Influence of COX-2-induced PGE2 on the initiation and progression of tail regeneration in Northern House Gecko, Hemidactylus flaviviridis. Folia biologica 20080101
FTIR studies on differential intermolecular association in crystalline and amorphous states of structurally related non-steroidal anti-inflammatory drugs. Molecular pharmaceutics 20080101
The effect of etoricoxib, a cyclooxygenase-2-specific inhibitor, on the 1,2-dimethylhydrazine-administered rat intestinal membrane structure and function. Toxicology mechanisms and methods 20080101
Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan. Indian journal of pharmaceutical sciences 20080101
Optimization of fast dissolving etoricoxib tablets prepared by sublimation technique. Indian journal of pharmaceutical sciences 20080101
Aspirin-exacerbated asthma. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20080101
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorganic & medicinal chemistry letters 20071215
A randomized placebo-controlled trial comparing the efficacy of etoricoxib 30 mg and ibuprofen 2400 mg for the treatment of patients with osteoarthritis. Osteoarthritis and cartilage 20071201
Assessment of outcome in clinical trials of gout--a review of current measures. Rheumatology (Oxford, England) 20071201
Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet. Journal of clinical pharmacology 20071201
Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK. Current medical research and opinion 20071201
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. Prescrire international 20071201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20071201
[What is new about nonsteroidal antiinflamatory drugs?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20071201
Update on the treatment of ankylosing spondylitis. Therapeutics and clinical risk management 20071201
Etoricoxib challenge in patients with chronic urticaria with NSAID intolerance. Clinical and experimental dermatology 20071101
Analgesic effect of etoricoxib in secondary dysmenorrhea: a randomized, double-blind, crossover, controlled trial. The Journal of reproductive medicine 20071101
Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to allysine aldehyde in elastin of human aorta. Drug metabolism and disposition: the biological fate of chemicals 20071001
Lack of effect of antacids on single-dose pharmacokinetics of etoricoxib. Journal of clinical pharmacology 20071001
COX-2 inhibitor. Rheumatology (Oxford, England) 20071001
Application of polyglycolized glycerides in protection of amorphous form of etoricoxib during compression. Chemical & pharmaceutical bulletin 20071001
Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice? Therapeutics and clinical risk management 20071001
Etoricoxib versus naproxen in patients with rheumatoid arthritis: a prospective, randomized, comparator-controlled 121-week trial. Current medical research and opinion 20070901
Preparation and characterization of etoricoxib-beta-cyclodextrin complexes prepared by the kneading method. Acta pharmaceutica (Zagreb, Croatia) 20070901
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20070901
Rosiglitazone: a disappointing DREAM. Future cardiology 20070901
Keeping science on top in drug evaluation. The New England journal of medicine 20070816
Anti-inflammatory and analgesic actions of etoricoxib (an NSAID) combined with misoprostol. Inflammopharmacology 20070801
Evaluation of the efficacy and safety of etoricoxib compared with naproxen in two, 138-week randomised studies of patients with osteoarthritis. Annals of the rheumatic diseases 20070701
Risk of myocardial infarction associated with selective COX-2 inhibitors: meta-analysis of randomised controlled trials. Pharmacoepidemiology and drug safety 20070701
Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs): a systematic structured review of the literature. Archives of dermatological research 20070701
Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070701
COX-2 in play at the AHA and the FDA. Trends in pharmacological sciences 20070701
Association of baseline disease and patient characteristics with response to etoricoxib and indomethacin for acute gout. Current medical research and opinion 20070701
Oral etoricoxib for pain relief during fractional curettage: a randomized controlled trial. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20070601
Few options available for arthritis pain relief. FDA declines to approve Merck's Arcoxia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070515
Is administration time of oral non-steroid anti-inflammatory drugs important? A clinical study in patients undergoing arthroscopic subacromial decompression. European journal of anaesthesiology 20070501
The effect of etoricoxib on the pharmacodynamics and pharmacokinetics of warfarin. Journal of clinical pharmacology 20070501
Effects of COX-2 inhibitor in temporomandibular joint acute inflammation. Journal of dental research 20070501
A study on the effects of diclofenac sodium and etoricoxib in the treatment of osteoarthritis. Journal of the Indian Medical Association 20070501
