4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
Title | Journal |
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Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome. | Expert opinion on drug metabolism & toxicology 20130401 |
Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease. | Journal of medicinal chemistry 20121108 |
Pharmacokinetics of single and repeated oral doses prucalopride in healthy Chinese volunteers. | International journal of clinical pharmacology and therapeutics 20121101 |
Opioid-induced bowel dysfunction: pathophysiology and management. | Drugs 20121001 |
Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation. | Expert opinion on drug metabolism & toxicology 20121001 |
Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment). | World journal of gastroenterology 20120928 |
[Functional and motility gastrointestinal disorders]. | Gastroenterologia y hepatologia 20120901 |
The use of Resolor (prucalopride) for chronic constipation in women. | British journal of nursing (Mark Allen Publishing) 20120901 |
The successful treatment of acute refractory pseudo-obstruction with prucalopride. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20120801 |
Recent advances in the management of difficult constipation. | Current gastroenterology reports 20120801 |
The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. | The Journal of pharmacology and experimental therapeutics 20120601 |
Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atrium. | Naunyn-Schmiedeberg's archives of pharmacology 20120601 |
Inotropic effects of prokinetic agents with 5-HT(4) receptor agonist actions on human isolated myocardial trabeculae. | Life sciences 20120409 |
The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4. | Neuropharmacology 20120401 |
Prucalopride in a case of severe opioid induced constipation. | Minerva anestesiologica 20120401 |
Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. | Alimentary pharmacology & therapeutics 20120401 |
Physiological, pathophysiological and therapeutic impact of the enteric serotonergic system. | Arzneimittel-Forschung 20120401 |
Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo- and positive-controlled thorough QT study. | British journal of clinical pharmacology 20120201 |
Prucalopride for chronic intestinal pseudo-obstruction. | Alimentary pharmacology & therapeutics 20120201 |
Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study. | Alimentary pharmacology & therapeutics 20120101 |
Prucalopride: safety, efficacy and potential applications. | Therapeutic advances in gastroenterology 20120101 |
[Three variants of pathogenesis and therapy of chronic constipation]. | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20120101 |
In-vitro acetylcholine release is not a straightforward model to study hippocampal 5-HT₄ receptors. | Neuroreport 20111207 |
Chronic constipation: current treatment options. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20111001 |
The approach to diagnosis and treatment of chronic constipation: suggestions for a general practitioner. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20111001 |
[Functional and motility gastrointestinal disorders]. | Gastroenterologia y hepatologia 20111001 |
Investigation of neurogenic excitatory and inhibitory motor responses and their control by 5-HT(4) receptors in circular smooth muscle of pig descending colon. | European journal of pharmacology 20110930 |
Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome. | Gut and liver 20110901 |
Diagnosis and treatment of chronic constipation--a European perspective. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110801 |
Estimating the relationship between preference-based generic utility instruments and disease-specific quality-of-life measures in severe chronic constipation: challenges in practice. | PharmacoEconomics 20110801 |
Evolving concepts in chronic constipation in Europe and elsewhere: not worlds apart. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110801 |
[Treatment of severe chronic constipation: differential roles of conventional laxatives and the prucalopride prokinetic]. | Zeitschrift fur Gastroenterologie 20110801 |
What role for prucalopride in constipation? | Drug and therapeutics bulletin 20110801 |
Development and validation of a sample stabilization strategy and a UPLC-MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF). | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715 |
Prucalopride for the treatment of women with chronic constipation in whom standard laxative regimens have failed to provide adequate relief. | Health technology assessment (Winchester, England) 20110501 |
Prucalopride. In chronic constipation: poorly documented risks. | Prescrire international 20110501 |
Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis. | Gut 20110201 |
Current and future therapies for chronic constipation. | Best practice & research. Clinical gastroenterology 20110201 |
[New treatment option for women with chronic constipation - prucalopride stimulates the disturbed gut motility again]. | Zeitschrift fur Gastroenterologie 20110101 |
The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. | Frontiers in pharmacology 20110101 |
Effectiveness of laxatives in elderly--a cross sectional study in nursing homes. | BMC geriatrics 20110101 |
[New drugs for small animals in 2010]. | Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere 20110101 |
[Prucalopride - oral (Resolor)]. | Journal de pharmacie de Belgique 20101201 |
Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation - follow-up of patients from the pivotal studies. | Alimentary pharmacology & therapeutics 20101101 |
Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. | Digestive diseases and sciences 20101001 |
Emerging pharmacologic therapies for irritable bowel syndrome. | Current gastroenterology reports 20101001 |
