Home Other Building Blocks Hydrazine, (2-phenylethyl)-, sulfate (1:1)

Hydrazine, (2-phenylethyl)-, sulfate (1:1)

CAS No.:
156-51-4
Catalog Number:
AG001OF3
Molecular Formula:
C8H14N2O4S
Molecular Weight:
234.2728
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
≥98%
1 week
United States
$147
- +
500mg
≥98%
1 week
United States
$193
- +
1g
≥98%
1 week
United States
$310
- +
Product Description
Catalog Number:
AG001OF3
Chemical Name:
Hydrazine, (2-phenylethyl)-, sulfate (1:1)
CAS Number:
156-51-4
Molecular Formula:
C8H14N2O4S
Molecular Weight:
234.2728
MDL Number:
MFCD00050687
IUPAC Name:
2-phenylethylhydrazine;sulfuric acid
InChI:
InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
InChI Key:
RXBKMJIPNDOHFR-UHFFFAOYSA-N
SMILES:
OS(=O)(=O)O.NNCCc1ccccc1
EC Number:
205-856-0
UNII:
2681D7P965
Properties
Complexity:
159  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
234.067g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
234.27g/mol
Monoisotopic Mass:
234.067g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
121A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction. Chemico-biological interactions 20150325
A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS chemical biology 20140620
Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-κB pathway in lipopolysaccharide-activated microglia cells. Neurochemical research 20121001
Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors. Journal of biomolecular screening 20120801
Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120801
The antidepressant phenelzine enhances memory in the double Y-maze and increases GABA levels in the hippocampus and frontal cortex of rats. Pharmacology, biochemistry, and behavior 20120701
The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE). Brain, behavior, and immunity 20111101
Could monoamine oxidase inhibitors promote asystole in electroconvulsive therapy patients? The journal of ECT 20110901
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS pathogens 20110801
The effect of riluzole augmentation in a patient with treatment-resistant obsessive-compulsive disorder, taking two other glutaminergic agents. The Journal of neuropsychiatry and clinical neurosciences 20110101
Phenelzine-induced myocardial injury: a case report. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
The antidepressant phenelzine protects neurons and astrocytes against formaldehyde-induced toxicity. Journal of neurochemistry 20100901
A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Archives of general psychiatry 20100301
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics. Pharmacology, biochemistry, and behavior 20100201
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. The American journal of pathology 20091001
Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression. Brain research 20090908
Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area. The international journal of neuropsychopharmacology 20090501
Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090501
Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes. Molecular pharmacology 20090501
[Irreversible, non-selective monoamine oxidase inhibitors]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20090416
Protective effect of tamoxifen, a synthetic non-steroidal antiestrogen, on phenelzine and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum. Research communications in molecular pathology and pharmacology 20090101
Differential effects of imipramine and phenelzine on corticosteroid receptor gene expression in mouse brain: potential relevance to antidepressant response. Brain research 20081031
Serotonin syndrome and the T102-->C polymorphism of the 5-HT2A receptor: a case report. Bipolar disorders 20080701
Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors. Pharmacological research 20080601
Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain research 20080523
Neurochemical effects of the monoamine oxidase inhibitor phenelzine on brain GABA and alanine: A comparison with vigabatrin. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080516
Modulation of dopaminergic neurotransmission in rat striatum upon in vitro and in vivo diclofenac treatment. Journal of neurochemistry 20080401
Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition. Neurochemical research 20080301
Acute myocarditis after massive phenelzine overdose. European journal of clinical pharmacology 20071101
The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats. Behavioural pharmacology 20071101
Not all monoamine oxidase inhibitors are created equal. Journal of the American Geriatrics Society 20071101
Efficacy and safety of antidepressant monotherapy in the treatment of bipolar-II depression. International clinical psychopharmacology 20070901
Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders? Journal of psychiatry & neuroscience : JPN 20070901
Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial. The Journal of clinical psychiatry 20070801
Treating DSM-IV depression with atypical features. The Journal of clinical psychiatry 20070401
Successful use of phenelzine in treatment-resistant panic disorder. The Journal of clinical psychiatry 20070201
Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator. Cold Spring Harbor symposia on quantitative biology 20070101
Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs. Anesthesia and analgesia 20061201
Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine. Brain research 20061129
Increased nicotine self-administration following prenatal exposure in female rats. Pharmacology, biochemistry, and behavior 20061101
Sustained effects of phenelzine and tranylcypromine on orthostatic challenge in antidepressant-refractory depression. Journal of clinical psychopharmacology 20061001
Tamoxifen protect against hydroxyl radical generation induced by phenelzine in rat striatum. Toxicology 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Leading the way: advances in the diagnosis, treatment, and management of neuropsychiatric illnesses. CNS spectrums 20060501
Transdermal selegiline: the new generation of monoamine oxidase inhibitors. CNS spectrums 20060501
An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. British journal of clinical pharmacology 20060501
Quetiapine for insomnia associated with refractory depression exacerbated by phenelzine. The Annals of pharmacotherapy 20060301
Treatment of depression with atypical features: a meta-analytic approach. Psychiatry research 20060130
Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone. Neuroscience 20060101
Screening antidepressants in the chick separation-stress paradigm. Psychopharmacology 20050801
Inhibition of monoamine oxidase-A activity in rat brain by synthetic hydrazines: structure-activity relationship (SAR). Journal of enzyme inhibition and medicinal chemistry 20050601
Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression. Endocrinology 20050301
Validity of sudden gains in acute phase treatment of depression. Journal of consulting and clinical psychology 20050201
Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. BMC pharmacology 20050101
Shy-Drager syndrome: multisystem atrophy with comorbid depression. Psychosomatics 20050101
In vivo evidence for reduced cortical glutamate-glutamine cycling in rats treated with the antidepressant/antipanic drug phenelzine. Neuroscience 20050101
Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients. The Journal of clinical psychiatry 20041101
Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus. Biochemical pharmacology 20041015
Modafinil augmentation of phenelzine for residual fatigue in dysthymia. The American journal of psychiatry 20040901
Coadministration of phenelzine and methylphenidate for treatment-resistant depression. The Annals of pharmacotherapy 20040301
Antioxidant effect of phenelzine on MPP+-induced cell viability loss in differentiated PC12 cells. Neurochemical research 20031201
Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants. Molecular psychiatry 20031101
[Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]. Nederlands tijdschrift voor geneeskunde 20031004
Comparing depression treatments. The American journal of psychiatry 20030601
Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. Journal of sleep research 20030301
Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine. European journal of pharmacology 20030117
Phenelzine efficacy in refractory social anxiety disorder: a case series. Nordic journal of psychiatry 20030101
Pharmacological treatment of social anxiety disorder: a meta-analysis. Depression and anxiety 20030101
Phenelzine treatment increases transcription factor AP-2 levels in rat brain. BMC pharmacology 20030101
Selective mutism: a review of the concept and treatment. The Israel Medical Association journal : IMAJ 20021201
Different effects of phenelzine treatment on EEG topography in waking and sleep in depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020901
Remission in major depressive disorder: a comparison of pharmacotherapy, psychotherapy, and control conditions. The American journal of psychiatry 20020801
Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice. Journal of psychiatry & neuroscience : JPN 20020501
Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum. Biochemical pharmacology 20020101
The management of panic disorder. The Journal of clinical psychiatry 20020101
Effect of chronic phenelzine treatment on REM sleep: report of three patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents. Bioorganic & medicinal chemistry letters 20011022
Effects of the antidepressant/antipanic drug phenelzine on alanine and alanine transaminase in rat brain. Cellular and molecular neurobiology 20010801
Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression. Molecular psychiatry 20010701
The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat. Pflugers Archiv : European journal of physiology 20010701
Application of capillary electrophoresis with laser-induced fluorescence detection to the determination of biogenic amines and amino acids in brain microdialysate and homogenate samples. Journal of chromatography. A 20010420
Animal models for the study of antidepressant activity. Brain research. Brain research protocols 20010401
Sleep and sleep electroencephalogram in depressed patients treated with phenelzine. Archives of general psychiatry 20010301
