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Home Other Building Blocks 4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)-

4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)-

CAS No.:
179248-59-0
Catalog Number:
AG0026VE
Molecular Formula:
C22H19N3O3
Molecular Weight:
373.4046
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
5mg
≥98%
1 week
United States
$133
- +
10mg
≥98%
1 week
United States
$193
- +
25mg
99%
1 week
United States
$423
- +
50mg
≥98%
1 week
United States
$669
- +
Product Description
Catalog Number:
AG0026VE
Chemical Name:
4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)-
CAS Number:
179248-59-0
Molecular Formula:
C22H19N3O3
Molecular Weight:
373.4046
MDL Number:
MFCD01815300
IUPAC Name:
6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
InChI:
InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
InChI Key:
DMWVGXGXHPOEPT-UHFFFAOYSA-N
SMILES:
COc1cc2c(ncnc2cc1OC)Nc1ccc(cc1)Oc1ccccc1
Properties
Complexity:
466  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
373.143g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
373.412g/mol
Monoisotopic Mass:
373.143g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
65.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.9  
Literature
Title Journal
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal 20130415
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nature biotechnology 20111101
Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Molecular cancer research : MCR 20100401
The selectivity of protein kinase inhibitors: a further update. The Biochemical journal 20071215
Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. Journal of medicinal chemistry 20050505
Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA. Journal of medicinal chemistry 20041007
Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry 20010619
Properties