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Sb 225002

CAS No.:
182498-32-4
Catalog Number:
AG0023XI
Molecular Formula:
C13H10BrN3O4
Molecular Weight:
352.1402
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$126
- +
10mg
99%
1 week
United States
$154
- +
50mg
99%
1 week
United States
$460
- +
100mg
99%
1 week
United States
$737
- +
200mg
99%
1 week
United States
$1223
- +
Product Description
Catalog Number:
AG0023XI
Chemical Name:
Sb 225002
CAS Number:
182498-32-4
Molecular Formula:
C13H10BrN3O4
Molecular Weight:
352.1402
MDL Number:
MFCD00954637
IUPAC Name:
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
InChI:
InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChI Key:
MQBZVUNNWUIPMK-UHFFFAOYSA-N
SMILES:
O=C(Nc1ccccc1Br)Nc1ccc(cc1O)[N+](=O)[O-]
Properties
Complexity:
390  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
350.985g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
352.144g/mol
Monoisotopic Mass:
350.985g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.6  
Literature
Title Journal
Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8. Journal of cellular and molecular medicine 20170701
Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. Journal of medicinal chemistry 20141023
Chemokine receptor antagonists. Journal of medicinal chemistry 20121126
The role of CXCR2 chemokine receptors in the oral squamous cell carcinoma. Investigational new drugs 20120801
Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain. The Journal of pharmacology and experimental therapeutics 20120301
CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. European journal of pharmacology 20111015
Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung. American journal of physiology. Lung cellular and molecular physiology 20110601
Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis. Journal of leukocyte biology 20110501
CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. The Journal of clinical investigation 20110401
Chemokine-related gene expression in the brain following ischemic stroke: no role for CXCR2 in outcome. Brain research 20110204
Cardiac glycosides are potent inhibitors of interferon-β gene expression. Nature chemical biology 20110101
Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice. Pain 20101101
The effects of the selective and non-peptide CXCR2 receptor antagonist SB225002 on acute and long-lasting models of nociception in mice. European journal of pain (London, England) 20100101
Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta. Bioorganic & medicinal chemistry 20091201
The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. American journal of physiology. Gastrointestinal and liver physiology 20091101
[Selective non-peptide CXCR2 antagonist SB225002 inhibits choroidal neovascularization in rat model]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20090801
Novel role of CXCR2 in regulation of gamma-secretase activity. ACS chemical biology 20081219
The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. Journal of leukocyte biology 20081001
Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice. Hepatology (Baltimore, Md.) 20081001
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. The Biochemical journal 20080601
Secreted protein acidic, rich in cysteine induces pulp cell migration via alphavbeta3 integrin and extracellular signal-regulated kinase. Oral diseases 20080501
Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorganic & medicinal chemistry letters 20070315
Differential calcium signaling in dairy cows with specific CXCR1 genotypes potentially related to interleukin-8 receptor functionality. Immunogenetics 20070101
Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils. Journal of leukocyte biology 20050701
IL-8 increases transmission of HIV type 1 in cervical explant tissue. AIDS research and human retroviruses 20050301
Beta 2-adrenergic receptor regulation of human neutrophil function is sexually dimorphic. British journal of pharmacology 20041201
Rabbit neutrophil chemotactic protein (NCP) activates both CXCR1 and CXCR2 and is the functional homologue for human CXCL6. Biochemical pharmacology 20041115
Cloning and pharmacological characterization of CXCR1 and CXCR2 from Macaca fascicularis. The Journal of pharmacology and experimental therapeutics 20040701
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. Biochemical pharmacology 20030301
Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. The Journal of pharmacology and experimental therapeutics 20011001
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. The Journal of biological chemistry 19980424
Properties