Gastrointestinal safety of NSAIDs versus COX-2 inhibitors. Lancet (London, England) 20070421
[Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain]. Nederlands tijdschrift voor geneeskunde 20070407
[By what means does the rheumatic patient with gastrointestinal risks fare best?]. MMW Fortschritte der Medizin 20070308
Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment of osteoarthritis in two identically designed, randomized, placebo-controlled, non-inferiority studies. Rheumatology (Oxford, England) 20070301
Etoricoxib pre-medication combined with intra-operative subacromial block for pain after arthroscopic acromioplasty. Acta anaesthesiologica Scandinavica 20070301
Therapeutic advances in gout. Current opinion in rheumatology 20070301
Dynamic simulations on the arachidonic acid metabolic network. PLoS computational biology 20070301
Cardiovascular safety of cyclo-oxygenase-2 inhibitors. Lancet (London, England) 20070217
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet (London, England) 20070210
Gastrointestinal side effects of etoricoxib in patients with osteoarthritis: results of the Etoricoxib versus Diclofenac Sodium Gastrointestinal Tolerability and Effectiveness (EDGE) trial. The Journal of rheumatology 20070201
Tolerance to etoricoxib in 37 patients with urticaria and angioedema induced by nonsteroidal anti-inflammatory drugs. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20070201
NSAID trials and the choice of comparators--questions of public health importance. The New England journal of medicine 20070125
Pharmacodynamic of cyclooxygenase inhibitors in humans. Prostaglandins & other lipid mediators 20070101
Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070101
Etoricoxib tolerability in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs. International archives of allergy and immunology 20070101
Stroke caused by small vessel occlusion in a patient taking etoricoxib and thalidomide. Journal of neuroimaging : official journal of the American Society of Neuroimaging 20070101
Evaluation of the patient acceptable symptom state in a pooled analysis of two multicentre, randomised, double-blind, placebo-controlled studies evaluating lumiracoxib and celecoxib in patients with osteoarthritis. Arthritis research & therapy 20070101
Etoricoxib was noninferior to diclofenac for cardiovascular outcomes in osteoarthritis and rheumatoid arthritis. ACP journal club 20070101
Emerging from the shadow of Vioxx. Current topics in medicinal chemistry 20070101
Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study. Arthritis research & therapy 20070101
An economic model of long-term use of celecoxib in patients with osteoarthritis. BMC gastroenterology 20070101
Evaluation of the prevalence and economic burden of adverse drug reactions presenting to the medical emergency department of a tertiary referral centre: a prospective study. BMC clinical pharmacology 20070101
Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk. BMC musculoskeletal disorders 20070101
Efficacy of the newest COX-2 selective inhibitors in rheumatic disease. Current pharmaceutical design 20070101
Global gastrointestinal safety profile of etoricoxib and lumiracoxib. Current pharmaceutical design 20070101
Molecular and thermodynamic aspects of solubility advantage from solid dispersions. Molecular pharmaceutics 20070101
The use of etoricoxib to treat an idiopathic stabbing headache: a case report. Journal of medical case reports 20070101
Chemopreventive effects of nonsteroidal anti-inflammatory drugs in the membrane lipid composition and fluidity parameters of the 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Drug and chemical toxicology 20070101
Multi-modal-analgesia for pain management after Hallux Valgus surgery: a prospective randomised study on the effect of ankle block. Journal of orthopaedic surgery and research 20070101
Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101
Role of early minimal-invasive spine fixation in acute thoracic and lumbar spine trauma. Indian journal of orthopaedics 20070101
Lumiracoxib: the evidence of its clinical impact on the treatment of osteoarthritis. Core evidence 20070101
Use of cyclo-oxygenase 2 inhibitors (COX-2) and prescription non-steroidal anti-inflammatory drugs (NSAIDS) in UK and USA populations. Implications for COX-2 cardiovascular profile. Pharmacoepidemiology and drug safety 20061201
Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials. Journal of clinical pharmacy and therapeutics 20061201
Pooled analysis of thrombotic cardiovascular events in clinical trials of the COX-2 selective Inhibitor etoricoxib. Current medical research and opinion 20061201
[Coronary risks with NSAID and coxibs. The end of hysteria]. MMW Fortschritte der Medizin 20061130
[3 questions about gastrointestinal risk. Are coxibs here clearly better than NSAID?]]. MMW Fortschritte der Medizin 20061130
The ever growing story of cyclo-oxygenase inhibition. Lancet (London, England) 20061118
Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet (London, England) 20061118
Effectiveness of interventions for the treatment of acute and prevention of recurrent gout--a systematic review. Rheumatology (Oxford, England) 20061101
In-line measurement of a drug substance via near infrared spectroscopy to ensure a robust crystallization process. Journal of pharmaceutical sciences 20061101
Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). PLoS clinical trials 20061101
Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors. Jornal de pediatria 20061101
Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA 20061004
Selective COX-2 inhibitors and risk of thromboembolic events - regulatory aspects. Thrombosis and haemostasis 20061001
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20061001
Preparation and characterization of etoricoxib-polyethylene glycol 4000 plus polyvinylpyrrolidone K30 solid dispersions. Acta pharmaceutica (Zagreb, Croatia) 20060901
An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models. European journal of pain (London, England) 20060801
Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. American heart journal 20060801
Cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs and the risk of ischemic stroke: a nested case-control study. Stroke 20060701
Safety of etoricoxib, a specific cyclooxygenase-2 inhibitor, in asthmatic patients with aspirin-exacerbated respiratory disease. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060701
Etoricoxib pre-medication for post-operative pain after laparoscopic cholecystectomy. Acta anaesthesiologica Scandinavica 20060701
Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia. Bioorganic & medicinal chemistry letters 20060615
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060601
Treating axial manifestations in ankylosing spondylitis in the presence of peripheral arthritis. Nature clinical practice. Rheumatology 20060601
Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo. Blood 20060501
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060501
Use of first- and second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction. Circulation 20060425
Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib. Biochemical and biophysical research communications 20060414
Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy. Blood 20060301
Editorial foreword. Therapeutics and clinical risk management 20060301
Etoricoxib for arthritis and pain management. Therapeutics and clinical risk management 20060301
Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats. Life sciences 20060209
The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases. The American journal of gastroenterology 20060201
Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection. Biomedical chromatography : BMC 20060101
Investigating the hydrate conversion propensity of different etoricoxib lots. Journal of pharmaceutical sciences 20060101
Multiple drug intolerance including etoricoxib. Allergy 20060101
Systematic review: coxibs, non-steroidal anti-inflammatory drugs or no cyclooxygenase inhibitors in gastroenterological high-risk patients? Alimentary pharmacology & therapeutics 20060101
The use of etoricoxib in patients with bronchial asthma associated with aspirin sensitivity. Saudi medical journal 20060101
[Brief coxib therapy lowers cardiovascular risk]. Zeitschrift fur Orthopadie und ihre Grenzgebiete 20060101
The inflammatory process of gout and its treatment. Arthritis research & therapy 20060101
Serious skin reactions and selective COX-2 inhibitors: a case series from prescription-event monitoring in England. Drug safety 20060101
Fixed drug eruption and generalised erythema following etoricoxib. Indian journal of dermatology, venereology and leprology 20060101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060101
Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis. Arthritis research & therapy 20060101
Validation of liquid chromatography and liquid chromatography/tandem mass spectrometry methods for the determination of etoricoxib in pharmaceutical formulations. Journal of AOAC International 20060101
Interaction of non-steroidal anti-inflammatory drugs, etoricoxib and parecoxib sodium, with human serum albumin studied by fluorescence spectroscopy. Drug metabolism and drug interactions 20060101
Meloxicam tolerance in hypersensitivity to nonsteroidal anti-inflammatory drugs. Journal of investigational allergology & clinical immunology 20060101
Adverse cutaneous reactions to selective cyclooxygenase 2 inhibitors: experience of an Italian drug-surveillance center. Journal of cutaneous medicine and surgery 20060101
C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation. Biomarker insights 20060101
Efficacy of etoricoxib 60 mg/day and diclofenac 150 mg/day in reduction of pain and disability in patients with chronic low back pain: results of a 4-week, multinational, randomized, double-blind study. Current medical research and opinion 20051201
