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BQ-788 Sodium

CAS No.:
156161-89-6
Catalog Number:
AG001OKH
Molecular Formula:
C34H50N5NaO7
Molecular Weight:
663.7799
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%
1 week
United States
$307
- +
5mg
98%
1 week
United States
$640
- +
10mg
98%
1 week
United States
$890
- +
Product Description
Catalog Number:
AG001OKH
Chemical Name:
BQ-788 Sodium
CAS Number:
156161-89-6
Molecular Formula:
C34H50N5NaO7
Molecular Weight:
663.7799
MDL Number:
MFCD00797882
IUPAC Name:
sodium;(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]-3-(1-methoxycarbonylindol-3-yl)propanoyl]amino]hexanoate
InChI:
InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1
InChI Key:
QCVIFBRTTLMEOV-FUKQNADPSA-M
SMILES:
CCCC[C@H](C(=O)[O-])NC(=O)[C@@H](Cc1cn(c2c1cccc2)C(=O)OC)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C.[Na+]
UNII:
44OLL8XEJ4
Properties
Complexity:
1080  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
663.361g/mol
Formal Charge:
0
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
663.792g/mol
Monoisotopic Mass:
663.361g/mol
Rotatable Bond Count:
14  
Topological Polar Surface Area:
162A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. The American journal of pathology 20141101
Endothelins reciprocally regulate VEGF-A and angiopoietin-1 production in cultured rat astrocytes: implications on astrocytic proliferation. Glia 20121201
Endothelin-1 increases superoxide production in human coronary artery bypass grafts. Life sciences 20121015
The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-κB signaling pathway in heart. General physiology and biophysics 20120901
Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Investigative ophthalmology & visual science 20120608
EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn-Schmiedeberg's archives of pharmacology 20120401
BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. PloS one 20120101
Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase. Journal of vascular research 20120101
Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes. Mechanisms of ageing and development 20120101
ETA and ETB receptors are expressed in vascular adventitial fibroblasts. American journal of physiology. Heart and circulatory physiology 20111201
Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats. Brain research 20111028
Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway. American journal of physiology. Lung cellular and molecular physiology 20110601
Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes. Diabetologia 20110401
20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. American journal of physiology. Heart and circulatory physiology 20110401
Effect of avosentan (SPP-301) in porcine ciliary arteries. Current eye research 20110201
Endothelin modulates the cardiovascular effects of clonidine in the rat. Pharmacological research 20101201
Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney international 20101101
Molecular signaling of pruritus induced by endothelin-1 in mice. Experimental biology and medicine (Maywood, N.J.) 20101101
Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus. Neurochemistry international 20101001
Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation. Circulation 20100914
Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. Canadian journal of physiology and pharmacology 20100601
Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain 20100501
Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro. The Journal of clinical endocrinology and metabolism 20100501
Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults. American journal of physiology. Regulatory, integrative and comparative physiology 20100201
Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction. Peptides 20100201
Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction. Reproduction, fertility, and development 20100101
Intracerebroventricular administration of an endothelin ET(B)-receptor agonist increases expression of matrix metalloproteinase-2 and -9 in rat brain. Journal of pharmacological sciences 20100101
Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance. Hypertension (Dallas, Tex. : 1979) 20091201
Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions. American journal of physiology. Regulatory, integrative and comparative physiology 20090901
Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin. American journal of physiology. Regulatory, integrative and comparative physiology 20090801
Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development (Cambridge, England) 20090801
Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. Neuroscience letters 20090703
Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein. The Journal of pharmacology and experimental therapeutics 20090601
Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. American journal of physiology. Heart and circulatory physiology 20090501
Fibrinogen-induced endothelin-1 production from endothelial cells. American journal of physiology. Cell physiology 20090401
ETB2 receptor subtype stimulation relaxes the iris sphincter muscle. Physiological research 20090101
The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat. Anesthesia and analgesia 20090101
Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism. Journal of nephrology 20090101
Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity. Cellular signalling 20081201
Regulation of glial inflammatory mediators synthesis: possible role of endothelins. Peptides 20081201
Role of nitric oxide in regulation of retinal blood flow in response to hyperoxia in cats. Investigative ophthalmology & visual science 20081001
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1. Journal of leukocyte biology 20080901
Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. American journal of physiology. Heart and circulatory physiology 20080901
The role of endothelin pathway in modulation of airway reactivity to methacholine in C57Bl/6 and BALB/c mice. European journal of pharmacology 20080820
Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes. Canadian journal of physiology and pharmacology 20080801
Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart. American journal of physiology. Heart and circulatory physiology 20080701
Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats. British journal of pharmacology 20080701
Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats. Pharmacological research 20080601
Role of endothelin receptors on basal and endothelin-1-stimulated lung myofibroblast proliferation. Canadian journal of physiology and pharmacology 20080601
Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder. The journal of sexual medicine 20080501
Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum. Biology of reproduction 20080401
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. American journal of physiology. Lung cellular and molecular physiology 20080201
Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium. Naunyn-Schmiedeberg's archives of pharmacology 20080201
The endothelin-1 pathway and the development of cardiovascular defects in the haemodynamically challenged chicken embryo. Journal of vascular research 20080101
Endothelin-1 potentiation of coronary artery contraction after ischemia-reperfusion. Vascular pharmacology 20080101
Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes. American journal of physiology. Heart and circulatory physiology 20071001
NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. Cardiovascular research 20070901
Short-term regulation of tyrosine hydroxylase activity and expression by endothelin-1 and endothelin-3 in the rat posterior hypothalamus. Regulatory peptides 20070816
Endothelin-1 and pancreatic islet vasculature: studies in vivo and on isolated, vascularly perfused pancreatic islets. American journal of physiology. Endocrinology and metabolism 20070601
Multiple signaling pathways involved in the effect of endothelin type B receptor in rat median eminence. Acta biologica Hungarica 20070601
Endothelin-B receptors on suprachoroidal melanocytes mediate an endothelin-1-induced increase in the intracellular calcium concentration of rabbit ocular suprachoroidal tissue. Current eye research 20070601
Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. British journal of pharmacology 20070501
Endogenous endothelin in human coronary vascular function: differential contribution of endothelin receptor types A and B. Hypertension (Dallas, Tex. : 1979) 20070501
Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Prostaglandins, leukotrienes, and essential fatty acids 20070501
Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease. Diabetes care 20070301
Intraindividual comparison of human radial and internal thoracic arteries in vitro and the effect of preoperative calcium blocker therapy. Fundamental & clinical pharmacology 20070201
Endothelin-A and -B receptors, superoxide, and Ca2+ signaling in afferent arterioles. American journal of physiology. Renal physiology 20070101
Endothelin-1-mediated wave-like [Ca2+]i oscillations in intact rabbit inferior vena cava. Journal of vascular research 20070101
Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress. Calcified tissue international 20061201
Paradoxical coronary microcirculatory constriction during ischemia: a synergic function for nitric oxide and endothelin. American journal of physiology. Heart and circulatory physiology 20061001
Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis. American journal of physiology. Renal physiology 20061001
Synergistic activation of salmon cardiac function by endothelin and beta-adrenergic stimulation. American journal of physiology. Heart and circulatory physiology 20060901
Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells. Molecules and cells 20060831
Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid. The Journal of pharmacology and experimental therapeutics 20060801
Vagally mediated cholestatic and choleretic effects of centrally applied Endothelin-1 through ETA receptors. Regulatory peptides 20060715
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. Pain 20060701
Autocrine effects of endothelin on in vitro proliferation of vascular smooth muscle cells from spontaneously hypertensive and normotensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20060701
Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta. British journal of pharmacology 20060601
Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents. Experimental biology and medicine (Maywood, N.J.) 20060601
Effects of antagonists for endothelin ET(A) and ET(B) receptors on coronary endothelial and myocardial function after ischemia-reperfusion in anesthetized goats. Vascular pharmacology 20060501
Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo. Journal of cardiovascular pharmacology 20060501
Effect of age on insulin-induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats. Experimental gerontology 20060301
Selective endothelin B receptor blockade does not influence BNP-induced natriuresis in man. Kidney international 20060301
Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance. Journal of cardiovascular pharmacology 20060301
Difference in the characteristics of ETA-receptor-stimulated response between rat small pulmonary and renal arteries. Journal of cardiovascular pharmacology 20060301
Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway. Hypertension (Dallas, Tex. : 1979) 20060201
Pharmacological properties of endothelin-1 in the rabbit corpus cavernosum. In vivo (Athens, Greece) 20060101
Endothelin-1 enhances glutamate-induced retinal cell death, possibly through ETA receptors. Investigative ophthalmology & visual science 20051201
Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201
Pathways of glomerular toxicity of cyclosporine-A: an 'in vitro' study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201
Enhanced response of pig coronary arteries to endothelin-1 after ischemia-reperfusion. Role of endothelin receptors, nitric oxide and prostanoids. European journal of pharmacology 20051107
Endothelin-1-dependent leptin induction in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. Biochemical and biophysical research communications 20051104
Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation. British journal of pharmacology 20051101
Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries. Journal of cardiovascular pharmacology 20051001
Endothelin-1 causes systemic vasodilatation in anaesthetised turtles (Trachemys scripta) through activation of ETB-receptors. The Journal of experimental biology 20051001
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus. Biochemical and biophysical research communications 20050902
Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues. Peptides 20050801
Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle. European journal of pharmacology 20050711
Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway. Peptides 20050701
Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. American journal of physiology. Endocrinology and metabolism 20050601
Characterization of endothelin-converting enzyme activities in ARPE-19 cells, a human retinal pigmented epithelial cell line. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601
Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure. Vascular pharmacology 20050601
NO and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat. American journal of physiology. Regulatory, integrative and comparative physiology 20050501
Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Cardiovascular research 20050501
Endothelin receptor blockade improves endothelial function in atherosclerotic patients on angiotensin converting enzyme inhibition. Journal of internal medicine 20050301
Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway. Experimental eye research 20050301
Receptor subtypes mediating the inotropic effects and Ca(2+) signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium. Journal of pharmacological sciences 20050301
Endothelin-1-induced proliferation of human endothelial cells depends on activation of K+ channels and Ca+ influx. Acta physiologica Scandinavica 20050201
Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. Experimental dermatology 20041201
Significance of the endothelin ETA receptor in the haemodynamic and inotropic effects of endothelin-1 in rats. Clinical science (London, England : 1979) 20041101
Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery. Peptides 20041101
The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants. Journal of cardiovascular pharmacology 20041101
Inhibitory actions of endothelin-1 on pain processing. Journal of cardiovascular pharmacology 20041101
Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist. Journal of cardiovascular pharmacology 20041101
The effect of cerivastatin therapy on vascular responses to endothelin antagonists in humans. Journal of cardiovascular pharmacology 20041101
Endothelin-1-induced vasodilatation in rat breast tumor is mediated through endothelin-B receptors. Journal of cardiovascular pharmacology 20041101
The endothelin/sarafotoxin-induced increase of the proliferation of undifferentiated and DMSO-differentiated GEM-81 goldfish erythrophoroma cells is mediated by ETB receptors. Pigment cell research 20041001
Endothelin-B-receptor-selective antagonist inhibits endothelin-1 induced potentiation on the vasoconstriction to noradrenaline and angiotensin II. Journal of hypertension 20041001
Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism. Journal of the American Society of Nephrology : JASN 20041001
Association of endothelin with lung hemorrhage induced by immune complexes in rats. Inflammation 20041001
Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. European journal of pharmacology 20040913
Endothelin-3 induced mesenteric vasoconstriction and PMN infiltration in the rat small intestine: role of endothelin receptors. Regulatory peptides 20040615
Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide. British journal of clinical pharmacology 20040601
Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation. Acta physiologica Scandinavica 20040601
Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20040501
Modulatory effect of endothelin-1 and -3 on neuronal norepinephrine release in the rat posterior hypothalamus. Regulatory peptides 20040415
ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo. American journal of physiology. Heart and circulatory physiology 20040401
Intraportal nicotine infusion in rats decreases hepatic blood flow through endothelin-1 and both endothelin A and endothelin B receptors. Toxicology and applied pharmacology 20040401
Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats. European journal of clinical investigation 20040401
Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice. Cellular and molecular neurobiology 20040401
Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors. Regulatory peptides 20040315
Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats. Diabetes research and clinical practice 20040301
Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery. European journal of pharmacology 20040223
Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice. British journal of pharmacology 20040201
Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats. British journal of pharmacology 20040201
Inward current oscillation underlying tonic contraction caused via ETA receptors in pig detrusor smooth muscle. American journal of physiology. Renal physiology 20040101
Stimulation of NHE3 in OKP cells by an autocrine mechanism. Nephron. Experimental nephrology 20040101
In-vivo interaction of nitric oxide and endothelin. Journal of hypertension 20040101
Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. Circulation research 20031212
Endothelin-like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague Dawley rats. Methods and findings in experimental and clinical pharmacology 20031201
Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1. American journal of physiology. Endocrinology and metabolism 20030801
Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice. American journal of physiology. Heart and circulatory physiology 20030701
Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin. The Journal of physiology 20030615
Endothelin ET(A) but not ET(B) receptors mediate contraction of common bile duct. Regulatory peptides 20030515
Endothelin-1 directly modulates its own secretion: studies utilising the cell immunoblot technique. Regulatory peptides 20030515
Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro. Hypertension (Dallas, Tex. : 1979) 20030501
Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology 20030401
Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs. European journal of pharmacology 20030328
Will endothelin receptor antagonists have a role in heart failure? The Medical clinics of North America 20030301
Effect of endothelin-1 (1-31) on the renal resistance vessels. The journal of medical investigation : JMI 20030201
Evidence for the involvement of ET(B) receptors in ET-1-induced changes in blood flow to the rat breast tumor. Cancer chemotherapy and pharmacology 20030101
ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels. Journal of cardiovascular pharmacology 20030101
Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism and high-to-normal renin hypertension. Cardiovascular research 20030101
Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia. Acta radiologica (Stockholm, Sweden : 1987) 20030101
Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach. Journal of pharmacological sciences 20030101
Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat. Stroke 20021201
Role of endothelin type B receptor in NO/cGMP signaling pathway in rat median eminence. Cellular and molecular neurobiology 20021201
Mechanism of endothelin-1-induced cytosolic Ca(2+) mobility in cultured H9c2 myocardiac ventricular cells. Cellular signalling 20021001
Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation 20021001
Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro. Pharmacological research 20021001
Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. The Journal of endocrinology 20021001
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death. Brain research 20020906
The vascular endothelin system is not overactive in normotensive hemodialysis patients. Kidney international 20020901
Endothelin-1 receptor antagonists reduce cardiac electrical instability induced by high glucose in rats. Naunyn-Schmiedeberg's archives of pharmacology 20020901
Mechanism of RhoA/Rho kinase activation in endothelin-1- induced contraction in rabbit basilar artery. American journal of physiology. Heart and circulatory physiology 20020901
Endothelin-1 and -3 diminish neuronal NE release through an NO mechanism in rat anterior hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology 20020901
Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. European journal of immunology 20020901
Possible mechanism of endothelin-induced Ca2+ mobility in A7r5 cultured vascular smooth muscle cells. The Kaohsiung journal of medical sciences 20020901
Local administration of ETA (but not ETB) blockers into the PAG area of the brain decreases blood pressure of DOCA-salt rats. Naunyn-Schmiedeberg's archives of pharmacology 20020801
Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. Pharmacogenetics 20020801
Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ET(B) receptors in the guinea pig perfused lung. Clinical science (London, England : 1979) 20020801
Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet. Clinical science (London, England : 1979) 20020801
Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl. Clinical science (London, England : 1979) 20020801
Two classes of endothelin receptors mediating contraction in esophageal muscularis mucosae. Regulatory peptides 20020530
Endothelin B receptor-mediated regulation of endothelin-1 content and release in cultured porcine aorta endothelial cell. Journal of cardiovascular pharmacology 20020501
Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats. Journal of hypertension 20020401
A novel bioactive 31-amino acid ET-1 peptide stimulates eosinophil recruitment and increases the levels of eotaxin and IL-5. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401
Mechanisms transducing the aldosterone secretagogue signal of endothelins in the human adrenal cortex. Peptides 20020301
Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro. Journal of gastroenterology and hepatology 20020301
Role of endothelin ET(A)- and ET(B)-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats. British journal of pharmacology 20020201
Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation 20020129
Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth. The Journal of clinical endocrinology and metabolism 20020101
Coronary and femoral arterial contraction with high glucose, insulin, and glucose-insulin-potassium solution: effects of hypoxia. Heart and vessels 20020101
Functional cross-talk of Ca2+-mobilizing endothelin receptors in C6 glioma cells. Physiological research 20020101
Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons. Neuroreport 20011204
Endothelin resets renal blood flow autoregulatory efficiency during acute blockade of NO in the rat. American journal of physiology. Renal physiology 20011201
Myocardial contractile responsiveness to endothelin-1 in the post-infarction rat model of heart failure: effects of chronic quinapril. Journal of molecular and cellular cardiology 20011101
Endothelin-1 induces contraction of human and Australian possum gallbladder in vitro. Regulatory peptides 20011015
Endothelin receptor blockade and nitric oxide bioactivity. Cardiovascular research 20011001
The effect of endothelin-1 on nuclear factor kappa B in macrophages. Biochemical and biophysical research communications 20010907
High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism. American journal of physiology. Cell physiology 20010901
Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice. Hypertension (Dallas, Tex. : 1979) 20010901
Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man. British journal of clinical pharmacology 20010801
Differential desensitization of Ca2+ mobilization and vasoconstriction by ET(A) receptors in the gerbil spiral modiolar artery. The Journal of membrane biology 20010801
The role of endothelin-B receptors in myocardial and endothelial reperfusion injury after heart transplantation. The Thoracic and cardiovascular surgeon 20010601
A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes. American journal of physiology. Regulatory, integrative and comparative physiology 20010501
Endothelin receptors in human and guinea-pig gallbladder muscle. Regulatory peptides 20010420
Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin. The Journal of pharmacology and experimental therapeutics 20010401
Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats. Hepatology (Baltimore, Md.) 20010401
Endothelin B receptor-mediated protection against anoxia-reoxygenation injury in perfused rat liver: nitric oxide-dependent and -independent mechanisms. Hepatology (Baltimore, Md.) 20010401
Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart. Circulation 20010320
Potentiation by endothelin-1 of vasoconstrictor response in stroke-prone spontaneously hypertensive rats. European journal of pharmacology 20010309
Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex. International journal of molecular medicine 20010301
Inhibition of Na(+)/K(+)-atpase by endothelin-1 in human nonpigmented ciliary epithelial cells. The Journal of pharmacology and experimental therapeutics 20010301
Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells. The American journal of pathology 20010301
Endothelin-1-induced potentiation of adrenergic responses in the rabbit pulmonary artery: role of thromboxane A(2). European journal of pharmacology 20010216
Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function. The Journal of clinical endocrinology and metabolism 20010201
Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits. Journal of neurosurgery 20010201
Endothelin receptor blockade improves endothelial function in human internal mammary arteries. Cardiovascular research 20010101
Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes. Journal of the American College of Cardiology 20001001
Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus. British journal of pharmacology 19990701
Characterization of the binding of endothelin ETB selective ligands in human and rat heart. British journal of pharmacology 19961001
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