Home Other Building Blocks Dl-o-phosphoserine

Dl-o-phosphoserine

CAS No.:
17885-08-4
Catalog Number:
AG0026EP
Molecular Formula:
C3H8NO6P
Molecular Weight:
185.0725
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
≥ 98% (Titration)
1 week
United States
$67
- +
5g
≥ 98% (Titration)
1 week
United States
$140
- +
25g
≥ 98% (Titration)
1 week
United States
$462
- +
Product Description
Catalog Number:
AG0026EP
Chemical Name:
Dl-o-phosphoserine
CAS Number:
17885-08-4
Molecular Formula:
C3H8NO6P
Molecular Weight:
185.0725
MDL Number:
MFCD00021723
IUPAC Name:
2-amino-3-phosphonooxypropanoic acid
InChI:
InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)
InChI Key:
BZQFBWGGLXLEPQ-UHFFFAOYSA-N
SMILES:
OC(=O)[C@H](COP(=O)(O)O)N
EC Number:
241-834-7
NSC Number:
90791
Properties
Complexity:
186  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
185.009g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
185.072g/mol
Monoisotopic Mass:
185.009g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
130A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
-5.1  
Literature
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Identification of a small molecule inhibitor of serine 276 phosphorylation of the p65 subunit of NF-kappaB using in silico molecular docking. Cancer letters 20100528
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CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. Journal of cellular biochemistry 20100501
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Laminar shear stress modulates phosphorylation and localization of RNA polymerase II on the endothelial nitric oxide synthase gene. Arteriosclerosis, thrombosis, and vascular biology 20100301
Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circulation research 20100219
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Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues. Apoptosis : an international journal on programmed cell death 20100201
Glucuronic acid and phosphoserine act as mineralization mediators of collagen I based biomimetic substrates. Journal of materials science. Materials in medicine 20100201
Regulation of heat shock protein 60 and 72 expression in the failing heart. Journal of molecular and cellular cardiology 20100201
GGA autoinhibition revisited. Traffic (Copenhagen, Denmark) 20100201
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Developmental biology 20100115
Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity. Journal of cell science 20100115
Selective control of gene expression by CDK9 in human cells. Journal of cellular physiology 20100101
Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt. Cellular signalling 20100101
VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen. Journal of cellular physiology 20100101
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. The Journal of biological chemistry 20100101
HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2. The Journal of biological chemistry 20100101
Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells. The Journal of biological chemistry 20100101
Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. The Journal of biological chemistry 20100101
Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta. American journal of physiology. Lung cellular and molecular physiology 20100101
Cell lines derived from a medaka radiation-sensitive mutant have defects in DNA double-strand break responses. Journal of radiation research 20100101
The masticatory contractile load induced expression and activation of Akt1/PKBalpha in muscle fibers at the myotendinous junction within muscle-tendon-bone unit. Journal of biomedicine & biotechnology 20100101
Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain. Molecular pain 20100101
Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. Experimental cell research 20091210
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase. The Biochemical journal 20091210
Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping. DNA repair 20091203
Site-specifically phosphorylated forms of H1.5 and H1.2 localized at distinct regions of the nucleus are related to different processes during the cell cycle. Chromosoma 20091201
L-Serine-O-phosphate in the central nervous system. Brain research 20091201
Focus on phosphoarginine and phospholysine. Current protein & peptide science 20091201
Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nature cell biology 20091201
Ultraviolet photodissociation at 266 nm of phosphorylated peptide cations. Rapid communications in mass spectrometry : RCM 20091201
Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies. American journal of reproductive immunology (New York, N.Y. : 1989) 20091201
Potentiation of spinal NMDA-mediated nociception by cocaine- and amphetamine-regulated transcript peptide via PKA and PKC signaling pathways in rats. Regulatory peptides 20091127
Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. Blood 20091126
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Molecular cell 20091125
Analysis of phosphorylated peptides by double pseudoneutral loss extraction coupled with derivatization using N-(4-bromobenzoyl)aminoethanethiol. Analytical chemistry 20091115
Phosphorylation at S384 regulates the activity of the TaALMT1 malate transporter that underlies aluminum resistance in wheat. The Plant journal : for cell and molecular biology 20091101
Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability. American journal of physiology. Lung cellular and molecular physiology 20091101
The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats. The international journal of biochemistry & cell biology 20091101
Basal autophagy induction without AMP-activated protein kinase under low glucose conditions. Autophagy 20091101
The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin. Journal of molecular biology 20091030
The Ess1 prolyl isomerase is required for transcription termination of small noncoding RNAs via the Nrd1 pathway. Molecular cell 20091023
Phosphorylation of phospholipase C-delta 1 regulates its enzymatic activity. Journal of cellular biochemistry 20091015
Developmental switch in NF-kappaB signalling required for neurite growth. Development (Cambridge, England) 20091015
Controlling peptide folding with repulsive interactions between phosphorylated amino acids and tryptophan. Journal of the American Chemical Society 20091007
Protein phosphorylation influences proteolytic cleavage and kinase substrate properties exemplified by analysis of in vitro phosphorylated Plasmodium falciparum glideosome-associated protein 45 by nano-ultra performance liquid chromatography-tandem mass spectrometry. Analytical biochemistry 20091001
Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation. Molecular endocrinology (Baltimore, Md.) 20091001
Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. Diabetes 20091001
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DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20091001
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Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. Journal of proteome research 20091001
Involvement of protein kinase C and Src tyrosine kinase in acute tolerance to ethanol inhibition of spinal NMDA-induced pressor responses in rats. British journal of pharmacology 20091001
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Molecular cancer therapeutics 20091001
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CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression. Journal of biochemistry 20090901
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Molecular & cellular proteomics : MCP 20090901
SADB phosphorylation of gamma-tubulin regulates centrosome duplication. Nature cell biology 20090901
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO reports 20090901
SAD kinase keeps centrosomes lonely. Nature cell biology 20090901
Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. Journal of cell science 20090815
Parathyroid hormone suppresses insulin signaling in adipocytes. Molecular and cellular endocrinology 20090813
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mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3. Experimental cell research 20090610
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TLR4/MyD88/PI3K interactions regulate TLR4 signaling. Journal of leukocyte biology 20090601
Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3. Journal of proteome research 20090601
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p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. The Journal of biological chemistry 20090529
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Structure and in vivo requirement of the yeast Spt6 SH2 domain. Journal of molecular biology 20090529
Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK. The Journal of biological chemistry 20090522
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. The Journal of biological chemistry 20090522
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14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. The Journal of biological chemistry 20090501
Phosphoserine and specific types of its coordination in copper(II) and adenosine nucleotides systems - Potentiometric and spectroscopic studies. Journal of inorganic biochemistry 20090501
Functional involvement of protein kinase C-betaII and its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), in insulin-stimulated glucose transport in L6 rat skeletal muscle cells. Diabetologia 20090501
Identification of casein kinase-1 phosphorylation sites on TDP-43. Biochemical and biophysical research communications 20090501
Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis. Arthritis and rheumatism 20090501
RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways. Proteomics 20090501
EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma. Cancer science 20090501
Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochimica et biophysica acta 20090501
Probing the mechanism of electron capture and electron transfer dissociation using tags with variable electron affinity. Journal of the American Chemical Society 20090422
Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis. The Journal of biological chemistry 20090403
Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. The Journal of biological chemistry 20090403
Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Molecular biology reports 20090401
Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Molecular & cellular proteomics : MCP 20090401
Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & cellular proteomics : MCP 20090401
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nature cell biology 20090401
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nature cell biology 20090401
Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting. Journal of cell science 20090401
Skp2: caught in the Akt. Nature cell biology 20090401
Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells. Developmental cell 20090401
Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. BMB reports 20090331
[Preparation and preliminary application of rabbit polyclonal antibodies against intracellular peptides of human platelet glycoprotein GPIbalpha]. Zhonghua yi xue za zhi 20090331
Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiological genomics 20090303
Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites. Molecular & cellular proteomics : MCP 20090301
TTP at Ser245 phosphorylation by AKT is required for binding to 14-3-3. Journal of biochemistry 20090301
[Development of a functional cell-based HTS assay for the identification mGluR4 modulators]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20090301
The effect of post-translational and process-induced modifications on the multistage gas-phase fragmentation reactions of protonated peptides. Combinatorial chemistry & high throughput screening 20090201
Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2. The Journal of biological chemistry 20090123
Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916. The Journal of biological chemistry 20090123
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. The Journal of biological chemistry 20090123
Inhibition of lactoperoxidase by its own catalytic product: crystal structure of the hypothiocyanate-inhibited bovine lactoperoxidase at 2.3-A resolution. Biophysical journal 20090121
Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex. Biochemical and biophysical research communications 20090116
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Molecular cell 20090116
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations. Movement disorders : official journal of the Movement Disorder Society 20090115
The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms. Experimental cell research 20090115
The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. The Journal of biological chemistry 20090109
Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells. Circulation research 20090102
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury. Endocrinology 20090101
PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Experimental cell research 20090101
Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc. Experimental cell research 20090101
Detection and assignment of phosphoserine and phosphothreonine residues by (13)C- (31)P spin-echo difference NMR spectroscopy. Journal of biomolecular NMR 20090101
PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Molecular cancer therapeutics 20090101
Transient dynamic actin cytoskeletal change stimulates the osteoblastic differentiation. Journal of bone and mineral metabolism 20090101
Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. PloS one 20090101
Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. PloS one 20090101
Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining. Methods in molecular biology (Clifton, N.J.) 20090101
Selective enrichment in phosphopeptides for the identification of phosphorylated mitochondrial proteins. Methods in enzymology 20090101
Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway. Cytotherapy 20090101
Protein phosphorylation by semisynthesis: from paper to practice. Methods in enzymology 20090101
Glutamatergic neurotransmission in the first retinal synapse mediated by metabotropic receptors--electroretinographic study. Folia medica 20090101
Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease. Molecular brain 20090101
Phosphorylation regulates human T-cell leukemia virus type 1 Rex function. Retrovirology 20090101
The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PloS one 20090101
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. PloS one 20090101
Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation. PloS one 20090101
Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. Journal of cellular physiology 20081201
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. Journal of cellular physiology 20081201
BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway. Journal of cellular physiology 20081201
DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell death and differentiation 20081201
Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium. Virchows Archiv : an international journal of pathology 20081201
Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily. The FEBS journal 20081201
Magnetic electrochemical immunoassays with quantum dot labels for detection of phosphorylated acetylcholinesterase in plasma. Analytical chemistry 20081115
Characterization of Ser338 phosphorylation for Raf-1 activation. The Journal of biological chemistry 20081114
Integrin cross-talk in endothelial cells is regulated by protein kinase A and protein phosphatase 1. The Journal of biological chemistry 20081114
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochemical and biophysical research communications 20081107
Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression. Oncogene 20081106
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. Biochemistry 20081104
Mass spectrometry analysis of oxidized phospholipids. Chemistry and physics of lipids 20081101
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin. Cellular signalling 20081101
Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase. American journal of physiology. Lung cellular and molecular physiology 20081101
Hyaluronan-mediated leukocyte adhesion and dextran sulfate sodium-induced colitis are attenuated in the absence of signal transducer and activator of transcription 1. The American journal of pathology 20081101
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation. Development (Cambridge, England) 20081101
Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism. Hepatology (Baltimore, Md.) 20081101
P53 transcription-independent activity mediates selenite-induced acute promyelocytic leukemia NB4 cell apoptosis. BMB reports 20081031
Temperature sensitivity of phospho-Ser(473)-PKB/AKT. Biochemical and biophysical research communications 20081024
Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells. Chemico-biological interactions 20081022
CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 20081002
Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry. Molecular & cellular proteomics : MCP 20081001
WNK2 modulates MEK1 activity through the Rho GTPase pathway. Cellular signalling 20081001
Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites. Cellular signalling 20081001
Cdk5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion. Cellular signalling 20081001
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA repair 20081001
The role of phosphorylated residues in peptide-peptide noncovalent complexes formation. Journal of the American Society for Mass Spectrometry 20081001
Cyclophosphoramidate ion as mass defect marker for efficient detection of protein serine phosphorylation. Analytical chemistry 20081001
O-phospho-L-serine: a modulator of bone healing in calcium-phosphate cements. Biomedizinische Technik. Biomedical engineering 20081001
Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. Molecular cancer therapeutics 20081001
[The preparation of bioglass/collagen/phosphoserine biomemetic composite scaffold and a study on its cytocompatibility]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20081001
Identification and characterization of a general nuclear translocation signal in signaling proteins. Molecular cell 20080926
Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Molecular cell 20080926
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Molecular cell 20080926
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molecular cell 20080926
RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. Proceedings of the National Academy of Sciences of the United States of America 20080923
ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.) 20080915
p21 activated kinase 5 activates Raf-1 and targets it to mitochondria. Journal of cellular biochemistry 20080901
Phosphorylation and kinetics of mammalian cytochrome c oxidase. Molecular & cellular proteomics : MCP 20080901
Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37. Molecular and cellular biochemistry 20080901
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. Molecular pharmacology 20080901
RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila. Development (Cambridge, England) 20080901
Involvement of the p53 and p73 transcription factors in neuroAIDS. Cell cycle (Georgetown, Tex.) 20080901
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS letters 20080820
Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. Journal of cellular biochemistry 20080815
Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction. Bioorganic & medicinal chemistry 20080815
Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei. The Journal of biological chemistry 20080808
The homotetrameric phosphoseryl-tRNA synthetase from Methanosarcina mazei exhibits half-of-the-sites activity. The Journal of biological chemistry 20080808
TGF-beta inhibits prolactin-induced expression of beta-casein by a Smad3-dependent mechanism. Journal of cellular biochemistry 20080801
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. Journal of cellular biochemistry 20080801
Glucocorticoid receptor phosphorylation differentially affects target gene expression. Molecular endocrinology (Baltimore, Md.) 20080801
Phosphoserine aminoacylation of tRNA bearing an unnatural base anticodon. Biochemical and biophysical research communications 20080801
The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses. Plant molecular biology 20080801
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8. The Journal of biological chemistry 20080718
Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. The Journal of biological chemistry 20080718
Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity. The Journal of biological chemistry 20080718
Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells. Journal of cell science 20080715
A wide-ranging cellular response to UV damage of DNA. Cell cycle (Georgetown, Tex.) 20080715
Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal kinase at Ser92 attenuates its phosphatase activity. Biochemistry 20080708
The cell cycle control protein cdc25C is present, and phosphorylated on serine 214 in the transition from germinal vesicle to metaphase II in human oocyte meiosis. Molecular reproduction and development 20080701
Structural consequences of phosphorylation of two serine residues in the cytoplasmic domain of HIV-1 VpU. Journal of peptide science : an official publication of the European Peptide Society 20080701
Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. Diabetes 20080701
Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria. Cellular signalling 20080701
Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways. Cellular signalling 20080701
Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells. Cellular signalling 20080701
G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes. Cellular signalling 20080701
The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. American journal of physiology. Renal physiology 20080701
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cellular signalling 20080701
Akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity. Cellular signalling 20080701
MEK1/2 induces STAT5-mediated germline transcription of the TCRgamma locus in response to IL-7R signaling. Journal of immunology (Baltimore, Md. : 1950) 20080701
Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. Journal of immunology (Baltimore, Md. : 1950) 20080701
A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 20080612
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. Journal of cellular physiology 20080601
Polo-box domains confer target specificity to the Polo-like kinase family. Biochimica et biophysica acta 20080601
The PIP2 binding mode of the C2 domains of rabphilin-3A. Protein science : a publication of the Protein Society 20080601
Role of the C-terminal domain of RNA polymerase II in expression of small nuclear RNA genes. Biochemical Society transactions 20080601
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. Molecular cancer therapeutics 20080601
Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression. The Keio journal of medicine 20080601
Proton chemical shift anisotropy measurements of hydrogen-bonded functional groups by fast magic-angle spinning solid-state NMR spectroscopy. Chemical communications (Cambridge, England) 20080528
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. The Journal of biological chemistry 20080523
Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation. The Journal of biological chemistry 20080509
A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression. The Journal of biological chemistry 20080509
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. Journal of molecular biology 20080509
Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. The Journal of biological chemistry 20080502
The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5. The Biochemical journal 20080501
Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation. Molecular pharmacology 20080501
Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys). Nature structural & molecular biology 20080501
Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080430
The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. The Biochemical journal 20080415
Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation. Oncogene 20080410
Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK. Molecular immunology 20080401
cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells. Journal of lipid research 20080401
Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. Molecular and cellular biology 20080401
Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function. American journal of physiology. Lung cellular and molecular physiology 20080401
The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain. The FEBS journal 20080401
Selective roles of MAPKs during the macrophage response to IFN-gamma. Journal of immunology (Baltimore, Md. : 1950) 20080401
Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. Journal of immunology (Baltimore, Md. : 1950) 20080401
14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding. FEBS letters 20080305
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS letters 20080305
Gymnemic acid interacts with mammalian glycerol-3-phosphate dehydrogenase. Molecular and cellular biochemistry 20080301
Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2. Journal of biochemistry 20080301
The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats. Neuropharmacology 20080301
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Diabetologia 20080301
Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation. Cell cycle (Georgetown, Tex.) 20080301
Analysis of the cell adhesion molecule sticks-and-stones reveals multiple redundant functional domains, protein-interaction motifs and phosphorylated tyrosines that direct myoblast fusion in Drosophila melanogaster. Genetics 20080301
Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells. Cell cycle (Georgetown, Tex.) 20080301
In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nature structural & molecular biology 20080301
