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Almotriptan malate

CAS No.:
181183-52-8
Catalog Number:
AG0022QH
Molecular Formula:
C21H31N3O7S
Molecular Weight:
469.5517
Pack Size
Purity
Availability
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Price(USD)
Quantity
  
5mg
98%(HPLC)powder
In Stock USA
United States
$68
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10mg
98%(HPLC)powder
In Stock USA
United States
$108
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25mg
98%(HPLC)powder
In Stock USA
United States
$197
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100mg
98%(HPLC)powder
In Stock USA
United States
$553
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Product Description
Catalog Number:
AG0022QH
Chemical Name:
Almotriptan malate
CAS Number:
181183-52-8
Molecular Formula:
C21H31N3O7S
Molecular Weight:
469.5517
MDL Number:
MFCD08067740
IUPAC Name:
N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine;2-hydroxybutanedioic acid
InChI:
InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
InChI Key:
QHATUKWEVNMHRY-UHFFFAOYSA-N
SMILES:
OC(=O)CC(C(=O)O)O.CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C
Properties
Complexity:
612  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
469.188g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
469.553g/mol
Monoisotopic Mass:
469.188g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
160A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Treatment of perimenstrual migraine with triptans: an update. Current pain and headache reports 20121001
Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study. The journal of headache and pain 20120701
Stability, responsiveness, and reproducibility of a visual analog scale for treatment satisfaction in migraine. Headache 20120601
Cost-effectiveness analysis of early versus non-early intervention in acute migraine based on evidence from the 'Act when Mild' study. Applied health economics and health policy 20120501
Oral sumatriptan and almotriptan--delimiting the MAOI effect. Headache 20120501
LC-ESI-MS/MS determination of in vivo metabolites of almotriptan in rat plasma, urine and feces: application to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120401
The impact of allodynia on the efficacy of almotriptan when given early in migraine: data from the 'Act when mild' study. The International journal of neuroscience 20111201
Effect of iontophoresis on in vitro transdermal absorption of almotriptan. International journal of pharmaceutics 20110915
Almotriptan for menstrually related migraine. Expert opinion on pharmacotherapy 20110801
A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine. The journal of headache and pain 20110601
Improved patient satisfaction and pain evolution with almotriptan in migraine: a primary care study. Current medical research and opinion 20110301
Almotriptan 12.5 mg in menstrually related migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia : an international journal of headache 20110101
Almotriptan for the acute treatment of adolescent migraine. Expert opinion on pharmacotherapy 20101001
Almotriptan: a review of 10 years' clinical experience. Expert review of neurotherapeutics 20101001
Almotriptan efficacy in migraine with allodynia: a rebuttal to Burstein and Jakubowski's critique of Schoenen et al. Cephalalgia : an international journal of headache 20100901
Influence of trigger factors on the efficacy of almotriptan as early intervention for the treatment of acute migraine in a primary care setting: the START study. Expert review of neurotherapeutics 20100901
Evolution of migraine-associated symptoms in menstrually related migraine following symptomatic treatment with almotriptan. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601
Efficacy of almotriptan in early intervention for treatment of acute migraine in a primary care setting: the START study. International journal of clinical practice 20100601
Long-term, open-label safety study of oral almotriptan 12.5 mg for the acute treatment of migraine in adolescents. Headache 20100501
Drug dependence associated with triptans and ergot derivatives: a case/non-case study. European journal of clinical pharmacology 20100401
Almotriptan for the treatment of acute migraine: a review of early intervention trials. Expert review of neurotherapeutics 20100301
[Acute migraine: a treatment reserved for adults now recommended for adolescents]. Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec 20100101
Almotriptan efficacy in migraine with allodynia: a critique of Schoenen et al. Cephalalgia : an international journal of headache 20091001
Variation in almotriptan effectiveness according to different prophylactic treatments. Headache 20091001
Migraine treatment with rizatriptan and almotriptan: a crossover study. Headache 20090501
[Almotriptan vs. ergotamine plus caffeine for acute migraine treatment. A cost-efficacy analysis]. Neurologia (Barcelona, Spain) 20090401
Allodynia-associated symptoms, pain intensity and time to treatment: predicting treatment response in acute migraine intervention. Headache 20090301
Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia--but is it the same in migraine with established allodynia? Headache 20090301
Efficacy and tolerability of almotriptan in adolescents: a randomized, double-blind, placebo-controlled trial. Headache 20081001
Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia. Cephalalgia : an international journal of headache 20081001
Seizure after use of almotriptan. Clinical neurology and neurosurgery 20080901