Efficacy of cyclo-oxygenase-2 inhibition by etoricoxib and naproxen on the axial manifestations of ankylosing spondylitis in the presence of peripheral arthritis. Annals of the rheumatic diseases 20051101
Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug metabolism and disposition: the biological fate of chemicals 20051101
Short-term tolerability of etoricoxib in patients with cutaneous hypersensitivity reactions to nonsteroidal anti-inflammatory drugs. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20051101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20051101
Systematic review and meta-analysis of the risk of major cardiovascular events with etoricoxib therapy. The New Zealand medical journal 20051007
A general method for the synthesis of aryl [11C]methylsulfones: potential PET probes for imaging cyclooxygenase-2 expression. Bioorganic & medicinal chemistry letters 20051001
Stabilization and improved in vivo performance of amorphous etoricoxib using Gelucire 50/13. Pharmaceutical research 20051001
Etoricoxib provides analgesic efficacy to patients after knee or hip replacement surgery: a randomized, double-blind, placebo-controlled study. Anesthesia and analgesia 20051001
An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices. Journal of pharmaceutical and biomedical analysis 20050915
Adverse effects of etoricoxib: other considerations. Mayo Clinic proceedings 20050901
Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS PharmSciTech 20050901
Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis. Arthritis and rheumatism 20050815
[The efficacy of selective Cox-2-inhibitors in comparison with conventional NSAIDs]. MMW Fortschritte der Medizin 20050804
The molecular basis for coxib inhibition of p38alpha MAP kinase. Bioorganic & medicinal chemistry letters 20050801
Analgesic efficacy of pre-operative etoricoxib for termination of pregnancy in an ambulatory centre. Singapore medical journal 20050801
Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray? Current medical research and opinion 20050801
Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050801
Clinical pharmacology of etoricoxib. Expert opinion on drug metabolism & toxicology 20050801
3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation. Journal of medicinal chemistry 20050602
Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats. Journal of periodontal research 20050601
Etoricoxib: a highly selective COX-2 inhibitor. The Annals of pharmacotherapy 20050501
Association between health-related quality of life and clinical efficacy endpoints in rheumatoid arthritis patients after four weeks treatment with anti-inflammatory agents. International journal of clinical pharmacology and therapeutics 20050501
The incidence of upper gastrointestinal adverse events in clinical trials of etoricoxib vs. non-selective NSAIDs: an updated combined analysis. Current medical research and opinion 20050501
Quantitation of itopride in human serum by high-performance liquid chromatography with fluorescence detection and its application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425
[COX-2 inhibitors--one step forward and two steps back]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20050407
Evaluation of the efficacy of etoricoxib in ankylosing spondylitis: results of a fifty-two-week, randomized, controlled study. Arthritis and rheumatism 20050401
Evaluation of the comparative efficacy of etoricoxib and ibuprofen for treatment of patients with osteoarthritis: A randomized, double-blind, placebo-controlled trial. Mayo Clinic proceedings 20050401
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20050401
A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma. Biomedical chromatography : BMC 20050301
Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. The Journal of pharmacology and experimental therapeutics 20050301
Coxibs: can this class of drugs survive? Vascular health and risk management 20050301
Validated liquid chromatographic ultraviolet method for the quantitation of Etoricoxib in human plasma using liquid-liquid extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225
Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins. Circulation research 20050107
Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? Drugs & aging 20050101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20050101
The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain. Current medical research and opinion 20050101
Relative thromboembolic risks associated with COX-2 inhibitors. The Annals of pharmacotherapy 20050101
COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. Current topics in medicinal chemistry 20050101
Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK. PharmacoEconomics 20050101
Current state of therapy for pain and inflammation. Arthritis research & therapy 20050101
Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance. Arthritis research & therapy 20050101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20050101
Etoricoxib in the treatment of osteoarthritis over 52-weeks: a double-blind, active-comparator controlled trial [NCT00242489]. BMC musculoskeletal disorders 20050101
