Home Carbonyls D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1)

D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1)

CAS No.:
157810-81-6
Catalog Number:
AG001PQM
Molecular Formula:
C36H49N5O8S
Molecular Weight:
711.8680
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
500mg
≥98%
1 week
United States
$96
- +
1g
≥98%
1 week
United States
$119
- +
5g
≥98%
1 week
United States
$193
- +
Product Description
Catalog Number:
AG001PQM
Chemical Name:
D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1)
CAS Number:
157810-81-6
Molecular Formula:
C36H49N5O8S
Molecular Weight:
711.8680
MDL Number:
MFCD00920346
IUPAC Name:
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide;sulfuric acid
InChI:
InChI=1S/C36H47N5O4.H2O4S/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43;1-5(2,3)4/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45);(H2,1,2,3,4)/t28-,29+,31+,32-,33+;/m1./s1
InChI Key:
NUBQKPWHXMGDLP-BDEHJDMKSA-N
SMILES:
OS(=O)(=O)O.O[C@H](CN1CCN(C[C@H]1C(=O)NC(C)(C)C)Cc1cccnc1)C[C@H](C(=O)N[C@@H]1[C@H](O)Cc2c1cccc2)Cc1ccccc1
UNII:
771H53976Q
NSC Number:
697197
Properties
Complexity:
1030  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
711.33g/mol
Formal Charge:
0
Heavy Atom Count:
50  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
711.875g/mol
Monoisotopic Mass:
711.33g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
201A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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Hair versus plasma concentrations as indicator of indinavir exposure in HIV-1-infected patients treated with indinavir/ritonavir combination. AIDS (London, England) 20070102
Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070101
Influence of body temperature on indinavir crystallization under loop of Henle conditions. The Journal of antimicrobial chemotherapy 20070101
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Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells. AIDS research and human retroviruses 20070101
Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire. AIDS research and human retroviruses 20070101
MSE with mass defect filtering for in vitro and in vivo metabolite identification. Rapid communications in mass spectrometry : RCM 20070101
Infant of 22 months of age with no anomalies born from a HCV- and HIV-infected mother under treatment with pegylated interferon, ribavirin and antiretroviral therapy during the first 16 weeks of pregnancy. Reproductive toxicology (Elmsford, N.Y.) 20070101
Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes. Antiviral therapy 20070101
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Validation of high-performance liquid chromatography methods for determination of zidovudine, stavudine, lamivudine and indinavir in human plasma. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101
Morphological and biochemical appraisal of the liver and renal effects of indinavir on rat pregnancy. Clinical and experimental obstetrics & gynecology 20070101
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Association of total bilirubin with indinavir and lopinavir plasma concentrations in HIV-infected patients receiving three different double-boosted dosing regimens. The Journal of antimicrobial chemotherapy 20060801
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Feasibility of weekly HIV drug delivery to enhance drug localization in lymphoid tissues based on pharmacokinetic models of lipid-associated indinavir. Pharmaceutical research 20060801
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[Central nervous system HIV-associated polyarteritis nodosa: long-term outcome]. La Revue de medecine interne 20060801
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Urinary NO3 excretion and renal failure in indinavir-treated patients. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060801
High prevalence of indinavir-associated renal complications in Thai HIV-infected patients. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801
Pharmacokinetics and tolerability of a combination of indinavir, lopinavir and ritonavir in multiply pretreated HIV-1 infected adults. European journal of medical research 20060630
Gated binding of ligands to HIV-1 protease: Brownian dynamics simulations in a coarse-grained model. Biophysical journal 20060601
The use of pharmacokinetically guided indinavir dose reductions in the management of indinavir-associated renal toxicity. The Journal of antimicrobial chemotherapy 20060601
Real-time nucleic acid sequence-based amplification assay to quantify changes in mitochondrial DNA concentrations in cell cultures and blood cells from HIV-infected patients receiving antiviral therapy. Clinical chemistry 20060601
Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques. Journal of acquired immune deficiency syndromes (1999) 20060601
Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation. Journal of molecular biology 20060519
HIV protease inhibitor therapy reverses neutrophil apoptosis in AIDS patients by direct calpain inhibition. Apoptosis : an international journal on programmed cell death 20060501