Social phobia: etiology, neurobiology, and treatment. The Journal of clinical psychiatry 20010101
Current status of psychotherapeutic interventions for social phobia. The Journal of clinical psychiatry 20010101
Treatment of social phobia with antidepressants. The Journal of clinical psychiatry 20010101
Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression. Depression and anxiety 20010101
Changes in vesicular monoamine transporter (VMAT2) and synaptophysin in rat Substantia nigra and prefrontal cortex induced by psychotropic drugs. Neuropsychobiology 20010101
Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience 19991201
[Clinical case of the month. Mental confusion due to the administration of tramadol in a patient treated with MOAI]. Revue medicale de Liege 19991201
Seizures in a diabetic patient on monoamine oxidase inhibitors. The American journal of emergency medicine 19990101
Phenelzine-induced sexual dysfunction treated with sildenafil. Journal of sex & marital therapy 19990101
Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports. Neurology 19980701
Stroke resulting from a rapid switch from phenelzine to tranylcypromine. The Journal of clinical psychiatry 19980701
Serotonin syndrome secondary to phenelzine-venlafaxine interaction. Pharmacotherapy 19980101
Seizure resulting from a venlafaxine overdose. The Annals of pharmacotherapy 19970201
Phenelzine-induced fulminant hepatic failure. Annals of internal medicine 19960401
Serotonin syndrome induced by administration of venlafaxine and phenelzine. The Annals of pharmacotherapy 19960101
Extreme suicidality following serotonin syndrome. The British journal of psychiatry : the journal of mental science 19950901
Phenelzine and venlafaxine interaction. The American journal of psychiatry 19950901
Monoamine oxidase inhibitors and sleep movements. The American journal of psychiatry 19940501
Dose-related visual hallucinations in macular degeneration patients receiving phenelzine. The American journal of psychiatry 19940301
Hypertensive episode associated with phenelzine and tap beer--a reanalysis of the role of pressor amines in beer. Journal of clinical psychopharmacology 19940201
Depression after cyproheptadine: MAO treatment. Biological psychiatry 19920601
Possible interaction between an MAOI and 'ecstasy'. The American journal of psychiatry 19920301
The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain research 19920214
Abuse of monoamine oxidase inhibitors. The American journal of drug and alcohol abuse 19920101
Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats. Oncology research 19920101
Phenelzine associated peripheral neuropathy--clinical and electrophysiologic findings. Australian and New Zealand journal of medicine 19910601
Outcome and clinical course in inpatient bulimic women: a 2- to 9-year follow-up study. The Journal of clinical psychiatry 19910601
Delayed excitatory reaction following interaction of cocaine and monoamine oxidase inhibitor (phenelzine). British journal of anaesthesia 19910401
Drug interaction. Hospital & community psychiatry 19900701
Case of delirium secondary to phenelzine/L-tryptophan combination. The Journal of clinical psychiatry 19900701
Adverse consequences of fluoxetine-MAOI combination therapy. The Journal of clinical psychiatry 19900601
Acute dystonic reaction induced by a monoamine oxidase inhibitor. Journal of clinical psychopharmacology 19900401
MAOI-induced hypersomnia in patients with bulimia. The American journal of psychiatry 19890801
Phenelzine-associated inappropriate ADH secretion. Journal of clinical psychopharmacology 19890801
The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients. International psychogeriatrics 19890101
Common side effects associated with monoamine oxidase inhibitors. Progress in neuro-psychopharmacology & biological psychiatry 19890101
Mania associated with high percentage of inhibition of monoamine oxidase. The American journal of psychiatry 19890101
Bradycardia induced by an interaction between phenelzine and beta blockers. Psychosomatics 19890101
Severe daytime somnolence in patients treated with an MAOI. The American journal of psychiatry 19881201
Drug-induced catatonia. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19881001
Phenelzine vs placebo in 50 patients with bulimia. Archives of general psychiatry 19880501
Sexual dysfunction related to alprazolam treatment of social phobia. The American journal of psychiatry 19880401
Is monoamine oxidase inhibitor induced myoclonus serotoninergically mediated? Journal of neural transmission 19880101
A placebo-controlled comparison of the effect of nortriptyline and phenelzine on orthostatic hypotension in elderly depressed patients. Journal of clinical psychopharmacology 19871201
Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment. Clinical neuropharmacology 19871201
Possible toxic interaction between cyproheptadine and phenelzine. The American journal of psychiatry 19870901
Myoclonus and episodic delirium associated with phenelzine: a case report. The Journal of clinical psychiatry 19870801
