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Home Other Building Blocks 2,6-Piperazinedione, 4,4'-(1,2-ethanediyl)bis-

2,6-Piperazinedione, 4,4'-(1,2-ethanediyl)bis-

CAS No.:
1506-47-4
Catalog Number:
AG001MR6
Molecular Formula:
C10H14N4O4
Molecular Weight:
254.2426
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Product Description
Catalog Number:
AG001MR6
Chemical Name:
2,6-Piperazinedione, 4,4'-(1,2-ethanediyl)bis-
CAS Number:
1506-47-4
Molecular Formula:
C10H14N4O4
Molecular Weight:
254.2426
MDL Number:
MFCD00446913
IUPAC Name:
4-[2-(3,5-dioxopiperazin-1-yl)ethyl]piperazine-2,6-dione
InChI:
InChI=1S/C10H14N4O4/c15-7-3-13(4-8(16)11-7)1-2-14-5-9(17)12-10(18)6-14/h1-6H2,(H,11,15,16)(H,12,17,18)
InChI Key:
GBLIGNUYGOFIKS-UHFFFAOYSA-N
SMILES:
O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1
UNII:
QML51S42CD
NSC Number:
129942
Properties
Complexity:
339  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
254.102g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
254.246g/mol
Monoisotopic Mass:
254.102g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
98.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.8  
Literature
Title Journal
Antimetastatic activities and mechanisms of bisdioxopiperazine compounds. Anti-cancer agents in medicinal chemistry 20100901
A mouse model for studying the interaction of bisdioxopiperazines with topoisomerase IIalpha in vivo. Molecular pharmacology 20071001
Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II. Biochemical and biophysical research communications 20050902
Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase II alpha. Molecular pharmacology 20030501
Evidence from studies with intact mammalian cells that merbarone and bis(dioxopiperazine)s are topoisomerase II poisons. Drug and chemical toxicology 20030201
The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Experimental hematology 20021101
Properties