A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100901 |
Fixed combination of oxycodone with naloxone: a new way to prevent and treat opioid-induced constipation. | Advances in therapy 20100901 |
[New drugs for the treatment of constipation]. | Medizinische Klinik (Munich, Germany : 1983) 20100701 |
New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders. | Expert opinion on investigational drugs 20100601 |
Influence of 5-HT4 receptor activation on acetylcholine release in human large intestine with endometriosis. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100501 |
Effect of ICU interventions on gastrointestinal motility. | Current opinion in critical care 20100401 |
Comments on tegaserod trial on irritable bowel syndrome. | Journal of neurogastroenterology and motility 20100401 |
Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201 |
Prucalopride for constipation. | Expert opinion on pharmacotherapy 20100201 |
Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat. | PloS one 20100101 |
Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice. | PloS one 20100101 |
Investigations into the binding affinities of different human 5-HT4 receptor splice variants. | Pharmacology 20100101 |
Psychometric evaluation of a visual analog scale for the assessment of anxiety. | Health and quality of life outcomes 20100101 |
Update on the management of constipation in the elderly: new treatment options. | Clinical interventions in aging 20100101 |
Lubiprostone: evaluation of the newest medication for the treatment of adult women with constipation-predominant irritable bowel syndrome. | International journal of women's health 20100101 |
[Treatment of constipation in the palliative care phase]. | Nederlands tijdschrift voor geneeskunde 20100101 |
Constipation in adults. | BMJ clinical evidence 20100101 |
Role of prucalopride, a serotonin (5-HT(4)) receptor agonist, for the treatment of chronic constipation. | Clinical and experimental gastroenterology 20100101 |
Grand challenges in pharmacoeconomics and health outcomes. | Frontiers in pharmacology 20100101 |
Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091201 |
Translating 5-HT receptor pharmacology. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091201 |
Prucalopride for chronic constipation. | Drugs of today (Barcelona, Spain : 1998) 20091201 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20091201 |
Prucalopride: a new drug for the treatment of chronic constipation. | Expert review of gastroenterology & hepatology 20090801 |
Motility: prucalopride for chronic constipation. | Nature reviews. Gastroenterology & hepatology 20090601 |
The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. | Advances in therapy 20090501 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090401 |
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. | Bioorganic & medicinal chemistry 20090315 |
Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. | Gut 20090301 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090301 |
Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study. | Alimentary pharmacology & therapeutics 20090201 |
Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach. | British journal of pharmacology 20090101 |
Prucalopride. | Drugs 20090101 |
New treatments for irritable bowel syndrome in women. | Women's health (London, England) 20081101 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20081001 |
[Functional and motor gastrointestinal disorders]. | Gastroenterologia y hepatologia 20081001 |
Management of constipation in the elderly: emerging therapeutic strategies. | World journal of gastroenterology 20080907 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20080901 |
Alternative splicing and exon duplication generates 10 unique porcine 5-HT 4 receptor splice variants including a functional homofusion variant. | Physiological genomics 20080612 |
Prucalopride: the evidence for its use in the treatment of chronic constipation. | Core evidence 20080601 |
A placebo-controlled trial of prucalopride for severe chronic constipation. | The New England journal of medicine 20080529 |
The long and short of a constipation-reducing medication. | The New England journal of medicine 20080529 |
Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080501 |
Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. | Behavioural brain research 20080305 |
5-HT4 receptor agonists: similar but not the same. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080201 |
Gastric and enteric involvement in progressive systemic sclerosis. | Journal of clinical gastroenterology 20080101 |
Gateways to clinical trials. July-August 2008. | Methods and findings in experimental and clinical pharmacology 20080101 |
Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070801 |
5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. | British journal of pharmacology 20070401 |
The action of the novel gastrointestinal prokinetic prucalopride on the HERG K+ channel and the common T897 polymorph. | European journal of pharmacology 20070112 |
Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation. | Journal of molecular and cellular cardiology 20070101 |
Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract. | British journal of pharmacology 20070101 |
The serotonin signaling system: from basic understanding to drug development for functional GI disorders. | Gastroenterology 20070101 |
5HT4 agonists inhibit interferon-gamma-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes. | Journal of neuroimmunology 20061001 |
5-HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20060901 |
Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: an operational framework to explain and quantify organ-specific behavior. | The Journal of pharmacology and experimental therapeutics 20060601 |
