1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide
Title | Journal |
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Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia. | Expert opinion on pharmacotherapy 20121001 |
Benign prostatic hyperplasia (BPH) management in the primary care setting. | The Canadian journal of urology 20121001 |
Emerging therapies: what's new is old and what's old is new. | The Canadian journal of urology 20121001 |
Effects of tamsulosin and silodosin on isolated albino and pigmented rabbit iris dilators: possible mechanism of intraoperative floppy-iris syndrome. | Journal of cataract and refractive surgery 20120901 |
Re: Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients. | International journal of urology : official journal of the Japanese Urological Association 20120801 |
Comparison of the effects of four α1-adrenoceptor antagonists on ejaculatory function in rats. | Urology 20120801 |
Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat. | BJU international 20120701 |
Excitatory effect of propiverine hydrochloride on urethral activity in rats. | International journal of urology : official journal of the Japanese Urological Association 20120601 |
Re: silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe. | The Journal of urology 20120501 |
Silodosin: erectile and ejaculatory disorders. | Prescrire international 20120501 |
Prescriber monitoring for benign prostatic hyperplasia within a family medicine clinic: a comparison of medication classes. | Journal of pharmacy practice 20120401 |
New clinical evidence of silodosin, an α(1A) selective adrenoceptor antagonist, in the treatment for lower urinary tract symptoms. | International journal of urology : official journal of the Japanese Urological Association 20120401 |
Effects of α1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats. | European journal of pharmacology 20120315 |
Silodosin and its potential for treating premature ejaculation: a preliminary report. | International journal of urology : official journal of the Japanese Urological Association 20120301 |
Benign prostatic hyperplasia: from bench to clinic. | Korean journal of urology 20120301 |
α-Blockers for benign prostatic hyperplasia: the new era. | Current opinion in urology 20120101 |
Tamsulosin potently and selectively antagonizes human recombinant α(1A/1D)-adrenoceptors: slow dissociation from the α(1A)-adrenoceptor may account for selectivity for α(1A)-adrenoceptor over α(1B)-adrenoceptor subtype. | Biological & pharmaceutical bulletin 20120101 |
Non-inferiority of silodosin to tamsulosin in treating patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). | BJU international 20111201 |
Comparison of prophylactic naftopidil, tamsulosin, and silodosin for 125I brachytherapy-induced lower urinary tract symptoms in patients with prostate cancer: randomized controlled trial. | International journal of radiation oncology, biology, physics 20111115 |
Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients. | International journal of urology : official journal of the Japanese Urological Association 20111101 |
[Medical expulsive therapy facilitated by alpha 1 adrenoceptor antagonist]. | Clinical calcium 20111001 |
Silodosin in the treatment of the signs and symptoms of benign prostatic hyperplasia: profile report. | Drugs & aging 20111001 |
Efficacy of selective α1A adrenoceptor antagonist silodosin in the medical expulsive therapy for ureteral stones. | International journal of urology : official journal of the Japanese Urological Association 20110901 |
Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia. | International neurourology journal 20110901 |
α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics. | British journal of clinical pharmacology 20110801 |
Re: Christopher R. Chapple, Francesco Montorsi, Teuvo L.J. Tammela, et al. Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe. Eur Urol 2011;59:342-52. | European urology 20110801 |
Silodosin for men with chronic prostatitis/chronic pelvic pain syndrome: results of a phase II multicenter, double-blind, placebo controlled study. | The Journal of urology 20110701 |
Symptomatic and urodynamic responses in patients with reduced or no seminal emission during silodosin treatment for LUTS and BPH. | Prostate cancer and prostatic diseases 20110601 |
[Optimum initial dose of silodosin for treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20110601 |
Silodosin: treatment of the signs and symptoms of benign prostatic hyperplasia. | Drugs 20110507 |
Alpha1-adrenoceptor antagonists improve bladder storage function through reduction of afferent activity in rats with bladder outlet obstruction. | Neurourology and urodynamics 20110301 |
Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe. | European urology 20110301 |
Does the use of silodosin to treat benign prostatic hyperplasia really offer something new? | European urology 20110301 |
Characterization of α1-adrenoceptor subtypes mediating contraction in human isolated ureters. | Urology 20110301 |
Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20110301 |
Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. | Cancer prevention research (Philadelphia, Pa.) 20110101 |
BHP: Silodosin an effective new drug for BPH-associated LUTS. | Nature reviews. Urology 20110101 |
(RS)-1-[5-(2-Chloro-prop-yl)indolin-1-yl]ethanone. | Acta crystallographica. Section E, Structure reports online 20110101 |
A randomized crossover study comparing patient preference for tamsulosin and silodosin in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia. | The Journal of international medical research 20110101 |
Silodosin. | Prescrire international 20110101 |
Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia. | Clinical interventions in aging 20110101 |