Identification of p32 as a novel substrate for ATM in heart. Biochemical and biophysical research communications 20080222
Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation 20080219
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation 20080219
Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells. Nature 20080207
Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo. European journal of pharmacology 20080202
PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells. Journal of cellular biochemistry 20080201
MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080201
Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood 20080201
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. Journal of molecular and cellular cardiology 20080201
A sulfated, phosphorylated 7 kDa secreted peptide characterized by direct analysis of cell culture media. Journal of proteome research 20080201
Mechanistic insights into the multistage gas-phase fragmentation behavior of phosphoserine- and phosphothreonine-containing peptides. Journal of proteome research 20080201
Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida. Development (Cambridge, England) 20080201
Ectopic histone H3S10 phosphorylation causes chromatin structure remodeling in Drosophila. Development (Cambridge, England) 20080201
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nature medicine 20080201
Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. International journal of molecular medicine 20080201
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature medicine 20080201
Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals. Molecular cell 20080118
Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase. The Journal of biological chemistry 20080111
Fibrous and helical calcite crystals induced by synthetic polypeptides containing o-phospho-L-serine and o-phospho-L-threonine. Macromolecular bioscience 20080109
Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes. Cell biology and toxicology 20080101
DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochimica et biophysica acta 20080101
Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation. Aging cell 20080101
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer cell 20080101
Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation. Genetics 20080101
The transactivation domain of heterogeneous nuclear ribonucleoprotein K overlaps its nuclear shuttling domain. The international journal of biochemistry & cell biology 20080101
Decorin derived antiangiogenic peptide LRR5 inhibits endothelial cell migration by interfering with VEGF-stimulated NO release. The international journal of biochemistry & cell biology 20080101
Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis. Molecular systems biology 20080101
PKC putative phosphorylation site Ser235 is required for MIP/AQP0 translocation to the plasma membrane. Molecular vision 20080101
Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1. BMC molecular biology 20080101
Shark skeletal muscle tropomyosin is a phosphoprotein. Journal of muscle research and cell motility 20080101
Phosphorylation sites on Tyr28 and the C-terminus of Rad9 are required for inhibition of premature chromosomal condensation across the entire S phase. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101
Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. Breast cancer research : BCR 20080101
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor. Biochemistry 20071211
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America 20071211
The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Experimental cell research 20071210
The tolerance property of human D3 dopamine receptor is determined by specific amino acid residues in the second cytoplasmic loop. Biochimica et biophysica acta 20071201
Acinus-provoked protein kinase C delta isoform activation is essential for apoptotic chromatin condensation. Cell death and differentiation 20071201
Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27. Molecular endocrinology (Baltimore, Md.) 20071201
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Mass spectrometric studies on mouse hippocampal synapsins Ia, IIa, and IIb and identification of a novel phosphorylation site at serine-546. Journal of proteome research 20070701
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The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070601
Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors. Molecular and cellular biochemistry 20070601
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Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Diabetes 20070601
FcepsilonRI and Thy-1 domains have unique protein and lipid compositions. Journal of lipid research 20070601
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Identification of a molecular target for the Yersinia protein kinase A. Molecular cell 20070525
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Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. Experimental & molecular medicine 20070430
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Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. The Journal of biological chemistry 20070413
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Structural determinants of LL5beta subcellular localisation and association with filamin C. Cellular signalling 20070401
Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid. Journal of cellular physiology 20070401
Effect of modification of hydroxyapatite/collagen composites with sodium citrate, phosphoserine, phosphoserine/RGD-peptide and calcium carbonate on bone remodelling. Bone 20070401
CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochimica et biophysica acta 20070401
Activation of caspase 3 in HepG2 cells by elaidic acid (t18:1). Biochimica et biophysica acta 20070401
Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea. Nature structural & molecular biology 20070401
Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G(1) phase of the cell cycle. Biochimica et biophysica acta 20070401
Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy? Biochemical Society transactions 20070401
Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Molecular cancer therapeutics 20070401
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. The Biochemical journal 20070315
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Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. Biochimica et biophysica acta 20070301
Acute impairment of insulin signalling by dexamethasone in primary cultured rat skeletal myocytes. Molecular and cellular biochemistry 20070301
