Home Carbonyls D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-

D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-

CAS No.:
150378-17-9
Catalog Number:
AG001MJU
Molecular Formula:
C36H47N5O4
Molecular Weight:
613.7895
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%(HPLC)powder
In Stock USA
United States
$150
- +
25mg
98%(HPLC)powder
In Stock USA
United States
$384
- +
100mg
98%(HPLC)powder
In Stock USA
United States
$1111
- +
Product Description
Catalog Number:
AG001MJU
Chemical Name:
D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-
CAS Number:
150378-17-9
Molecular Formula:
C36H47N5O4
Molecular Weight:
613.7895
MDL Number:
MFCD00866938
IUPAC Name:
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
InChI:
InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1
InChI Key:
CBVCZFGXHXORBI-PXQQMZJSSA-N
SMILES:
O[C@H](CN1CCN(C[C@H]1C(=O)NC(C)(C)C)Cc1cccnc1)C[C@H](C(=O)N[C@@H]1[C@H](O)Cc2c1cccc2)Cc1ccccc1
UNII:
9MG78X43ZT
Properties
Complexity:
952  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
613.363g/mol
Formal Charge:
0
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
613.803g/mol
Monoisotopic Mass:
613.363g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
118A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
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Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection. Clinical chemistry 20090101
Pharmacokinetic study of the variability of indinavir drug levels when boosted with ritonavir in HIV-infected children. Pharmacology 20090101
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HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis. PloS one 20090101
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A randomized, controlled trial of initial anti-retroviral therapy with abacavir/lamivudine/zidovudine twice-daily compared to atazanavir once-daily with lamivudine/zidovudine twice-daily in HIV-infected patients over 48 weeks (ESS100327, the ACTION Study). AIDS research and therapy 20090101
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Supporting children to adhere to anti-retroviral therapy in urban Malawi: multi method insights. BMC pediatrics 20090101
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Management of invasive aspergillosis in patients with COPD: rational use of voriconazole. International journal of chronic obstructive pulmonary disease 20090101
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Vertebral compression fractures in an HIV-positive patient with steroid-induced Cushing syndrome: a case report. Cases journal 20090101
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Quantifying the treatment efficacy of reverse transcriptase inhibitors: new analyses of clinical data based on within-host modeling. BMC public health 20090101
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German-Austrian recommendations for HIV1-therapy in pregnancy and in HIV1-exposed newborn, update 2008. European journal of medical research 20090101
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Combination antiretroviral drugs in PLGA nanoparticle for HIV-1. BMC infectious diseases 20090101
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Conivaptan and its role in the treatment of hyponatremia. Drug design, development and therapy 20090101
Disfiguring molluscum contagiosum in a HIV-positive patient responding to antiretroviral therapy. Indian journal of dermatology 20090101
A comprehensive review of immunosuppression used for liver transplantation. Journal of transplantation 20090101
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Short and Long-Term Incidence of Tuberculosis and CD4-Cell Count Dynamic on HAART in Senegal. The open AIDS journal 20090101
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An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients. Therapeutic drug monitoring 20081201
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Using AutoDock for ligand-receptor docking. Current protocols in bioinformatics 20081201
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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry 20081009
Trends in the prescription of antiretroviral drugs and impact on plasma HIV-RNA measurements. The Journal of antimicrobial chemotherapy 20081001
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Impedance method for detecting HIV-1 protease and screening for its inhibitors using ferrocene-peptide conjugate/Au nanoparticle/single-walled carbon nanotube modified electrode. Analytical chemistry 20080915
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The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis. AIDS (London, England) 20080912
Kinetics and mechanism of the hydrolytic degradation of indinavir: intramolecular catalysis. Journal of pharmaceutical sciences 20080901
A survey of the syntheses of active pharmaceutical ingredients for antiretroviral drug combinations critical to access in emerging nations. Antiviral research 20080901
Automated molecular simulation based binding affinity calculator for ligand-bound HIV-1 proteases. Journal of chemical information and modeling 20080901
A study of the analytical behaviour of selected new molecular entities using electrospray ionisation ion trap mass spectrometry, liquid chromatography, gas chromatography and polarography and their determination in serum at therapeutic concentrations. Analytica chimica acta 20080815