Naftopidil for the treatment of urinary symptoms in patients with benign prostatic hyperplasia. | Therapeutics and clinical risk management 20110101 |
Safety and pharmacokinetic studies of silodosin, a new α1A-adrenoceptor selective antagonist, in healthy Chinese male subjects. | Biological & pharmaceutical bulletin 20110101 |
Efficacy of electroacupuncture at Zhongliao point (BL33) for mild and moderate benign prostatic hyperplasia: study protocol for a randomized controlled trial. | Trials 20110101 |
Ejaculation disorder is associated with increased efficacy of silodosin for benign prostatic hyperplasia. | Urology 20101201 |
Silodosin for the treatment of benign prostatic hyperplasia: pharmacology and cardiovascular tolerability. | Pharmacotherapy 20101201 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20101101 |
Selective α1A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity. | World journal of urology 20101001 |
Role of supraspinal and spinal alpha1-adrenergic receptor subtypes in micturition reflex in conscious rats. | American journal of physiology. Renal physiology 20101001 |
Short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20101001 |
Editorial comment to short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20101001 |
(RS)-1-(1-Acetyl-indolin-5-yl)-2-chloro-propan-1-one. | Acta crystallographica. Section E, Structure reports online 20100701 |
Effects of the selective alpha 1a-adrenoceptor antagonist silodosin on ECGs of healthy men in a randomized, double-blind, placebo- and moxifloxacin-controlled study. | Clinical pharmacology and therapeutics 20100501 |
Urodynamic effects of silodosin, a new alpha 1A-adrenoceptor selective antagonist, for the treatment of benign prostatic hyperplasia. | Neurourology and urodynamics 20100401 |
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice. | Clinical and experimental nephrology 20100401 |
Lack of pharmacodynamic interaction of silodosin, a highly selective alpha1a-adrenoceptor antagonist, with the phosphodiesterase-5 inhibitors sildenafil and tadalafil in healthy men. | Urology 20100301 |
Impact of dry ejaculation caused by highly selective alpha1A-blocker: randomized, double-blind, placebo-controlled crossover pilot study in healthy volunteer men. | The journal of sexual medicine 20100301 |
Visualization and tissue distribution of alpha1L-adrenoceptor in human prostate by the fluorescently labeled ligand Alexa-488-silodosin. | The Journal of urology 20100201 |
Silodosin for benign prostatic hyperplasia. | The Annals of pharmacotherapy 20100201 |
New Drugs2010, PART 1. | Nursing 20100201 |
Effects of silodosin and naftopidil on the distal ureter and cardiovascular system in anesthetized dogs: comparison of potential medications for distal ureteral stone passage. | The Journal of urology 20100101 |
[Investigation of adverse events and the continuance rate of silodosin in all patients who received silodosin for lower urinary tract symptoms suggestive of benign prostatic hyperplasia]. | Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20100101 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20100101 |
The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction. | Advances in urology 20100101 |
Silodosin in the treatment of benign prostatic hyperplasia. | Drug design, development and therapy 20100101 |
Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter. | World journal of urology 20091201 |
Silodosin in the treatment of the signs and symptoms of benign prostatic hyperplasia: a 9-month, open-label extension study. | Urology 20091201 |
Efficacy of silodosin for relieving benign prostatic obstruction: prospective pressure flow study. | The Journal of urology 20091201 |
Determination of silodosin in human plasma by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101 |
Silodosin: a selective alpha1A-adrenergic receptor antagonist for the treatment of benign prostatic hyperplasia. | Clinical therapeutics 20091101 |
Expression of distinct alpha 1-adrenoceptor phenotypes in the iris of pigmented and albino rabbits. | British journal of pharmacology 20090901 |
Orgasm is preserved regardless of ejaculatory dysfunction with selective alpha1A-blocker administration. | International journal of impotence research 20090901 |
Mechanical function and gene expression of alpha(1)-adrenoceptor subtypes in dog intravesical ureter. | Urology 20090801 |
Effects of four different alpha(1)-adrenoceptor antagonists on alpha-adrenoceptor agonist-induced contractions in isolated mouse and hamster ureters. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20090801 |
Effects of silodosin and tamsulosin on the urethra and cardiovascular system in young and old dogs with benign prostatic hyperplasia. | European journal of pharmacology 20090624 |
Short- and long-term effects of silodosin, a selective alpha 1A-adrenoceptor antagonist, on ejaculatory function in rats. | BJU international 20090601 |
Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies. | The Journal of urology 20090601 |
Silodosin (Rapaflo) for benign prostatic hyperplasia. | The Medical letter on drugs and therapeutics 20090112 |
Role of alpha1-adrenergic receptors in detrusor overactivity induced by cold stress in conscious rats. | Neurourology and urodynamics 20090101 |
New drugs: milnacipran hydrochloride, fesoterodine fumarate, and silodosin. | Journal of the American Pharmacists Association : JAPhA 20090101 |
Efficacy of alpha-Adrenergic Receptor Blockers in the Treatment of Male Lower Urinary Tract Symptoms. | Reviews in urology 20090101 |
Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout. | British journal of pharmacology 20081201 |
[Multi-center trial on the early effects of silodosin on lower urinary tract symptoms associated with benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20081201 |
