Home Other Building Blocks 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2-hydroxyphenyl)-

4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2-hydroxyphenyl)-

CAS No.:
17348-76-4
Catalog Number:
AG001YY3
Molecular Formula:
C15H12O3
Molecular Weight:
240.2540
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
>98.0%(HPLC)
1 week
United States
$146
- +
Product Description
Catalog Number:
AG001YY3
Chemical Name:
4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2-hydroxyphenyl)-
CAS Number:
17348-76-4
Molecular Formula:
C15H12O3
Molecular Weight:
240.2540
MDL Number:
MFCD00017702
IUPAC Name:
2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
InChI:
InChI=1S/C15H12O3/c16-12-7-3-1-5-10(12)15-9-13(17)11-6-2-4-8-14(11)18-15/h1-8,15-16H,9H2
InChI Key:
KZKWCKFDCPVDFJ-UHFFFAOYSA-N
SMILES:
Oc1ccccc1C1CC(=O)c2c(O1)cccc2
Properties
Complexity:
315  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
240.079g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
240.258g/mol
Monoisotopic Mass:
240.079g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
46.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.5  
Literature
Title Journal
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The influence of β-cyclodextrin encapsulation on the binding of 2'-hydroxyflavanone with calf thymus DNA. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121201
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. Journal of medicinal chemistry 20120913
Evaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography. Analytica chimica acta 20120813
2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells. Molecular nutrition & food research 20120501
Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. The Journal of investigative dermatology 20120401
2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma. Carcinogenesis 20110401
Optical isomer separation of flavanones and flavanone glycosides by nano-liquid chromatography using a phenyl-carbamate-propyl-beta-cyclodextrin chiral stationary phase. Journal of chromatography. A 20100212
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids. Bioorganic & medicinal chemistry 20100101
Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression. Bioorganic & medicinal chemistry letters 20090415
Screening of flavonoids as candidate antibiotics against Enterococcus faecalis. Journal of natural products 20090401
AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chemico-biological interactions 20090316
Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. Journal of medicinal chemistry 20080724
Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors. Journal of chromatography. A 20080425
[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. Ai zheng = Aizheng = Chinese journal of cancer 20071201
Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chemico-biological interactions 20070501
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. The Journal of biological chemistry 20040430
A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity. Molecular and cellular endocrinology 20031230
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. Journal of medicinal chemistry 19960607
Properties