Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.

Journal of medicinal chemistry 20120823

Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis.

International journal of molecular medicine 20120601

The Na+/H+ exchanger-1 inhibitor cariporide prevents glutamate-induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload.

Journal of neuroscience research 20120401

NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts.

Pflugers Archiv : European journal of physiology 20120301

Effect of thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse dendritic cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice.

Cardiovascular diabetology 20120101

Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.

American journal of physiology. Heart and circulatory physiology 20111201

Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways.

The Journal of pharmacology and experimental therapeutics 20111101

Chronic neurological deficits in mice after perinatal hypoxia and ischemia correlate with hemispheric tissue loss and white matter injury detected by MRI.

Developmental neuroscience 20111001

Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains.

Journal of neurochemistry 20111001

Reversal of Imatinib resistance in BCR-ABL-positive leukemia after inhibition of the Na+/H+ exchanger.

Cancer letters 20110901

Disruption of chronic cariporide treatment abrogates myocardial ion homeostasis during acute ischemia reperfusion.

Journal of cardiovascular pharmacology 20110901

Synthesis and Na+/H+ exchanger inhibitory activity of benzoylguanidine derivatives.

European journal of medicinal chemistry 20110901

Evidence for NHE3-mediated Na transport in sheep and bovine forestomach.

American journal of physiology. Regulatory, integrative and comparative physiology 20110801

Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance.

American journal of physiology. Cell physiology 20110701

Oxidative stress augments the secretion of atrial natriuretic peptide in isolated rat atria.

Peptides 20110601

Mitochondrial KATP channels participate in the limitation of infarct size by cariporide.

Naunyn-Schmiedeberg's archives of pharmacology 20110601

Inhibition of Na+/H+ exchanger isoform 1 is neuroprotective in neonatal hypoxic ischemic brain injury.

Antioxidants & redox signaling 20110515

A recombinant human neuregulin-1 peptide improves preservation of the rodent heart after prolonged hypothermic storage.

Transplantation 20110515

Effect of glucose and insulin on oxidized low-density lipoprotein phagocytosis by human monocytes: a pilot study.

Angiology 20110201

Inhibiting the Na+/H+ exchanger reduces reperfusion injury: a small animal MRI study.

Frontiers in bioscience (Elite edition) 20110101

Myocardial reperfusion injury: reactive oxygen species vs. NHE-1 reactivation.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.

Brain research 20101202

Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20101110

[Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100201

Effect of bacterial lipopolysaccharide on Na(+)/H(+) exchanger activity in dendritic cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats.

American journal of physiology. Regulatory, integrative and comparative physiology 20091101

Synthesis and Na(+)/H(+) exchanger-1 inhibitory activity of substituted (quinolinecarbonyl)guanidine derivatives.

Chemistry & biodiversity 20091001

Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives.

European journal of medicinal chemistry 20090901

Combining cariporide with glyceryl trinitrate optimizes cardiac preservation during porcine heart transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20090901

Na+ currents in cardioprotection: better to be late.

Journal of medicinal chemistry 20090723

Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors.

Bioorganic & medicinal chemistry letters 20090615

Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL.

Journal of gastroenterology and hepatology 20090501

Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart.

Journal of applied physiology (Bethesda, Md. : 1985) 20090401

Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction.

American journal of physiology. Heart and circulatory physiology 20090401

Insulin inhibits Na+/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2.

American journal of physiology. Heart and circulatory physiology 20090201

Na+/H+ exchange inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion.

Journal of applied physiology (Bethesda, Md. : 1985) 20090101

Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells.

Biochemical and biophysical research communications 20081212

Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action.

Journal of applied physiology (Bethesda, Md. : 1985) 20081201

Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide in isolated perfused rabbit hearts.

Biological chemistry 20081201

Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain.

Cardiovascular research 20081101

Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils.

American journal of physiology. Cell physiology 20081101

Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.

Circulation research 20081010

Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart.

The Journal of experimental biology 20080801

Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions.

