Home Carbonyls (2E)-but-2-enedioic acid bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate

(2E)-but-2-enedioic acid bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate

CAS No.:
202138-50-9
Catalog Number:
AG002836
Molecular Formula:
C23H34N5O14P
Molecular Weight:
635.5149
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$13
- +
5g
98%
In Stock USA
United States
$32
- +
25g
98%
In Stock USA
United States
$100
- +
100g
98%
In Stock USA
United States
$319
- +
Product Description
Catalog Number:
AG002836
Chemical Name:
(2E)-but-2-enedioic acid bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate
CAS Number:
202138-50-9
Molecular Formula:
C23H34N5O14P
Molecular Weight:
635.5149
MDL Number:
MFCD08141829
IUPAC Name:
[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid
InChI:
InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
InChI Key:
VCMJCVGFSROFHV-WZGZYPNHSA-N
SMILES:
C[C@H](Cn1cnc2c1ncnc2N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.OC(=O)/C=C/C(=O)O
EC Number:
687-766-5
UNII:
OTT9J7900I
Properties
Complexity:
817  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Exact Mass:
635.184g/mol
Formal Charge:
0
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
635.52g/mol
Monoisotopic Mass:
635.184g/mol
Rotatable Bond Count:
19  
Topological Polar Surface Area:
260A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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Safety and adherence to intermittent pre-exposure prophylaxis (PrEP) for HIV-1 in African men who have sex with men and female sex workers. PloS one 20120101
Risk factors for suboptimal vitamin D levels among adults with HIV attending an inner-city clinic of New Orleans, Louisiana. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20120101
Stress studies of tenofovir disoproxil fumarate by HPTLC in bulk drug and pharmaceutical formulation. TheScientificWorldJournal 20120101
The deleterious influence of tenofovir-based therapies on the progression of atherosclerosis in HIV-infected patients. Mediators of inflammation 20120101
How good is 'good enough'? The case for varying standards of evidence according to need for new interventions in HIV prevention. The American journal of bioethics : AJOB 20120101
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Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal. Retrovirology 20120101
Pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against HIV-1 infection. PloS one 20120101
Proximal tubular renal dysfunction or damage in HIV-infected patients. AIDS reviews 20120101
Trends in HIV-1 reverse transcriptase resistance-associated mutations and antiretroviral prescription data from 2003-2010. Antiviral therapy 20120101
Profile of users of drugs for the treatment of chronic hepatitis B available through the Brazilian Public Health System. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20120101
Tenofovir use and renal insufficiency among pregnant and general adult population of HIV-infected, ART-naïve individuals in Lilongwe, Malawi. PloS one 20120101
Renal toxicity associated with antiretroviral therapy. HIV clinical trials 20120101
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FDA notifications. Complera approved. AIDS alert 20111101
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One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates. Journal of virology 20110801
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In utero exposure to tenofovir disoproxil fumarate does not impair growth and bone health in HIV-uninfected children born to HIV-infected mothers. Antiviral therapy 20110101
Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells. Antiviral therapy 20110101
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The rise and fall of K65R in a Portuguese HIV-1 Drug Resistance database, despite continuously increasing use of tenofovir. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20090701
Spectrum of chronic kidney disease in HIV-infected patients. HIV medicine 20090701
A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression. Journal of acquired immune deficiency syndromes (1999) 20090701
A randomized trial of two-drug versus three-drug tenofovir-containing maintenance regimens in virologically controlled HIV-1 patients. The Journal of antimicrobial chemotherapy 20090701
Reduced glomerular filtration rate but sustained virologic response in HIV/hepatitis B co-infected individuals on long-term tenofovir. Journal of viral hepatitis 20090701
Improvements in cheek volume in lipoatrophic individuals switching away from thymidine nucleoside reverse transcriptase inhibitors. HIV medicine 20090701
The simultaneous assay of tenofovir and emtricitabine in plasma using LC/MS/MS and isotopically labeled internal standards. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090701
Modulation of K65R selection by zidovudine inclusion: analysis of HIV resistance selection in subjects with virologic failure receiving once-daily abacavir/lamivudine/zidovudine and tenofovir DF (study COL40263). AIDS research and human retroviruses 20090701
Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats. Journal of acquired immune deficiency syndromes (1999) 20090701
Weight evolution in HIV-1 infected women in Rwanda after stavudine substitution due to lipoatrophy: comparison of zidovudine with tenofovir/abacavir. Transactions of the Royal Society of Tropical Medicine and Hygiene 20090601
Mitochondrial function, morphology and metabolic parameters improve after switching from stavudine to a tenofovir-containing regimen. The Journal of antimicrobial chemotherapy 20090601
Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients. Journal of acquired immune deficiency syndromes (1999) 20090601
Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues. Current opinion in organ transplantation 20090601
Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090601
[Renal tuberculosis and human immunodeficiency virus infection]. Enfermedades infecciosas y microbiologia clinica 20090601
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain. Bioorganic & medicinal chemistry 20090601
Safety evaluation of 1% tenofovir gel in healthy men. International journal of STD & AIDS 20090601
Long-term suppressive therapy for pulmonary aspergilloma in an immunocompromised man with AIDS. Is it always necessary? International journal of STD & AIDS 20090601
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector. Electrophoresis 20090601
FDA notifications. Tenofovir in India receives tentative approval. AIDS alert 20090601
Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090601
Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible. Prescrire international 20090601
Tenofovir: new indication. In chronic hepatitis B: beware bone toxicity. Prescrire international 20090601
[Therapy of chronic hepatitis B. Tenofovir--first choice in current EASL guidelines]. MMW Fortschritte der Medizin 20090528
Substituting tenofovir for stavudine in resource-limited settings: there are challenges ahead. AIDS (London, England) 20090515
Comment on: High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients. The Journal of antimicrobial chemotherapy 20090501
Long-term outcome of tenofovir disoproxil fumarate use against hepatitis B in an HIV-coinfected cohort. HIV medicine 20090501
[New molecules in the treatment of chronic hepatitis B]. Presse medicale (Paris, France : 1983) 20090501
Tenofovir renal toxicity targets mitochondria of renal proximal tubules. Laboratory investigation; a journal of technical methods and pathology 20090501
Generic Truvada approved. AIDS patient care and STDs 20090501
Emergency transplantation for acute reactivation of chronic hepatitis B with high viral load: role of antiviral therapy. Liver international : official journal of the International Association for the Study of the Liver 20090501
Rhabdomyolysis in an HIV-infected patient on anti-retroviral therapy precipitated by high-dose pravastatin. Current drug safety 20090501
Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only? Current HIV research 20090501
Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction. Clinical nephrology 20090501
Rationing antiretroviral therapy in Africa--treating too few, too late. The New England journal of medicine 20090430
[Current data on antiretroviral therapy. CROI 2009: tenofovir DR convinces by high effectiveness and tolerance]. MMW Fortschritte der Medizin 20090430
Tolerance and viral resistance after single-dose nevirapine with tenofovir and emtricitabine to prevent vertical transmission of HIV-1. AIDS (London, England) 20090427
Effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to tenofovir-emtricitabine (TDF-FTC) co-formulation (Truvada) in virologically suppressed HIV-infected patients on HAART. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20090401
Simultaneous quantification of a non-nucleoside reverse transcriptase inhibitor efavirenz, a nucleoside reverse transcriptase inhibitor emtricitabine and a nucleotide reverse transcriptase inhibitor tenofovir in plasma by liquid chromatography positive ion electrospray tandem mass spectrometry. Biomedical chromatography : BMC 20090401
Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy. Hepatology (Baltimore, Md.) 20090401
Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations. HIV medicine 20090401
Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice. Journal of hepatology 20090401
The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains. Hepatology (Baltimore, Md.) 20090401
Decision analysis model for hepatitis B prophylaxis one year after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20090401
FDA approves three generics. AIDS patient care and STDs 20090401