Biological characterization of human immunodeficiency virus type 1 subtype C protease carrying indinavir drug-resistance mutations. The Journal of general virology 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Pharmacogenetics and genomics 20060501
Electrochemical methods for determination of the protease inhibitor indinavir sulfate in pharmaceuticals and human serum. Die Pharmazie 20060501
Antiretroviral medications associated with elevated blood pressure among patients receiving highly active antiretroviral therapy. AIDS (London, England) 20060424
Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance. AIDS (London, England) 20060424
Maintenance of successful ritonavir-boosted indinavir and efavirenz therapy in an HIV-infected patient with tuberculosis. AIDS (London, England) 20060424
Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 20060415
[Drug-induced renal calculi]. Annales d'urologie 20060401
Indinavir-treated Cryptococcus neoformans promotes an efficient antifungal immune response in immunosuppressed hosts. Medical mycology 20060301
Simple and sensitive high-performance liquid chromatography method for the quantitation of indinavir in rat plasma and central nervous system. Journal of separation science 20060301
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. Journal of medicinal chemistry 20060223
LC-MS/MS determination of the HIV-1 protease inhibitor indinavir in brain and testis of mice. Journal of pharmaceutical and biomedical analysis 20060213
[Clinical trial comparing efficacy and safety of four highly active antiretroviral therapy (HAART) in antiretroviral-naive treatment with advanced HIV infection]. Revista clinica espanola 20060201
Once-daily directly observed therapy lopinavir/ritonavir plus indinavir as a protease inhibitor-only salvage therapy in heavily pretreated HIV-1-infected patients: a pilot study. AIDS (London, England) 20060102
HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents. The Journal of pharmacology and experimental therapeutics 20060101
Low urine pH is associated with reduced indinavir crystalluria in indinavir-treated HIV-infected individuals. Clinical nephrology 20060101
Effects of indinavir in a preliminary phase I study on dogs with stage III slenic hemangiosarcoma. In vivo (Athens, Greece) 20060101
Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic & clinical pharmacology & toxicology 20060101
T-cell line for HIV drug screening using EGFP as a quantitative marker of HIV-1 replication. BioTechniques 20060101
Adhesive capsulitis of the shoulder in human immunodeficiency virus-positive patients during highly active antiretroviral therapy. Journal of shoulder and elbow surgery 20060101
Boosted versus unboosted indinavir with zidovudine and lamivudine in nucleoside pre-treated patients: a randomized, open-label trial with 112 weeks of follow-up (HIV-NAT 005). Antiviral therapy 20060101
Incidence of and risk factors for insulin resistance in treatment-naive HIV-infected patients 48 weeks after starting highly active antiretroviral therapy. Antiviral therapy 20060101
[Pneumocystis jirovecii pneumonia: an old disease with a new name]. Medicina (Kaunas, Lithuania) 20060101
Investigation of baseline susceptibility to protease inhibitors in HIV-1 subtypes C, F, G and CRF02_AG. Antiviral therapy 20060101
Quantitative SNP-detection method for estimating HIV-1 replicative fitness: application to protease inhibitor-resistant viruses. Microbiology and immunology 20060101
Performance of six different ritonavir-boosted protease inhibitor-based regimens in heavily antiretroviral-experienced HIV-infected patients. HIV clinical trials 20060101
An immunological comparison of third companion in advanced drug-naive HIV-infected patients. HIV clinical trials 20060101
Lamivudine and indinavir/ritonavir maintenance therapy in highly pretreated HIV-infected patients (Vista ANRS 109). Antiviral therapy 20060101
Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy. AIDS (London, England) 20051202
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus. Bioorganic & medicinal chemistry letters 20051201
Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patients. Therapeutic drug monitoring 20051201
Possible reduction in indinavir serum concentrations by bosentan. Therapeutic drug monitoring 20051201
Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux. Die Pharmazie 20051201
In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug metabolism and disposition: the biological fate of chemicals 20051101
Tissue distribution of indinavir administered as solid lipid nanocapsule formulation in mdr1a (+/+) and mdr1a (-/-) CF-1 mice. Pharmaceutical research 20051101
Indinavir/ritonavir 800/100 mg bid and efavirenz 600 mg qd in patients failing treatment with combination nucleoside reverse transcriptase inhibitors: 96-week outcomes of HIV-NAT 009. HIV medicine 20051101
Indinavir impairs endothelial function in healthy HIV-negative men. American heart journal 20051101
HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. AIDS (London, England) 20051014
Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. The FEBS journal 20051001
Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes. Clinical cancer research : an official journal of the American Association for Cancer Research 20050915
Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. American journal of physiology. Endocrinology and metabolism 20050901
Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients. British journal of clinical pharmacology 20050901
Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. Journal of acquired immune deficiency syndromes (1999) 20050901
GLUT4 facilitative glucose transporter specifically and differentially contributes to agonist-induced vascular reactivity in mouse aorta. Arteriosclerosis, thrombosis, and vascular biology 20050801
TDM: therapeutic drug measuring or therapeutic drug monitoring? Therapeutic drug monitoring 20050801
Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers. Clinical pharmacology and therapeutics 20050801
Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis. The Journal of investigative dermatology 20050801
HIV associated arthritis: case report and review of the literature. European journal of medical research 20050729
Antileishmanial activity of HIV protease inhibitors. International journal of antimicrobial agents 20050701
Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapy. AIDS (London, England) 20050701
Effects on immunological and virological outcome of patients using one protease inhibitor or one non-nucleoside reverse transcriptase inhibitor in a triple antiretroviral therapy: normal clinical practice versus clinical trial findings. Current HIV research 20050701
Predicting drug metabolism--an evaluation of the expert system METEOR. Chemistry & biodiversity 20050701
[Consequences of replacing abacavir for indinavir in successful antiretroviral treatment of a patient with HIV infection]. Presse medicale (Paris, France : 1983) 20050604
[Outcome of HIV-infected patients after 5 years of antiretroviral therapy including a protease inhibitor: the Aproco/Copilote Cohort]. Presse medicale (Paris, France : 1983) 20050604
Highly active antiretroviral therapy and human immunodeficiency virus encephalitis. Annals of neurology 20050601
Low-doses of indinavir boosted with ritonavir in HIV-infected Thai patients: pharmacokinetics, efficacy and tolerability. The Journal of antimicrobial chemotherapy 20050601
Incidence of pancreatitis in HIV-1-infected individuals enrolled in 20 adult AIDS clinical trials group studies: lessons learned. Journal of acquired immune deficiency syndromes (1999) 20050601
Population pharmacokinetic analysis of indinavir in HIV-infected patient treated with a stable antiretroviral therapy. Fundamental & clinical pharmacology 20050601
Genotypic resistance analyses in nucleoside-pretreated patients failing an indinavir containing regimen: results from a randomized comparative trial: (Novavir ANRS 073). Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050601
Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor. AIDS (London, England) 20050520
Hepatotoxicity and nelfinavir: a meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20050501
Switch from ritonavir to indinavir in combination therapy for HIV-1-infected children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050415
A pilot, double-blind, placebo-controlled trial of indinavir in patients with ALS. Neurology 20050412
Pharmacokinetic interaction between chemotherapy for non-Hodgkin's lymphoma and protease inhibitors in HIV-1-infected patients. The Journal of antimicrobial chemotherapy 20050401
Postexposure prophylaxis after sexual assaults: a prospective cohort study. Sexually transmitted diseases 20050401
Simple and simultaneous determination of the hiv-protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir plus M8 nelfinavir metabolite and the nonnucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma by reversed-phase liquid chromatography. Therapeutic drug monitoring 20050401
Investigation of oral bioavailability and brain distribution of the Ind(8)-Val conjugate of indinavir in rodents. The Journal of pharmacy and pharmacology 20050401
Virtual screening of HIV-1 protease inhibitors against human cytomegalovirus protease using docking and molecular dynamics. AIDS (London, England) 20050325
Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis. European journal of clinical pharmacology 20050301
Contribution of cellular HIV-1 DNA quantification to the efficacy analysis of antiretroviral therapy: a randomized comparison of 2 regimens, including 3 drugs from 2 or 3 classes (TRIANON, ANRS 081). Journal of acquired immune deficiency syndromes (1999) 20050301
Comparable pharmacokinetics of generic indinavir (Inhibisam) versus brand indinavir (Crixivan) when boosted with ritonavir. Journal of acquired immune deficiency syndromes (1999) 20050301
Pharmacokinetic interaction study of indinavir/ritonavir and the enteric-coated capsule formulation of didanosine in healthy volunteers. Journal of clinical pharmacology 20050201
Indinavir plasma concentration and adherence score are codeterminant of early virologic response in HIV-infected patients of the APROCO cohort. Therapeutic drug monitoring 20050201
Dose reduction for the management of indinavir-related toxicity in human immunodeficiency virus type 1-infected patients in Taiwan: clinical and pharmacokinetic assessment. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20050201