Journal of neurochemistry 20080701

Na+/H+ exchange inhibition with cariporide prevents alterations of coronary endothelial function in streptozotocin-induced diabetes.

Molecular and cellular biochemistry 20080301

Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.

Molecular and cellular biochemistry 20080301

Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration.

Resuscitation 20080101

Inhibition of the Na+/H+ exchanger protects the immature rabbit myocardium from ischemia and reperfusion injury.

Pediatric cardiology 20080101

Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells.

American journal of physiology. Cell physiology 20080101

Na+/H+ exchanger inhibitor cariporide attenuates the mitochondrial Ca2+ overload and PTP opening.

American journal of physiology. Heart and circulatory physiology 20071201

Enhanced Na+/H+ exchange activity contributes to the pathogenesis of muscular dystrophy via involvement of P2 receptors.

The American journal of pathology 20071101

Effects of SM-20550 against myocardial infarction-induced arrhythmias, late infarct expansion, and left ventricular dysfunction.

Journal of cardiovascular pharmacology 20071101

The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001

[Cardioprotective effects of cariporide as an adjunct in different cardioplegic solutions: an experiment with rabbits].

Zhonghua yi xue za zhi 20070904

Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells.

Cancer research 20070815

Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors.

European journal of pharmacology 20070712

NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.

The Journal of biological chemistry 20070706

Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation.

Journal of cellular physiology 20070501

Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.

Bioorganic & medicinal chemistry letters 20070501

Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.

American journal of physiology. Gastrointestinal and liver physiology 20070301

3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors.

Bioorganic & medicinal chemistry letters 20070301

Sodium-hydrogen exchange inhibition and beta-blockade additively decrease infarct size.

The Annals of thoracic surgery 20070301

Invited commentary.

The Annals of thoracic surgery 20070301

Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070101

Reoxygenation-induced Ca2+ rise is mediated via Ca2+ influx and Ca2+ release from the endoplasmic reticulum in cardiac endothelial cells.

Cardiovascular research 20070101

Preconditioning with Na+/H+ exchange inhibitor HOE642 reduces calcium overload and exhibits marked protection on immature rabbit hearts.

ASAIO journal (American Society for Artificial Internal Organs : 1992) 20070101

Modification of intracellular calcium concentration in cardiomyocytes by inhibition of sarcolemmal Na+/H+ exchanger.

American journal of physiology. Heart and circulatory physiology 20061201

Cariporide attenuates myocardial ischaemia, reperfusion injury and apoptosis in isolated rat hearts.

Acta cardiologica 20061201

Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.

The Biochemical journal 20061101

Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1.

Life sciences 20060829

Signalling pathways involved in hypertonicity- and acidification-induced activation of Na+/H+ exchange in trout hepatocytes.

The Journal of experimental biology 20060801

The case for sodium-hydrogen exchanger isoform-1 inhibition during cardiac resuscitation remains strong.

Critical care medicine 20060501

Diastolic dysfunction in stunned myocardium: a state of abnormal excitation-contraction coupling that is limited by Na+-H+ exchange inhibition.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060401

17beta-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange.

Cardiovascular research 20060301

Protection of endothelial-derived vasorelaxation with cariporide, a sodium-proton exchanger inhibitor, after prolonged hypoxia and hypoxia-reoxygenation: effect of age.

European journal of pharmacology 20060215

Inhibition of Na+/H+ exchanger isoform 1 attenuates mitochondrial cytochrome C release in cortical neurons following in vitro ischemia.

Acta neurochirurgica. Supplement 20060101

Na+/H+ exchanger inhibition at the onset of reperfusion decreases myocardial infarct size: role of reactive oxygen species.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20060101

Inhibition of the Na+-H+ exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: a time course of events.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response.

Cardiovascular research 20051201

Insulin-sensitizing and cardiovascular effects of the sodium-hydrogen exchange inhibitor, cariporide, in the JCR: LA-cp rat and db/db mouse.