Almotriptan in triptan-naïve patients: new evidence of benefits. Cephalalgia : an international journal of headache 20080901
The 'Act when Mild' (AwM) study: a step forward in our understanding of early treatment in acute migraine. Cephalalgia : an international journal of headache 20080901
Applying the benefits of the AwM study in the clinic. Cephalalgia : an international journal of headache 20080901
Early vs. non-early intervention in acute migraine-'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan. Cephalalgia : an international journal of headache 20080401
A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate API. Journal of pharmaceutical and biomedical analysis 20080313
Migraine-like headache in intracranial haemorrhage is alleviated by sumatriptan and almotriptan. Cephalalgia : an international journal of headache 20080301
Effect of early intervention with almotriptan vs placebo on migraine-associated functional disability: results from the AEGIS Trial. Headache 20080301
Characteristics of migraine attacks and responses to almotriptan treatment: a comparison of menstrually related and nonmenstrually related migraines. Headache 20080201
Almotriptan, an antimigraine agent, and its malate salt. Acta crystallographica. Section C, Crystal structure communications 20080101
Almotriptan: meeting today's needs in acute migraine treatment. Expert review of neurotherapeutics 20071201
Use of almotriptan in triptan-experienced and triptan-naïve patients. Current medical research and opinion 20071001
Meta-analysis examining the efficacy and safety of almotriptan in the acute treatment of migraine. Headache 20070901
Do 5HT1B/1D receptor agonists have an effect on mood and anxiety disorders? Cephalalgia : an international journal of headache 20070501
Effect of pain intensity and time to administration on responsiveness to almotriptan: results from AXERT 12.5 mg Time Versus Intensity Migraine Study (AIMS). Headache 20070401
Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy. European journal of neurology 20070301
Early intervention with almotriptan: results of the AEGIS trial (AXERT Early Migraine Intervention Study). Headache 20070201
Patient preference in migraine therapy. A randomized, open-label, crossover clinical trial of acute treatment of migraine with oral almotriptan and rizatriptan. Journal of neurology 20070201
Almotriptan and zolmitriptan in the acute treatment of migraine. Acta neurologica Scandinavica 20070101
A pharmacoeconomic evaluation of oral triptans in the treatment of migraine in Italy. Minerva medica 20061201
Disposition and metabolism of almotriptan in rats, dogs and monkeys. Xenobiotica; the fate of foreign compounds in biological systems 20060901
Ethanol does not significantly affect the bioavailability of almotriptan: an open, randomized, crossover, single-dose, phase I clinical trial in healthy volunteers. International journal of clinical pharmacology and therapeutics 20060901
Efficacy and tolerability of almotriptan versus zolmitriptan for the acute treatment of menstrual migraine. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060501
Efficacy, speed of action and tolerability of almotriptan in the acute treatment of migraine: pooled individual patient data from four randomized, double-blind, placebo-controlled clinical trials. Cephalalgia : an international journal of headache 20060401
Effect of food intake on the bioavailability of almotriptan, an antimigraine compound, in healthy volunteers: an open, randomized, crossover, single-dose clinical trial. International journal of clinical pharmacology and therapeutics 20060401
Almotriptan in the acute treatment of migraine in patients 11-17 years old: an open-label pilot study of efficacy and safety. The journal of headache and pain 20060401
[Economic evaluation of acute migraine attack treatment with triptans in Spain]. Neurologia (Barcelona, Spain) 20060301
Value of postmarketing surveillance studies in achieving a complete picture of antimigraine agents: using almotriptan as an example. The journal of headache and pain 20060201
Evaluation of efficacy, tolerability, and treatment satisfaction with almotriptan in 3 consecutive migraine attacks. The migraine--satisfaction with treatment: reality with Almogran study. European neurology 20060101
Focus on trial endpoints of clinical relevance and the use of almotriptan for the acute treatment of migraine. International journal of clinical practice 20051101
Efficacy of almotriptan 12.5 mg in achieving migraine-related composite endpoints: a double-blind, randomized, placebo-controlled study in patients controlled study in patients with previous poor response to sumatriptan 50 mg. Current medical research and opinion 20051001
Multiple attack study on the available triptans in Italy versus placebo. European journal of neurology 20050701
Consistent efficacy, tolerability, and high levels of satisfaction with almotriptan 12.5 mg when used to treat multiple migraine attacks in routine clinical practice. Headache 20050601
Effects of symptomatic treatments on cutaneous hyperalgesia and laser evoked potentials during migraine attack. Cephalalgia : an international journal of headache 20050501
Early triptan intervention in migraine: an overview. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050501
Correlation between lipophilicity and triptan outcomes. Headache 20050101
[Tolerance to almotriptan and its effectiveness in primary care]. Atencion primaria 20050101
Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clinical pharmacokinetics 20050101
Efficacy and tolerability of almotriptan in controlled clinical trials. European neurology 20050101