No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080815
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance. Journal of medicinal chemistry 20080814
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Pharmacokinetics and therapeutic drug monitoring of antiretrovirals in pregnant women. British journal of clinical pharmacology 20080801
Prevalence of possible drug-drug interactions between antiretroviral agents in different age groups in a section of the private health care sector setting in South Africa. Journal of clinical pharmacy and therapeutics 20080801
Determination of unbound antiretroviral drug concentrations by a modified ultrafiltration method reveals high variability in the free fraction. Therapeutic drug monitoring 20080801
The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones? The European journal of neuroscience 20080801
Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy. Journal of Korean medical science 20080801
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The Relationship Between HIV Infection and Cardiovascular Disease. Current cardiology reviews 20080801
Recombinant protein of heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro. Virology 20080720
Synthesis and in vitro biological evaluation of valine-containing prodrugs derived from clinically used HIV-protease inhibitors. European journal of medicinal chemistry 20080701
Cellular accumulation of cholyl-glycylamido-fluorescein in sandwich-cultured rat hepatocytes: kinetic characterization, transport mechanisms, and effect of human immunodeficiency virus protease inhibitors. Drug metabolism and disposition: the biological fate of chemicals 20080701
A study of seven rule-based algorithms for the interpretation of HIV-1 genotypic resistance data in Thailand. Journal of virological methods 20080701
Quantitative analysis of antiretroviral drugs in lysates of peripheral blood mononuclear cells using MALDI-triple quadrupole mass spectrometry. Analytical chemistry 20080701
Profiling resistance-related mutations in the protease region of the pol gene: single genome sequencing of HIV in plasma and peripheral blood mononuclear cells. AIDS research and human retroviruses 20080701
Improved synthesis and pharmacological evaluation of racemic 11 -demethylcalanolide A. Yao xue xue bao = Acta pharmaceutica Sinica 20080701
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
Evaluation of thermal stability of indinavir sulphate using diffuse reflectance infrared spectroscopy. Journal of pharmaceutical and biomedical analysis 20080609
Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus. British journal of cancer 20080603
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[Bilateral papillary necrosis during indinavir treatment]. Presse medicale (Paris, France : 1983) 20080601
Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia. Pharmacology, biochemistry, and behavior 20080601
Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrobial agents and chemotherapy 20080601
Effects of HIV antiretrovirals on the pharmacokinetics of hormonal contraceptives. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20080601
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Atriplatrade mark - HIV therapy in one pill. Therapeutics and clinical risk management 20080601
Renal manifestations in HIV-infected Jamaican children. The West Indian medical journal 20080601
Analysis of correlated mutations in HIV-1 protease using spectral clustering. Bioinformatics (Oxford, England) 20080515
Quantitative analysis of HIV-1 protease inhibitors in cell lysates using MALDI-FTICR mass spectrometry. Analytical chemistry 20080515
Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis. Journal of ethnopharmacology 20080508
Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus. British journal of clinical pharmacology 20080501
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Determination of clinically relevant cutoffs for HIV-1 phenotypic resistance estimates through a combined analysis of clinical trial and cohort data. Journal of acquired immune deficiency syndromes (1999) 20080501
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Acute human immunodeficiency virus syndrome presenting with hemophagocytic lymphohistiocytosis. Yonsei medical journal 20080430
Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. Journal of computational chemistry 20080415
Chloropupukeananin, the first chlorinated pupukeanane derivative, and its precursors from Pestalotiopsis fici. Organic letters 20080403
Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742. Antimicrobial agents and chemotherapy 20080401
Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use. Chemical biology & drug design 20080401
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Association of antiretroviral therapy with fibrinogen levels in HIV-infection. AIDS (London, England) 20080330
Pharmacokinetic interaction between efavirenz and dual protease inhibitors in healthy volunteers. Biopharmaceutics & drug disposition 20080301
HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. American journal of physiology. Endocrinology and metabolism 20080301
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Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301
