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Ibutamoren Mesylate

CAS No.:
159752-10-0
Catalog Number:
AG001RDO
Molecular Formula:
C28H40N4O8S2
Molecular Weight:
624.7692
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$151
- +
10mg
98%
1 week
United States
$190
- +
50mg
98%
1 week
United States
$240
- +
100mg
98%
1 week
United States
$273
- +
500mg
98%
1 week
United States
$357
- +
Product Description
Catalog Number:
AG001RDO
Chemical Name:
Ibutamoren Mesylate
CAS Number:
159752-10-0
Molecular Formula:
C28H40N4O8S2
Molecular Weight:
624.7692
MDL Number:
MFCD00942284
IUPAC Name:
2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid
InChI:
InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1
InChI Key:
DUGMCDWNXXFHDE-VZYDHVRKSA-N
SMILES:
CS(=O)(=O)O.O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C
UNII:
R90JB6QJ2B
Properties
Complexity:
1010  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
624.229g/mol
Formal Charge:
0
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
624.768g/mol
Monoisotopic Mass:
624.229g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
193A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. Molecular pharmacology 20090101
Summaries for patients. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Annals of internal medicine 20081104
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Annals of internal medicine 20081104
(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues. Bioorganic & medicinal chemistry letters 20080715
Growth hormone and insulin-like growth factor-I as an endocrine axis in Alzheimer's disease. Endocrine, metabolic & immune disorders drug targets 20080601
Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Annals of the New York Academy of Sciences 20071101
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Molecular endocrinology (Baltimore, Md.) 20050901
Development of growth hormone secretagogues. Endocrine reviews 20050501
Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor. European journal of pharmacology 20040913
[Ghrelin and bone metabolism]. Nihon rinsho. Japanese journal of clinical medicine 20040901
[Ghrelin-related drugs: clinical perspectives]. Nihon rinsho. Japanese journal of clinical medicine 20040901
The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. Journal of the American Geriatrics Society 20040401
Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Basic research in cardiology 20031101
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin. Bioorganic & medicinal chemistry 20030220
Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin. Bioorganic & medicinal chemistry letters 20010723
Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics. Bioorganic & medicinal chemistry letters 20010723
Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children. Clinical pharmacology and therapeutics 20010701
Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. The Journal of clinical endocrinology and metabolism 20010301
Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. Journal of endocrinological investigation 20010301
Growth hormone secretagogue receptor family members and ligands. Endocrine 20010201
Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Molecular endocrinology (Baltimore, Md.) 19970401
Properties