Home Halogens (3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine hydrochloride

(3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine hydrochloride

CAS No.:
17321-77-6
Catalog Number:
AG001YPT
Molecular Formula:
C19H24Cl2N2
Molecular Weight:
351.3133
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
97%
In Stock USA
United States
$13
- +
5g
97%
In Stock USA
United States
$50
- +
25g
97%
In Stock USA
United States
$125
- +
100g
97%
In Stock USA
United States
$300
- +
500g
97%
In Stock USA
United States
$625
- +
Product Description
Catalog Number:
AG001YPT
Chemical Name:
(3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine hydrochloride
CAS Number:
17321-77-6
Molecular Formula:
C19H24Cl2N2
Molecular Weight:
351.3133
MDL Number:
MFCD00069234
IUPAC Name:
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
InChI:
InChI=1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
InChI Key:
WIMWMKZEIBHDTH-UHFFFAOYSA-N
SMILES:
CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C.Cl
EC Number:
241-344-3
UNII:
2LXW0L6GWJ
NSC Number:
759323
Properties
Complexity:
346  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
350.132g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
351.315g/mol
Monoisotopic Mass:
350.132g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
6.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080601
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Changes in cognitive dysfunction in children and adolescents with obsessive-compulsive disorder after treatment. Journal of psychiatric research 20080501
A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder. The American journal of psychiatry 20080501
Antidepressant-like effect of asiaticoside in mice. Pharmacology, biochemistry, and behavior 20080501
Increased sensitivity to antidepressants of D3 dopamine receptor-deficient mice in the forced swim test (FST). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080401
Effects of anti-depressants on olfactory sensitivity in mice. Progress in neuro-psychopharmacology & biological psychiatry 20080401
Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: possible relevance to depression and hyperactive-immune disorders. International immunopharmacology 20080401
Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma. International journal of oncology 20080401
Endoscopic removal of slow release clomipramine bezoars in two cases of acute poisoning. Clinical toxicology (Philadelphia, Pa.) 20080401
Psychogenic excoriation responding to fluoxetine: a case report. Journal of the Indian Medical Association 20080401
Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus. Behavioural brain research 20080317
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Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood. Behavioural brain research 20080211
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Photophysics and photochemistry of imipramine, desimipramine, and clomipramine in several solvents: a fluorescence, 266 nm laser flash, and theoretical study. The journal of physical chemistry. B 20080110
Serotonin syndrome caused by olanzapine and clomipramine. Minerva anestesiologica 20080101
Premature ejaculation: current and future treatments. Asian journal of andrology 20080101
[Efficacy and tolerability of clomipramine, pirlindole and escitalopram in the treatment of neurotic level depression]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101
Serotonin syndrome caused by olanzapine and clomipramine. Minerva anestesiologica 20080101
Aggravation of schizophrenia by clomipramine in a patient with comorbid obsessive-compulsive disorder. Psychopharmacology bulletin 20080101
Treatment for late-onset obsessive-compulsive disorder with parkinsonism. The Journal of neuropsychiatry and clinical neurosciences 20080101
Response to a combined treatment program with clomipramine, behavioral, and environmental management of compulsive tail chasing in a German Shepherd. Berliner und Munchener tierarztliche Wochenschrift 20080101
Pareidolias in obsessive-compulsive disorder: neglected symptoms that may respond to serotonin reuptake inhibitors. Neurocase 20080101
Long-term follow-up study of patients with refractory obsessive-compulsive disorder. The Journal of neuropsychiatry and clinical neurosciences 20080101
Obsessive-compulsive disorder. The Israel journal of psychiatry and related sciences 20080101
Synthesis of some tropane derivatives of anticipated activity on the reuptake of norepinephrine and/or serotonin. Bioorganic & medicinal chemistry 20071215
Obsessive-compulsive disorder revisited from a treatment perspective. Psychiatria Danubina 20071201
Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? European journal of pharmacology 20071114
L-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression. Journal of affective disorders 20071101