Journal of cardiovascular pharmacology 20051201

Effects of combined inhibition of the Na+-H+ exchanger and angiotensin-converting enzyme in rats with congestive heart failure after myocardial infarction.

British journal of pharmacology 20051101

Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation.

Critical care medicine 20051101

Cariporide in cardiac resuscitation--Does it really make a difference?

Critical care medicine 20051101

Multiple treatment approach to limit cardiac ischemia-reperfusion injury.

The Annals of thoracic surgery 20051001

Invited commentary.

The Annals of thoracic surgery 20051001

Cariporide counteracts atherosclerosis-related functions in monocytes from obese and normal individuals.

Obesity research 20050901

[Protection of HOE642 against cardiomyocyte injury caused by anoxia and reoxygenation].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050901

Improved preservation of the rat heart with celsior solution supplemented with cariporide plus glyceryl trinitrate.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050801

Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2.

Cellular and molecular life sciences : CMLS 20050701

Endothelin isoforms and the response to myocardial stretch.

American journal of physiology. Heart and circulatory physiology 20050601

Na+/H+ exchanger inhibitor prevented endothelial dysfunction induced by high glucose.

Journal of cardiovascular pharmacology 20050601

Reduction of myocardial infarct size by SM-198110, a novel Na+/H+ exchange inhibitor, in rabbits.

Naunyn-Schmiedeberg's archives of pharmacology 20050501

Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury.

The Canadian journal of cardiology 20050501

(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1.

Journal of medicinal chemistry 20050421

Na+/H+ exchange inhibition and antioxidants lack additive protective effects after reperfusion injury in the working heterotopic rat heart isograft.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050401

Cariporide potentiates the effects of epinephrine and vasopressin by nonvascular mechanisms during closed-chest resuscitation.

Chest 20050401

Protective effects of cariporide on endothelial dysfunction induced by high glucose.

Acta pharmacologica Sinica 20050301

Endothelin-1 stimulates the Na+/Ca2+ exchanger reverse mode through intracellular Na+ (Na+i)-dependent and Na+i-independent pathways.

Hypertension (Dallas, Tex. : 1979) 20050201

Neurologic preservation by Na+-H+ exchange inhibition prior to 90 minutes of hypothermic circulatory arrest.

The Annals of thoracic surgery 20050201

Na+/H+ exchange inhibition in hypertrophied myocardium subjected to cardioplegic arrest: an effective cardioprotective approach.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050101

The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size.

Journal of the American College of Surgeons 20041001

Na+ / H+ exchanger-3 is involved in mouse blastocyst formation.

Journal of experimental zoology. Part A, Comparative experimental biology 20040901

Activation of Na+-H+ exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart.

The Journal of physiology 20040815

Inhibition of Na+-H+ exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction.

British journal of pharmacology 20040801

The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction.

International journal of molecular medicine 20040801

Myocardial protection at a crossroads: the need for translation into clinical therapy.

Circulation research 20040723

The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.

American journal of physiology. Gastrointestinal and liver physiology 20040701

Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis.

Cell death and differentiation 20040701

Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia.

Basic & clinical pharmacology & toxicology 20040701

The many targets of aldosterone.

Hypertension (Dallas, Tex. : 1979) 20040501

Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury.

Life sciences 20040430

Emergency donor heart protection: application of the port access catheter technique using a pig heart transplantation model.

Transplantation 20040427

Experimental studies on myocardial protection with intermittent cross-clamp fibrillation: additive effect of the sodium-hydrogen exchanger inhibitor, cariporide.

The Annals of thoracic surgery 20040401

American Heart Association scientific sessions.

Expert opinion on investigational drugs 20040401

Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors.

Regulatory peptides 20040315

Na+-H+ exchange activity in taste receptor cells.

Journal of neurophysiology 20040301

Involvement of Na+/H+ exchanger in hypoxia/re-oxygenation-induced neonatal rat cardiomyocyte apoptosis.

European journal of pharmacology 20040220

Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model.

