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Molecular pharmacology 20120201

Peripheral antinociception induced by δ-opioid receptors activation, but not μ- or κ-, is mediated by Ca²⁺-activated Cl⁻ channels.

European journal of pharmacology 20120115

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

Bioorganic & medicinal chemistry 20120115

New insights into opioid regulatory pathways: influence of opioids on Wnt1 expression in zebrafish embryos.

Neuroscience 20120103

Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway.

Circulation journal : official journal of the Japanese Circulation Society 20120101

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.

Behavioural brain research 20111001

Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis.

Psychopharmacology 20110801

Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

Pain 20110601

Effects of delta opioid receptors activation on a response inhibition task in rats.

Psychopharmacology 20110401

Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.

Neuroscience 20101124

Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.

Bioorganic & medicinal chemistry letters 20101101

Synthesis and in vivo brain distribution of carbon-11-labeled δ-opioid receptor agonists.

Nuclear medicine and biology 20101101

Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety.

The Journal of pharmacology and experimental therapeutics 20101001

Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.

Journal of anesthesia 20100401

Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys.

Life sciences 20100313

Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment.

Journal of neuroscience research 20100301

Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle.

The Journal of pharmacology and experimental therapeutics 20100301

Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.

Pain 20100101

Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.

ChemMedChem 20091201

N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models.

Bioorganic & medicinal chemistry letters 20091101

Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: evidence for differential mu opioid receptor activation.

Pharmacology, biochemistry, and behavior 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.

Bioorganic & medicinal chemistry 20090901

Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.

The Journal of biological chemistry 20090703

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.

Bioorganic & medicinal chemistry letters 20090515

Syntheses of novel high affinity ligands for opioid receptors.

Bioorganic & medicinal chemistry letters 20090415

Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.

American journal of physiology. Heart and circulatory physiology 20090401

The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats.

European journal of pharmacology 20090214

In vivo delta opioid receptor internalization controls behavioral effects of agonists.

PloS one 20090101

Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.

Bioorganic & medicinal chemistry letters 20081215

Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.

Journal of neurochemistry 20081201

Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.

Journal of pharmacological sciences 20081101

Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

Journal of medicinal chemistry 20081009

The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum.

Neuropharmacology 20081001

Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.

Brain research bulletin 20080905

The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.

British journal of pharmacology 20080701

Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model.

Brain research 20080507

Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.

Psychoneuroendocrinology 20080501

Inflammatory pain is enhanced in delta opioid receptor-knockout mice.

The European journal of neuroscience 20080501

Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.

Bioorganic & medicinal chemistry 20080415

Opioid modulation of ferret vagal afferent mechanosensitivity.

American journal of physiology. Gastrointestinal and liver physiology 20080401

Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety.

Bioorganic & medicinal chemistry 20080315

Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats.

The journal of pain : official journal of the American Pain Society 20080301

Dopamine-independent psychostimulant activity of a delta-agonist.

Behavioural pharmacology 20080301

The delta-opioid receptor agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] synergistically enhances the locomotor-activating effects of some psychomotor stimulants, but not direct dopamine agonists, in rats.

The Journal of pharmacology and experimental therapeutics 20080201

Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat.

Neuropharmacology 20080201

Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats.

Journal of anesthesia 20080101

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.

Journal of medicinal chemistry 20070809

Use of Freund's Complete Adjuvant (FCA) in inflammatory pain models: consequences on the metabolism and pharmacokinetics of the non-peptidic delta receptor agonist SNC80 in the rat.

Xenobiotica; the fate of foreign compounds in biological systems 20070801

Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.

Journal of medicinal chemistry 20070419

Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.

Brain : a journal of neurology 20070401

Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.

Journal of pharmacological and toxicological methods 20070101

Differential effects of micro-opioid, delta-opioid and kappa-opioid receptor agonists on dopamine receptor agonist-induced climbing behavior in mice.

Behavioural pharmacology 20061201

Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy.