Penile self-mutilation as an unusual sign of a separation-related problem in a crossbreed dog. The Journal of small animal practice 20071101
Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects. Clinical pharmacology and therapeutics 20071101
Sustained response versus relapse: the pharmacotherapeutic goal for obsessive-compulsive disorder. International clinical psychopharmacology 20071101
Social anxiety disorder: psychobiological and evolutionary underpinnings. CNS spectrums 20071101
Systematic review: pharmacological and behavioral treatment for trichotillomania. Biological psychiatry 20071015
Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids. Journal of separation science 20071001
Successful augmentation with aripiprazole in clomipramine-refractory obsessive-compulsive disorder. Progress in neuro-psychopharmacology & biological psychiatry 20071001
Comparative oxidative metabolic profiles of clomipramine in cats, rats and dogs: preliminary results from an in vitro study. Journal of veterinary pharmacology and therapeutics 20071001
CE of tricyclic antidepressant clomipramine and metabolites: electromigration and wall adsorption. Electrophoresis 20071001
Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry. Journal of mass spectrometry : JMS 20071001
Addition of cognitive-behavioral therapy for nonresponders to medication for obsessive-compulsive disorder: a naturalistic study. The Journal of clinical psychiatry 20071001
Serotonin concentrations in the lumbosacral spinal cord of the adult rat following microinjection or dorsal surface application. Journal of neurophysiology 20070901
Reversible acute renal failure associated with clomipramine-induced interstitial nephritis. Clinical and experimental nephrology 20070901
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 20070823
Effect of chronic treatment with clomipramine on food intake, macronutrient selection and body weight gain in rats. Biological & pharmaceutical bulletin 20070801
Issues in the pharmacological treatment of obsessive-compulsive disorder. International journal of clinical practice 20070701
The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men. The journal of sexual medicine 20070701
Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents. Neuroscience letters 20070621
The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical pharmacology 20070615
Sertraline and clomipramine inhibit nucleotide catabolism in rat brain synaptosomes. Toxicology in vitro : an international journal published in association with BIBRA 20070601
Clomipramine-induced mood and perceived performance changes in selected healthy individuals. Journal of clinical psychopharmacology 20070601
Aripiprazole augmentation of clomipramine-refractory obsessive-compulsive disorder. The Journal of clinical psychiatry 20070601
Supported liquid membranes in hollow fiber liquid-phase microextraction (LPME)--practical considerations in the three-phase mode. Journal of separation science 20070601
A kinetic-pharmacodynamic model for clinical trial simulation of antidepressant action: application to clomipramine-lithium interaction. Contemporary clinical trials 20070501
Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake. Regulatory peptides 20070405
Effects of physiological covariables on pharmacokinetic parameters of clomipramine in a large population of cats after a single oral administration. Journal of veterinary pharmacology and therapeutics 20070401
Motor cortex excitability after vagus nerve stimulation in major depression. Journal of clinical psychopharmacology 20070401
[Study on Modified Xiaoyao Decoction combining Clomipramine treating depression]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070401
Thirty cases of obsession treated by point-stimulation and with small dose of chlorimipramine. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20070301
[Narcolepsy and anesthesia]. Revista espanola de anestesiologia y reanimacion 20070301
Benefits of cognitive-behavioural therapy for children and youth with obsessive-compulsive disorder: re-examination of the evidence. The Australian and New Zealand journal of psychiatry 20070301
Neurocardiogenic mechanisms of unexplained syncope in idiopathic dilated cardiomyopathy. The American journal of cardiology 20070215
Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Annals of emergency medicine 20070201
Post-traumatic spontaneous recurrent hypothermia: a variant of Shapiro's syndrome. European journal of neurology 20070201
Age onset subtypes of obsessive compulsive disorder: differences in clinical response to treatment with clomipramine. Journal of child and adolescent psychopharmacology 20070201
Antidepressant use in treatment of psychosis with comorbid depression in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry 20070130