The Newcastle chronic depression study: results of a treatment regime. International clinical psychopharmacology 19870701
Spontaneous remission of MAOI-induced anorgasmia. The American journal of psychiatry 19870601
Hypomania related to phenelzine and isoetharine interaction in one patient. The Journal of clinical psychiatry 19870401
Anorgasmia caused by an MAOI. The American journal of psychiatry 19870401
Myoclonic seizures after abrupt withdrawal from phenelzine and alprazolam. The Journal of nervous and mental disease 19870201
Comparative efficacy and safety of MAOIs versus TCAs in treating depression in the elderly. Biological psychiatry 19861001
Phenelzine induced grand mal seizure. The British journal of clinical practice 19860401
Parkinsonism induced by a monoamine oxidase inhibitor. Postgraduate medical journal 19860301
Urinary amine metabolite excretion in a patient with adrenergic hyperactivity state: reaction to phenelzine withdrawal and combined treatment. The Journal of clinical psychiatry 19860201
Two cases of hypomania following the addition of L-tryptophan to a monoamine oxidase inhibitor. The American journal of psychiatry 19851201
Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine-tryptophan combination treatment. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19851001
Phenelzine-induced hypomania: effect of verapamil. Biological psychiatry 19850901
Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan. The American journal of psychiatry 19850401
Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management. Journal of clinical psychopharmacology 19850201
Acute psychosis following phenelzine discontinuation. Journal of clinical psychopharmacology 19850201
Possible interaction between pheneizine and amantadine. Archives of general psychiatry 19840701
Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics. Journal of the Royal Society of Medicine 19840401
Case report of a toxic reaction from a combination of tryptophan and phenelzine. The American journal of psychiatry 19840201
The treatment of phenelzine-induced hypotension with salt tablets: case report. The Journal of clinical psychiatry 19840201
Parkinsonian side effects induced by a monoamine oxidase inhibitor. The American journal of psychiatry 19840101
MAOIs, anorgasmia, and weight gain. The American journal of psychiatry 19830901
Adverse reactions to abrupt discontinuation of phenelzine. Journal of clinical psychopharmacology 19830601
Pure motor hemiplegia associated with phenelzine use. IMJ. Illinois medical journal 19830401
Anorgasmia caused by MAOIs. The American journal of psychiatry 19830401
Interaction of phenelzine and sulfisoxazole. The American journal of psychiatry 19830201
More cases of anorgasmia after MAOI treatment. The American journal of psychiatry 19830201
Combination monoamine oxidase inhibitor/tricyclic antidepressants interaction. Lancet (London, England) 19820821
Cardiovascular effects of phenelzine and amitriptyline in depressed outpatients. The Journal of clinical psychiatry 19820501
Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients. Archives of general psychiatry 19820501
MAOI-induced rapid cycling bipolar affective disorder in an adolescent. The American journal of psychiatry 19810501
Ejaculatory impairment from both phenelzine and imipramine, with tinnitus from phenelzine. Journal of clinical psychopharmacology 19810501
Angiosarcoma of liver associated with phenelzine. British medical journal 19790623
Clinical consequences of polymorphic acetylation of basic drugs. Clinical pharmacology and therapeutics 19770901
Pharmacological and biochemical studies with three metabolites of nomifensine. Psychopharmacology 19770131
Tumorigenicity of beta-phenylethylhydrazine sulfate in mice. Cancer research 19760301
Letter: Withdrawal symptoms after stopping phenelzine? British medical journal 19740511
A study of refractory cases of depressive illnesses and their response to combined antidepressant treatment. The British journal of psychiatry : the journal of mental science 19740301
The mechanism of the potentiating effect of antidepressant drugs on the protective influenc oe of diphenhydramine in experimental catatonia. The role of histamine. Pharmacology 19740101
Adverse reactions to phenelzine: results of a nine-hospital depression study. The Journal of clinical pharmacology and new drugs 19720101
Treatment of intractable narcolepsy with a monoamine oxidase inhibitor. The New England journal of medicine 19711028
Tricyclic antidepressants and monoamine oxidase inhibitors. Archives of general psychiatry 19710601
Monoamine oxidase inhibitors and L-dopa. British medical journal 19700815
Low serum pseudocholinesterase levels complicating treatment with phenelzine. British medical journal 19690830
'Cold' cures and monoamine-oxidase inhibitors. British medical journal 19690329
Hypertension from cold remedies. British medical journal 19690329
Effects of a hydrazine monoamine oxidase inhibitor (phenelzine) on isoproterenol-induced myocardiopathies in the rat. The Journal of pharmacology and experimental therapeutics 19670901
Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats. Proceedings of the Western Pharmacology Society 19660101
Properties