Drug-induced crystal nephropathy: an update. Expert opinion on drug safety 20080301
Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. The AAPS journal 20080301
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic. Journal of medicinal chemistry 20080227
pH-dependent interactions of indinavir and lipids in nanoparticles and their ability to entrap a solute. Journal of pharmaceutical sciences 20080201
An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection. Journal of mass spectrometry : JMS 20080201
Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure. Bioorganic & medicinal chemistry 20080201
Prevalence of chronic kidney disease in an urban HIV infected population. The American journal of the medical sciences 20080201
HIV therapy, metabolic syndrome, and cardiovascular risk. Current atherosclerosis reports 20080201
Indinavir-associated toxicity mimicking urinary tuberculosis in a patient with AIDS. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20080201
Therapeutic options for chronic myeloid leukemia: focus on imatinib (Glivec, Gleevectrade mark). Therapeutics and clinical risk management 20080201
The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease. Biochemistry 20080115
Efficacy and tolerability of long-term efavirenz plus nucleoside reverse transcriptase inhibitors for HIV-1 infection. AIDS (London, England) 20080111
Unmeasured confounding caused slightly better response to HAART within than outside a randomized controlled trial. Journal of clinical epidemiology 20080101
Acquired reactive perforating collagenosis induced by indinavir in 2 patients with HIV disease. European journal of dermatology : EJD 20080101
Pharmacokinetics of an indinavir-ritonavir-fosamprenavir regimen in patients with human immunodeficiency virus. Pharmacotherapy 20080101
Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Archives of virology 20080101
Oral adverse effects due to the use of Nevirapine. The journal of contemporary dental practice 20080101
Drug interactions between HIV protease inhibitors and acid-reducing agents. Clinical pharmacokinetics 20080101
Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience. HIV clinical trials 20080101
Application of rat in situ single-pass intestinal perfusion in the evaluation of presystemic extraction of indinavir under different perfusion rates. Journal of the Formosan Medical Association = Taiwan yi zhi 20080101
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Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report. Annals of clinical microbiology and antimicrobials 20080101
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Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement. Journal of neurovirology 20080101
Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir. BMC neuroscience 20080101
Dangerous medicines: unproven AIDS cures and counterfeit antiretroviral drugs. Globalization and health 20080101
Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy. Retrovirology 20080101
Infection of semen-producing organs by SIV during the acute and chronic stages of the disease. PloS one 20080101
High grade B-cell gastric lymphoma with complete pathologic remission after eradication of Helicobacter pylori infection: report of a case and review of the literature. World journal of surgical oncology 20080101
Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Molecular pain 20080101
Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT. AIDS research and therapy 20080101
Proteochemometric modeling of HIV protease susceptibility. BMC bioinformatics 20080101
[Urinary lithiasis secondary to medication in HIV+ patients receiving Indinavir]. Archivos espanoles de urologia 20080101
Cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in HIV-positive patients in the HAART era. PloS one 20080101
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Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. Journal of Asian natural products research 20080101
Pharmacokinetic monitoring of HIV-1 protease inhibitors in the antiretroviral therapy. Acta poloniae pharmaceutica 20080101
An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. PloS one 20080101
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Clinically relevant safety issues associated with St. John's wort product labels. BMC complementary and alternative medicine 20080101
Clinical drugs that interact with St. John's wort and implication in drug development. Current pharmaceutical design 20080101
Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome. Indian journal of ophthalmology 20080101
Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir. BMC complementary and alternative medicine 20080101
Beneficial effects of HIV peptidase inhibitors on Fonsecaea pedrosoi: promising compounds to arrest key fungal biological processes and virulence. PloS one 20080101
High risk for occupational exposure to HIV and utilization of post-exposure prophylaxis in a teaching hospital in Pune, India. BMC infectious diseases 20080101
Outcome of protease inhibitor substitution with nevirapine in HIV-1 infected children. BMC infectious diseases 20080101
A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method. Drug metabolism and pharmacokinetics 20080101
25 years of HIV-1 research - progress and perspectives. BMC medicine 20080101
Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters. Journal of biopharmaceutical statistics 20080101
Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report. Journal of medical case reports 20080101
Three generic nevirapine-based antiretroviral treatments in Chinese HIV/AIDS patients: multicentric observation cohort. PloS one 20080101
The experiential health information processing model: supporting collaborative web-based patient education. BMC medical informatics and decision making 20080101
PocketMatch: a new algorithm to compare binding sites in protein structures. BMC bioinformatics 20080101
Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults. PloS one 20080101
Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo. Retrovirology 20080101
Cell engineering and molecular pharming for biopharmaceuticals. The open medicinal chemistry journal 20080101
Determinants of Treatment Access in a Population-based Cohort of HIV-positive Men and Women Living in Argentina. Journal of the International AIDS Society 20080101
Raltegravir in the management of HIV-infected patients. Drug design, development and therapy 20080101
[Dietary recommendations with practical examples of menus for people living with HIV/AIDS in sub-Saharan Africa]. The Pan African medical journal 20080101
Determinants of retention in care in an antiretroviral therapy (ART) program in urban Cameroon, 2003-2005. The Pan African medical journal 20080101
Overview of boosted protease inhibitors in treatment-experienced HIV-infected patients. The Journal of antimicrobial chemotherapy 20071201
[Indinavir-associated tubulointerstitial renal disease]. Nephrologie & therapeutique 20071201
Initiating highly active antiretroviral therapy with newer protease inhibitors is associated with better survival compared to first-generation protease inhibitors or nevirapine. AIDS patient care and STDs 20071201
Obstructive uropathy in a HIV+ infant under indinavir treatment. Journal of pediatric urology 20071201
The SAEM algorithm for group comparison tests in longitudinal data analysis based on non-linear mixed-effects model. Statistics in medicine 20071130
HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115
Prevalence of chronic kidney disease in Chinese HIV-infected patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071101
Population pharmacokinetic analysis of lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART. European journal of clinical pharmacology 20071101
Pharmacokinetics of two randomized trials evaluating the safety and efficacy of indinavir, saquinavir and lopinavir in combination with low-dose ritonavir: the MaxCmin1 and 2 trials. Basic & clinical pharmacology & toxicology 20071101
Evolution of antiretroviral drug costs in Brazil in the context of free and universal access to AIDS treatment. PLoS medicine 20071101
An evolutionary-network model reveals stratified interactions in the V3 loop of the HIV-1 envelope. PLoS computational biology 20071101
Tipranavir: the first nonpeptidic protease inhibitor for the treatment of protease resistance. Clinical therapeutics 20071101
Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers. AIDS (London, England) 20071018
Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC 20071001
Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. Cell death and differentiation 20071001
Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors. The Journal of antimicrobial chemotherapy 20071001
HIV antiretroviral drug combination induces endothelial mitochondrial dysfunction and reactive oxygen species production, but not apoptosis. Toxicology and applied pharmacology 20071001
Maintenance of indinavir by dose adjustment in HIV-1-infected patients with indinavir-related toxicity. European journal of clinical pharmacology 20071001
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus. Bioorganic & medicinal chemistry letters 20071001
Prevalence and factors associated with dry skin in HIV infection: the FRAM study. AIDS (London, England) 20071001
A 84-month follow up of adherence to HAART in a cohort of adult Senegalese patients. Tropical medicine & international health : TM & IH 20071001
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. The Journal of biological chemistry 20070928
Antiretroviral drug dosing errors in HIV-infected patients undergoing hemodialysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070915
Anti-adenoviral effect of anti-HIV agents in vitro in serotypes inducing keratoconjunctivitis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070901
Minimal effect of MDR1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of indinavir in HIV-infected patients. British journal of clinical pharmacology 20070901
In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV. Antimicrobial agents and chemotherapy 20070901
Prevalence of and risk factors for HIV-associated neuropathy in Melbourne, Australia 1993-2006. HIV medicine 20070901
Mycobacterium avium complex infection presenting as an endobronchial mass in a patient with acquired immune deficiency syndrome. The Korean journal of internal medicine 20070901
[Three patients with indinavir-related urolithiasis]. Nederlands tijdschrift voor geneeskunde 20070818
Identification and characterization of an aspartyl protease from Cryptococcus neoformans. FEBS letters 20070807