Warning about indinavir and pregnancy. AIDS patient care and STDs 20050201
Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 20050201
Influence of indinavir on virulence and growth of Cryptococcus neoformans. The Journal of infectious diseases 20050115
Antiretroviral drug pharmacokinetics in hepatitis with hepatic dysfunction. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050101
HIV type 1 protease inhibitors enhance bone marrow progenitor cell activity in normal subjects and in HIV type 1-infected patients. AIDS research and human retroviruses 20050101
Indinavir/ritonavir-based therapy in HIV-1-infected antiretroviral therapy-naive patients: comparison of 800/100 mg and 400/100 mg twice daily. HIV medicine 20050101
[Radio-opaque lithiasis and indinavir]. Actas urologicas espanolas 20050101
Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. Antiviral therapy 20050101
Pharmacokinetics of reduced-dose indinavir/ritonavir 400/100 mg twice daily in HIV-1-infected Thai patients. Antiviral therapy 20050101
The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life. Health and quality of life outcomes 20050101
Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid communications in mass spectrometry : RCM 20050101
HIV protease inhibitors prevent mitochondrial hyperpolarization and redox imbalance and decrease endogenous uncoupler protein-2 expression in gp 120-activated human T lymphocytes. Antiviral therapy 20050101
High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy. Clinical pharmacokinetics 20050101
Efficacy and safety of indinavir/ritonavir 400/100 mg twice daily plus two nucleoside analogues in treatment-naive HIV-1-infected patients with CD4+ T-cell counts <200 cells/mm3: 96-week outcomes. Antiviral therapy 20050101
A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity. The Journal of biological chemistry 20041231
Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity? Neurology 20041228
A comparison of dyslipidemias associated with either lopinavir/ritonavir- or indinavir/ritonavir-based antiretroviral therapy. Journal of acquired immune deficiency syndromes (1999) 20041215
C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. AIDS (London, England) 20041203
Antiretrovirals as antimalarial agents. The Journal of infectious diseases 20041201
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. The Journal of endocrinology 20041201
Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir. Journal of molecular modeling 20041201
Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats. Die Pharmazie 20041201
Health-related quality of life in HIV patients switching to twice-daily indinavir/ritonavir regimen or continuing with three-times-daily indinavir-based therapy. Antiviral therapy 20041201
Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. Clinical therapeutics 20041201
Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir. AIDS (London, England) 20041119
Residual analysis in linear regression models with an interval-censored covariate. Statistics in medicine 20041115
Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes. American journal of physiology. Cell physiology 20041101
Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations. Proteins 20041101
Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals. Journal of acquired immune deficiency syndromes (1999) 20041101
Optimization and statistical evaluation of dissolution tests for indinavir sulfate capsules. Farmaco (Societa chimica italiana : 1989) 20041101
Persistent HIV type 1 infection in semen and blood compartments in patients after long-term potent antiretroviral therapy. AIDS research and human retroviruses 20041101
Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells. The Journal of infectious diseases 20041015
Pseudoaneurysm of the femoral artery in a HIV-infected man. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20041001
The human immunodeficiency virus (HIV) protease inhibitor indinavir directly affects the opportunistic fungal pathogen Cryptococcus neoformans. FEMS immunology and medical microbiology 20041001
Antiretroviral protease inhibitors prevent l6 muscle cell fusion by reducing calpain activity. AIDS research and human retroviruses 20041001
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry 20040928
P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1. Bioorganic & medicinal chemistry letters 20040920
Indinavir increases glucose production in healthy HIV-negative men. AIDS (London, England) 20040903
Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20040901
The ICH guidance in practice: stress degradation studies on indinavir sulphate and development of a validated specific stability-indicating HPTLC assay method. Farmaco (Societa chimica italiana : 1989) 20040901
In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator. Journal of cellular biochemistry 20040815
HIV-1 drug resistance in subjects with advanced HIV-1 infection in whom antiretroviral combination therapy is failing: a substudy of AIDS Clinical Trials Group Protocol 388. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040815
Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases. Journal of virological methods 20040801