Progressive renal tubular dysfunction associated with long-term use of tenofovir DF. AIDS research and human retroviruses 20090401
Gilead is going strong. Fortune 20090330
Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS (London, England) 20090327
HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090315
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. Antimicrobial agents and chemotherapy 20090301
Assessment of the steady-state pharmacokinetic interaction between etravirine administered as two different formulations and tenofovir disoproxil fumarate in healthy volunteers. HIV medicine 20090301
Tenofovir use in human immunodeficiency virus-1-infected children in the United kingdom and Ireland. The Pediatric infectious disease journal 20090301
Bone pain due to fractures revealing osteomalacia related to tenofovir-induced proximal renal tubular dysfunction in a human immunodeficiency virus-infected patient. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20090301
Highly active antiretroviral therapy-associated ptosis in patients with human immunodeficiency virus. Archives of ophthalmology (Chicago, Ill. : 1960) 20090301
Successful treatment of refractory Behçet's disease with the TNF-alpha blocker infliximab. Iranian journal of immunology : IJI 20090301
Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases. The AIDS reader 20090301
Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice. The AIDS reader 20090301
Hepatitis B in HIV patients: what is the current treatment and what are the challenges? Journal of HIV therapy 20090301
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients. World journal of gastroenterology 20090214
Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109). Clinical pharmacology and therapeutics 20090201
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. Antiviral research 20090201
High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients. The Journal of antimicrobial chemotherapy 20090201
Glomerular filtration rates in HIV-infected patients treated with and without tenofovir: a prospective, observational study. The Journal of antimicrobial chemotherapy 20090201
Hepatitis B virus viral load and treatment decision. Hepatology (Baltimore, Md.) 20090201
A preemptive strike against HIV. Nature medicine 20090201
Rapid and specific liquid chromatographic tandem mass spectrometric determination of tenofovir in human plasma and its fragmentation study. Journal of chromatographic science 20090201
[Atazanavir-induced nephrolithiasis]. Enfermedades infecciosas y microbiologia clinica 20090201
HIV-1 infection of human penile explant tissue and protection by candidate microbicides. AIDS (London, England) 20090128
Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals. The Cochrane database of systematic reviews 20090121
Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090115
Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients. AIDS (London, England) 20090114
Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient. AIDS (London, England) 20090114
Hepatitis B and liver transplantation: 2008 update. Reviews in medical virology 20090101
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrobial agents and chemotherapy 20090101
Sensitivity of phenotypic susceptibility analyses for nonthymidine nucleoside analogues conferred by K65R or M184V in mixtures with wild-type HIV-1. The Journal of infectious diseases 20090101
Application of UV-spectrophotometric methods for estimation of tenofovir disoproxil fumarate in tablets. Pakistan journal of pharmaceutical sciences 20090101
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males. AIDS patient care and STDs 20090101
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues. Liver international : official journal of the International Association for the Study of the Liver 20090101
Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance. Retrovirology 20090101
Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues. Antiviral chemistry & chemotherapy 20090101
Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients. Antiviral therapy 20090101
Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure. Antiviral therapy 20090101
The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study. Retrovirology 20090101
Emtricitabine/tenofovir disoproxil fumarate: in combination with a protease inhibitor in HIV-1 infection. Drugs 20090101
Changes in hematological parameters after switching treatment of HIV-infected patients from zidovudine to abacavir or tenofovir DF. HIV clinical trials 20090101
Switch from a ZDV/3TC-based regimen to a completely once daily (QD) regimen of emtricitabine/tenofovir DF fixed dose combination plus a third QD agent (SONETT). European journal of medical research 20090101
Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys. Molecular pharmaceutics 20090101
Steady-state amprenavir, tenofovir, and emtricitabine pharmacokinetics before and after reducing ritonavir boosting of a fosamprenavir/tenofovir/emtricitabine regimen from 200 mg to 100 mg once daily (TELEX II). HIV clinical trials 20090101
Analogs and fibrosis regression in hepatitis B. Gastroenterologie clinique et biologique 20090101
Acute renal failure in patients with AIDS on tenofovir while receiving prolonged vancomycin course for osteomyelitis. The AIDS reader 20090101
Editorial comment: mixing tenofovir with other nephrotoxins--how safe is this? The AIDS reader 20090101
Expert review of drug patent applications: improving health in the developing world. Health affairs (Project Hope) 20090101
Primary HIV-1 drug resistance and polymorphic patterns among injecting drug users (IDUs) in Chennai, Southern India. Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101
Tenofovir-emtricitabine-efavirenz in HIV-I-infected adults in Senegal: a 96-week pilot trial in treatment-naive patients. Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101
[Budget impact of a set-dose combination of efavirenz-emtricitabine-tenofovir in the treatment of patients infected with HIV-1]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101
Lower limb high arterial flow induced by tenofovir and emtricitabine treatment. Antiviral therapy 20090101
Viral load decay in antiretroviral-naïve patients receiving once-daily tenofovir and emtricitabine plus twice-daily nevirapine. HIV clinical trials 20090101
Safety and efficacy of once-daily nevirapine dosing: a multicohort study. Antiviral therapy 20090101
Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antiviral therapy 20090101
Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety. Antiviral therapy 20090101
Tenofovir-induced osteomalacia. Clinical and experimental rheumatology 20090101
Long-term efficacy and safety of once-daily nevirapine in combination with tenofovir and emtricitabine in the treatment of HIV-infected patients: a 72-week prospective multicenter study (TENOR-trial). European journal of medical research 20090101
[Protocol for the antiviral therapy of chronic hepatitis B]. Orvosi hetilap 20081207
Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. The New England journal of medicine 20081204
Chronic hepatitis B--new goals, new treatment. The New England journal of medicine 20081204
Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance. Clinical pharmacology and therapeutics 20081201
A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20081201
Efficacy of pegylated interferon plus ribavirin treatment in HIV/hepatitis C virus co-infected patients receiving abacavir plus lamivudine or tenofovir plus either lamivudine or emtricitabine as nucleoside analogue backbone. The Journal of antimicrobial chemotherapy 20081201
Disinhibition and risk compensation: scope, definitions, and perspective. Sexually transmitted diseases 20081201
Kidney disease in patients with HIV infection and AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081201
Pharmacokinetics of emtricitabine/tenofovir disoproxil fumarate and tacrolimus at steady state when administered alone or in combination. International journal of clinical pharmacology and therapeutics 20081201
Changes in sexual risk behavior among participants in a PrEP HIV prevention trial. Sexually transmitted diseases 20081201
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of tenofovir and emtricitabine in human plasma and its application to a bioequivalence study. Journal of pharmaceutical and biomedical analysis 20081104
Determinants of high-risk sexual behavior during post-exposure prophylaxis to prevent HIV infection. AIDS and behavior 20081101
The discovery of antiviral agents: ten different compounds, ten different stories. Medicinal research reviews 20081101
Human immunodeficiency virus-induced uveitis: intraocular and plasma human immunodeficiency virus-1 RNA loads. Ophthalmology 20081101
Population pharmacokinetics of tenofovir in AIDS patients. Journal of clinical pharmacology 20081101
Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy? Journal of hepatology 20081101
Adverse effects of tenofovir use in HIV-infected pregnant women and their infants. The Annals of pharmacotherapy 20081101
Two-year data released on Viread for chronic hepatitis B. AIDS patient care and STDs 20081101
96-week CASTLE data show similar efficacy results. AIDS patient care and STDs 20081101
[A case of acute renal failure involving high amounts of tenofovir after HAART start]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20081101
[Chronic hepatitis B: current therapy]. Bulletin de l'Academie nationale de medecine 20081101
Low trough levels of tipranavir in a combination antiretroviral therapy of tipranavir/ritonavir and tenofovir require therapeutic drug monitoring. European journal of medical research 20081027
Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient. European journal of medical research 20081027
The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients. AIDS (London, England) 20081018
Rosiglitazone reverses tenofovir-induced nephrotoxicity. Kidney international 20081001
A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in Thailand. Hepatology (Baltimore, Md.) 20081001
Drug-susceptible HIV-1 infection despite intermittent fixed-dose combination tenofovir/emtricitabine as prophylaxis is associated with low-level viremia, delayed seroconversion, and an attenuated clinical course. Journal of acquired immune deficiency syndromes (1999) 20081001
Combination antiretroviral therapy with tenofovir, emtricitabine or lamivudine, and nevirapine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081001
The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV. AIDS (London, England) 20081001
[Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic perspectives, in patients naïve and in subjects pre-treated with antiretrovirals]. Recenti progressi in medicina 20081001
Tenofovir-associated decline in renal function. The Journal of infectious diseases 20080915
Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s. Journal of the American College of Cardiology 20080812
Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study. HIV medicine 20080801
The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation. Journal of acquired immune deficiency syndromes (1999) 20080801
Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: successful rescue therapy with tenofovir. European journal of gastroenterology & hepatology 20080801
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS medicine 20080801
Can a topical microbicide prevent rectal HIV transmission? PLoS medicine 20080801
Tenofovir: what have over 1 million years of patient experience taught us? International journal of clinical practice 20080801
CD4 count improvement following tenofovir to abacavir switch in a patient with persistent lymphopenia despite an undetectable viral load. The AIDS reader 20080801
Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis. Liver international : official journal of the International Association for the Study of the Liver 20080701
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases. Molecular pharmacology 20080701
Review article: current antiviral therapy of chronic hepatitis B. Alimentary pharmacology & therapeutics 20080701
Cost and cost-effectiveness of switching from stavudine to tenofovir in first-line antiretroviral regimens in South Africa. Journal of acquired immune deficiency syndromes (1999) 20080701
A new assay based on solid-phase extraction procedure with LC-MS to measure plasmatic concentrations of tenofovir and emtricitabine in HIV infected patients. Journal of chromatographic science 20080701
Zidovudine/lamivudine/abacavir plus tenofovir in HIV-infected naive patients: a 96-week prospective one-arm pilot study. AIDS research and human retroviruses 20080701
Genetic basis of variation in tenofovir drug susceptibility in HIV-1. AIDS (London, England) 20080619
Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy. The Journal of antimicrobial chemotherapy 20080601
Changing patterns in HIV reverse transcriptase resistance mutations after availability of tenofovir. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080601
Switch from ritonavir-boosted to unboosted atazanavir guided by therapeutic drug monitoring. AIDS research and human retroviruses 20080601
Addition of single-dose tenofovir and emtricitabine to intrapartum nevirapine to reduce perinatal HIV transmission. Journal of acquired immune deficiency syndromes (1999) 20080601
[Introduction. Tenofovir]. Enfermedades infecciosas y microbiologia clinica 20080601
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[Tenofovir as a strategy to avoid or limit adverse effects]. Enfermedades infecciosas y microbiologia clinica 20080601
[Tenofovir DF in rescue regimens]. Enfermedades infecciosas y microbiologia clinica 20080601
[Role of tenofovir in HIV and hepatitis C virus coinfection]. Enfermedades infecciosas y microbiologia clinica 20080601
[Are all analogue combinations equal?]. Enfermedades infecciosas y microbiologia clinica 20080601
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[Current role of tenofovir in clinical medicine]. Enfermedades infecciosas y microbiologia clinica 20080601
Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV). Hepatology international 20080601
[Chronic hepatitis B. Tenofovir--the right choice from the beginning]. MMW Fortschritte der Medizin 20080522
[Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients]. MMW Fortschritte der Medizin 20080522
Does tenofovir increase efavirenz hepatotoxicity? AIDS (London, England) 20080511
Experience with tenofovir disoproxil fumarate for antiretroviral therapy. Expert opinion on pharmacotherapy 20080501
[Acute renal failure associated with the use of tenofovir combined with atazanavir in patients with HIV infection]. Enfermedades infecciosas y microbiologia clinica 20080501
[Severe hypokalemia and tenofovir]. Enfermedades infecciosas y microbiologia clinica 20080501
[Nucleoside and nucleotide analogs in the treatment of chronic hepatitis B]. Enfermedades infecciosas y microbiologia clinica 20080501
[Resistance in hepatitis B virus]. Enfermedades infecciosas y microbiologia clinica 20080501
[Clinical management of patients with chronic hepatitis B virus infection]. Enfermedades infecciosas y microbiologia clinica 20080501
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[First line therapy. Tenofovir DF/emtricitabine--the potent backbone]. MMW Fortschritte der Medizin 20080428
Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080415
Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma. Clinical pharmacology and therapeutics 20080401
Tenofovir DF plus lamivudine or emtricitabine for nonoccupational postexposure prophylaxis (NPEP) in a Boston Community Health Center. Journal of acquired immune deficiency syndromes (1999) 20080401
Recent availability of two novel, fixed formulations of antiretroviral nucleoside analogues: a 12-month prospective, open-label survey of their practical use and therapeutic perspectives in antiretroviral-naive and -experienced patients. AIDS patient care and STDs 20080401
Acceptability of tenofovir gel as a vaginal microbicide among women in a phase I trial: a mixed-methods study. Journal of women's health (2002) 20080401
The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers. British journal of clinical pharmacology 20080401
Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus. The Journal of pediatrics 20080401
Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques. AIDS research and human retroviruses 20080401
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position. Nucleosides, nucleotides & nucleic acids 20080401
An open-label pilot study to determine the efficacy of lopinavir/ritonavir and tenofovir DF in the treatment of HIV-infected patients experiencing first virologic failure on a non-nucleoside-based regimen. AIDS patient care and STDs 20080401
Europe extends Viread indication for chronic hepatitis B. AIDS patient care and STDs 20080401
Risk of early virological failure of once-daily tenofovir-emtricitabine plus twice-daily nevirapine in antiretroviral therapy-naive HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401
Test of new vaginal microbicide gel show promise for women. The AIDS reader 20080401
[AIDS: ethics and scientific investigation on human beings]. Bulletin de la Societe de pathologie exotique (1990) 20080401
Abacavir/3TC vs. tenofovir/FTC: interim results from ACTG 5202. AIDS clinical care 20080401
Potency of tenofovir in chronic hepatitis B: mono or combination therapy? Journal of hepatology 20080301
The pharmacokinetics and viral activity of tenofovir in the male genital tract. Journal of acquired immune deficiency syndromes (1999) 20080301
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations. Journal of hepatology 20080301
Kidney biopsy in HIV: beyond HIV-associated nephropathy. American journal of kidney diseases : the official journal of the National Kidney Foundation 20080301
Syncope as a probable side effect to combination antiretroviral therapy initiated during primary HIV-1 infection. Sexual health 20080301
Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999) 20080301
pH-dependent interactions of indinavir and lipids in nanoparticles and their ability to entrap a solute. Journal of pharmaceutical sciences 20080201
The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients. Clinical pharmacology and therapeutics 20080201
Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells. Journal of mass spectrometry : JMS 20080201
Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. Antimicrobial agents and chemotherapy 20080201
Minor emtricitabine intolerance in treatment-stable patients switched from tenofovir/lamivudine to a fixed-dose combination of tenofovir/emtricitabine (Truvada). The Journal of antimicrobial chemotherapy 20080201
Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080201
Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression. Journal of viral hepatitis 20080201
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS medicine 20080201
Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system. AIDS patient care and STDs 20080201
Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients. Clinical therapeutics 20080201
Urolithiasis under atazanavir boosted and tenofovir therapy: a case report. Journal of chemotherapy (Florence, Italy) 20080201
Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors. European journal of pharmacology 20080128