Management of faecal incontinence and constipation in adults with central neurological diseases. | The Cochrane database of systematic reviews 20060419 |
Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium. | British journal of pharmacology 20060101 |
Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development. | British journal of pharmacology 20060101 |
Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4 agonist--tegaserod. | BMC gastroenterology 20060101 |
Investigation of serotonin receptors in the isolated penile bulb of rats. | International journal of impotence research 20060101 |
5-HT4 receptors located on cholinergic nerves in human colon circular muscle. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050601 |
Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants. | Naunyn-Schmiedeberg's archives of pharmacology 20050601 |
Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. | Biological psychiatry 20050415 |
Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. | The Journal of pharmacology and experimental therapeutics 20050401 |
Rationale for using serotonergic agents to treat irritable bowel syndrome. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050401 |
Presynaptic modulation of cholinergic and non-cholinergic fast synaptic transmission in the myenteric plexus of guinea pig ileum. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040601 |
New and emerging treatment options for chronic constipation. | Reviews in gastroenterological disorders 20040101 |
Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease. | Neuroscience 20040101 |
The treatment of chronic constipation in elderly people: an update. | Drugs & aging 20040101 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20031001 |
Effect of enterokinetic prucalopride on intestinal motility in fast rats. | World journal of gastroenterology 20030915 |
Gastrointestinal motility disorders and gastrointestinal prokinetic therapy. | The Veterinary clinics of North America. Small animal practice 20030901 |
Irritable bowel syndrome: an overview of diagnosis and pharmacologic treatment. | Cleveland Clinic journal of medicine 20030601 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20030501 |
5-HT4 receptor ligands: applications and new prospects. | Journal of medicinal chemistry 20030130 |
The serotonin 5-HT4 receptor and the amyloid precursor protein processing. | Experimental gerontology 20030101 |
[Visceral hypersensitivity: a concept within our reach]. | Revista medica de Chile 20030101 |
Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial. | Digestion 20030101 |
Central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of dopamine in the rat striatum: in vivo studies with morphine, amphetamine and cocaine. | Neuropharmacology 20021201 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20021001 |
5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity. | The European journal of neuroscience 20020901 |
Prucalopride, a systemic enterokinetic, for the treatment of constipation. | Alimentary pharmacology & therapeutics 20020701 |
New and emerging treatments for irritable bowel syndrome and functional dyspepsia. | Expert opinion on emerging drugs 20020501 |
Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation. | Alimentary pharmacology & therapeutics 20020401 |
Efficacy and tolerability of prucalopride in patients with constipation due to spinal cord injury. | Scandinavian journal of gastroenterology 20020401 |
Review article: the complexity of drug development for irritable bowel syndrome. | Alimentary pharmacology & therapeutics 20020301 |
The effects of the specific 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers. | Alimentary pharmacology & therapeutics 20020301 |
Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins. | Molecular pharmacology 20020101 |
Emerging treatments for irritable bowel syndrome. | Expert opinion on pharmacotherapy 20020101 |
Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach. | British journal of pharmacology 20020101 |
Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride. | The American journal of gastroenterology 20020101 |
Irritable bowel syndrome: update on pathogenesis and management. | Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20020101 |
Pharmacological treatment of irritable bowel syndrome--from concept to sales. | The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 20020101 |
Serotoninergic neuroenteric modulators. | Lancet (London, England) 20011215 |
Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel. | The Journal of pharmacology and experimental therapeutics 20011201 |
The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein. | The Journal of biological chemistry 20011130 |
Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle. | British journal of pharmacology 20011101 |
Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20011001 |
Drug therapy options for patients with irritable bowel syndrome. | The American journal of managed care 20010701 |
The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. | European journal of pharmacology 20010629 |
5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study. | British journal of pharmacology 20010401 |
Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. | Gastroenterology 20010201 |
Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. | Drugs 20010101 |
Serotonin: a mediator of the brain-gut connection. | The American journal of gastroenterology 20001001 |
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. | Journal of neurochemistry 20000201 |
Signal transduction pathways for serotonin as an intestinal secretagogue. | Comparative biochemistry and physiology. Part A, Physiology 19971001 |
Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon. | The American journal of physiology 19961101 |