Lopinavir/ritonavir combined with twice-daily 400 mg indinavir: pharmacokinetics and pharmacodynamics in blood, CSF and semen. The Journal of antimicrobial chemotherapy 20040801
Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir. Infection 20040801
Impact of indinavir on the quality of life in patients with advanced HIV infection treated with zidovudine and lamivudine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040801
Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus. American journal of obstetrics and gynecology 20040801
ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antiviral therapy 20040801
[Drug-induced lithiasis]. Revue medicale de la Suisse romande 20040801
Nail, hair and skin hyperpigmentation associated with indinavir therapy. AIDS (London, England) 20040723
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. The Journal of clinical investigation 20040715
Incidence of and risk factors for adverse drug reactions in a prospective cohort of HIV-infected adults initiating protease inhibitor-containing therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040715
Reversed-phase liquid chromatography with ultraviolet detection for simultaneous quantitation of indinavir and propranolol from ex-vivo rat intestinal permeability studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705
HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). The Journal of pharmacology and experimental therapeutics 20040701
Determination of indinavir and nelfinavir trough plasma concentration efficacy thresholds according to virological response in HIV-infected patients. HIV medicine 20040701
Thrombosis and a hypercoagulable state in HIV-infected patients. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20040701
Triple nucleoside treatment with abacavir plus the lamivudine/zidovudine combination tablet (COM) compared to indinavir/COM in antiretroviral therapy-naïve adults: results of a 48-week open-label, equivalence trial (CNA3014). Current medical research and opinion 20040701
Predictors of adherence and virologic outcome in HIV-infected patients treated with abacavir- or indinavir-based triple combination HAART also containing lamivudine/zidovudine. Current medical research and opinion 20040701
Direct interference of HIV protease inhibitors with pancreatic beta-cell function. Naunyn-Schmiedeberg's archives of pharmacology 20040601
The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients. Antiviral therapy 20040601
[Highly Active AntiRetroviral Therapy and cryptosporidiosis]. Parassitologia 20040601
HIV protease inhibitors increase adiponectin levels in HIV-negative men. Journal of acquired immune deficiency syndromes (1999) 20040501
Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines. Pharmaceutical research 20040501
Ritonavir boosted indinavir treatment as a simplified maintenance 'mono'-therapy for HIV infection. AIDS (London, England) 20040409
Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected patients: immunovirological outcome and side effects. Antiviral research 20040401
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site. European journal of biochemistry 20040401
Comparison of two reduced-dose regimens of indinavir (600 mg vs 400 mg twice daily) and ritonavir (100 mg twice daily) in healthy volunteers (COREDIR). Antiviral therapy 20040401
Lamivudine 300 mg in HIV infection: dose change. Once-a-day dosing. Prescrire international 20040401
Effect of indinavir used alone or in double or triple combination with AZT and ddC on human immune functions. Life sciences 20040319
Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles? The Journal of infectious diseases 20040315
Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine. The Journal of infectious diseases 20040315
Indinavir and rifabutin drug interactions in healthy volunteers. Journal of clinical pharmacology 20040301
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301
Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a combination of Efavirenz and Indinavir for 48 weeks. Chinese medical journal 20040301
Spectrophotometric determination of indinavir in bulk and pharmaceutical formulations using bromocresol purple and bromothymol blue. Die Pharmazie 20040301
Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors. Journal of acquired immune deficiency syndromes (1999) 20040301
Buffalo hump: what the experts suggest. AIDS clinical care 20040301
Efficacy of two modalities of triple HIV therapy: probable superiority of indinavir. International journal of antimicrobial agents 20040301
Chemokine mRNA levels in mononucleated cells of HIV-infected patients before and after initiation of PI- versus NNRTI-containing HAART. Antiviral research 20040301
The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma. International journal of cancer 20040210
Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity. Organic & biomolecular chemistry 20040207
Capillary electrophoretic method for determination of protease inhibitor indinavir sulfate used in human immunodeficiency virus therapy. Journal of pharmaceutical and biomedical analysis 20040204
Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia. Brain : a journal of neurology 20040201
Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040201
Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir. Analytical chemistry 20040201
[Indinavir urolithiasis in HIV-positive patients. Treatment and prophylaxis]. Der Urologe. Ausg. A 20040201
Strategies to decrease viral load rebound, and prevent loss of CD4 and onset of resistance during structured treatment interruptions. Antiviral therapy 20040201
IDV concentrations plummet with rifampicin. IAPAC monthly 20040201
Relapsing blepharitis in patients under highly active antiretroviral therapy including indinavir. AIDS (London, England) 20040123
Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7alpha-hydroxylase mRNA levels. Biochemical pharmacology 20040115
The effect of nevirapine on the pharmacokinetics of indinavir/ritonavir 800/100 mg BID. Journal of acquired immune deficiency syndromes (1999) 20040101
Risk factors and occurrence of rash in HIV-positive patients not receiving nonnucleoside reverse transcriptase inhibitor: data from a randomized study evaluating use of protease inhibitors in nucleoside-experienced patients with very low CD4 levels (<50 cells/microL). HIV medicine 20040101
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors. Journal of molecular recognition : JMR 20040101
Peptidomimetic inhibitors of HIV protease. Current topics in medicinal chemistry 20040101
Pharmacokinetics of indinavir in Koreans and Caucasians. Scandinavian journal of infectious diseases 20040101
Urologic problems in patients with acquired immunodeficiency syndrome. TheScientificWorldJournal 20040101
Effects of HIV drug combinations on endothelin-1 and vascular cell proliferation. Cardiovascular toxicology 20040101
Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy. Cardiovascular toxicology 20040101
[Indinavir and renal lithiasis]. Actas urologicas espanolas 20040101
HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants. Cardiovascular toxicology 20040101
Urolithiasis associated with indinavir in a patient with spinal cord injury. The journal of spinal cord medicine 20040101
HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis. Cardiovascular toxicology 20040101
Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N. Biochemistry 20031230
Shape signatures: a new approach to computer-aided ligand- and receptor-based drug design. Journal of medicinal chemistry 20031218
Plasma levels of indinavir and nelfinavir at time of virologic response may have a different impact on the risk of further virologic failure in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999) 20031215
TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen. AIDS (London, England) 20031205
Lipid-drug association enhanced HIV-1 protease inhibitor indinavir localization in lymphoid tissues and viral load reduction: a proof of concept study in HIV-2287-infected macaques. Journal of acquired immune deficiency syndromes (1999) 20031201
No clinically significant pharmacokinetic interactions between voriconazole and indinavir in healthy volunteers. British journal of clinical pharmacology 20031201
Clinical use of a simultaneous HPLC assay for indinavir, saquinavir, ritonavir and nelfinavir in children and adults. Therapeutic drug monitoring 20031201
Photophobia in a patient with high indinavir plasma concentrations. Therapeutic drug monitoring 20031201
A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir. Antiviral therapy 20031201
Efficacy and safety of ritonavir/indinavir 100/400 mg twice daily in combination with two nucleoside analogues in antiretroviral treatment-naive HIV-infected individuals. Antiviral therapy 20031201
HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma/RANKL cross-talk. The Journal of biological chemistry 20031128
Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation. AIDS (London, England) 20031121
Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir. Bioorganic & medicinal chemistry letters 20031117
Resolution of HCV infection in a HIV-infected patient under HAART after several hepatitis flare-ups. European journal of medical research 20031112
Six-year follow-up of HIV-1-infected adults in a clinical trial of antiretroviral therapy with indinavir, zidovudine, and lamivudine. AIDS (London, England) 20031107
Influence of goldenseal root on the pharmacokinetics of indinavir. Journal of clinical pharmacology 20031101
Field evaluation of an improved assay using a heat-dissociated p24 antigen for adults mainly infected with HIV-1 CRF02_AG strains in Côte d'Ivoire, West Africa. Journal of acquired immune deficiency syndromes (1999) 20031101
Treating advanced HIV infection. Journal of acquired immune deficiency syndromes (1999) 20031101
The safety and efficacy of indinavir and ritonavir (400/400 mg BID) in HIV-1-infected individuals from an inner-city minority population: a pilot study. International journal of STD & AIDS 20031101
A 6-base pair insertion in the protease gene of HIV type 1 detected in a protease inhibitor-naive patient is not associated with indinavir treatment failure. AIDS research and human retroviruses 20031101
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Differential effect of HIV protease inhibitors on adipogenesis: intracellular ritonavir is not sufficient to inhibit differentiation. AIDS (London, England) 20031017