Computational studies of the binding site of alpha1A-adrenoceptor antagonists. | Journal of molecular modeling 20081001 |
Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography. | International journal of urology : official journal of the Japanese Urological Association 20081001 |
Early efficacy of silodosin in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20081001 |
The involvement of urothelial alpha1A adrenergic receptor in controlling the micturition reflex. | Biomedical research (Tokyo, Japan) 20081001 |
Inhibition of Seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers. | The journal of sexual medicine 20080901 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20080601 |
Different affinities of native alpha1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations. | European journal of pharmacology 20080428 |
Identification of the alpha1L-adrenoceptor in rat cerebral cortex and possible relationship between alpha1L- and alpha1A-adrenoceptors. | British journal of pharmacology 20080401 |
Mutational analysis of the alpha 1a-adrenergic receptor binding pocket of antagonists by radioligand binding assay. | Biological & pharmaceutical bulletin 20080401 |
In vivo study on the effects of alpha1-adrenoceptor antagonists on intraurethral pressure in the prostatic urethra and intraluminal pressure in the vas deferens in male dogs. | European journal of pharmacology 20080202 |
Silodosin, a novel selective alpha 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia. | Expert opinion on investigational drugs 20071201 |
Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter. | European journal of pharmacology 20071114 |
Alpha1-adrenoceptors and ejaculatory function. | British journal of pharmacology 20071001 |
Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia. | Biological & pharmaceutical bulletin 20070701 |
Identification of alpha-1L and alpha-1A adrenoceptors in human prostate by tissue segment binding. | The Journal of urology 20070101 |
Search for new alpha1a-adrenoceptor-selective antagonist for treating lower urinary tract symptoms associated with benign prostatic hyperplasia. | Indian journal of urology : IJU : journal of the Urological Society of India 20070101 |
Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men. | BJU international 20061101 |
[Pharmacological and clinical profile of silodosin (URIEF Cap. 2 mg, 4 mg)]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20061001 |
A selective alpha1A-adrenoceptor antagonist inhibits detrusor overactivity in a rat model of benign prostatic hyperplasia. | The Journal of urology 20060901 |
[Alpha1-adrenoceptor subtypes and alpha1-adrenoceptor antagonists]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Alpha1-adrenoceptor subtype selectivity and organ specificity of silodosin (KMD-3213)]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Effects of silodosin (KMD-3213) on phenylephrine-induced increase in intraurethral pressure and blood pressure in rats--study of the selectivity for lower urinary tract]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Duration of action of silodosin (KMD-3213) against phenylephrine-induced increase in intraurethral pressure in rats]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Pharmacokinetics and disposition of silodosin (KMD-3213)]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Toxicity profile of silodosin (KMD-3213)]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Pharmacokinetic profile of silodosin in clinical practice]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for the obstructive component of benign prostatic hyperplasia. | Neurourology and urodynamics 20060101 |
Cardiovascular effects of the selective alphalA-adrenoceptor antagonist silodosin (KMD-3213), a drug for the treatment of voiding dysfunction. | Arzneimittel-Forschung 20060101 |
Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice. | British journal of pharmacology 20051001 |
Identification of alpha-1L adrenoceptor in rabbit ear artery. | The Journal of pharmacology and experimental therapeutics 20040901 |
Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. | Cardiovascular research 20040901 |
Alpha-1D adrenoceptors are involved in reserpine-induced supersensitivity of rat tail artery. | British journal of pharmacology 20040601 |
KMD 3213: KAD 3213, silodosin. | Drugs in R&D 20040101 |
Systemic alpha 1A-adrenoceptor antagonist inhibits neointimal growth after balloon injury of rat carotid artery. | American journal of physiology. Heart and circulatory physiology 20030101 |
Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling. | Life sciences 20021011 |
Alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. | American journal of physiology. Heart and circulatory physiology 20021001 |
Effects of KMD-3213, a uroselective alpha 1A-adrenoceptor antagonist, on the tilt-induced blood pressure response in normotensive rats. | Japanese journal of pharmacology 20021001 |
Alpha-1 adrenoceptor up-regulation induced by prazosin but not KMD-3213 or reserpine in rats. | British journal of pharmacology 20020401 |
Differences in the subcellular localization of alpha1-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin. | Life sciences 20020322 |
Effect of KMD-3213, an alpha1A-adrenoceptor antagonist, on the prostatic urethral pressure and blood pressure in male decerebrate dogs. | International journal of urology : official journal of the Japanese Urological Association 20010401 |
In vivo demonstration of alpha(1A)-adrenoceptor subtype selectivity of KMD-3213 in rat tissues. | The Journal of pharmacology and experimental therapeutics 20010101 |
KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. | Molecular pharmacology 19950801 |