Experience of indinavir/ritonavir 400/100 mg twice-daily highly active antiretroviral therapy-containing regimen in HIV-1-infected patients in Bamako, Mali: the NOGOMA Study. Journal of acquired immune deficiency syndromes (1999) 20070801
Hair loss induced by lopinavir-ritonavir. Pharmacotherapy 20070801
Identification of drugs that interact with herbs in drug development. Drug discovery today 20070801
Central nervous system distribution kinetics of indinavir in rats. The Journal of pharmacy and pharmacology 20070801
The renaissance of fixed dose combinations: Combivir. Therapeutics and clinical risk management 20070801
Review of tipranavir in the treatment of drug-resistant HIV. Therapeutics and clinical risk management 20070801
Comparison of indinavir + ritonavir 600 + 100 mg vs. 400 + 100 mg BID combinations in HIV1-infected patients guided by therapeutic drug monitoring. European journal of medical research 20070726
Forecast of demand for antiretroviral drugs in low and middle-income countries: 2007-2008. AIDS (London, England) 20070701
Optimal timing and duration of induction therapy for HIV-1 infection. PLoS computational biology 20070701
Alopecia induced by lopinavir plus ritonavir therapy in an HIV patient. Journal of drugs in dermatology : JDD 20070701
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The role of compartment penetration in PI-monotherapy: the Atazanavir-Ritonavir Monomaintenance (ATARITMO) Trial. AIDS (London, England) 20070619
Bayesian network analysis of resistance pathways against HIV-1 protease inhibitors. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070601
Doxorubicin cardiomyopathy via TLR-2 stimulation: potential for prevention using current anti-retroviral inhibitors such as ritonavir and nelfinavir. Hematological oncology 20070601
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro. Antimicrobial agents and chemotherapy 20070601
HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha + TSA. Biochemical pharmacology 20070601
Therapeutic issues in HIV/HCV-coinfected patients. Journal of viral hepatitis 20070601
Assessment of adverse events associated with antiretroviral regimens for postexposure prophylaxis for occupational and nonoccupational exposures to prevent transmission of human immunodeficiency virus. Infection control and hospital epidemiology 20070601
Indinavir/ritonavir remains an important component of HAART for the treatment of HIV/AIDS, particularly in resource-limited settings. Expert opinion on drug metabolism & toxicology 20070601
Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment. Infection 20070601
Antiretroviral Drug Levels and Interactions Affect Lipid, Lipoprotein, and Glucose Metabolism in HIV-1 Seronegative Subjects: A Pharmacokinetic-Pharmacodynamic Analysis. Metabolic syndrome and related disorders 20070601
Chronic renal failure among HIV-1-infected patients. AIDS (London, England) 20070531
A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS. Neurology 20070529
Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Nephrotoxicity of antiretroviral therapy in an HIV-infected patient. Kidney international 20070501
Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women. Journal of acquired immune deficiency syndromes (1999) 20070501
Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens. Journal of acquired immune deficiency syndromes (1999) 20070501
Indinavir: the forgotten HIV-protease inhibitor. Does it still have a role? Expert opinion on pharmacotherapy 20070501
Absent reduction by HIV protease inhibitors of Candida albicans adhesion to endothelial cells. Mycoses 20070501
Effects of antiretroviral therapy on tube-like network formation of human endothelial cells. Biological & pharmaceutical bulletin 20070501
Nephrotoxicity associated with antiretroviral therapy in HIV-infected patients. Current drug safety 20070501
Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070401
An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease. Acta crystallographica. Section F, Structural biology and crystallization communications 20070401
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS pathogens 20070401
Indinavir trough concentration as a determinant of early nephrolithiasis in HIV-1-infected adults. Therapeutic drug monitoring 20070401
Drug reactions affecting the nail unit: diagnosis and management. Dermatologic clinics 20070401
High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications. Journal of pharmaceutical and biomedical analysis 20070312
Differential protein binding of indinavir and saquinavir in matched maternal and umbilical cord plasma. British journal of clinical pharmacology 20070301
Abacavir sulfate/lamivudine/zidovudine fixed combination in the treatment of HIV infection. Expert opinion on pharmacotherapy 20070301
Dyslipidemia in an Asian population after treatment for two years with protease inhibitor-containing regimens. Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20070301
Evaluating drug prices, availability, affordability, and price components: implications for access to drugs in Malaysia. PLoS medicine 20070301
Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial. PLoS clinical trials 20070301
Progressive outer retinal necrosis combined with vitreous hemorrhage in a patient with acquired immunodeficiency syndrome. Korean journal of ophthalmology : KJO 20070301
[Indinavir stones]. Actas urologicas espanolas 20070301