Approach to systematic analysis of serine/threonine phosphoproteome using Beta elimination and subsequent side effects: intramolecular linkage and/or racemisation. Journal of cellular biochemistry 20070301
Effect of HPr phosphorylation on structure, dynamics, and interactions in the course of transcriptional control. Journal of molecular modeling 20070301
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. Journal of molecular and cellular cardiology 20070301
Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein. Biochimica et biophysica acta 20070301
[Shigella flexneri modulates host cell epigenetic information as a strategy to shape the transcriptional response]. Medecine sciences : M/S 20070301
Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators. The Journal of steroid biochemistry and molecular biology 20070301
Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides. Journal of molecular biology 20070202
Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. The Journal of biological chemistry 20070202
p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis. Cell death and differentiation 20070201
Mobile phone base station-emitted radiation does not induce phosphorylation of Hsp27. Bioelectromagnetics 20070201
c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells. American journal of physiology. Lung cellular and molecular physiology 20070201
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology 20070201
[VE-cadherin takes a walk on the wild side]. Medecine sciences : M/S 20070201
Synthesis, platelet adhesion and cytotoxicity studies of new glycerophosphoryl-containing polyurethanes. The International journal of artificial organs 20070201
Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder. Biological psychiatry 20070115
Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells. Journal of immunology (Baltimore, Md. : 1950) 20070115
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes & development 20070115
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Molecular cell 20070112
Involvement of PKCalpha in insulin-induced PKCdelta expression: Importance of SP-1 and NFkappaB transcription factors. Biochemical and biophysical research communications 20070105
The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas. Molecular and cellular biochemistry 20070101
Immunoassay of serine-phosphorylated isoform of insulin-like growth factor (IGF) binding protein (IGFBP)-1. Clinical biochemistry 20070101
Selective activation of group III metabotropic glutamate receptors by L-(+)-2-amino-4-phosphonobutryic acid protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo. The Journal of pharmacology and experimental therapeutics 20070101
Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Molecular pharmacology 20070101
Raf kinase inhibitor protein affects activity of Plasmodium falciparum calcium-dependent protein kinase 1. Molecular and biochemical parasitology 20070101
A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor. The Biochemical journal 20070101
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. The Journal of cell biology 20070101
Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS biology 20070101
Stress-associated MAP kinase fills in the map of filamin-mediated neuronal migration. Developmental cell 20070101
Analysis of mitotic phosphorylation of borealin. BMC cell biology 20070101
p42MAPK-mediated phosphorylation of xEIAP/XLX in Xenopus cytostatic factor-arrested egg extracts. BMC biochemistry 20070101
Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis. Journal of vascular research 20070101
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke. BMC cell biology 20070101
UDP-acetyl-mannosamine dehydrogenase is an endogenous protein substrate of Staphylococcus aureus protein-tyrosine kinase activity. Journal of molecular microbiology and biotechnology 20070101
ODF1 phosphorylation by Cdk5/p35 enhances ODF1-OIP1 interaction. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. PloS one 20070101
Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas. Anticancer research 20070101
KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer research 20061215
Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite. Cancer research 20061215
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. The EMBO journal 20061213
Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation. The EMBO journal 20061213
Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis. Oncogene 20061207
Differential effects of systemic ethanol administration on protein kinase cepsilon, gamma, and beta isoform expression, membrane translocation, and target phosphorylation: reversal by chronic ethanol exposure. The Journal of pharmacology and experimental therapeutics 20061201
Post-translational control of Nur77. Biochemical Society transactions 20061201
Protein phosphatases types 2Calpha and 2Cbeta in apoptosis. Biochemical Society transactions 20061201
Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell cycle (Georgetown, Tex.) 20061201
TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner. Cell cycle (Georgetown, Tex.) 20061201
Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320. Cell cycle (Georgetown, Tex.) 20061201
Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling. The Journal of biological chemistry 20061110
Signaling pathways regulating murine cardiac CREB phosphorylation. Biochemical and biophysical research communications 20061110
The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. The Journal of biological chemistry 20061103
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. The Journal of biological chemistry 20061103
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. The Journal of biological chemistry 20061103
Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL. Cell death and differentiation 20061101
Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis. Cell death and differentiation 20061101
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Molecular therapy : the journal of the American Society of Gene Therapy 20061101
Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. Journal of pineal research 20061101
PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function. Biochemical and biophysical research communications 20061027
Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells. FEBS letters 20061016
Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. FEBS letters 20061016
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (New York, N.Y.) 20061013
Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. Oncogene 20061012
PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. Cellular signalling 20061001
AKT can be activated in the nucleus. Cellular signalling 20061001
Hypertonicity activates GSK3beta in tumor cells. Molecular and cellular biochemistry 20061001
Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia 20061001
Supercell and subcell description of the crystal structure of triammonium bis(O-phospho-L-serinate) trihydrate. Acta crystallographica. Section B, Structural science 20061001
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature 20060914
Regulation of connexin-43-mediated growth inhibition by a phosphorylatable amino-acid is independent of gap junction-forming ability. Molecular and cellular biochemistry 20060901
Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine. The Journal of biological chemistry 20060901
Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors. Neuropharmacology 20060901
Ethanol inhibition of NMDA-induced responses and acute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 20060901
Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line. Biochemical and biophysical research communications 20060901
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes to cells : devoted to molecular & cellular mechanisms 20060901
Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Molecular cell 20060901
Wip1 phosphatase modulates ATM-dependent signaling pathways. Molecular cell 20060901
Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression. Endocrine-related cancer 20060901
Histone phosphorylation and pericentromeric histone modifications in oocyte meiosis. Cell cycle (Georgetown, Tex.) 20060901
Learning induces long-term potentiation in the hippocampus. Science (New York, N.Y.) 20060825
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science (New York, N.Y.) 20060825
Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science (New York, N.Y.) 20060818
Single crystals of L-O-serine phosphate X-irradiated at low temperatures: EPR, ENDOR, EIE, and DFT studies. The journal of physical chemistry. A 20060810
Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells. Biochemical and biophysical research communications 20060804
Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease. Biochemical and biophysical research communications 20060804
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cellular signalling 20060801
Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of neuroscience research 20060801
Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway. Cell cycle (Georgetown, Tex.) 20060801
CDC25B phosphorylation by p38 and MK-2. Cell cycle (Georgetown, Tex.) 20060801
Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species. Cell cycle (Georgetown, Tex.) 20060801
Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes 20060801
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase. Cell cycle (Georgetown, Tex.) 20060801
Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis. Cell cycle (Georgetown, Tex.) 20060801
Participation of superoxide in neutrophil activation and cytokine production. Biochimica et biophysica acta 20060801
Revealing successive steps of deprotonation of L- phosphoserine through 13C and 31P chemical shielding tensor fingerprints. The journal of physical chemistry. A 20060727
Distinct signaling functions for Shc isoforms in the heart. The Journal of biological chemistry 20060721
Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts. Role in suppression of c/EBP/NF-kappaB-mediated MEKK1-induced MMP-1 expression. The Journal of biological chemistry 20060721
Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrest. Chemico-biological interactions 20060710
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62. FEBS letters 20060710
Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger. Circulation 20060704
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain 20060701
Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity 20060701
Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation. FEBS letters 20060626
Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. The EMBO journal 20060621
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The EMBO journal 20060621
Increased expression of LGI1 gene triggers growth inhibition and apoptosis of neuroblastoma cells. Journal of cellular physiology 20060601
Phosphorylation of the p34(cdc2) target site on goldfish germinal vesicle lamin B3 before oocyte maturation. European journal of cell biology 20060601
The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability. Cell cycle (Georgetown, Tex.) 20060601
Posttranslational phosphorylation of mutant p53 protein in tumor development. Medical molecular morphology 20060601
Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis. Nature 20060525
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 20060518
Characterization of yeast pyruvate kinase 1 as a protein kinase A substrate, and specificity of the phosphorylation site sequence in the whole protein. The Biochemical journal 20060515
Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. The Biochemical journal 20060515
Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. The Biochemical journal 20060515
Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product (AGE)-induced C-reactive protein expression in hepatoma cells by suppressing Rac-1 activation. FEBS letters 20060515
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. The Journal of biological chemistry 20060512
Hyperphosphorylation of tau induces local polyproline II helix. Biochemistry 20060502
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha. The Biochemical journal 20060501
Metabolipidomics: profiling metabolism of glycerophospholipid species by stable isotopic precursors and tandem mass spectrometry. Analytical biochemistry 20060501
Characterization of a monoclonal antibody B1 that recognizes phosphorylated Ser-158 in the activation peptide region of human coagulation factor IX. The Journal of biological chemistry 20060407
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060401
Molecular verification of stereotactic radiotherapy in rats using ATMpS1981 immunofluorescence. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060401
p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation. Cell cycle (Georgetown, Tex.) 20060401
The biochemical effect of Ser167 phosphorylation on Chlamydomonas reinhardtii centrin. Biochemical and biophysical research communications 20060331
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Molecular cell 20060317
Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. The Biochemical journal 20060301
Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function. Diabetologia 20060301
CDK9 phosphorylates p53 on serine residues 33, 315 and 392. Cell cycle (Georgetown, Tex.) 20060301
Nek1 shares structural and functional similarities with NIMA kinase. Biochimica et biophysica acta 20060301
Structural mechanism of plant aquaporin gating. Nature 20060209
Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage. Brain research 20060209
Antioxidative stress activity of oligophosphopeptides derived from hen egg yolk phosvitin in Caco-2 cells. Journal of agricultural and food chemistry 20060208
Structure and desorption energetics of ultrathin D2O ice overlayers on serine- and serinephosphate-terminated self-assembled monolayers. The journal of physical chemistry. B 20060202
Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis. Proteomics 20060201
Autophosphorylation of Ser66 on Xenopus Myt1 is a prerequisite for meiotic inactivation of Myt1. Cell cycle (Georgetown, Tex.) 20060201
Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling. Journal of molecular biology 20060127
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125
Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. The Biochemical journal 20060115
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. The Journal of biological chemistry 20060113
Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction. The Journal of biological chemistry 20060113
ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity. Cell cycle (Georgetown, Tex.) 20060101
UV photodissociation of phospho-seryl-containing peptides: laser stabilization of the phospho-seryl bond with multistage mass spectrometry. Rapid communications in mass spectrometry : RCM 20060101
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. BMC biochemistry 20060101
Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage. Methods in molecular biology (Clifton, N.J.) 20060101
TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent. Journal of endotoxin research 20060101
Spindle checkpoint protein hMad2 and histone H3 phosphoserine 10 mitosis marker in pediatric solid tumors. Anticancer research 20060101
Individual and combined effects of methamphetamine and ketamine on conditioned place preference and NR1 receptor phosphorylation in rats. Neuro-Signals 20060101
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 20051222
Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. Diabetes 20051201
A universal assay for vitellogenin in fish mucus and plasma. Environmental toxicology and chemistry 20051201
Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428. The Biochemical journal 20051115
HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding. The Journal of biological chemistry 20051111
The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal. The Journal of biological chemistry 20051111
Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. The Journal of biological chemistry 20051111
Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma. Biochemical and biophysical research communications 20051111
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus. Brain research. Molecular brain research 20051031
Septin1, a new interaction partner for human serine/threonine kinase aurora-B. Biochemical and biophysical research communications 20051028
A phosphorylation-dependent export structure in ROMK (Kir 1.1) channel overrides an endoplasmic reticulum localization signal. The Journal of biological chemistry 20051021
Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder. Schizophrenia research 20051015
Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: potential role of protein phosphatase 2A-protein kinase CbetaII complex. Journal of cellular physiology 20051001
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. Endocrinology 20051001
Method development and measurements of endogenous serine/threonine Akt phosphorylation using capillary electrophoresis for systems biology. Electrophoresis 20051001
Phospho-eNOS Ser-114 in human mesenchymal stem cells: constitutive phosphorylation, nuclear localization and upregulation during mitosis. European journal of cell biology 20051001
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Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. Journal of cellular physiology 20050901
Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by pre-secretory pathway underlying the action of a proteinase cleaving ProAla bonds. Peptides 20050901
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Molecular cloning and characterization of two different cDNAs encoding the molecular chaperone Hsp90 in the oomycete Achlya ambisexualis. Fungal genetics and biology : FG & B 20040201
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Analyzing the regulation and function of ATM. Methods in molecular biology (Clifton, N.J.) 20040101
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A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1. FEBS letters 20030911
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Synthesis of a radioactive thiol reagent, 1-S-[3H]carboxymethyl-dithiothreitol: identification of the phosphorylation sites by N-terminal peptide sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical biochemistry 20030801
Novel effect of N-palmitoyl-L-serine phosphoric acid on cytosolic Ca2+ levels in human osteoblasts. Pharmacology & toxicology 20030801
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An experimental and theoretical study of the 13C and 31P chemical shielding tensors in solid O-phosphorylated amino acids. Journal of the American Chemical Society 20030409
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New perspectives on the regulation of intermembrane glycerophospholipid traffic. Journal of lipid research 20030301
Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex. The European journal of neuroscience 20030301
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Human recombinant anti-La (SS-B) autoantibodies demonstrate the accumulation of phosphoserine-366-containing la isoforms in nucleoplasmic speckles. European journal of cell biology 20030301
Reconstitution of water channel function of an aquaporin overexpressed and purified from Pichia pastoris. FEBS letters 20030227
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Phosphoserine/threonine-binding domains. Current opinion in cell biology 20010401
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Tale of a tail kinase. Nature structural biology 20010201
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