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Lomitapide

CAS No.:
182431-12-5
Catalog Number:
AG0023VL
Molecular Formula:
C39H37F6N3O2
Molecular Weight:
693.7204
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
>98.0%(HPLC)
1 week
United States
$289
- +
Product Description
Catalog Number:
AG0023VL
Chemical Name:
Lomitapide
CAS Number:
182431-12-5
Molecular Formula:
C39H37F6N3O2
Molecular Weight:
693.7204
MDL Number:
MFCD16620494
IUPAC Name:
N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
InChI:
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChI Key:
MBBCVAKAJPKAKM-UHFFFAOYSA-N
SMILES:
O=C(c1ccccc1c1ccc(cc1)C(F)(F)F)NC1CCN(CC1)CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2c2c1cccc2
UNII:
82KUB0583F
Properties
Complexity:
1110  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
693.279g/mol
Formal Charge:
0
Heavy Atom Count:
50  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
693.734g/mol
Monoisotopic Mass:
693.279g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
61.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
8.6  
Literature
Title Journal
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet (London, England) 20130105
Multiple functions of microsomal triglyceride transfer protein. Nutrition & metabolism 20120101
Mipomersen: evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia. Core evidence 20120101
New clinical perspectives of hypolipidemic drug therapy in severe hypercholesterolemia. Current medicinal chemistry 20120101
Familial hypercholesterolemia: present and future management. Current cardiology reports 20111201
Lomitapide. American journal of cardiovascular drugs : drugs, devices, and other interventions 20111001
Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats. Clinical and experimental pharmacology & physiology 20110501
Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia. IDrugs : the investigational drugs journal 20100201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20090601
Dyslipidemia and cardiovascular diseases. Current opinion in lipidology 20090401
Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Current atherosclerosis reports 20090101
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nature clinical practice. Cardiovascular medicine 20080801
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. The New England journal of medicine 20070111
5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorganic & medicinal chemistry letters 20041018
Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor. European journal of pharmacology 20021129
A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. Journal of medicinal chemistry 20010315
Properties