Cytidine, 3'-c-ethynyl-
| Title | Journal |
|---|---|
| Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells. | International journal of cancer 20121101 |
| A phase I study to determine the safety and pharmacokinetics of intravenous administration of TAS-106 once per week for three consecutive weeks every 28 days in patients with solid tumors. | Anticancer research 20120501 |
| Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies. | Investigational new drugs 20120201 |
| Cytostatic activity of the duplex drug linking 2'-deoxy-5-fluorouridine (5FdU) with 3'-C-ethynylcytidine (ECyd) against gastric adenocarcinoma cell lines. | Investigational new drugs 20111201 |
| ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof. | Investigational new drugs 20110601 |
| Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine. | Investigational new drugs 20110401 |
| Acceptance of oral chemotherapy in breast cancer patients - a survey study. | BMC cancer 20110101 |
| RNA polymerase III transcription in cancer: the BRF2 connection. | Molecular cancer 20110101 |
| A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression. | Molecular cancer 20110101 |
| Cytotoxicity and antileukaemic activity of new duplexes linking 3-C-ethynylcytidine and 5-fluorodeoxyuridine. | Anticancer research 20101201 |
| Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. | The FEBS journal 20101101 |
| An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation. | Biochemical pharmacology 20100615 |
| Synthesis and in vitro activities of new anticancer duplex drugs linking 2'-deoxy-5-fluorouridine (5-FdU) with 3'-C-ethynylcytidine (ECyd) via a phosphodiester bonding. | Bioorganic & medicinal chemistry 20091001 |
| PK-PD modeling of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes. | International journal of pharmaceutics 20090730 |
| Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives. | Bioorganic & medicinal chemistry 20090701 |
| 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo. | International journal of oncology 20090501 |
| Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. | Cancer chemotherapy and pharmacology 20090401 |
| Molecular mechanisms of apoptosis induced by 3'-ethynylcytidine. | Nucleic acids symposium series (2004) 20090101 |
| Inhibition of HIF-1alpha by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo. | British journal of cancer 20081104 |
| Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy. | Current medicinal chemistry 20080101 |
| In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine. | Nucleic acids symposium series (2004) 20080101 |
| Cellular localization and functional characterization of the equilibrative nucleoside transporters of antitumor nucleosides. | Cancer science 20071001 |
| Mechanism of action of a new antitumor ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), differs from that of 5-fluorouracil. | Oncology reports 20070601 |
| Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice. | International journal of radiation oncology, biology, physics 20070501 |
| A novel apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis--the possibility of RNase L activated pathway as a target of ECyd. | Nucleic acids symposium series (2004) 20070101 |
| An apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis mediated by RNase L. | Nucleic acids symposium series (2004) 20060101 |
| X irradiation induces the proapoptotic state independent of the loss of clonogenic ability in Chinese hamster V79 cells. | Radiation research 20050701 |
| Possible antitumor activity of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line. | Cancer science 20050501 |
| Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd). | Bioorganic & medicinal chemistry 20050401 |
| Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd). | Bioorganic & medicinal chemistry 20050215 |
| Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd). | Nucleosides, nucleotides & nucleic acids 20050101 |
| A novel anticancer ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells. | Radiation research 20041201 |
| A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. | Drug metabolism and disposition: the biological fate of chemicals 20041001 |
| New nucleoside analogs in the treatment of solid tumors. | Acta poloniae pharmaceutica 20040101 |
| Synthesis of the cyclic and acyclic acetal derivatives of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, a potent antitumor nucleoside. Design of prodrugs to be selectively activated in tumor tissues via the bio-reduction-hydrolysis mechanism. | Bioorganic & medicinal chemistry 20030529 |
| Determination of 3'-C-ethynylcytidine in human plasma and urine by liquid chromatographic-electrospray ionization tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20030205 |
| Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. | Japanese journal of cancer research : Gann 20020701 |
| Cellular and biochemical mechanisms of the resistance of human cancer cells to a new anticancer ribo-nucleoside, TAS-106. | Japanese journal of cancer research : Gann 20020401 |
| Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. | Nucleic acids research. Supplement (2001) 20020101 |
| Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). | Nucleic acids research. Supplement (2001) 20020101 |
| Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells. | International journal of molecular medicine 20010901 |
| An efficient method for the preparation of 1'alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: the first conversion of a natural nucleoside into 1'-substituted ribonucleosides. | Chemistry (Weinheim an der Bergstrasse, Germany) 20010601 |
| Improvement in precision of the liquid chromatographic-electrospray ionization tandem mass spectrometric analysis of 3'-C-ethynylcytidine in rat plasma. | Journal of chromatography. B, Biomedical sciences and applications 20010415 |
| Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. | Japanese journal of cancer research : Gann 20010301 |
| 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106)1: antitumor effect and mechanism of action. | Nucleosides, nucleotides & nucleic acids 20010101 |
| Anticancer molecular mechanism of 3'-ethynylcytidine (ECyd). | Nucleic acids research. Supplement (2001) 20010101 |