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Jaceosidin

CAS No.:
18085-97-7
Catalog Number:
AG0022DU
Molecular Formula:
C17H14O7
Molecular Weight:
330.2889
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$94
- +
5mg
≥98%
1 week
United States
$226
- +
10mg
≥98%
1 week
United States
$357
- +
25mg
≥98%
1 week
United States
$714
- +
Product Description
Catalog Number:
AG0022DU
Chemical Name:
Jaceosidin
CAS Number:
18085-97-7
Molecular Formula:
C17H14O7
Molecular Weight:
330.2889
MDL Number:
MFCD01081948
IUPAC Name:
5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one
InChI:
InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3
InChI Key:
GLAAQZFBFGEBPS-UHFFFAOYSA-N
SMILES:
COc1cc(ccc1O)c1cc(=O)c2c(o1)cc(c(c2O)OC)O
Properties
Complexity:
505  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
330.074g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
330.292g/mol
Monoisotopic Mass:
330.074g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7  
Literature
Title Journal
Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chemico-biological interactions 20161225
Flavonoids from the Japanese monotypic genus, Nipponanthemum. Natural product communications 20120801
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. Bioorganic & medicinal chemistry letters 20120401
Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells. Nutrition research and practice 20120401
[Chemical constituents of Eupatorium lindleyanum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401
A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. Natural product research 20120101
Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. Evidence-based complementary and alternative medicine : eCAM 20120101
Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. Evidence-based complementary and alternative medicine : eCAM 20120101
In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. Journal of agricultural and food chemistry 20111228
The relevance of higher plants in lead compound discovery programs. Journal of natural products 20110624
Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. European journal of pharmacology 20110125
Neuropharmacological activity of Lippia nodiflora Linn. Pharmacognosy research 20110101
Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacognosy reviews 20110101
Jaceosidin induces p53-dependent G2/M phase arrest in U87 glioblastoma cells. Asian Pacific journal of cancer prevention : APJCP 20110101
Metabolism study of botanical drugs. Archives of pharmacal research 20101201
In vitro metabolism of jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes. Archives of pharmacal research 20101201
Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes. Molecules (Basel, Switzerland) 20100916
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorganic & medicinal chemistry 20100201
Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. Journal of ethnopharmacology 20090925
Liquid chromatography-tandem mass spectrometry for the determination of jaceosidin in rat plasma. Journal of pharmaceutical and biomedical analysis 20090220
Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. Journal of ethnopharmacology 20081030
In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal. Archives of pharmacal research 20080401
Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. Journal of biomedicine & biotechnology 20080101
Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. International immunopharmacology 20071215
Anti-inflammatory activity of flavonoids from Eupatorium arnottianum. Journal of ethnopharmacology 20070725
Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana. Phytochemistry 20070301
Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Annals of the New York Academy of Sciences 20070101
Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. Annals of the New York Academy of Sciences 20070101
Salicylic acid enhances Jaceosidin and Syringin production in cell cultures of Saussurea medusa. Biotechnology letters 20060701
Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa. Applied biochemistry and biotechnology 20060701
Flavonoids from Artemisia copa with anti-inflammatory activity. Planta medica 20060101
Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16. Journal of ethnopharmacology 20050426
Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa. Biotechnology letters 20050101
Transformation of Saussurea medusa for hairy roots and jaceosidin production. Plant cell reports 20041201
Free radical scavengers and antioxidants from Baccharis grisebachii. Journal of ethnopharmacology 20041201
Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity. Phytotherapy research : PTR 20040101
[Study on the flavonoids of Eupatorium lindleyanum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040101
Effect of aggregate size in cell cultures of Saussurea medusa on cell growth and jaceosidin production. Plant cell reports 20030701
Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. Biological & pharmaceutical bulletin 20020701
Properties