Diagnosis and treatment of obsessive-compulsive disorder and related disorders. International journal of clinical practice 20070101
Treatment of compulsive sexual behaviour with clomipramine and valproic acid. Clinical drug investigation 20070101
Which panic disorder patients benefit from which treatment: cognitive therapy or antidepressants? Psychotherapy and psychosomatics 20070101
Photosensitivity might be associated with drug-induced hypersensitivity syndrome. Dermatology (Basel, Switzerland) 20070101
[The influence of clomipramine on CYP2D6 activity]. Psychiatria polska 20070101
[Serotoninergic syndrome after the administration of clomipramine tablet in a critical patient]. Medicina intensiva 20070101
Therapeutic drug monitoring of tricyclic antidepressants in everyday clinical practice. Journal of neural transmission. Supplementum 20070101
[Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy]. Revista medica de Chile 20061201
Voluntary exercise and clomipramine treatment elevate prepro-galanin mRNA levels in the locus coeruleus in rats. Neuroscience letters 20061106
Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport. The Canadian veterinary journal = La revue veterinaire canadienne 20061101
Antidepressant treatment reduces Fos-like immunoreactivity induced by swim stress in different columns of the periaqueductal gray matter. Brain research bulletin 20061016
Melatonin affects the immobility time of rats in the forced swim test: the role of serotonin neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20061001
Comparative effects of clomipramine and duloxetine on detrusor and striated sphincter function in male and female rabbits. Archivos espanoles de urologia 20061001
Animal behavior case of the month. Separation anxiety. Journal of the American Veterinary Medical Association 20060915
New-onset narcolepsy with cataplexy in a geriatric patient. Sleep medicine 20060901
Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder. Saudi medical journal 20060901
Pharmacokinetics of clomipramine and desmethylclomipramine after single-dose intravenous and oral administrations in cats. Journal of veterinary pharmacology and therapeutics 20060801
Premature ejaculation. Urologic nursing 20060801
Tramadol for neuropathic pain. The Cochrane database of systematic reviews 20060719
Non-antiepileptic drugs for trigeminal neuralgia. The Cochrane database of systematic reviews 20060719
Adverse drug reactions following nonresponse in a depressed patient with CYP2D6 deficiency and low CYP 3A4/5 activity. Pharmacopsychiatry 20060701
Generalised urticaria in a young woman treated with clomipramine and after ingestion of codfish. Pharmacopsychiatry 20060701
[Peculiarities of tactics in the treatment of chronic pain syndrome in women]. Voenno-meditsinskii zhurnal 20060701
Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders. The Psychiatric clinics of North America 20060601
Oral contraceptive pill use and changes in obsessive-compulsive symptoms. Journal of psychosomatic research 20060601
Female hormones affect symptom severity in obsessive-compulsive disorder. International clinical psychopharmacology 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
[Therapeutic drug monitoring: A pharmacotherapeutic tool in psychiatry]. Praxis 20060426
Antidepressant drugs during pregnancy and infant congenital heart defect. Reproductive toxicology (Elmsford, N.Y.) 20060401
Serotonin-norepinephrine reuptake inhibitors in the treatment of obsessive-compulsive disorder: A critical review. The Journal of clinical psychiatry 20060401
Sexual pleasure in women with obsessive-compulsive disorder? Journal of affective disorders 20060301
Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity. Journal of pharmacological sciences 20060301
Placental passage of tricyclic antidepressants. Biological psychiatry 20060201
Pulse-loaded intravenous clomipramine in treatment-resistant obsessive-compulsive disorder. Journal of clinical psychopharmacology 20060201
Clomipramine and selegiline: do they influence impulse control? Journal of veterinary pharmacology and therapeutics 20060201
Response versus remission in obsessive-compulsive disorder. The Journal of clinical psychiatry 20060201
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. The Journal of biological chemistry 20060127
Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060101
Shared obsessive-compulsive disorder. Psychopathology 20060101
Study of the efficacy of fluoxetine and clomipramine in the treatment of premature ejaculation after opioid detoxification. The American journal on addictions 20060101
Cognitive behavioral therapy versus psychosurgery for refractory obsessive-compulsive disorder. The Journal of neuropsychiatry and clinical neurosciences 20060101
Hippocampal upregulation of the cyclooxygenase-2 gene following neonatal clomipramine treatment (a model of depression). The pharmacogenomics journal 20060101
