1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
| Title | Journal |
|---|---|
| Application of [¹¹C]SA4503 to selection of novel σ₁ selective agonists. | Nuclear medicine and biology 20121101 |
| Re-evaluation of in vivo selectivity of [(11)C]SA4503 to σ(1) receptors in the brain: contributions of emopamil binding protein. | Nuclear medicine and biology 20121001 |
| Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor. | Synapse (New York, N.Y.) 20120701 |
| Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats. | American journal of respiratory cell and molecular biology 20120301 |
| Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. | PloS one 20120101 |
| Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor. | Journal of neurochemistry 20111101 |
| Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors. | Journal of medicinal chemistry 20110811 |
| The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine. | Drug and alcohol dependence 20110701 |
| The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. | Brain : a journal of neurology 20110301 |
| SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus. | Pharmacology, biochemistry, and behavior 20110201 |
| Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP₃ receptors. | European journal of pharmacology 20101201 |
| SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. | Neuroscience letters 20100129 |
| High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. | The international journal of neuropsychopharmacology 20090901 |
| Imaging of sigma1 receptors in the human brain using PET and [11C]SA4503. | Central nervous system agents in medicinal chemistry 20090901 |
| Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats. | European journal of nuclear medicine and molecular imaging 20090701 |
| Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies. | The international journal of neuropsychopharmacology 20080601 |
| Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification. | Annals of nuclear medicine 20080201 |
| A change of in vivo characteristics depending on specific activity of radioiodinated (+)-2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-pIV] as a ligand for sigma receptor imaging. | Nuclear medicine and biology 20080101 |
| Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. | PloS one 20080101 |
| Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells. | Pharmacological reports : PR 20080101 |
| High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503. | Biological psychiatry 20071015 |
| Role of N-methyl-D-aspartate receptors in antidepressant-like effects of sigma 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA-4503) in olfactory bulbectomized rats. | The Journal of pharmacology and experimental therapeutics 20070901 |
| Rapid reduction of sigma1-receptor binding and 18F-FDG uptake in rat gliomas after in vivo treatment with doxorubicin. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070801 |
| In vivo characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol as a potential sigma-1 receptor imaging agent. | Nuclear medicine and biology 20070801 |
| American Chemical Society--233rd National Meeting. CNS, cancer and cardiovascular targets. 25-29 March 2007, Chicago, IL, USA. | IDrugs : the investigational drugs journal 20070501 |
| Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070301 |
| Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503. | NeuroImage 20070301 |
| Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT1A receptor agonist in the forced swimming test in rats. | Pharmacological reports : PR 20070101 |
| A feasibility study of [11C]SA4503-PET for evaluating sigmal receptor occupancy by neuroleptics: the binding of haloperidol to sigma1 and dopamine D2-like receptors. | Annals of nuclear medicine 20061001 |
| The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601 |
| Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. | Synapse (New York, N.Y.) 20060501 |
| Evaluation of (+)-p-[11C]methylvesamicol for mapping sigma1 receptors: a comparison with [11C]SA4503. | Nuclear medicine and biology 20060501 |
| Function of sigma1 receptors in Parkinson's disease. | Acta neurologica Scandinavica 20050801 |
| Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20041101 |
| Behavioral pharmacology of sigma-ligands. | Pharmacopsychiatry 20041101 |
| Improved synthesis of [11C]SA4503, [11C]MPDX and [11C]TMSX by use of [11C]methyl triflate. | Annals of nuclear medicine 20040401 |
| Different brain kinetics of two sigma 1 receptor ligands, [3H](+)-pentazocine and [11C]SA4503, by P-glycoprotein modulation. | Synapse (New York, N.Y.) 20030501 |
| Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands. | Nuclear medicine and biology 20030501 |
| Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain. | Annals of nuclear medicine 20030201 |
| Potential antidepressant activity of sigma ligands. | Polish journal of pharmacology 20030101 |
| A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist. | Behavioural pharmacology 20021101 |
| Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors. | Pharmacology, biochemistry, and behavior 20021001 |
| Effect of SA4503 on the electrically evoked release of (3)H-acetylcholine from striatal and hippocampal rat brain slices. | Synapse (New York, N.Y.) 20021001 |
| Synthesis and evaluation of [18F]fluoroethyl SA4503 as a PET ligand for the sigma receptor. | Synapse (New York, N.Y.) 20020315 |
| [11C]Raclopride binding was reduced in vivo by sigma(1) receptor ligand SA4503 in the mouse brain, while [11C]SA4503 binding was not by raclopride. | Nuclear medicine and biology 20011001 |
| The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats. | European journal of pharmacology 20010824 |
| The anti-amnesic effects of sigma1 (sigma1) receptor agonists confirmed by in vivo antisense strategy in the mouse. | Brain research 20010413 |
| Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401 |
| Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates alpha-adrenergic system. a behavioral study. | Polish journal of pharmacology 20010101 |
| SA4503, a novel cognitive enhancer with sigma1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice. | European journal of pharmacology 19970605 |