Comparative efficacy of aceclofenac and etoricoxib in post extraction pain control: randomized control trial. Indian journal of dental research : official publication of Indian Society for Dental Research 20050101
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs. Atherosclerosis 20041201
Novel insights and therapeutical applications in the field of inhibitors of COX-2. Current medicinal chemistry 20041201
Isolation and structural characterization of the photolysis products of etoricoxib. Die Pharmazie 20041201
[Comparison of preemptive analgesia efficacy between etoricoxib and rofecoxib in ambulatory gynecological surgery]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201
Use of gastroprotective agents and discontinuations due to dyspepsia with the selective cyclooxygenase-2 inhibitor etoricoxib compared with non-selective NSAIDs. Current medical research and opinion 20041201
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters 20041101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20041101
The effects of modifying in vivo cytochrome P450 3A (CYP3A) activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity. Journal of clinical pharmacology 20041001
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20041001
The analgesic efficacy of etoricoxib compared with oxycodone/acetaminophen in an acute postoperative pain model: a randomized, double-blind clinical trial. Anesthesia and analgesia 20040901
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20040901
First and second generations of COX-2 selective inhibitors. Mini reviews in medicinal chemistry 20040801
The second generation of COX-2 inhibitors: clinical pharmacological point of view. Mini reviews in medicinal chemistry 20040801
Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors. Journal of medicinal chemistry 20040715
Gastrointestinal side-effects of traditional non-steroidal anti-inflammatory drugs and new formulations. Alimentary pharmacology & therapeutics 20040701
Prostaglandins: modulators of inflammation and cardiovascular risk. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20040601
Management strategies for osteoarthritis, ankylosing spondylitis, and gouty arthritis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20040601
Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501
Evaluation of quality of life following treatment with etoricoxib in patients with arthritis or low-back pain: an open label, uncontrolled pilot study in Mexico. Current medical research and opinion 20040501
Etoricoxib in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. Clinical therapeutics 20040501
[Etoricoxib (Arcoxia)]. Revue medicale de Liege 20040501
Etoricoxib. Drugs of today (Barcelona, Spain : 1998) 20040501
[Pharmacology and classification of cyclooxygenase inhibitors]. Gastroenterologie clinique et biologique 20040401
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. Journal of medicinal chemistry 20040212
Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout: a randomized controlled trial. Arthritis and rheumatism 20040201
Cyclooxygenase-2 inhibitors: do they have a role in emergency department prescribing? Emergency medicine Australasia : EMA 20040201
Pharmacological characterisation of a rat model of incisional pain. British journal of pharmacology 20040101
Pharmacokinetics of etoricoxib in patients with renal impairment. Journal of clinical pharmacology 20040101
Clinical pharmacology of novel selective COX-2 inhibitors. Current pharmaceutical design 20040101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20040101
Renal effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs in controlled clinical trials. Clinical therapeutics 20040101
A randomized, double-blind, parallel-group study comparing the analgesic effect of etoricoxib to placebo, naproxen sodium, and acetaminophen with codeine using the dental impaction pain model. The Clinical journal of pain 20040101
Selective cyclooxygenase-2 inhibitors: similarities and differences. Scandinavian journal of rheumatology 20040101
A mechanistic perspective on the specificity and extent of COX-2 inhibition in pregnancy. Drug safety 20040101
Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK. PharmacoEconomics 20040101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20040101
Etoricoxib reduced pain and disability and improved quality of life in patients with chronic low back pain: a 3 month, randomized, controlled trial. Scandinavian journal of rheumatology 20040101
[Rapidly acting and powerful antirheumatic drug now also approved in Germany. Arcoxia (etoricoxib, MSD)]]. Krankenpflege Journal 20040101
The role of cyclooxygenase selective inhibitors in the gastrointestinal tract. Current gastroenterology reports 20031201
Pharmacokinetics of etoricoxib in patients with hepatic impairment. Journal of clinical pharmacology 20031001
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events. The American journal of gastroenterology 20030801