Cardiovascular research 20040215

Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201

Effects of cariporide (HOE642) on myocardial infarct size and ventricular arrhythmias in a rat ischemia/reperfusion model: comparison with other drugs.

Pharmacology 20040201

Na+/H+ exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts.

British journal of pharmacology 20040201

Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning.

The Annals of thoracic surgery 20040201

Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.

Journal of molecular and cellular cardiology 20040101

The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina.

Diabetes/metabolism research and reviews 20040101

Na /H+ exchange inhibitor cariporide: effects on respiratory dysfunction after cardiopulmonary bypass.

Perfusion 20040101

The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart.

Pflugers Archiv : European journal of physiology 20031201

A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release.

Cardiovascular research 20031201

Sodium-hydrogen inhibitor cariporide (HOE 642) improves in situ protection of hearts from non-heart-beating donors.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031201

Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.

Annals of the New York Academy of Sciences 20031201

Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway.

Circulation 20031104

Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031101

Enhanced cardioprotection of the rat heart during hypothermic storage with combined Na+ - H+ exchange inhibition and ATP-dependent potassium channel activation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031101

Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury.

Cardiovascular research 20031101

A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts?

The Journal of thoracic and cardiovascular surgery 20031101

Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability.

The Journal of thoracic and cardiovascular surgery 20031101

Cariporide enhances lactate clearance upon reperfusion but does not alter lactate accumulation during global ischaemia.

Pflugers Archiv : European journal of physiology 20031001

Role of the Na+-H+ exchanger (NHE1) in heart muscle function during transient acidosis. A study in papillary muscles from rat and guinea pig hearts.

Canadian journal of physiology and pharmacology 20031001

[Effect of cariporide on immature rabbit heart].

Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001

Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions.

American journal of physiology. Heart and circulatory physiology 20030901

Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis.

Endocrinology 20030901

Prognostic significance of elevated creatine kinase MB after coronary bypass surgery and after an acute coronary syndrome: results from the GUARDIAN trial.

The Journal of thoracic and cardiovascular surgery 20030901

Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study.

The Journal of thoracic and cardiovascular surgery 20030801

Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide.

Molecular and cellular biochemistry 20030801

Myocardial protection during resuscitation from cardiac arrest.

Current opinion in critical care 20030601

An overview of inhibitors of Na(+)/H(+) exchanger.

European journal of medicinal chemistry 20030601

Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium.

Circulation research 20030516

Is microvascular protection by cariporide and ischemic preconditioning causally linked to myocardial salvage?

American journal of physiology. Heart and circulatory physiology 20030401

Pre-treatment with the Na+/H+ exchange inhibitor cariporide delays cell-to-cell electrical uncoupling during myocardial ischemia.

Cardiovascular research 20030401

Blood cardioplegic protection in profoundly damaged hearts: role of Na+-H+ exchange inhibition during pretreatment or during controlled reperfusion supplementation.

The Annals of thoracic surgery 20030401

Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride.

Naunyn-Schmiedeberg's archives of pharmacology 20030401

Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model.

Cardiovascular research 20030315

Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade.

American journal of physiology. Heart and circulatory physiology 20030301

Cariporide (HOE642) limits S-100B release during cardiac surgery.

Journal of cardiovascular pharmacology 20030301

Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury.

Hypertension (Dallas, Tex. : 1979) 20030301

Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.

European journal of pharmacology 20030214

Selective Na+/H+ exchange inhibition by cariporide reduces liver fibrosis in the rat.

Hepatology (Baltimore, Md.) 20030201

Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells.

Gastroenterology 20030201

Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection.

The Annals of thoracic surgery 20030201

Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.

European journal of pharmacology 20030101

Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model.

The Journal of thoracic and cardiovascular surgery 20030101

A review of the GUARDIAN trial results: clinical implications and the significance of elevated perioperative CK-MB on 6-month survival.

Journal of cardiac surgery 20030101

Effects of the NHE-1 inhibitor cariporide alone or together with the P2Y12 antagonist AR-C 69331 MX on CD62p expression and formation of platelet-leukocyte aggregates.