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The long-term effects of anti-retroviral protease inhibitors on sugar transport in L6 cells. The Journal of endocrinology 20030901
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Joint models for efficient estimation in proportional hazards regression models. Statistics in medicine 20030715
Indinavir reduces Cryptosporidium parvum infection in both in vitro and in vivo models. International journal for parasitology 20030701
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Nucleoside-free regimen tested. AIDS patient care and STDs 20030601
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Report from the 4th International Workshop on Clinical Pharmacology of HIV Therapy. Drinking lots of water still necessary with new indinavir regimens. TreatmentUpdate 20030101
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Simultaneous determination of indinavir, ritonavir and lopinavir (ABT 378) in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805
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Engineering an indene bioconversion process for the production of cis-aminoindanol: a model system for the production of chiral synthons. Applied microbiology and biotechnology 20020801
Effect of coadministration of nelfinavir, indinavir, and saquinavir on the pharmacokinetics of amprenavir. Clinical pharmacology and therapeutics 20020801
Therapeutic drug monitoring of indinavir and nelfinavir to assess adherence to therapy in human immunodeficiency virus-infected children. The Pediatric infectious disease journal 20020801
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial. JAMA 20020710
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Immunophenotypic analyses of CD34(+) cell subsets in bone marrow from HIV-infected patients during highly- active antiretroviral therapy. European journal of clinical investigation 20020701
High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma. Therapeutic drug monitoring 20020601
Urinary cytology associated with human polyomavirus and indinavir therapy in HIV-infected patients. American journal of clinical pathology 20020601
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Select HIV protease inhibitors alter bone and fat metabolism ex vivo. The Journal of biological chemistry 20020531
A neutravidin-based assay for reverse transcriptase suitable for high throughput screening of retroviral activity. Journal of biochemistry and molecular biology 20020531
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Extrapyramidal symptoms with ritonavir/indinavir plus risperidone. The Annals of pharmacotherapy 20020501
Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers. Pharmacotherapy 20020501
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AIDS-related primary central nervous system lymphoma: prolonged remission associated with highly active antiretroviral therapy. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020501
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Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. AIDS (London, England) 20020412
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Simultaneous determination of the six HIV protease inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir) plus M8 nelfinavir metabolite and the nonnucleoside reverse transcription inhibitor efavirenz in human plasma by solid-phase extraction and column liquid chromatography. Therapeutic drug monitoring 20020401
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The utility of inhibitory quotients in determining the relative potency of protease inhibitors. AIDS (London, England) 20020329
Osteosclerosis and periostal new bone formation during indinavir therapy. AIDS (London, England) 20020329
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The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir. AIDS (London, England) 20020308
Concentration-controlled compared with conventional antiretroviral therapy for HIV infection. AIDS (London, England) 20020308
Final analysis of the Trilège induction-maintenance trial: results at 18 months. AIDS (London, England) 20020308
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Characterizing the relationship between HIV-1 genotype and phenotype: prediction-based classification. Biometrics 20020301
A combinatorial library of indinavir analogues and its in vitro and in vivo studies. Bioorganic & medicinal chemistry letters 20020225
A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation. Brain research 20020215
Reduction of HIV-1 viral load in saliva by indinavir-containing antiretroviral regimen. AIDS (London, England) 20020215
Targeted delivery of indinavir to HIV-1 primary reservoirs with immunoliposomes. Biochimica et biophysica acta 20020201
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. Protein science : a publication of the Protein Society 20020201
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Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia. AIDS (London, England) 20020125
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Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection. The Journal of infectious diseases 20020101