Treatment of chronic low back pain with etoricoxib, a new cyclo-oxygenase-2 selective inhibitor: improvement in pain and disability--a randomized, placebo-controlled, 3-month trial. The journal of pain : official journal of the American Pain Society 20030801
Characterization of etoricoxib, a novel, selective COX-2 inhibitor. Journal of clinical pharmacology 20030601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20030601
A literature review of the epidemiology and treatment of acute gout. Clinical therapeutics 20030601
Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525
Etoricoxib in the treatment of chronic pain. International journal of clinical practice 20030501
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20030501
[Coxibs: highly selective cyclooxygenase-2 inhibitors. Part II. Side effects]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030401
Single- and multiple-dose pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, in man. Journal of clinical pharmacology 20030301
Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers. Drug metabolism and disposition: the biological fate of chemicals 20030201
Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor. Expert opinion on pharmacotherapy 20030201
The second generation of COX-2 inhibitors: what advantages do the newest offer? Drugs 20030101
Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib. Alimentary pharmacology & therapeutics 20030101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20030101
Cox-2: where are we in 2003? - Cardiovascular risk and Cox-2 inhibitors. Arthritis research & therapy 20030101
COX-2: Where are we in 2003? - Be strong and resolute: continue to use COX-2 selective inhibitors at recommended dosages in appropriate patients. Arthritis research & therapy 20030101
COX-2: where are we in 2003?--distinction from NSAIDs becoming blurred. Arthritis research & therapy 20030101
Analgesic efficacy of etoricoxib in primary dysmenorrhea: results of a randomized, controlled trial. Gynecologic and obstetric investigation 20030101
Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population. The American journal of hospice & palliative care 20030101
Clinical pharmacology of selective COX-2 inhibitors. International journal of immunopathology and pharmacology 20030101
A comparison of the therapeutic efficacy and tolerability of etoricoxib and diclofenac in patients with osteoarthritis. Current medical research and opinion 20030101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20021201
Results of a randomized, dose-ranging trial of etoricoxib in patients with osteoarthritis. Rheumatology (Oxford, England) 20020901
COX-2 inhibition and the control of pain. Current opinion in investigational drugs (London, England : 2000) 20020901
Another selective COX-2 inhibitor: more questions than answers? The Journal of rheumatology 20020801
A randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis. The Journal of rheumatology 20020801
Role of COX-2 inhibitors in the evolution of acute pain management. Journal of pain and symptom management 20020701
Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis. BMJ (Clinical research ed.) 20020622
Gateways to Clinical Trials. June 2002. Methods and findings in experimental and clinical pharmacology 20020601
Cox-2 inhibitors: today and tomorrow. The American journal of the medical sciences 20020401
Simultaneous determination of unlabeled and carbon-13-labeled etoricoxib, a new cyclooxygenase-2 inhibitor, in human plasma using HPLC-MS/MS. Journal of pharmaceutical sciences 20020201
Efficacy and tolerability profile of etoricoxib in patients with osteoarthritis: A randomized, double-blind, placebo and active-comparator controlled 12-week efficacy trial. Current medical research and opinion 20020101
A multinational randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis [ISRCTN25142273]. BMC family practice 20020101
COX-2-selective inhibitors in the treatment of arthritis. Cleveland Clinic journal of medicine 20020101
Development and clinical application of COX-2-selective inhibitors for the treatment of osteoarthritis and rheumatoid arthritis. Cleveland Clinic journal of medicine 20020101
Etoricoxib. Drugs 20020101
The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity. Current medical research and opinion 20020101
Dose proportionality of oral etoricoxib, a highly selective cyclooxygenase-2 inhibitor, in healthy volunteers. Journal of clinical pharmacology 20011001
Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. Drug metabolism and disposition: the biological fate of chemicals 20010601
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663). Bioorganic & medicinal chemistry letters 20010423
Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. The Journal of pharmacology and experimental therapeutics 20010201
Investigational COX-2 inhibitor relieves pain in dental model. Current pain and headache reports 20010201
Preparation and novel reduction reactions of vinamidinium salts. The Journal of organic chemistry 20010112
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