Thrombosis research 20030101

Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes.

American journal of physiology. Endocrinology and metabolism 20021201

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na/H exchange.

The Journal of thoracic and cardiovascular surgery 20021201

Upregulation of myocardial Na+/H+ exchanger induced by chronic treatment with a selective inhibitor.

Journal of molecular and cellular cardiology 20021101

Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart.

Journal of cardiovascular pharmacology 20021001

Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

European journal of pharmacology 20020906

Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.

British journal of cancer 20020715

Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives.

Journal of medicinal chemistry 20020704

Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury.

Cardiovascular drugs and therapy 20020701

Angiotensin II increases L-type Ca2+ current in gramicidin D-perforated adult rabbit ventricular myocytes: comparison with conventional patch-clamp method.

Pflugers Archiv : European journal of physiology 20020501

Effects of inhibiting Na(+)/H(+)-exchange or angiotensin converting enzyme on atrial tachycardia-induced remodeling.

Cardiovascular research 20020501

Ammonia inhibits sodium and chloride absorption in rat distal colon.

Experimental physiology 20020501

In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559.

British journal of pharmacology 20020401

Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure.

Circulation 20020319

Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.

The Biochemical journal 20020301

Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+) exchanger.

Cardiovascular research 20020301

[Protective effect of Na(+)-H+ exchanger inhibitor cariporide on the injury of vascular endothelial function induced by hypercholesterolemia].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20020227

Role of the cardiac Na(+)/H(+)exchanger in [Ca(2+)](i)and [Na(+)](i)handling during intracellular acidosis. Effect of cariporide (Hoe 642).

Pharmacological research 20020101

Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium.

Diabetes/metabolism research and reviews 20020101

Cariporide (HOE 642) attenuates leukocyte activation in ischemia and reperfusion.

Anesthesia and analgesia 20011201

Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs.

American journal of physiology. Renal physiology 20011001

Na(+)/H(+) exchange subtype 1 inhibition reduces endothelial dysfunction in vessels from stunned myocardium.

American journal of physiology. Heart and circulatory physiology 20011001

[Rapid acid extrusion response triggered by alpha-1a adrenoceptor in CHO cells].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011001

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

Journal of medicinal chemistry 20010927

Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium.

Journal of molecular and cellular cardiology 20010901

Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cells.

The Journal of physiology 20010815

Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.

The Journal of pharmacology and experimental therapeutics 20010801

Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide.

Circulation 20010710

NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells.

American journal of physiology. Heart and circulatory physiology 20010601

Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.

European journal of pharmacology 20010518

Na(+)/H(+)-exchange inhibition and aprotinin administration: promising tools for myocardial protection during minimally invasive CABG.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010501

Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding site.

Biochemistry 20010424

Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.

Bioorganic & medicinal chemistry letters 20010326

Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury.

Journal of the American College of Cardiology 20010301

Inhibition of the Na(+)/H(+) exchanger delays the development of rapid pacing-induced atrial contractile dysfunction.

Circulation 20010206

Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats.

American journal of physiology. Heart and circulatory physiology 20010201

HOE-642 (cariporide) alters pH(i) and diastolic function after ischemia during reperfusion in pig hearts in situ.

American journal of physiology. Heart and circulatory physiology 20010201

Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?

The Journal of thoracic and cardiovascular surgery 20010101

Verapamil prevents stretch-induced shortening of atrial effective refractory period in langendorff-perfused rabbit heart.

Journal of cardiovascular electrophysiology 20010101

Hearts from non-heart-beating donors: sodium-hydrogen-inhibitor cariporide improves functional recovery.

Transplantation proceedings 20010101

The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure.

Drugs 20010101

[The Na+/Ca2+ exchanger as responsible for myocardial stunning].

Medicina 20010101

Influence of ammonia on sodium absorption in rat proximal colon.

Pflugers Archiv : European journal of physiology 20000801

Antiarrhythmic effects of HOE642, a novel Na(+)-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts.

European journal of pharmacology 19961219