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Cabazitaxel

CAS No.:
183133-96-2
Catalog Number:
AG0024ES
Molecular Formula:
C45H57NO14
Molecular Weight:
835.9324
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%(HPLC)
In Stock USA
United States
$60
- +
5mg
98%(HPLC)
In Stock USA
United States
$103
- +
10mg
98%(HPLC)
In Stock USA
United States
$169
- +
50mg
98%(HPLC)
In Stock USA
United States
$336
- +
500mg
95%
In Stock USA
United States
$408
- +
Product Description
Catalog Number:
AG0024ES
Chemical Name:
Cabazitaxel
CAS Number:
183133-96-2
Molecular Formula:
C45H57NO14
Molecular Weight:
835.9324
MDL Number:
MFCD18827611
IUPAC Name:
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
InChI:
InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
InChI Key:
BMQGVNUXMIRLCK-OAGWZNDDSA-N
SMILES:
CO[C@H]1C(=O)[C@]2(C)[C@@H](OC)C[C@@H]3[C@]([C@H]2[C@@H]([C@]2(C(C1=C(C)[C@@H](OC(=O)[C@@H]([C@H](c1ccccc1)NC(=O)OC(C)(C)C)O)C2)(C)C)O)OC(=O)c1ccccc1)(CO3)OC(=O)C
UNII:
51F690397J
NSC Number:
761432
Properties
Complexity:
1690  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Defined Bond Stereocenter Count:
0
Exact Mass:
835.378g/mol
Formal Charge:
0
Heavy Atom Count:
60  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
835.944g/mol
Monoisotopic Mass:
835.378g/mol
Rotatable Bond Count:
15  
Topological Polar Surface Area:
202A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Molecular alterations and emerging targets in castration resistant prostate cancer. European journal of cancer (Oxford, England : 1990) 20140301
Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20130415
Management of docetaxel failures in metastatic castrate-resistant prostate cancer. The Urologic clinics of North America 20121101
Metastatic castrate-resistant prostate cancer: dawn of a new age of management. BJU international 20121001
A new era for castrate resistant prostate cancer: a treatment review and update. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120901
Optimizing the care of patients with advanced prostate cancer in the UK: current challenges and future opportunities. BJU international 20120901
Cabazitaxel rechallenge at prostate-specific antigen relapse after previous cabazitaxel and docetaxel chemotherapy: case report. Clinical genitourinary cancer 20120901
Medical strategies for treatment of castration resistant prostate cancer (CRPC) docetaxel resistant. Cancer biology & therapy 20120901
Novel and bone-targeted agents for CRPC. Annals of oncology : official journal of the European Society for Medical Oncology 20120901
Management of advanced prostate cancer in senior adults: the new landscape. The oncologist 20120901
Cabazitaxel in metastatic castration-resistant prostate cancer. Expert review of anticancer therapy 20120901
New treatment options for patients with metastatic castration-resistant prostate cancer. Cancer treatment reviews 20120801
Urologists and oncologists: adapting to a new treatment paradigm in castration-resistant prostate cancer (CRPC). BJU international 20120801
Cabazitaxel (jevtana): a novel agent for metastatic castration-resistant prostate cancer. P & T : a peer-reviewed journal for formulary management 20120801
Managing side effects of the novel taxane cabazitaxel in castrate-resistant prostate cancer. Clinical journal of oncology nursing 20120601
NICE guidance on cabazitaxel for hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing regimen. The Lancet. Oncology 20120601
Novel molecular targets for the therapy of castration-resistant prostate cancer. European urology 20120501
Cabazitaxel for prostate cancer: patient preparation and ongoing care. British journal of nursing (Mark Allen Publishing) 20120501
The European Medicines Agency review of cabazitaxel (Jevtana®) for the treatment of hormone-refractory metastatic prostate cancer: summary of the scientific assessment of the committee for medicinal products for human use. The oncologist 20120401
Castration-resistant prostate cancer: systemic therapy in 2012. Clinics (Sao Paulo, Brazil) 20120401
[Second line therapy for castration-resistant prostate cancer (CRPC)]. Der Urologe. Ausg. A 20120301
Advances in the management of high-risk localised and metastatic prostate cancer. BJU international 20120301
Practical aspects of metastatic castration-resistant prostate cancer management: patient case studies. BJU international 20120301
[Compassionate use of abiraterone and cabazitaxel: first experiences in docetaxel-pretreated castration-resistant prostate cancer patients]. Der Urologe. Ausg. A 20120301
Quantification of cabazitaxel in human plasma by liquid chromatography/triple-quadrupole mass spectrometry: a practical solution for non-specific binding. Journal of pharmaceutical and biomedical analysis 20120205
[Promising on advanced cancer, several new drugs coming]. Lakartidningen 20120201