Journal of pharmacological sciences 20061201

Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys.

European journal of pharmacology 20061010

Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats.

European journal of pharmacology 20061010

Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys.

Pharmacology, biochemistry, and behavior 20061001

Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions.

The Journal of pharmacology and experimental therapeutics 20060801

The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol.

The Journal of pharmacology and experimental therapeutics 20060601

Role of delta-opioid receptor function in neurogenesis and neuroprotection.

Journal of neurochemistry 20060601

Modulation of delta opioid-evoked hypothermia in rats by WAY 100635 and fluoxetine.

Neuroscience letters 20060508

Nitric oxide synthase mediates delta opioid receptor-induced hypothermia in rats.

European journal of pharmacology 20060424

Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401

Delta opioid receptor ligands modulate anxiety-like behaviors in the rat.

British journal of pharmacology 20060401

Dissociation between sex differences in the immunological, behavioral, and physiological effects of kappa- and delta-opioids in Fischer rats.

Psychopharmacology 20060301

Effects of mu-, delta- and kappa-opioid receptor agonists on methamphetamine-induced self-injurious behavior in mice.

European journal of pharmacology 20060217

Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects.

European journal of pharmacology 20060215

Delta opioid agonists attenuate TAT(1-72)-induced oxidative stress in SK-N-SH cells.

Neurotoxicology 20060101

delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway.

Life sciences 20051119

Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats.

Psychopharmacology 20051101

Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats.

Psychopharmacology 20051101

Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats.

The Journal of pharmacology and experimental therapeutics 20051001

Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice.

The European journal of neuroscience 20051001

3D-QSAR comparative molecular field analysis on delta opioid receptor agonist SNC80 and its analogs.

Journal of molecular graphics & modelling 20050901

Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats.

Brain research 20050705

Interactions between delta and mu opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice in rhesus monkeys: studies with SNC80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and heroin.

The Journal of pharmacology and experimental therapeutics 20050701

The antinociceptive effect of zolpidem and zopiclone in mice.

Pharmacology, biochemistry, and behavior 20050701

Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids.

International immunopharmacology 20050701

A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80.

Basic & clinical pharmacology & toxicology 20050701

Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats.

Psychopharmacology 20050601

Molecular modeling directed synthesis of a bicyclic analogue of the delta opioid receptor agonist SNC 80.

Archiv der Pharmazie 20050601

The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats.

Brain research 20050531

Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels.

European journal of pharmacology 20050404

Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.

The Journal of pharmacology and experimental therapeutics 20050401

Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.

European journal of pharmacology 20050328

In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323

Reciprocal regulation of agonist and inverse agonist signaling efficacy upon short-term treatment of the human delta-opioid receptor with an inverse agonist.

Molecular pharmacology 20050101

Enhanced striatal opioid receptor-mediated G-protein activation in L-DOPA-treated dyskinetic monkeys.

Neuroscience 20050101

Increased survival of tumor-bearing mice by the delta opioid SNC 80.

Anticancer research 20050101

Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons.

Neuropharmacology 20041201

Different regulation of human delta-opioid receptors by SNC-80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and endogenous enkephalins.

The Journal of pharmacology and experimental therapeutics 20040801

Delta-opioid agonist SNC80 can attenuate the development of dynorphin A-induced tactile allodynia in rats.

Anesthesiology 20040801

Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.

Journal of pharmacological sciences 20040701

The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury after spinal cord ischemia in rats.

Anesthesia and analgesia 20040701

N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.

Bioorganic & medicinal chemistry letters 20040503

Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats.

The Journal of pharmacology and experimental therapeutics 20040401

Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].

Journal of medicinal chemistry 20040311

Functional interaction among opioid receptor types: up-regulation of mu- and delta-opioid receptor functions after repeated stimulation of kappa-opioid receptors.

