(8S,9S,10R,13S,14S,17R)-17-((2S,3R)-3-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
| Title | Journal |
|---|---|
| Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. | Toxicology and applied pharmacology 20170901 |
| In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. | Molecular and cellular endocrinology 20140305 |
| Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. | Chemico-biological interactions 20120930 |
| LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. | Anticancer research 20120701 |
| Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. | Lipids 20120501 |
| Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | American journal of physiology. Renal physiology 20120301 |
| The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. | The Journal of steroid biochemistry and molecular biology 20120201 |
| A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. | Steroids 20120201 |
| Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. | Journal of neuroendocrinology 20120101 |
| Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. | Biology of reproduction 20120101 |
| Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20111001 |
| Dysregulation of SREBP2 induces BACE1 expression. | Neurobiology of disease 20111001 |
| The human placenta expresses CYP17 and generates androgens de novo. | The Journal of clinical endocrinology and metabolism 20110501 |
| Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. | The Journal of biological chemistry 20110218 |
| Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | Placenta 20110201 |
| Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. | Anticancer research 20100901 |
| Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. | Journal of natural products 20100827 |
| Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. | Experimental dermatology 20100501 |
| Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. | The Journal of biological chemistry 20100416 |
| LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | Atherosclerosis 20091101 |
| Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. | Animal reproduction science 20091001 |
| Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. | Journal of neuroscience research 20090815 |
| OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | Journal of lipid research 20090701 |
| Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. | Experimental dermatology 20090701 |
| Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | Journal of lipid research 20090201 |
| Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. | Molecular pharmaceutics 20090101 |
| Androgen deprivation by activating the liver X receptor. | Endocrinology 20080801 |
| Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. | Arteriosclerosis, thrombosis, and vascular biology 20080601 |
| Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | Bioorganic & medicinal chemistry 20080415 |
| Expression and biological activity of ABCA1 in alveolar epithelial cells. | American journal of respiratory cell and molecular biology 20080301 |
| Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. | Toxicology letters 20080104 |
| 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. | Neuroscience 20070824 |
| Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). | Journal of toxicology and environmental health. Part A 20070601 |
| 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. | Biochimica et biophysica acta 20061201 |
| Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. | Reproductive toxicology (Elmsford, N.Y.) 20061101 |
| Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. | Endocrinology 20060801 |
| Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. | Shock (Augusta, Ga.) 20060801 |
| HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. | Lipids 20060601 |
| Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. | The Journal of pharmacology and experimental therapeutics 20060401 |
| Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. | Toxicology 20060301 |
| Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. | The Journal of steroid biochemistry and molecular biology 20051201 |
| Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. | Placenta 20051101 |
| Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. | International journal of molecular medicine 20051001 |
| Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. | Journal of cellular biochemistry 20050815 |
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. | Journal of natural products 20050801 |
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. | Bioorganic & medicinal chemistry letters 20050602 |
| Effects of fenvalerate on steroidogenesis in cultured rat granulosa cells. | Biomedical and environmental sciences : BES 20050401 |
| Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. | Life sciences 20050211 |
| Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. | Molecular endocrinology (Baltimore, Md.) 20050201 |
| Cellular physiology of cholesterol efflux in vascular endothelial cells. | Circulation 20041102 |
| Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. | Journal of lipid research 20041101 |
| Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. | Molecular and cellular endocrinology 20040930 |
| Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | Arteriosclerosis, thrombosis, and vascular biology 20040801 |
| The effect of LXR activators on AP-1 proteins in keratinocytes. | The Journal of investigative dermatology 20040701 |
| Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. | Acta pharmacologica Sinica 20040501 |
| Role of p160 coactivator complex in the activation of liver X receptor. | Arteriosclerosis, thrombosis, and vascular biology 20040401 |
| Oxysterols regulate expression of the steroidogenic acute regulatory protein. | Journal of molecular endocrinology 20040401 |
| Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. | The Journal of biological chemistry 20040312 |
| Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
| Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. | Hepatology (Baltimore, Md.) 20040301 |
| Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). | The Journal of biological chemistry 20040227 |
| Inhibitory actions of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. | Archives of andrology 20040101 |
| Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. | Steroids 20040101 |
| Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. | The Biochemical journal 20031201 |
| Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. | American journal of physiology. Lung cellular and molecular physiology 20031001 |
| Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. | The Journal of biological chemistry 20030919 |
| Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. | Molecular endocrinology (Baltimore, Md.) 20030701 |
| Oxysterols suppress constitutive fibrinogen expression. | Thrombosis and haemostasis 20030701 |
| Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). | The Journal of investigative dermatology 20030601 |
| Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. | FEBS letters 20030522 |
| The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. | Toxicology 20030503 |
| Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. | Experimental cell research 20030501 |
| 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. | The Journal of biological chemistry 20030411 |
| Formation and functioning of fused cholesterol side-chain cleavage enzymes. | DNA and cell biology 20030401 |
| Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. | Molecular endocrinology (Baltimore, Md.) 20030301 |
| Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | The Journal of investigative dermatology 20030201 |
| Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. | Biochemical and biophysical research communications 20021220 |
| 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. | Journal of neurochemistry 20021201 |
| Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. | Journal of lipid research 20021101 |
| ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. | Arteriosclerosis, thrombosis, and vascular biology 20021101 |
| Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. | The Journal of endocrinology 20020401 |
| Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway. | Toxicology 20020227 |
| Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. | Biochemical and biophysical research communications 20020208 |
| Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. | Biochemical and biophysical research communications 20020118 |
| Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. | The Journal of investigative dermatology 20020101 |
| Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene. | Biochemical and biophysical research communications 20011005 |
| Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action. | Endocrinology 20010601 |
| Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system. | Endocrinology 20010601 |
| Luteinization factor-stimulated steroidogenesis in porcine granulosa cells. | General physiology and biophysics 20010601 |
| Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. | Journal of medicinal chemistry 20010315 |
| Genomic sequence and structure of the human ABCG1 (ABC8) gene. | Biochemical and biophysical research communications 20010112 |
| The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. | Life sciences 20010112 |
| Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). | Gene 20010110 |
| Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells. | Journal of andrology 20010101 |
| Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | Proceedings of the National Academy of Sciences of the United States of America 19970513 |
| Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | The Journal of biological chemistry 19970207 |
| An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. | Nature 19961024 |