Efficacy and tolerability of almotriptan in postmarketing surveillance studies. European neurology 20050101
Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial. European neurology 20050101
Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial. Headache 20050101
Pharmacokinetics and safety of oral almotriptan in healthy male volunteers. Biopharmaceutics & drug disposition 20041001
Evaluating triptan usage: a rebuttal. Headache 20041001
TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management. Acta neurologica Scandinavica 20040901
[Meta-analysis of triptan treatment in migraine]. No to shinkei = Brain and nerve 20040901
Meta-analysis of oral triptans. Cephalalgia : an international journal of headache 20040801
Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. Naunyn-Schmiedeberg's archives of pharmacology 20040701
[Almotriptan. One more triptan for migraines]. Revue de l'infirmiere 20040601
Oral almotriptan: practical uses in the acute treatment of migraine. Expert review of neurotherapeutics 20040501
A comparison of the pharmacokinetics and tolerability of the anti-migraine compound almotriptan in healthy adolescents and adults. Cephalalgia : an international journal of headache 20040401
Almotriptan improves response rates when treatment is within 1 hour of migraine onset. Headache 20040401
Evaluating triptan usage. Headache 20040201
A comparison of the cost-effectiveness of almotriptan and sumatriptan in the treatment of acute migraine using a composite efficacy/tolerability end point. Journal of managed care pharmacy : JMCP 20040101
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What do patients want from acute migraine treatment? Cephalalgia : an international journal of headache 20040101
Clinical profile and practice experience of almotriptan. Cephalalgia : an international journal of headache 20040101
Clinical benefits of early triptan therapy for migraine. Cephalalgia : an international journal of headache 20040101
Cost-effectiveness of almotriptan and rizatriptan in the treatment of acute migraine. Clinical therapeutics 20031101
A review of the clinical efficacy and tolerability of almotriptan in acute migraine. Expert opinion on pharmacotherapy 20030701
Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug metabolism and disposition: the biological fate of chemicals 20030401
Interaction between ketoconazole and almotriptan in healthy volunteers. Journal of clinical pharmacology 20030401
A case of carotidynia with response to almotriptan. Cephalalgia : an international journal of headache 20030301
A review of the effects of almotriptan and other triptans on clinical trial outcomes that are meaningful to patients with migraine. Clinical therapeutics 20030201
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Almotriptan versus rizatriptan in patients with migraine in Spain. Headache 20030101
Early intervention with almotriptan improves sustained pain-free response in acute migraine. Headache 20030101
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Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers. Journal of clinical pharmacology 20021201
Efficacy and safety of almotriptan malate for migraine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021115
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Triptan medications to treat acute migraine. Lancet (London, England) 20020330
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Cardiovascular effect of almotriptan in treated hypertensive patients. Clinical pharmacology and therapeutics 20020301
Almotriptan (Axert) and frovatriptan (Frova) for migrane. The Medical letter on drugs and therapeutics 20020218
Cost savings in migraine associated with less chest pain on new triptan therapy. The American journal of managed care 20020201
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Impact of chest pain on cost of migraine treatment with almotriptan and sumatriptan. Headache 20020101
Almotriptan increases sustained pain-free outcomes in acute migraine: results from three controlled clinical trials. Headache 20020101
Within-patient early versus delayed treatment of migraine attacks with almotriptan: the sooner the better. Headache 20020101
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Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries. Cephalalgia : an international journal of headache 20011001
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Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans). Archives of neurology 20010701
Oral almotriptan vs. oral sumatriptan in the abortive treatment of migraine: a double-blind, randomized, parallel-group, optimum-dose comparison. Archives of neurology 20010601
Oral almotriptan in the treatment of migraine: safety and tolerability. Headache 20010501
Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans. British journal of clinical pharmacology 20010501
[Current topics: expectation for new triptans]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410
Hemodynamic and electrocardiographic effects of almotriptan in healthy volunteers. Journal of cardiovascular pharmacology 20010301
Acute treatment of migraine and the role of triptans. Current neurology and neuroscience reports 20010301
Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers. Journal of clinical pharmacology 20010201
Almotriptan: a balanced approach to migraine. Hospital medicine (London, England : 1998) 20010201
Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers. Cephalalgia : an international journal of headache 20010201
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