Optimizing outcomes of advanced prostate cancer: drug sequencing and novel therapeutic approaches. Oncology (Williston Park, N.Y.) 20120101
Successful Treatment of Advanced Metastatic Prostate Cancer following Chemotherapy Based on Molecular Profiling. Case reports in oncology 20120101
[Cabazitaxel for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: the TROPIC study in France]. Bulletin du cancer 20120101
Case report: responses to cabazitaxel in metastatic castration-resistant prostate cancer after extensive docetaxel treatment. Clinical genitourinary cancer 20111201
Novel therapies for metastatic castrate-resistant prostate cancer. Journal of the National Cancer Institute 20111116
Novel therapeutic strategies for metastatic prostate cancer in the post-docetaxel setting. The oncologist 20111101
Recent advances in the therapy of castration-resistant prostate cancer: the price of progress. Maturitas 20111001
Current paradigms and evolving concepts in metastatic castration-resistant prostate cancer. Asian journal of andrology 20110901
Abiraterone and increased survival in metastatic prostate cancer. The New England journal of medicine 20110825
New treatment options for castrate-resistant prostate cancer: a urology perspective. The Canadian journal of urology 20110801
Cabazitaxel: a novel microtubule inhibitor. Drugs 20110709
Overcoming chemotherapy resistance in prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20110615
Optimal management of bone metastases in prostate cancer. Current oncology reports 20110601
Current clinical trials in castrate-resistant prostate cancer. Current urology reports 20110601
[The trend toward development of novel agents based on the mechanism of prostate cancer progression]. Nihon rinsho. Japanese journal of clinical medicine 20110601
[Jevtana: clinically significant improvement in survival of patients previously treated with docetaxel]. Revue medicale suisse 20110525
A multicentre dose-escalating study of cabazitaxel (XRP6258) in combination with capecitabine in patients with metastatic breast cancer progressing after anthracycline and taxane treatment: a phase I/II study. European journal of cancer (Oxford, England : 1990) 20110501
Contemporary management of metastatic castration-resistant prostate cancer. Current opinion in urology 20110501
Cabazitaxel for the treatment of prostate cancer. Expert opinion on pharmacotherapy 20110401
TROPIC: Phase III trial of cabazitaxel for the treatment of metastatic castration-resistant prostate cancer. Future oncology (London, England) 20110401
Cabazitaxel: a new drug for metastatic prostate cancer. Asian journal of andrology 20110301
Role of second-line systemic treatment post-docetaxel in metastatic castrate resistant prostate cancer- current strategies and future directions. Anti-cancer agents in medicinal chemistry 20110301
[Castration resistant prostate cancer 2011]. Aktuelle Urologie 20110301
Phase III data for abiraterone in an evolving landscape for castration-resistant prostate cancer. Maturitas 20110201
New options for the management of castration-resistant prostate cancer: a case perspective. Journal of the National Comprehensive Cancer Network : JNCCN 20110201
Cabazitaxel for castration-resistant prostate cancer. Lancet (London, England) 20110108
Cabazitaxel for castration-resistant prostate cancer. Lancet (London, England) 20110108
Cabazitaxel for the treatment of castration-resistant prostate cancer. Future oncology (London, England) 20110101
Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer. Drug design, development and therapy 20110101
Cabazitaxel: filling one of the gaps in the treatment of prostate cancer. Cancer biology & therapy 20101215
Improving outcomes with recent advances in chemotherapy for castrate-resistant prostate cancer. Clinical genitourinary cancer 20101201
A renaissance in the medical treatment of advanced prostate cancer. Oncology (Williston Park, N.Y.) 20101201
Cabazitaxel in prostate cancer: stretching a string. Lancet (London, England) 20101002
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet (London, England) 20101002
Cabazitaxel, a new taxane with favorable properties. Drugs of today (Barcelona, Spain : 1998) 20101001
Cabazitaxel, a taxane for men with hormone-refractory metastatic prostate cancer. Oncology (Williston Park, N.Y.) 20101001
New treatments for metastic prostate cancer. The Medical letter on drugs and therapeutics 20100906
Cabazitaxel. Nature reviews. Drug discovery 20100901
New taxane treats advanced prostate cancer. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801
Castration refractory prostate cancer: cinderella finally comes to the ball. Onkologie 20100101
Critical appraisal of cabazitaxel in the management of advanced prostate cancer. Clinical interventions in aging 20100101
Properties