[Anti-viral therapy of type B chronic hepatitis. 3. Future of anti-viral agents]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20080110
Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection. AIDS (London, England) 20080102
Tenofovir renal safety in HIV-infected patients: results from the SCOLTA Project. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080101
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450. Physiological research 20080101
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis. Journal of acquired immune deficiency syndromes (1999) 20080101
Treatment options for lipodystrophy in HIV-positive patients. Expert opinion on pharmacotherapy 20080101
Effects of the change from Stavudine to tenofovir in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy: studies on mitochondrial toxicity and thymic function. The Pediatric infectious disease journal 20080101
Tenofovir nephrotoxicity: focusing research questions and putting them into clinical context. The Journal of infectious diseases 20080101
Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy. The Journal of infectious diseases 20080101
Can the new humanized mouse model give HIV research a boost. PLoS medicine 20080101
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS medicine 20080101
Plasma HIV load and proviral DNA decreases after two standard antiretroviral regimens in HIV-positive patients naïve to antiretrovirals. Current HIV research 20080101
Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement. Journal of neurovirology 20080101
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues. Antiviral therapy 20080101
FDA grants tentative approval to first generic version of antiretroviral Viread. AIDS patient care and STDs 20080101
European Commission approves Atripla. AIDS patient care and STDs 20080101
Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV. HIV clinical trials 20080101
Impact of switching virologically suppressed, HIV-1-infected patients from twice-daily fixed-dose zidovudine/lamivudine to once-daily fixed-dose tenofovir disoproxil fumarate/emtricitabine. HIV clinical trials 20080101
Partial immunological and mitochondrial recovery after reducing didanosine doses in patients on didanosine and tenofovir-based regimens. Antiviral therapy 20080101
FDA notifications. FDA's tentative approval for generic Tenofovir. AIDS alert 20080101
Evidence of long-term suppression of hepatitis B virus DNA by tenofovir as rescue treatment in patients coinfected by HIV. Antiviral therapy 20080101
Treatment of chronic hepatitis B infection: an update of Swedish recommendations. Scandinavian journal of infectious diseases 20080101
Evaluation of efficacy, safety, pharmacokinetics, and adherence in HIV-1-infected, antiretroviral-naïve patients treated with ritonavir-boosted atazanavir plus fixed-dose tenofovir DF/emtricitabine given once daily. HIV clinical trials 20080101
'White coat compliance' limits the reliability of therapeutic drug monitoring in HIV-1-infected patients. HIV clinical trials 20080101
Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients. Antiviral therapy 20080101
Effect of tenofovir subtraction on HIV plasma viraemia, CD4+ T-cell count and resistance in a patient with baseline K65R and M184V mutations. Antiviral therapy 20080101
Renal dysfunction and tenofovir toxicity in HIV-infected patients. Topics in HIV medicine : a publication of the International AIDS Society, USA 20080101
Pharmacotherapy of hepatitis B infection: a brief review. Nephrology nursing journal : journal of the American Nephrology Nurses' Association 20080101
Effectiveness and safety of generic fixed-dose combination of tenofovir/emtricitabine/efavirenz in HIV-1-infected patients in Western India. Medscape journal of medicine 20080101
[Drugs treatment of hepatitis B]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20080101
No residual activity of raltegravir after development of 148 complex mutations in vivo. Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20080101
Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues. Best practice & research. Clinical gastroenterology 20080101
Tenofovir use is associated with an increase in serum alkaline phosphatase in the Swiss HIV Cohort Study. Antiviral therapy 20080101
Improvements in subcutaneous fat, lipid profile, and parameters of mitochondrial toxicity in patients with peripheral lipoatrophy when stavudine is switched to tenofovir (LIPOTEST study). HIV clinical trials 20080101
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates. Bioorganic & medicinal chemistry letters 20071215
Observational study on HIV-infected subjects failing HAART receiving tenofovir plus didanosine as NRTI backbone. Infection 20071201
Congenital pyelectasis in children born from mothers on tenofovir containing therapy during pregnancy: report of two cases. Infection 20071201
Resistance testing methodologies and mechanisms of resistance. Journal of HIV therapy 20071201
Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B. Journal of HIV therapy 20071201
Selection of L74V mutation in reverse transcriptase of HIV-1 subtype D by a tenofovir DF-lamivudine based regimen. AIDS (London, England) 20071130
Reply to Crane et al., 'Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir'. AIDS (London, England) 20071130
Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet (London, England) 20071117
Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro. Bioorganic & medicinal chemistry letters 20071115
Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS (London, England) 20071112
Pharmacokinetic interaction between TMC114/ritonavir and tenofovir disoproxil fumarate in healthy volunteers. British journal of clinical pharmacology 20071101
Acute renal failure in HIV patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071001
Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells. Antiviral research 20071001
Tenofovir comedication does not impair the steady-state pharmacokinetics of ritonavir-boosted atazanavir in HIV-1-infected adults. European journal of clinical pharmacology 20071001
Bioequivalence of efavirenz/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen. Journal of acquired immune deficiency syndromes (1999) 20071001
Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine. Journal of acquired immune deficiency syndromes (1999) 20071001
Predictors and kinetics of occult hepatitis B virus infection in HIV-infected persons. Journal of medical virology 20071001
Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. Journal of acquired immune deficiency syndromes (1999) 20071001
Is phosphatemia the best tool to monitor renal tenofovir toxicity? Journal of acquired immune deficiency syndromes (1999) 20071001
Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen. Therapeutic drug monitoring 20071001
Increased beta-2 microglobulinuria in human immunodeficiency virus-1-infected children and adolescents treated with tenofovir. The Pediatric infectious disease journal 20071001
Female-initiated prevention strategies key to tackling HIV. The Lancet. Infectious diseases 20071001
Tenofovir resistance among HIV-infected patients failing a fixed-dose combination of stavudine, lamivudine, and nevirapine in a resource-limited setting. AIDS patient care and STDs 20071001
Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis. AIDS (London, England) 20070912
Diverse approaches useful for microbicide trials. Nature 20070906
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Renal function in Tenofovir-exposed and Tenofovir-unexposed patients receiving highly active antiretroviral therapy in the HIV Outpatient Study. Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20070901
Adverse events experienced by three children taking tenofovir and didanosine in combination. HIV medicine 20070901
Pregnancy prevention practices among women with multiple partners in an HIV prevention trial. Journal of acquired immune deficiency syndromes (1999) 20070901
Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070901
HIV-1 infection and the kidney: an evolving challenge in HIV medicine. Mayo Clinic proceedings 20070901
Determination of plasma tenofovir concentrations using a conventional LC-MS method. Biological & pharmaceutical bulletin 20070901
Acceptability of tenofovir gel as a vaginal microbicide by US male participants in a Phase I clinical trial (HPTN 050). AIDS care 20070901
Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase. Journal of acquired immune deficiency syndromes (1999) 20070815
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs. Bioorganic & medicinal chemistry 20070815
Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B. World journal of gastroenterology 20070814
Lopinavir/Ritonavir pharmacokinetic profile: impact of sex and other covariates following a change from twice-daily to once-daily therapy. Journal of clinical pharmacology 20070801
Compromised immunologic recovery in patients receiving tipranavir/ritonavir coadministered with tenofovir and didanosine in Randomized Evaluation of Strategic Intervention in multidrug-resiStant patients with tipranavir (RESIST) studies. Journal of acquired immune deficiency syndromes (1999) 20070801
Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy. Journal of medical primatology 20070801
Direct stringency comparison of two macaque models (single-high vs. repeat-low) for mucosal HIV transmission using an identical anti-HIV chemoprophylaxis intervention. Journal of medical primatology 20070801
Second tenofovir phase III study for the chronic HBV reaches primary endpoint. AIDS patient care and STDs 20070801
Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase. AIDS (London, England) 20070711
Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir. AIDS (London, England) 20070711
Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate. AIDS (London, England) 20070711
Effect of tenofovir on renal glomerular and tubular function. AIDS (London, England) 20070711
Porphyria cutanea tarda in an HIV-1-infected patient after the initiation of tipranavir/ritonavir: case report. AIDS (London, England) 20070711
Pre-exposure prophylaxis for HIV infection: what if it works? Lancet (London, England) 20070707
A second chance for microbicides. Lancet (London, England) 20070707
Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137. Journal of acquired immune deficiency syndromes (1999) 20070701
Relevance of a combined UV and single mass spectrometry detection for the determination of tenofovir in human plasma by HPLC in therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701
The first once-daily single-tablet regimen for the treatment of HIV-infected patients. Drugs of today (Barcelona, Spain : 1998) 20070701
Tenofovir gel--the new HIV prevention 'banker'? South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20070701
[Hypophosphatemia and multiple fractures in patient with human immunodeficiency virus infection treated with tenofovir]. Medicina clinica 20070630
The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years. AIDS (London, England) 20070619
Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey. AIDS (London, England) 20070619
Fosamprenavir/ritonavir plus tenofovir does not affect amprenavir pharmacokinetics: no effect of tenofovir. AIDS (London, England) 20070619
Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases. AIDS (London, England) 20070619
Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjects. AIDS (London, England) 20070619
CD4+ T cell evolution and predictors of its trend before and after tenofovir/didanosine backbone in the presence of sustained undetectable HIV plasma viral load. The Journal of antimicrobial chemotherapy 20070601
Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies. Virchows Archiv : an international journal of pathology 20070601
Steady-state pharmacokinetics of emtricitabine and tenofovir disoproxil fumarate administered alone and in combination in healthy volunteers. Journal of clinical pharmacology 20070601
Assessment of adverse events associated with antiretroviral regimens for postexposure prophylaxis for occupational and nonoccupational exposures to prevent transmission of human immunodeficiency virus. Infection control and hospital epidemiology 20070601
HPV oral infection. Case report of an HIV-positive Nigerian sex worker. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20070601
Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome. The AIDS reader 20070601
Editorial comment: Fanconi syndrome and tenofovir--understanding proximal tubular function. The AIDS reader 20070601
Chronic renal failure among HIV-1-infected patients. AIDS (London, England) 20070531
Atazanavir-associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System. AIDS (London, England) 20070531
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein. Biochemical pharmacology 20070515
Possible allergic cross-reaction to didanosine and tenofovir in an HIV-1-infected woman. AIDS (London, England) 20070511
No response to first-line tenofovir+lamivudine+efavirenz despite optimization according to baseline resistance testing: impact of resistant minority variants on efficacy of low genetic barrier drugs. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20070501
No change in calculated creatinine clearance after tenofovir initiation among Thai patients. The Journal of antimicrobial chemotherapy 20070501
Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events. The Journal of infectious diseases 20070501
Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens. Journal of acquired immune deficiency syndromes (1999) 20070501
Could tenofovir modify the model end-stage liver disease (MELD) score in patients with end-stage liver disease eligible for liver transplantation? Journal of acquired immune deficiency syndromes (1999) 20070501
Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression. AIDS (London, England) 20070423
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. Biochemical pharmacology 20070401
Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir. The Journal of antimicrobial chemotherapy 20070401
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharmaceutical research 20070401
Tenofovir and abacavir combination therapy: lessons learned from an urban clinic population. AIDS patient care and STDs 20070401
Long-term follow-up of patients taking tenofovir DF with low-level HIV-1 viremia and the K65R substitution in HIV-1 RT. AIDS (London, England) 20070330
Hepatitis B reverse seroconversion in HIV-positive patients: case series and review of the literature. AIDS (London, England) 20070330
Response to Schmutz et al., 'Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection'. AIDS (London, England) 20070330
Response to Blaas et al., 'Acute renal failure in HIV patients with liver cirrhosis receiving tenofovir: a report of two cases'. AIDS (London, England) 20070330
Impact of modelling intra-subject variability on tests based on non-linear mixed-effects models in cross-over pharmacokinetic trials with application to the interaction of tenofovir on atazanavir in HIV patients. Statistics in medicine 20070315
Treatment of hepatitis B with lamivudine and tenofovir in HIV/HBV-coinfected patients: factors associated with response. Journal of viral hepatitis 20070301
Antiviral therapy for pre- and post-liver transplantation patients with hepatitis B. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301
Treatment of patients with lamivudine-resistant and adefovir dipivoxil-resistant chronic hepatitis B virus infection: is tenofovir the answer? Gut 20070301
Tenofovir-induced kidney injury. Expert opinion on drug safety 20070301
Treatment of chronic hepatitis B in HIV-infected patients in 2007. Journal of HIV therapy 20070301
Metabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients. European journal of medical research 20070226
Prevention. Anti-HIV drug could prevent transmission in women. AIDS policy & law 20070223
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Molecular pharmacology 20070201
Efficacy and safety of tenofovir double-dose in treatment-experienced HIV-infected patients: the TENOPLUS study. Journal of medical virology 20070201
Visual loss secondary to acquired immunodeficiency virus-related progressive multifocal leukoencephalopathy demonstrating clinical improvement with highly active antiretroviral therapy. Optometry (St. Louis, Mo.) 20070201
Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all? Expert opinion on pharmacotherapy 20070201
Progressive multifocal leukoencephalopathy: serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy. AJNR. American journal of neuroradiology 20070201
Renal safety of tenofovir disoproxil fumarate. The AIDS reader 20070201
Editorial comment: tenofovir-related nephrotoxicity--who's at risk? The AIDS reader 20070201
Induction therapy with enfuvirtide-based highly active antiretroviral therapy in a patient with acute HIV-1 infection. AIDS patient care and STDs 20070201
Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy. Journal of medical primatology 20070201
K65R development among subtype C HIV-1-infected patients in tenofovir DF clinical trials. AIDS (London, England) 20070111
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. The Journal of antimicrobial chemotherapy 20070101
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. Retrovirology 20070101
Treatment of HIV/HBV coinfection: clinical and virologic issues. AIDS reviews 20070101
Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors. Antiviral therapy 20070101
Reversibility of cirrhosis in HIV/HBV coinfection. Antiviral therapy 20070101
Renal function in antiretroviral-experienced patients treated with tenofovir disoproxil fumarate associated with atazanavir/ritonavir. Antiviral therapy 20070101
Does tenofovir influence efavirenz pharmacokinetics? Antiviral therapy 20070101
Improvements in parameters of end-stage liver disease in patients with HIV/HBV-related cirrhosis treated with tenofovir. Antiviral therapy 20070101
Development of a sensitive and specific liquid chromatography/mass spectrometry method for the determination of tenofovir in human plasma. Rapid communications in mass spectrometry : RCM 20070101
In vitro selection and characterization of human immunodeficiency virus type 1 resistant to Zidovudine and tenofovir. Nucleosides, nucleotides & nucleic acids 20070101
Normalization of fat accrual in lipoatrophic, HIV-infected children switched from stavudine to tenofovir and from protease inhibitor to efavirenz. Antiviral therapy 20070101
The impact of reducing stavudine dose versus switching to tenofovir on plasma lipids, body composition and mitochondrial function in HIV-infected patients. Antiviral therapy 20070101
The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients. HIV clinical trials 20070101
Safety and tolerability of sequential pegylated IFN-alpha2a and tenofovir for hepatitis B infection in HIV(+) individuals. HIV clinical trials 20070101
Simplified maintenance therapy with abacavir/lamivudine/zidovudine plus tenofovir after sustained HIV load suppression: four years of follow-up. HIV clinical trials 20070101
Renal safety of tenofovir in HIV-infected children: a prospective, 96-week longitudinal study. Clinical drug investigation 20070101
Early onset of tenofovir-induced renal failure: case report and review of the literature. TheScientificWorldJournal 20070101
Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV. Antiviral therapy 20070101
A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment. Antiviral therapy 20070101
Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview. HIV clinical trials 20070101
Development of a novel mouse model to evaluate drug candidates against hepatitis B virus. Antiviral chemistry & chemotherapy 20070101
CD4+ T-cell count increase in HIV-1-infected patients with suppressed viral load within 1 year after start of antiretroviral therapy. Antiviral therapy 20070101
Randomized controlled trial of once-daily tenofovir, lamivudine, and lopinavir/ritonavir versus remaining on the same regimen in virologically suppressed HIV-infected patients on their first PI-containing HAART regimen. HIV clinical trials 20070101
Effectiveness and safety of simplification therapy with once-daily tenofovir, lamivudine, and efavirenz in HIV-1-infected patients with undetectable plasma viral load on HAART. HIV clinical trials 20070101
Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors. Antiviral therapy 20070101
The safety and efficacy of switching stavudine to tenofovir df in combination with lamivudine and efavirenz in hiv-1-infected patients: three-year follow-up after switching therapy. HIV clinical trials 20070101
[Analysis of the causes and predictive factors for discontinuing treatment with tenofovir in pretreated HIV patients]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101
Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir. Nucleosides, nucleotides & nucleic acids 20070101
Acute renal failure after initiation of tenofovir disoproxil fumarate. Renal failure 20070101
Predicting tenofovir concentration on the basis of renal factors determined by routine tests. American journal of therapeutics 20070101
Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the Swiss HIV Cohort Study. Antiviral therapy 20070101
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes--a 96-week analysis. Journal of acquired immune deficiency syndromes (1999) 20061215
Virologic response of zidovudine, lamivudine, and tenofovir disoproxil fumarate combination in antiretroviral-naive HIV-1-infected patients. Journal of acquired immune deficiency syndromes (1999) 20061215
Renal function in patients receiving tenofovir with ritonavir/lopinavir or ritonavir/atazanavir in the HIV Outpatient Study (HOPS) cohort. Journal of acquired immune deficiency syndromes (1999) 20061215
In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine. Antimicrobial agents and chemotherapy 20061201
Toward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity. The Journal of infectious diseases 20061201
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. The Journal of infectious diseases 20061201
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen. European journal of gastroenterology & hepatology 20061201
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3. Neuro endocrinology letters 20061201
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir. Xenobiotica; the fate of foreign compounds in biological systems 20061201
Aminotransferase elevation in HIV/hepatitis B virus co-infected patients treated with two active hepatitis B virus drugs. AIDS patient care and STDs 20061201
Atripla approval in Europe. AIDS patient care and STDs 20061201
Rate of virologic failure and selection of drug resistance mutations using different triple nucleos(t)ide analogue combinations in HIV-infected patients. AIDS research and human retroviruses 20061201
Five-year data out on Viread. AIDS patient care and STDs 20061201
Hepatitis B virus treatment in HIV-infected patients. Topics in HIV medicine : a publication of the International AIDS Society, USA 20061201
[Use study of tenofovir DF in highly active anti-retroviral therapy]. Anales de medicina interna (Madrid, Spain : 1984) 20061201
A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient. AIDS (London, England) 20061114
Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061107
In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells. Antimicrobial agents and chemotherapy 20061101
Acquired Fanconi's syndrome associated with tenofovir therapy. Journal of general internal medicine 20061101
Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127. Hepatology (Baltimore, Md.) 20061101
Evolving simplified treatment strategies for HIV infection: the role of a single-class quadruple-nucleoside/nucleotide regimen of trizivir and tenofovir. Expert opinion on pharmacotherapy 20061101
Pharmacokinetics and safety of tenofovir disoproxil fumarate on coadministration with lopinavir/ritonavir. Journal of acquired immune deficiency syndromes (1999) 20061101
HIV prophylaxis still has no clear cut answer. AIDS alert 20061101
Report from the XVI International AIDS Conference. Preexposure prophylaxis studies move forward. AIDS clinical care 20061101
A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy. AIDS (London, England) 20061024
Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate. Virology 20061010
Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection. AIDS (London, England) 20061003
The role of tenofovir in the prevention of HIV infections. AIDS (London, England) 20061003
Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903. HIV medicine 20061001
Evaluation of hypophosphataemia in tenofovir disoproxil fumarate (TDF)-exposed and TDF-unexposed HIV-infected out-patients receiving highly active antiretroviral therapy. HIV medicine 20061001
Estimating renal function in patients on tenofovir disoproxil fumarate: suggestions for safer use. HIV medicine 20061001
Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061001
Chemoprophylaxis of HIV infection: moving forward with caution. The Journal of infectious diseases 20061001
Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges. The Journal of infectious diseases 20061001
[Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients]. Gastroenterologie clinique et biologique 20061001
A once-daily combination tablet (Atripla) for HIV. The Medical letter on drugs and therapeutics 20060925
Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus. Journal of acquired immune deficiency syndromes (1999) 20060901
Perspectives on the development of acyclic nucleotide analogs as antiviral drugs. Antiviral research 20060901
Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children. Pediatrics 20060901
Change to a once-daily combination including boosted atazanavir in HIV-1-infected children. The Pediatric infectious disease journal 20060901
Hepatitis delta virus super-infection in a co-infected patient with the human immunodeficiency virus type 1 and a surface antigen-negative hepatitis B virus variant. International journal of STD & AIDS 20060901
Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjögren-associated myelopathy. Archives of neurology 20060901
Long-term follow-up of patients with initial early virologic failure after being treated with once-daily tenofovir/abacavir/lamivudine. AIDS patient care and STDs 20060901
Virological outcome of chronic hepatitis B virus infection in HIV-coinfected patients receiving anti-HBV active antiretroviral therapy. AIDS research and human retroviruses 20060901
A rapid and sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase. AIDS research and human retroviruses 20060901
One pill, once daily: now an option for HIV patients. AIDS clinical care 20060901
Once-daily dosing and the treatment of HIV disease. The AIDS reader 20060901
Pre-exposure prophylaxis effective. AIDS patient care and STDs 20060901
[Renal toxicity in HIV-infected patients receiving HAART including tenofovir]. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20060901
Acute renal failure in HIV patients with liver cirrhosis receiving tenofovir: a report of two cases. AIDS (London, England) 20060822
An update and review of antiretroviral therapy. Pharmacotherapy 20060801
Hypokalemia in HIV patients on tenofovir. AIDS (London, England) 20060801
Tenofovir disoproxil fumarate: role in hepatitis B treatment. Hepatology (Baltimore, Md.) 20060801
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. Hepatology (Baltimore, Md.) 20060801
Rapid improvement of liver function in a patient with HIV and hepatitis B coinfection treated with lamivudine and tenofovir. Infection 20060801
Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate. AIDS research and human retroviruses 20060801
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Absence of clinically relevant pharmacokinetic interaction between ribavirin and tenofovir in healthy subjects. Journal of clinical pharmacology 20060501
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Workshop explores racial PK differences, TDF-PI interaction. IAPAC monthly 20060501
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Higher risk of hyperglycemia in HIV-infected patients treated with didanosine plus tenofovir. AIDS research and human retroviruses 20060401
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Report from the 13th retrovirus conference. Renal tenofovir debate continues. AIDS clinical care 20060401
96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures. AIDS (London, England) 20060321
Serum creatinine changes in HIV-seropositive patients receiving tenofovir. AIDS (London, England) 20060321
Registration problems for antiretrovirals in Africa. Lancet (London, England) 20060311
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Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients. Hepatology (Baltimore, Md.) 20060301
Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women. AIDS (London, England) 20060227
Retrovirus meeting. Novel attacks on HIV move closer to reality. Science (New York, N.Y.) 20060217
Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure. The Journal of infection 20060201
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Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV. The New England journal of medicine 20060119
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Sensitive assay for determining plasma tenofovir concentrations by LC/MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Improved lipid profiles and maintenance of virologic control in heavily pretreated HIV-infected patients who switched from stavudine to tenofovir treatment. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060101
Assessment of drug-drug interactions between tenofovir disoproxil fumarate and the nonnucleoside reverse transcriptase inhibitors nevirapine and efavirenz in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999) 20060101
Case study: an active, 24-year-old woman positive for HIV. JAAPA : official journal of the American Academy of Physician Assistants 20060101
Longitudinal study on mitochondrial effects of didanosine-tenofovir combination. AIDS research and human retroviruses 20060101
Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients. Antiviral therapy 20060101
An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy. Antiviral therapy 20060101
Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy. Antiviral therapy 20060101
Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues. Annals of clinical microbiology and antimicrobials 20060101
Clinically stable treatment-experienced adults receiving tenofovir and didanosine. HIV clinical trials 20060101
Salvage therapy with atazanavir/ritonavir combined to tenofovir in HIV-infected patients with multiple treatment failures: randomized ANRS 107 trial. Antiviral therapy 20060101
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[Role of bone gammagraphy in the diagnosis of secondary osteomalacia in a patient treated with tenofovir]. Revista espanola de medicina nuclear 20060101
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Brazil: Gilead cuts tenofovir price in half. AIDS treatment news 20060101
Efavirenz/emtricitabine/tenofovir disoproxil fumarate: triple combination tablet. Drugs 20060101
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Short communication metabolic and mitochondrial effects of switching antiretroviral-experienced patients to enfuvirtide, tenofovir and saquinavir/ritonavir. Antiviral therapy 20060101
Pharmacokinetics and dosing recommendations of tenofovir disoproxil fumarate in hepatic or renal impairment. Clinical pharmacokinetics 20060101
Tenofovir plus didanosine as Nrti backbone in HIV-infected subjects. Current medicinal chemistry 20060101
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[The Tenovofir trial in Cameroun. Analysis of the controversial positions and proposal for an ethical alternative]. Sante (Montrouge, France) 20060101
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Report from the 2nd International Workshop on HIV and Hepatitis Co-Infection, January 12-14, 2006, Amsterdam, Netherlands. Tenofovir or adefovir for hepatitis B. TreatmentUpdate 20060101
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Antiretroviral efficacy and virological profile of a zidovudine/lamivudine/tenofovir disoproxil fumarate combination therapy in antiretroviral-naive patients. Antiviral therapy 20060101
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Less than the sum of its parts: failure of a tenofovir-abacavir-Lamivudine triple-nucleoside regimen. The Journal of infectious diseases 20051201
Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects. The Journal of infectious diseases 20051201
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Protective effect of the acyclic nucleoside phosphonate tenofovir toward human T-cell leukemia/lymphotropic virus type 1 infection of human peripheral blood mononuclear cells in vitro. Antiviral research 20051201
A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected children. Journal of acquired immune deficiency syndromes (1999) 20051201
Drug-drug and drug-food interactions between tenofovir disoproxil fumarate and didanosine. Journal of clinical pharmacology 20051201
Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection. Pediatrics 20051201
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[The treatment of HIV infection]. Presse medicale (Paris, France : 1983) 20051119
Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir. AIDS (London, England) 20051118
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High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir. AIDS (London, England) 20051014
Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have a comparable effect on the CD4 cell change after switching to tenofovir-based regimens. AIDS (London, England) 20051014
Absence of new thymidine-associated mutations and evidence of an immune virologic response over a 12-month period in a cohort of antiretroviral-experienced HIV-1-infected subjects treated with tenofovir combination therapy. Journal of acquired immune deficiency syndromes (1999) 20051001
The tenofovir pre-exposure prophylaxis trial in Thailand: researchers should show more openness in their engagement with the community. PLoS medicine 20051001
Response to Joep M. A. Lange. PLoS medicine 20051001
HIV prevention research in a resource-limited setting: the experience of planning a trial in Cambodia. Lancet (London, England) 20051001
HIV Pathogenesis and Treatment - Third International AIDS Society Conference. IDrugs : the investigational drugs journal 20051001
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The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. HIV medicine 20050901
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Tenofovir and changes in renal function. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815
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Progression of renal impairment under therapy with tenofovir. AIDS (London, England) 20050812
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Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). The Journal of pharmacology and experimental therapeutics 20050801
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Resistance mutations before and after tenofovir regimen failure in HIV-1 infected patients. Journal of medical virology 20050701
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Fatal lactic acidosis associated with tenofovir and abacavir. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20050701
Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results. Transplant international : official journal of the European Society for Organ Transplantation 20050701
Risk factors for CD4 lymphopenia in patients treated with a tenofovir/didanosine high dose-containing highly active antiretroviral therapy regimen. AIDS (London, England) 20050701
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Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report and review of the literature. The AIDS reader 20050701
Editorial comment: tenofovir nephrotoxicity--vigilance required. The AIDS reader 20050701
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Long-term hepatitis B virus dynamics in HIV-hepatitis B virus-co-infected patients treated with tenofovir disoproxil fumarate. AIDS (London, England) 20050610
SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy. Journal of medical primatology 20050601
[Acute renal failure, Fanconi syndrome and insipidus diabetes in a HIV-infected patient treated with Tenofovir]. La Revue de medecine interne 20050601
Stakeholder consultation to address issues related to tenofovir prophylactic research. IAPAC monthly 20050601
Switching from protease inhibitors to a single-class regimen of abacavir/lamivudine/zidovudine plus tenofovir in patients with HIV load suppression. AIDS (London, England) 20050520
Tenofovir in chronic hepatitis B. Hepatology (Baltimore, Md.) 20050501
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrobial agents and chemotherapy 20050501
The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily. HIV medicine 20050501
The use of a triple nucleoside-nucleotide regimen for nonoccupational HIV post-exposure prophylaxis. HIV medicine 20050501
Unethical clinical trials in Thailand: a community response. Lancet (London, England) 20050501
Unethical clinical trials in Thailand: a community response. Lancet (London, England) 20050501
Tenofovir helpful for patients with HBV. AIDS patient care and STDs 20050501
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures. AIDS (London, England) 20050429
High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir. AIDS (London, England) 20050429
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Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050415
Long-term renal safety of tenofovir disoproxil fumarate in antiretroviral-naive HIV-1-infected patients. Data from a double-blind randomized active-controlled multicentre study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050401
Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudine. The Journal of infectious diseases 20050401
The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy. Journal of neurovirology 20050401
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AIDS clinical trials. More woes for novel HIV prevention approach. Science (New York, N.Y.) 20050318
Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050301
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Adverse effects of antiretroviral therapy for HIV infection: a review of selected topics. Expert opinion on drug safety 20050301
