Home Other Building Blocks 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-

24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-

CAS No.:
156722-18-8
Catalog Number:
AG001OX3
Molecular Formula:
C23H34O4
Molecular Weight:
374.5137
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
5mg
98%
1 week
United States
$161
- +
10mg
98%
1 week
United States
$244
- +
25mg
≥98%
1 week
United States
$491
- +
50mg
98%
1 week
United States
$682
- +
100mg
98%
1 week
United States
$1098
- +
Product Description
Catalog Number:
AG001OX3
Chemical Name:
24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
CAS Number:
156722-18-8
Molecular Formula:
C23H34O4
Molecular Weight:
374.5137
MDL Number:
MFCD00927279
IUPAC Name:
(3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
InChI:
InChI=1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
InChI Key:
AEAPORIZZWBIEX-DTBDINHYSA-N
SMILES:
O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@]1(O)CC[C@]2(O)c1ccoc1)C)C
UNII:
P848LCX62B
Properties
Complexity:
609  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
374.246g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
374.521g/mol
Monoisotopic Mass:
374.246g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
73.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3  
Literature
Title Journal
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Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochimica et biophysica acta 20101201
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies. Science translational medicine 20101124
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies. Science translational medicine 20101124
Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach. Medical hypotheses 20070101
Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension. Cellular and molecular biology (Noisy-le-Grand, France) 20061230
Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase. Kidney international 20060601
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. American journal of physiology. Regulatory, integrative and comparative physiology 20060301
A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin. Cardiovascular & hematological agents in medicinal chemistry 20060101
Adducin and hypertension. Pharmacogenomics 20051001
OASIS-HT: design of a pharmacogenomic dose-finding study. Pharmacogenomics 20051001
PST 2238 as an antihypertensive compound that antagonizes the effect of endogenous cardiac glycosides. Acta poloniae pharmaceutica 20050101
Ouabain antagonists as antihypertensive agents. Current pharmaceutical design 20050101
Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238. The Journal of biological chemistry 20040806
Antihypertensive compounds that modulate the Na-K pump. Annals of the New York Academy of Sciences 20030401
Genes and hypertension. Current pharmaceutical design 20030101
PST 2238: a new antihypertensive compound that modulates renal Na-K pump function without diuretic activity in Milan hypertensive rats. Journal of cardiovascular pharmacology 20021201
Endogenous cardiotonic steroids. Cellular and molecular biology (Noisy-le-Grand, France) 20010301
Properties