Rheumatological complications associated with the use of indinavir and other protease inhibitors. Annals of the rheumatic diseases 20020101
Pharmacokinetic variability caused by gender: do women have higher indinavir exposure than men? Journal of acquired immune deficiency syndromes (1999) 20020101
The HIV protease inhibitor saquinavir impairs lipid metabolism and glucose transport in cultured adipocytes. The Journal of endocrinology 20020101
Changing morbidity of cutaneous diseases in patients with HIV after the introduction of highly active antiretroviral therapy including a protease inhibitor. American journal of clinical dermatology 20020101
Differences in the detection of three HIV-1 protease inhibitors in non-blood compartments: clinical correlations. HIV clinical trials 20020101
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CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. Xenobiotica; the fate of foreign compounds in biological systems 20020101
Epidural lipomatosis secondary to indinavir in an HIV-positive patient. Clinical neuropharmacology 20020101
Therapeutic drug monitoring of indinavir in HIV-infected patients undergoing HAART. Infection 20020101
Interaction between levothyroxine and indinavir in a patient with HIV infection. Infection 20020101
HIV postexposure prophylaxis in the remote prehospital environment. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors 20020101
The role of pharmacokinetics in drug discovery: finding drug candidates with the greatest potential for success. Ernst Schering Research Foundation workshop 20020101
Successful simplification of HAART in patients with acute primary HIV infection. Journal of biological regulators and homeostatic agents 20020101
Long-term efficacy and safety of ritonavir/indinavir at 400/400 mg twice a day in combination with two nucleoside reverse transcriptase inhibitors as first line antiretroviral therapy. HIV medicine 20020101
A critical evaluation of the therapeutic range of indinavir. The Annals of pharmacotherapy 20020101
Evaluation of the origins of the selectivity of polymers imprinted with a HIV protease inhibitor using infrared spectroscopy and high performance liquid chromatography. Enantiomer 20020101
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Immune reconstitution during intensive chemotherapy in patients with human immunodeficiency virus related non-Hodgkin lymphoma. The hematology journal : the official journal of the European Haematology Association 20020101
[Prophylactic antiretroviral therapy after sexual exposure to HIV: 93 cases]. Annales de dermatologie et de venereologie 20020101
Toxicity. Milk thistle and indinavir. TreatmentUpdate 20020101
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Indinavir-induced retinoid-like effects: incidence, clinical features and management. Drug safety 20020101
[Drug-induced acute pancreatitis: a personal contribution]. Chirurgia italiana 20020101
Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavir. HIV clinical trials 20020101
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Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320. Annals of internal medicine 20011204
Summaries for patients. Predictors of outcomes in patients with HIV infection treated with indinavir, zidovudine, and lamivudine. Annals of internal medicine 20011204
The chemotherapeutic agent bleomycin in a two-drug combination with zidovudine, ritonavir or indinavir synergistically inhibits HIV Type-1 replication in peripheral blood lymphocytes. International journal of antimicrobial agents 20011201
Reduction of signal suppression effects in ESI-MS using a nanosplitting device. Analytical chemistry 20011201
Has there been a decrease in the prevalence of mood disorders in HIV-seropositive individuals since the introduction of combination therapy? European psychiatry : the journal of the Association of European Psychiatrists 20011201
[Urinary lithiasis secondary to indinavir in an HIV-positive patient]. Archivos espanoles de urologia 20011201
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Correlation between reduction in plasma HIV-1 RNA concentration 1 week after start of antiretroviral treatment and longer-term efficacy. Lancet (London, England) 20011124
Protease inhibitors and erectile dysfunction. AIDS (London, England) 20011123
HIV protease inhibitors reduce IL-2 release from normal human phytohaemagglutinin-activated T cells. AIDS (London, England) 20011123
Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir. Carbohydrate research 20011121
Synergistic antiadipogenic effects of HIV type 1 protease inhibitors with tumor necrosis factor alpha: suppression of extracellular insulin action mediated by extracellular matrix-degrading proteases. AIDS research and human retroviruses 20011120
Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo. The Journal of infectious diseases 20011115
Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy. The Journal of infectious diseases 20011101
Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte cultures. Drug and alcohol dependence 20011101
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