Molecular genetics and treatment of narcolepsy. Annals of medicine 20060101
Clinical features associated with treatment response in obsessive-compulsive disorder. Comprehensive psychiatry 20060101
A novel treatment option of bipolar depression with psychotic and catatonic features. General hospital psychiatry 20060101
The effects of clomipramine hydrochloride in cats with psychogenic alopecia: a prospective study. Journal of the American Animal Hospital Association 20060101
Therapeutic tricyclic antidepressant drug monitoring in younger and older depressive patients. Pharmacological reports : PR 20060101
[Case report: taeniasis, is it a cause of psychiatric and neural symptoms?]. Turkiye parazitolojii dergisi 20060101
Outcome predictors in cocaine dependence treatment trials. The American journal on addictions 20060101
Sucrose preference is restored by electro-acupuncture combined with chlorimipramine in the depression-model rats. Acupuncture & electro-therapeutics research 20060101
Effect of paroxetine on marble-burying behavior in mice. Methods and findings in experimental and clinical pharmacology 20051201
Obsessions with aggressive content emerging during the course of panic disorder: a different subtype of obsessive-compulsive disorder? International clinical psychopharmacology 20051101
Clomipramine-induced hypersensitivity syndrome with unusual clinical features. Journal of the American Academy of Dermatology 20051101
Memantine for treatment-resistant OCD. The American journal of psychiatry 20051101
In vitro release of clomipramine HCl and buprenorphine HCl from poly adipic anhydride (PAA) and poly trimethylene carbonate (PTMC) blends. Journal of biomedical materials research. Part A 20051001
A fatal clomipramine intoxication case of a chronic alcoholic patient: application of postmortem hair analysis method of clomipramine and ethyl glucuronide using LC/APCI/MS. Legal medicine (Tokyo, Japan) 20051001
Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area. Experimental parasitology 20051001
Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test). European journal of pharmacology 20050927
Animal behavior case of the month. Separation anxiety. Journal of the American Veterinary Medical Association 20050915
Role of serotonin receptors in panic-like behavior induced by nitric oxide in the rat dorsolateral periaqueductal gray: effects of chronic clomipramine treatment. Life sciences 20050902
Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters. Psychopharmacology 20050901
[Clinical study on treatment of obsessive compulsive neurosis by acupoint stimulating control]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050901
Elevated thyroid indices in children and adolescents with obsessive-compulsive disorder: effects of clomipramine treatment. Journal of child and adolescent psychopharmacology 20050801
Antidepressant drugs for narcolepsy. The Cochrane database of systematic reviews 20050720
Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters. The Journal of pharmacology and experimental therapeutics 20050701
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats. British journal of pharmacology 20050701
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701
Dysbetalipoproteinemia and clomipramine. The American journal of psychiatry 20050701
Antidepressant effects of different schedules of repetitive transcranial magnetic stimulation vs. clomipramine in patients with major depression: relationship to changes in cortical excitability. The international journal of neuropsychopharmacology 20050601
Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers. Journal of pharmacological sciences 20050601
Comparison of the efficacy of a synthetic dog-appeasing pheromone with clomipramine for the treatment of separation-related disorders in dogs. The Veterinary record 20050423
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine. European journal of pharmacology 20050404
Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse. BMJ (Clinical research ed.) 20050402
Serotonin modulation of cerebral blood flow measured with positron emission tomography (PET) in humans. Synapse (New York, N.Y.) 20050315
Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochemical and biophysical research communications 20050311
Evidence-based pharmacotherapy of obsessive-compulsive disorder. The international journal of neuropsychopharmacology 20050301
Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trial. The international journal of neuropsychopharmacology 20050301
Effects of clomipramine on self-control choice in Lewis and Fischer 344 rats. Pharmacology, biochemistry, and behavior 20050301
Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking. Psychiatry research 20050227
Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats. Journal of the American Veterinary Medical Association 20050201
Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine. Progress in neuro-psychopharmacology & biological psychiatry 20050101
Nicotine augmentation for refractory obsessive-compulsive disorder. A case report. Progress in neuro-psychopharmacology & biological psychiatry 20050101
Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. The American journal of psychiatry 20050101
Effects of clomipramine on cats presented for urine marking. Journal of the American Animal Hospital Association 20050101
Increased maintenance of obsessive-compulsive disorder remission after integrated serotonergic treatment and cognitive psychotherapy compared with medication alone. Psychotherapy and psychosomatics 20050101
Chronic treatment with clomipramine and desipramine induces deficit in long-term visuo-spatial memory of rats. The International journal of neuroscience 20050101
Standard criteria for relapse are needed in obsessive-compulsive disorder. Depression and anxiety 20050101
Orthostatic side effects of clomipramine and moclobemide during treatment for depression. Nordic journal of psychiatry 20050101
Stereotypy II: a review of neurobiological interpretations and suggestions for an integration with behavioral methods. Research in developmental disabilities 20050101
Effect of short- and long-term treatment with antidepressant drugs on the activity of rat CYP2A in the liver. Pharmacological reports : PR 20050101
Clomipramine induced neuroleptic malignant syndrome and pyrexia of unknown origin. BMJ (Clinical research ed.) 20041204
Intrahepatic flow disturbance by clomipramine in the isolated perfused rat liver. Biochemical pharmacology 20041201
Treatment-response by age at onset in obsessive-compulsive disorder. Journal of affective disorders 20041201
Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males. Revista do Hospital das Clinicas 20041201
Case study: successful medication withdrawal using cognitive-behavioral therapy for a preadolescent with OCD. Journal of the American Academy of Child and Adolescent Psychiatry 20041101
[Paroxetine versus clomipramine in female adolescents suffering from anorexia nervosa and depressive episode--a retrospective study on tolerability, reasons for discontinuing the antidepressive treatment and different outcome measurements]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 20041101
In vivo rat model to measure hypogastric nerve stimulation-induced seminal vesicle and vasal pressure responses simultaneously. International journal of impotence research 20041001
Pharmacotherapy for cataplexy. Sleep medicine reviews 20041001
On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. European urology 20041001
Weight gain during long-term treatment of obsessive-compulsive disorder: a prospective comparison between serotonin reuptake inhibitors. The Journal of clinical psychiatry 20041001
Differential effects on somatic and reflex development by chronic clomipramine treatment. Physiology & behavior 20040915
Determination of the dosage of clomipramine for the treatment of urine spraying in cats. Journal of the American Veterinary Medical Association 20040915
Does oxidative stress contribute in tricyclic antidepressants-induced cardiotoxicity? Toxicology letters 20040910
Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews. Behavioural pharmacology 20040901
Two cases involving clomipramine intoxication. Journal of analytical toxicology 20040901
Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. International journal of impotence research 20040801
Predicting responsiveness to the treatment of rapid ejaculation with 25 mg clomipramine as needed. International journal of impotence research 20040801
Age differences in an animal model of obsessive-compulsive disorder: participation of dopamine: dopamine in an animal model of OCD. Pharmacology, biochemistry, and behavior 20040801
Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugs. Pharmacology, biochemistry, and behavior 20040801
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design. The Journal of biological chemistry 20040709
Antidepressants blunt the effects of inescapable stress on male mating behaviour and decrease corticotropin-releasing hormone mRNA expression in the hypothalamic paraventricular nucleus of the Syrian hamster (Mesocricetus auratus). Journal of neuroendocrinology 20040701
Clomipramine, fluoxetine and CYP2D6 metabolic capacity in depressed patients. Human psychopharmacology 20040701
Weekly treatments with a burst-firing magnetic field alters behavior in the elevated plus maze after two sessions. Perceptual and motor skills 20040601
[Non-respiratory cyanosis in the newborn]. Nederlands tijdschrift voor geneeskunde 20040508
Divergent actions of serotonin receptor activation during fictive swimming in frog embryos. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20040501
Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors. Annals of the New York Academy of Sciences 20040401
Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus. The European journal of neuroscience 20040201
[Effect of concurrent treatment of SSRI on the tyrosine hydroxylase immunoreactivity in the rat locus coeruleus treated with chronic variable stress]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20040201
Serotonin uptake and metabolism by cultured guinea pig airway smooth muscle cells. Pulmonary pharmacology & therapeutics 20040101
Combined oral venlafaxine and intravenous clomipramine-A: successful temporary response in a patient with extremely refractory depression. Canadian journal of psychiatry. Revue canadienne de psychiatrie 20040101
Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta biochimica Polonica 20040101
Tramadol for neuropathic pain. The Cochrane database of systematic reviews 20040101
A case of social phobia with obsessive-compulsive symptoms improved by paroxetine in combination with risperidone. General hospital psychiatry 20040101
Placebo-controlled clomipramine trial for the treatment of feather picking disorder in cockatoos. Journal of the American Animal Hospital Association 20040101
A case of prolonged seizure activity after combined use of bupropion and clomipramine. Clinical neuropharmacology 20040101
Charles Bonnet syndrome and panic disorder. The Journal of neuropsychiatry and clinical neurosciences 20040101
[Antihyperalgesic activity of chlorimipramine and sodium phenytoin in an induced model of neuropathic pain in rats]. Cirugia y cirujanos 20040101
Peripheral effects of serotonin on the contractile responses of rat seminal vesicles and vasa deferentia. Journal of andrology 20040101
A qualitative analysis of nonresponse: management of treatment-refractory obsessive-compulsive disorder. The Journal of clinical psychiatry 20040101
[Cotard's delusion of negations]. Acta medica portuguesa 20040101
[Therapeutic strategy for drug resistant depression]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20040101
Cortical alpha-adrenoceptor downregulation by tricyclic antidepressants in the rat brain. Neurochemistry international 20031201
Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats. Neuropharmacology 20031201
Nitric oxide involvement in depression during interferon-alpha therapy. The international journal of neuropsychopharmacology 20031201
Intravenous clomipramine in severe and refractory obsessive-compulsive disorder. Journal of clinical psychopharmacology 20031201
Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine. Brain research 20031121
Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine. The Journal of urology 20031101
Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder. The American journal of psychiatry 20031101
[Olanzapine in therapy of a somatoform disorder]. Psychiatrische Praxis 20031101
Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. British journal of cancer 20031006
Evidence for an involvement of supraspinal delta- and spinal mu-opioid receptors in the antihyperalgesic effect of chronically administered clomipramine in mononeuropathic rats. The Journal of pharmacology and experimental therapeutics 20031001
Obsessive-compulsive disorder: unearthing a hidden problem. Cleveland Clinic journal of medicine 20031001
Displacement of the PET ligand 18F-MPPF by the electrically evoked serotonin release in the rat hippocampus. Synapse (New York, N.Y.) 20030915
The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030901
Age may affect response to antidepressants with serotonergic and noradrenergic actions. Journal of affective disorders 20030901
Multicenter double-blind randomized parallel-group clinical trial of efficacy of the combination clomipramine (150 mg/day) plus lithium carbonate (750 mg/day) versus clomipramine (150 mg/day) plus placebo in the treatment of unipolar major depression. Journal of affective disorders 20030901
Are gender differences important for the clinical effects of antidepressants? The American journal of psychiatry 20030901
The tricyclic antidepressant clomipramine increases plasma glucose levels of mice. Journal of pharmacological sciences 20030901
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacological research 20030801
A review of pharmacologic treatments for obsessive-compulsive disorder. Psychiatric services (Washington, D.C.) 20030801
[Pharmacotherapy of compulsive disorders in childhood and adolescence]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 20030801
Chronic treatment with antidepressants decreases intraoperative core hypothermia. Anesthesia and analgesia 20030701
Plasma levels of corticosterone and testosterone after sexual activity in male rats treated neonatally with clomipramine. Behavioural pharmacology 20030701
