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Distigmine bromide

CAS No.:
15876-67-2
Catalog Number:
AG001QU9
Molecular Formula:
C22H32Br2N4O4
Molecular Weight:
576.3219
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%(HPLC)powder
In Stock USA
United States
$408
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Product Description
Catalog Number:
AG001QU9
Chemical Name:
Distigmine bromide
CAS Number:
15876-67-2
Molecular Formula:
C22H32Br2N4O4
Molecular Weight:
576.3219
MDL Number:
MFCD00867188
IUPAC Name:
(1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate;dibromide
InChI:
InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2
InChI Key:
GJHSNEVFXQVOHR-UHFFFAOYSA-L
SMILES:
C[n+]1cccc(c1)OC(=O)N(CCCCCCN(C(=O)Oc1ccc[n+](c1)C)C)C.[Br-].[Br-]
EC Number:
240-013-0
UNII:
750F36OP6J
Properties
Complexity:
487  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
576.077g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
576.33g/mol
Monoisotopic Mass:
574.079g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
66.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Cholinergic drugs for treatment of recurrent urinary retention in high surgical risk/elderly BPH patients. A pilot study. Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20120901
Effect of distigmine combined with propiverine on bladder activity in rats with spinal cord injury. International journal of urology : official journal of the Japanese Urological Association 20120501
Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis. Cytokine 20120201
[Acute respiratory failure associated with cholinergic crisis: report of five cases and review of the literature]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20111201
[Establishing indicators for diagnosis of cholinergic crisis]. Rinsho byori. The Japanese journal of clinical pathology 20101001
Demonstration of muscarinic and nicotinic receptor binding activities of distigmine to treat detrusor underactivity. Biological & pharmaceutical bulletin 20100101
Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug metabolism and pharmacokinetics 20100101
Effect of distigmine bromide on the central cholinergic system. Journal of psychopharmacology (Oxford, England) 20090301
[Treatment approach to congenital myasthenic syndrome in a patient with acetylcholine receptor deficiency]. No to hattatsu = Brain and development 20090101
[Acute poisoning due to distigmine bromide]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20080401
[Three cases of cholinergic crisis in which serum distigmine bromide concentrations were measured]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20080101
Nocturnal hypersalivation caused by distigmine bromide in a patient with multiple system atrophy. Internal medicine (Tokyo, Japan) 20080101
Ubretid (distigmine bromide) taken to treat urinary retention prolongs the effect of suxamethonium. Journal of anesthesia 20080101
Screening procedure for the analysis of distigmine bromide in serum by high-performance liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
[Distigmine bromide improves chronic intestinal pseudo-obstruction in a case of MELAS]. Rinsho shinkeigaku = Clinical neurology 20070401
Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction. The Journal of urology 20050901
[Distigmine bromide induced Parkinsonism. A case report]. Rinsho shinkeigaku = Clinical neurology 20050801
[A case of acute distigmine bromide intoxication in the therapeutic dosage for treatment of underactive neurogenic bladder]. No to shinkei = Brain and nerve 20040501
Combination of a cholinergic drug and an alpha-blocker is more effective than monotherapy for the treatment of voiding difficulty in patients with underactive detrusor. International journal of urology : official journal of the Japanese Urological Association 20040201
Clinical efficacy of distigmine bromide in the treatment of patients with underactive detrusor. International urology and nephrology 20040101
Rhabdomyolysis caused by distigmine bromide. Internal medicine (Tokyo, Japan) 20031101
Distigmine bromide induced acute psychotic disorder in a patient with multiple sclerosis. European psychiatry : the journal of the Association of European Psychiatrists 20031001
[Cholinergic crisis following administration of distigmine bromide: a case report]. Hinyokika kiyo. Acta urologica Japonica 20020101
Symptomatic and urodynamic improvement by oral distigmine bromide in poor voiders after transurethral resection of the prostate. Urology 20010201
Properties