Home Other Building Blocks Neotame

Neotame

CAS No.:
165450-17-9
Catalog Number:
AG001W5N
Molecular Formula:
C20H30N2O5
Molecular Weight:
378.4626
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
97%
In Stock USA
United States
$13
- +
5g
97%
In Stock USA
United States
$25
- +
25g
97%
In Stock USA
United States
$75
- +
100g
97%
In Stock USA
United States
$188
- +
500g
97%
In Stock USA
United States
$500
- +
Product Description
Catalog Number:
AG001W5N
Chemical Name:
Neotame
CAS Number:
165450-17-9
Molecular Formula:
C20H30N2O5
Molecular Weight:
378.4626
MDL Number:
MFCD09039056
IUPAC Name:
(3S)-3-(3,3-dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
InChI:
InChI=1S/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)/t15-,16-/m0/s1
InChI Key:
HLIAVLHNDJUHFG-HOTGVXAUSA-N
SMILES:
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NCCC(C)(C)C
EC Number:
605-408-8
UNII:
VJ597D52EX
Properties
Complexity:
495  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
378.215g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
378.469g/mol
Monoisotopic Mass:
378.215g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.1  
Literature
Title Journal
Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine. Journal of chromatography. A 20121109
Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins. Biochemical and biophysical research communications 20121019
Artificial sweeteners--a recently recognized class of emerging environmental contaminants: a review. Analytical and bioanalytical chemistry 20120701
Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners. Journal of the Academy of Nutrition and Dietetics 20120501
Nonnutritive, low caloric substitutes for food sugars: clinical implications for addressing the incidence of dental caries and overweight/obesity. International journal of dentistry 20120101
Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds. PloS one 20120101
Taste quality and intensity of 100 stimuli as reported by rats: the taste-location association task. Frontiers in behavioral neuroscience 20120101
The content of high-intensity sweeteners in different categories of foods available on the Polish market. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101
Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20120101
Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium. Biochemical and biophysical research communications 20111216
Advantame--an overview of the toxicity data. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101
Pharmacokinetics and metabolism of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-L-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat, dog, and man. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101
[Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation]. Se pu = Chinese journal of chromatography 20111001
Molecular mechanism of species-dependent sweet taste toward artificial sweeteners. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727
Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection. Analytical and bioanalytical chemistry 20110601
Nonnutritive sweeteners, fructose, and other aspects of diet. Diabetes care 20110501
Sugar substitutes: Health controversy over perceived benefits. Journal of pharmacology & pharmacotherapeutics 20110101
[Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography 20101101
Retention behaviour of some high-intensity sweeteners on different SPE sorbents. Talanta 20101015
Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16. The Journal of biological chemistry 20100903
Determination of neotame in beverages, cakes and preserved fruits by column-switching high-performance liquid chromatography. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100901
[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography 20100801
Gain weight by 'going diet?' Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. The Yale journal of biology and medicine 20100601
Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. Journal of molecular biology 20100514
Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. Proceedings of the National Academy of Sciences of the United States of America 20100309
Standards of medical care in diabetes--2010. Diabetes care 20100101
Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). Analytical and bioanalytical chemistry 20090701
Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS. Journal of agricultural and food chemistry 20090422
Standards of medical care in diabetes--2009. Diabetes care 20090101
Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora. The Journal of heredity 20090101
Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study. Journal of AOAC International 20090101
[Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography]. Se pu = Chinese journal of chromatography 20090101
Development of rebiana, a natural, non-caloric sweetener. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701
The potential toxicity of artificial sweeteners. AAOHN journal : official journal of the American Association of Occupational Health Nurses 20080601
[Simultaneous determination of neotame, alitame and aspartame in foods by HPLC]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080201
Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation. Journal of chromatography. A 20070720
The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC structural biology 20070101
Taste responses to sweet stimuli in alpha-gustducin knockout and wild-type mice. Chemical senses 20060701
The G protein-coupled receptor subset of the chicken genome. PLoS computational biology 20060601
The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Current pharmaceutical design 20060101
Artificial sweeteners: no calories...sweet! FDA consumer 20060101
Quantitation of crystalline and amorphous forms of anhydrous neotame using 13C CPMAS NMR spectroscopy. Journal of pharmaceutical sciences 20051201
Artificial sweeteners--do they bear a carcinogenic risk? Annals of oncology : official journal of the European Society for Medical Oncology 20041001
Different functional roles of T1R subunits in the heteromeric taste receptors. Proceedings of the National Academy of Sciences of the United States of America 20040928
Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. Journal of the American Dietetic Association 20040201
Evaluation of certain food additives and contaminants. World Health Organization technical report series 20040101
[Effect of food additive Neotame (N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine-1-methyl) on glucose level in blood of patients with diabetes mellitus type 2]. Voprosy pitaniia 20040101
Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies. Regulatory toxicology and pharmacology : RTP 20031001
Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions. Regulatory toxicology and pharmacology : RTP 20031001
Crystal structure of neotame anhydrate polymorph G. Pharmaceutical research 20021001
Conformational flexibility and hydrogen-bonding patterns of the neotame molecule in its various solid forms. Journal of pharmaceutical sciences 20020901
Neotame anhydrate polymorphs. II: Quantitation and relative physical stability. Pharmaceutical research 20020901
Neotame - a new artificial sweetener. The Medical letter on drugs and therapeutics 20020819
Dehydration kinetics of neotame monohydrate. Journal of pharmaceutical sciences 20020601
Neotame anhydrate polymorphs I: preparation and characterization. Pharmaceutical research 20020301
Structure, dynamics, and stability of beta-cyclodextrin inclusion complexes of aspartame and neotame. Journal of agricultural and food chemistry 20010401
Modifying the temporal profile of the high-potency sweetener neotame. Journal of agricultural and food chemistry 20010201
Properties