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Home Other Building Blocks Pyridine, 3-ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]-

Pyridine, 3-ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]-

CAS No.:
179120-92-4
Catalog Number:
AG0026TE
Molecular Formula:
C12H14N2
Molecular Weight:
186.2530
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Product Description
Catalog Number:
AG0026TE
Chemical Name:
Pyridine, 3-ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]-
CAS Number:
179120-92-4
Molecular Formula:
C12H14N2
Molecular Weight:
186.2530
MDL Number:
MFCD08056271
IUPAC Name:
3-ethynyl-5-[(2S)-1-methylpyrrolidin-2-yl]pyridine
InChI:
InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1
InChI Key:
NUPUDYKEEJNZRG-LBPRGKRZSA-N
SMILES:
C#Cc1cncc(c1)[C@@H]1CCCN1C
UNII:
RJ9V9V09VM
Properties
Complexity:
240  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
186.116g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
186.258g/mol
Monoisotopic Mass:
186.116g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
16.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.4  
Literature
Title Journal
Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications. The Journal of organic chemistry 20110805
Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist. Brain research 20081009
Expedient five-step synthesis of SIB-1508Y from natural nicotine. The Journal of organic chemistry 20061027
Randomized placebo-controlled study of the nicotinic agonist SIB-1508Y in Parkinson disease. Neurology 20060214
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. Journal of medicinal chemistry 20050728
Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030501
Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. The Journal of pharmacology and experimental therapeutics 20000901
Properties