How to treat OCD in patients with Tourette syndrome. Journal of psychosomatic research 20030701
Prolonged asystole during head-up tilt testing with clomipramine infusion. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20030701
Differential neurochemical properties of central serotonergic transmission in Roman high- and low-avoidance rats. Journal of neurochemistry 20030701
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 20030605
[Obsessive-compulsive disorders in general practice. How the obsessive-compulsive neurotic is revealed by skin and hair]. MMW Fortschritte der Medizin 20030526
5-HT1A responsivity in patients with panic disorder before and after treatment with aerobic exercise, clomipramine or placebo. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030501
Long-term efficacy of exposure and ritual prevention therapy and serotonergic medications for obsessive-compulsive disorder. CNS spectrums 20030501
Head-up tilt test with clomipramine challenge in vasovagal syndrome--a new tilt testing protocol. European heart journal 20030401
Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: a randomized controlled trial. Psychiatry and clinical neurosciences 20030401
High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography. Archives of general psychiatry 20030401
An exploration of emotional response to erotic stimulation in men with premature ejaculation: effects of treatment with clomipramine. Archives of sexual behavior 20030401
Use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. Journal of the American Veterinary Medical Association 20030315
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder. Psychopharmacology 20030301
Fluvoxamine as effective as clomipramine against symptoms of severe depression: results from a multicentre, double-blind study. Human psychopharmacology 20030301
Analgesic effect of caffeine and clomipramine: a possible interaction between adenosine and serotonin systems. Acta pharmaceutica (Zagreb, Croatia) 20030301
Influence of synaptic serotonin level on [18F]altanserin binding to 5HT2 receptors in man. Behavioural brain research 20030217
Clinical features in two cases with musical obsessions who successfully responded to clomipramine. Psychiatry and clinical neurosciences 20030201
Reply to Dr Mahendran. We have not found reported cases of [obsessive-compulsive] OC arising from de novo with olanzapine treatment. The Australian and New Zealand journal of psychiatry 20030201
Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression. Psychopharmacology 20030101
Paroxetine versus clomipramine in adolescents with severe major depression: a double-blind, randomized, multicenter trial. Journal of the American Academy of Child and Adolescent Psychiatry 20030101
Evaluation of the effects of clomipramine on canine thyroid function tests. Journal of veterinary internal medicine 20030101
Obsessive-compulsive disorder in childhood and adolescence. Psychopathology 20030101
[The treatment of OCD]. Ryoikibetsu shokogun shirizu 20030101
[Compulsion(ritual)]. Ryoikibetsu shokogun shirizu 20030101
[The usage of different antidepressants in therapy of obsessive-compulsive disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101
Corticosterone and testosterone levels after chronic stress in an animal model of depression. Neuropsychobiology 20030101
Quetiapine treatment in a patient with Tourette's syndrome, obsessive-compulsive disorder and drug-induced mania. The Israel journal of psychiatry and related sciences 20030101
Chronic, but not acute, clomipramine or fluoxetine treatment reduces the spontaneous firing rate in the mesoaccumbens neurons of the rat. Neuropsychobiology 20030101
[Obsessive-compulsive disorder in childhood and adolescence]. Ryoikibetsu shokogun shirizu 20030101
Effects of classic and newer antidepressants on the oxidation pathways of caffeine in rat liver. In vitro study. Polish journal of pharmacology 20030101
Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Polish journal of pharmacology 20030101
Augmenting treatment of obsessive-compulsive disorder with Antonovsky's sense of coherence theory. Perspectives in psychiatric care 20030101
Differential effects of the 5-HT2 receptor antagonist on the anti-immobility effects of noradrenaline and serotonin reuptake inhibitors in the forced swimming test. Brain research 20021220
Comparison of microencapsulation techniques for the water-soluble drugs nitenpyram and clomipramine HCl. Journal of controlled release : official journal of the Controlled Release Society 20021213
Calcium channel blocking activity of thioridazine, clomipramine and fluoxetine in isolated rat vas deferens: a relative potency measurement study. The Journal of urology 20021201
Obsessive-compulsive-bipolar comorbidity: a systematic exploration of clinical features and treatment outcome. The Journal of clinical psychiatry 20021201
Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. European journal of pharmacology 20021115
Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000). Journal of the American Veterinary Medical Association 20021115
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat. British journal of pharmacology 20021101
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. Pharmacotherapy 20021101
Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study. The Journal of clinical psychiatry 20021101
Comparative evaluation of two serotonin transporter ligands in the human brain: [(11)C](+)McN5652 and [(11)C]cyanoimipramine. European journal of nuclear medicine and molecular imaging 20021001
Re: Clomipramine vs. Haloperidol in the treatment of autistic disorder: a double-blind, placebo, crossover study. Journal of clinical psychopharmacology 20021001
Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021001
Clomipramine-resistant, fluoxetine-responsive obsessive compulsive disorder: a case report. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20021001
Sleep-wake effects of yohimbine and atropine in rats with a clomipramine-based model of depression. Neuroreport 20020916
Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood. Neuroscience letters 20020913
[Disguised Tourette's syndrome. A contribution to the differential diagnosis on phobia and fear]. Der Nervenarzt 20020901
Memory performance in panic disorder patients after chronic use of clomipramine. Journal of psychopharmacology (Oxford, England) 20020901
Interaction of lithium with 5-HT(1B) receptors in depressed unipolar patients treated with clomipramine and lithium versus clomipramine and placebo: preliminary results. Psychiatry research 20020830
Relationship between prolactin responses to ECT and dopaminergic and serotonergic responsivity in depressed patients. European archives of psychiatry and clinical neuroscience 20020801
Serotonergic and dopaminergic neuroendocrine responses of male depressive patients before and after a therapeutic ECT course. European archives of psychiatry and clinical neuroscience 20020801
Prolactin responses to acute clomipramine and haloperidol of male schizophrenic patients in a drug-free state and after treatment with clozapine or with olanzapine. Schizophrenia research 20020701
Differences in behavior and monoamine laterality following neonatal clomipramine treatment. Developmental psychobiology 20020701
Simultaneous determination of clomipramine and its desmethyl and hydroxy metabolites in plasma of patients by high-performance liquid chromatography after solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020605
Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder. Journal of clinical psychopharmacology 20020601
Are gender differences in antiobsessional response related to different clomipramine metabolism? Journal of clinical psychopharmacology 20020601
Management of treatment resistant obsessive-compulsive disorder. Algorithms for pharmacotherapy. Panminerva medica 20020601
Trichotillomania. Journal of the American Academy of Dermatology 20020601
Sertraline: new indication. May help children with obsessive-compulsive disorder. Prescrire international 20020601
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Behavior modification and pharmacotherapy for separation anxiety in a 2-year-old pointer cross. The Canadian veterinary journal = La revue veterinaire canadienne 20020301
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Comment: serotonin syndrome and 5-HT2A antagonism. The Annals of pharmacotherapy 20010901
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Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. Journal of clinical psychopharmacology 20010801
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The exploding head syndrome. Current pain and headache reports 20010601
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A dose-finding and discontinuation study of clomipramine in panic disorder. Journal of psychopharmacology (Oxford, England) 20010301
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Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. International journal of impotence research 20010201
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Lithium therapy for corticosteroid-induced mood disorder. The Journal of clinical psychiatry 20010101
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Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats. Pharmacology 20010101
Effects of clomipramine on Trypanosoma cruzi infection in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101
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Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction. Anaesthesia 19870701
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