Neuropharmacology 20040301

Mutation S363A in the human delta-opioid receptor selectively reduces down-regulation by a peptide agonist.

European journal of pharmacology 20040206

SNC 80 and related delta opioid agonists.

Current pharmaceutical design 20040101

Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception.

The Journal of pharmacology and experimental therapeutics 20031201

Delta-opioid agonist-stimulated inositol phosphate formation in isolated, rabbit iris-ciliary bodies: role of G(i/o) proteins and Gbetagamma-subunits.

Experimental eye research 20031201

Effects of the delta-opioid receptor agonist SNC80 on learning relative to its antidepressant-like effects in rats.

Behavioural pharmacology 20031101

Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa.

British journal of pharmacology 20031001

Pharmacological characterization of AR-M1000390 at human delta opioid receptors.

Life sciences 20030815

Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment.

The Journal of pharmacology and experimental therapeutics 20030701

SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.

Journal of cardiovascular pharmacology 20030501

Development of opioid tolerance with repeated transcutaneous electrical nerve stimulation administration.

Pain 20030301

Agonist-specific down-regulation of the human delta-opioid receptor.

European journal of pharmacology 20030110

The molecular mechanisms of cellular tolerance to delta-opioid agonists. A minireview.

Acta biologica Hungarica 20030101

Chemotaxis of human and rat leukocytes by the delta-selective non-peptidic opioid SNC 80.

Revista latinoamericana de microbiologia 20030101

Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain.

Pharmacology, biochemistry, and behavior 20021201

Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice.

The Journal of pharmacology and experimental therapeutics 20021101

Delta opioid antagonist effects of buprenorphine in rhesus monkeys.

Behavioural pharmacology 20021101

Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats.

Psychopharmacology 20021001

Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.

Psychopharmacology 20021001

Antinociceptive effects of the selective delta opioid agonist SNC80 alone and in combination with mu opioids in the squirrel monkey titration procedure.

Psychopharmacology 20021001

Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists.

The Journal of pharmacology and experimental therapeutics 20020901

Behavioral effects of delta-opioid receptor agonists: potential antidepressants?

Japanese journal of pharmacology 20020901

The role of nitric oxide in the proconvulsant effect of delta-opioid agonist SNC80 in mice.

Neuroscience letters 20020830

Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020601

Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.

Brain research 20020524

Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.

The Journal of pharmacology and experimental therapeutics 20020201

Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells.

British journal of pharmacology 20020101

Delta opioid discrimination learning in the rat: assessment with the selective delta agonist SNC80.

Pharmacology, biochemistry, and behavior 20020101

Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.

Acta anaesthesiologica Belgica 20020101

Studies of tolerance and dependence with the delta-opioid agonist SNC80 in rhesus monkeys responding under a schedule of food presentation.

The Journal of pharmacology and experimental therapeutics 20011101

Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.

Molecular pharmacology 20011101

Antiparkinsonian action of a delta opioid agonist in rodent and primate models of Parkinson's disease.

Experimental neurology 20011101

Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand.

Bioorganic & medicinal chemistry 20011001

Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.

Bioorganic & medicinal chemistry letters 20010709

SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.

Brain research bulletin 20010701

delta-Opioid modulation of social interactions in juvenile mice weaned at different ages.

Physiology & behavior 20010601

Increased tumor necrosis factor-alpha and nitric oxide production by rat macrophages following in vitro stimulation and intravenous administration of the delta-opioid agonist SNC 80.

Life sciences 20010504

Effects of yohimbine on the antinociceptive and place conditioning effects of opioid agonists in rodents.

British journal of pharmacology 20010501

Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.

European journal of pharmacology 20010420

Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.

Life sciences 20010406

Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.

Journal of medicinal chemistry 20010315

Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.

The Journal of pharmacology and experimental therapeutics 20010301

Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse.

Neuroscience 20010101

Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.

European journal of pharmacology 19970512

Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.

Journal of medicinal chemistry 19940708