Early virologic failure in a pilot study evaluating the efficacy of therapy containing once-daily abacavir, lamivudine, and tenofovir DF in treatment-naive HIV-infected patients. AIDS patient care and STDs 20050301
The trials of tenofovir trials. Lancet (London, England) 20050301
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel. AIDS (London, England) 20050218
Tenofovir-induced acute renal failure in an HIV patient with normal renal function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050201
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Women testing tenofovir for HIV prevention. AIDS patient care and STDs 20050201
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Prevalence and conditions of selection of the K65R mutation in the reverse transcriptase gene of HIV-1. Journal of acquired immune deficiency syndromes (1999) 20050101
The experts speak. Studying the potential of tenofovir to prevent sexual transmission of HIV: first steps. Interview by Vicki Glaser. AIDS patient care and STDs 20050101
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Tenofovir regimen compared with Combivir. AIDS patient care and STDs 20050101
Meeting notes from ICAAC. Tenofovir + ddI: a combination to avoid. AIDS clinical care 20050101
Meeting notes from ICAAC. Tenofovir + emtricitabine vs. AZT + 3TC. AIDS clinical care 20050101
Early virological failure with a combination of tenofovir, didanosine and efavirenz. Antiviral therapy 20050101
[Cost-effectiveness analysis of tenofovir versus zidovudine in combination therapy with efavirenz and lamivudine for the treatment of HIV in naive patients]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101
In vitro combination studies of tenofovir and other nucleoside analogues with ribavirin against HIV-1. Antiviral therapy 20050101
The steady-state pharmacokinetics of nelfinavir in combination with tenofovir in HIV-infected patients. Antiviral therapy 20050101
Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine. Antiviral therapy 20050101
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Drugs in development for hepatitis B. Drugs 20050101
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Treatment news. What's 'The T'? Survival news (Atlanta, Ga.) 20050101
Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir. Antiviral therapy 20050101
Hepatic and renal safety profile of tenofovir in HIV-infected patients with hepatitis C, including patients on interferon plus ribavirin. HIV clinical trials 20050101
Simplification therapy with once-daily didanosine, tenofovir and efavirenz in HIV-1-infected adults with viral suppression receiving a more complex antiretroviral regimen: final results of the EFADITE trial. Antiviral therapy 20050101
Failure of tenofovir + abacavir + 3TC combination; full report published, more insight. AIDS treatment news 20050101
Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites. Xenobiotica; the fate of foreign compounds in biological systems 20050101
Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected children. Antiviral therapy 20050101
Anti-HIV agents. Dueling nukes: AZT + 3TC vs. tenofovir + FTC. TreatmentUpdate 20050101
CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related. AIDS (London, England) 20041203
Tenofovir therapy for lamivudine resistance following liver transplantation. The Annals of pharmacotherapy 20041201
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. Hepatology (Baltimore, Md.) 20041201
New once-daily HIV combination better tolerated. Expert review of anti-infective therapy 20041201
Renal dysfunction with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy regimens is not observed more frequently: a cohort and case-control study. Journal of acquired immune deficiency syndromes (1999) 20041201
Saquinavir trough concentration before and after switching NRTI to tenofovir in patients treated with once-daily saquinavir hard gel capsule/ritonavir 1600 mg/100 mg. Antiviral therapy 20041201
Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment. AIDS (London, England) 20041119
The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro. AIDS (London, England) 20041105
Impact of a treatment including tenofovir plus didanosine on the selection of the 65R mutation in highly drug-experienced HIV-infected patients. AIDS (London, England) 20041105
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Outcomes in liver transplant recipients with hepatitis B virus: resistance and recurrence patterns from a large transplant center over the last decade. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20041101
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Warning on two specific 3-drug regimens: Viread + Didanosine + either Sustiva or Viramune. AIDS treatment news 20041029
Tenofovir, equivalence, and noninferiority. JAMA 20041027
Predictors of selection of K65R: tenofovir use and lack of thymidine analogue mutations. AIDS (London, England) 20041021
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Acute onset of pancreatitis with concomitant use of tenofovir and didanosine. The Annals of pharmacotherapy 20041001
Correlation between rules-based interpretation and virtual phenotype interpretation of HIV-1 genotypes for predicting drug resistance in HIV-infected individuals. Journal of virological methods 20041001
Trial of antiretroviral for HIV prevention on hold. The Lancet. Infectious diseases 20041001
Ninety-six-week efficacy of combination therapy with lamivudine and tenofovir in patients coinfected with HIV-1 and wild-type hepatitis B virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041001
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6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity. Nucleosides, nucleotides & nucleic acids 20041001
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Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men. AIDS (London, England) 20040924
Intracellular pharmacology of emtricitabine and tenofovir. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040915
Lichenoid drug eruption to tenofovir in an HIV/hepatitis B virus co-infected patient. AIDS (London, England) 20040903
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Box warning updated for tenofovir. AIDS patient care and STDs 20040901
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AIDS research. Cambodian leader throws novel prevention trial into limbo. Science (New York, N.Y.) 20040820
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Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion. Antiviral research 20040801
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Haemolytic anaemia after nucleotide antiretroviral treatment discontinuation in a chronic hepatitis B-virus co-infected AIDS patient. AIDS (London, England) 20040723
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Preemptive use of antiretroviral drugs to prevent sexual transmission of HIV to high-risk uninfected MSM. American journal of public health 20030801
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Antiviral Research--16th Annual International Conference. Satellite symposium: clinical update on antiviral drugs. 27 April-1 May 2003, Savannah, GA, USA. IDrugs : the investigational drugs journal 20030601
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Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus. The Journal of infectious diseases 20021115
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Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta). Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20021101
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Tenofovir gel studied. AIDS patient care and STDs 20020801
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8th European Conference on Clinical Aspects and Treatment of HIV Infection, Athens, 28-31 October 2001. Sexually transmitted infections 20020401
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New antiretroviral for HIV infection. American family physician 20020301
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Prodrug of tenofovir diphosphate approved for combination HIV therapy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020101
Tenofovir (viread) receives FDA approval. AIDS alert 20020101
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Gilead sciences releases Viread. Survival news (Atlanta, Ga.) 20020101
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Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection. The Journal of infectious diseases 20010815
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Tenofovir ready for approval. AIDS patient care and STDs 20010701
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Kinetic studies of the degradation of oxycarbonyloxymethyl prodrug of Adefovir and Tenofovir in solution. Nucleosides, nucleotides & nucleic acids 20010101
LC/MS determination of the intracellular concentration of two novel aryl phosphoramidate prodrugs of PMPA and their metabolites in dog PBMC. Nucleosides, nucleotides & nucleic acids 20010101
Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes. Nucleosides, nucleotides & nucleic acids 20010101
Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340. Nucleosides, nucleotides & nucleic acids 20010101
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The importance of sequencing in treatment options. Positively aware : the monthly journal of the Test Positive Aware Network 20010101
Tenofovir DF on the horizon. Investigational nucleotide reverse transcriptor inhibitor could be on pharmacy shelves soon. Positive living (Los Angeles, Calif.) 20010101
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture. Journal of viral hepatitis 20000101
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