Neurokinin-1 receptor antagonist (aprepitant) inhibits drug-resistant HIV-1 infection of macrophages in vitro. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20070301
Venlafaxine extended release (XR) in the treatment of panic disorder. Therapeutics and clinical risk management 20070301
Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages. Virology 20070205
Improving data reliability using a non-compliance detection method versus using pharmacokinetic criteria. Journal of pharmacokinetics and pharmacodynamics 20070201
Modulation of human BCRP (ABCG2) activity by anti-HIV drugs. The Journal of antimicrobial chemotherapy 20070201
Less sensitive HIV-1 enzyme immunoassay as an adjuvant method for monitoring patients receiving antiretroviral therapy. AIDS patient care and STDs 20070201
HIV protease inhibitors selectively induce gene expression alterations associated with reduced calcium deposition in primary human osteoblasts. AIDS research and human retroviruses 20070201
Venlafaxine in the treatment of panic disorder. Neuropsychiatric disease and treatment 20070201
Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure. The Cochrane database of systematic reviews 20070124
Hair versus plasma concentrations as indicator of indinavir exposure in HIV-1-infected patients treated with indinavir/ritonavir combination. AIDS (London, England) 20070102
Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice. American journal of physiology. Endocrinology and metabolism 20070101
Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070101
In silico prediction of pregnane X receptor activators by machine learning approaches. Molecular pharmacology 20070101
Influence of body temperature on indinavir crystallization under loop of Henle conditions. The Journal of antimicrobial chemotherapy 20070101
Urological management of indinavir-associated acute renal failure in HIV-positive patients. International urology and nephrology 20070101
Efficacy and plasma concentrations of indinavir when boosted with ritonavir in human immunodeficiency virus-infected Thai children. The Pediatric infectious disease journal 20070101
The emergence of HIV transmitted resistance in Botswana: 'when will the WHO detection threshold be exceeded?'. PloS one 20070101
A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism. PLoS medicine 20070101
Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells. AIDS research and human retroviruses 20070101
Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire. AIDS research and human retroviruses 20070101
Retroviral rebound syndrome after treatment discontinuation in a 15 year old girl with HIV attracted through mother-to-child transmission: case report. AIDS research and therapy 20070101
Safety and efficacy of a generic fixed-dose combination of stavudine, lamivudine and nevirapine antiretroviral therapy between HIV-infected patients with baseline CD4 <50 versus CD4 > or = 50 cells/mm3. AIDS research and therapy 20070101
Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity. Retrovirology 20070101
HIV/AIDS drugs for Sub-Saharan Africa: how do brand and generic supply compare? PloS one 20070101
MSE with mass defect filtering for in vitro and in vivo metabolite identification. Rapid communications in mass spectrometry : RCM 20070101
Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study. Arzneimittel-Forschung 20070101
Gender-specific effects of HIV protease inhibitors on body mass in mice. AIDS research and therapy 20070101
Interpreting cerebrospinal fluid pleocytosis in HIV in the era of potent antiretroviral therapy. BMC infectious diseases 20070101
Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report. Journal of medical case reports 20070101
TRIPS, the Doha declaration and paragraph 6 decision: what are the remaining steps for protecting access to medicines? Globalization and health 20070101
AIDS in the Third World: how to stop the HIV infection? Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20070101
Anti-HIV drugs. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20070101
Predictive factors of virological success to salvage regimens containing protease inhibitors in HIV-1 infected children. BMC infectious diseases 20070101
HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms. AIDS research and therapy 20070101
Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20070101
Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus-1 (HIV-1) infected pediatric patients: a cross-sectional study. AIDS research and therapy 20070101
HIV-associated adipose redistribution syndrome (HARS): definition, epidemiology and clinical impact. AIDS research and therapy 20070101
Electrospray tandem mass spectroscopic characterisation of 18 antiretroviral drugs and simultaneous quantification of 12 antiretrovirals in plasma. Rapid communications in mass spectrometry : RCM 20070101
Dermatologic adverse effects of antiretroviral therapy: recognition and management. American journal of clinical dermatology 20070101
A randomized trial evaluating Prosaptide for HIV-associated sensory neuropathies: use of an electronic diary to record neuropathic pain. PloS one 20070101
Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. PloS one 20070101
Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antiviral therapy 20070101
Infant of 22 months of age with no anomalies born from a HCV- and HIV-infected mother under treatment with pegylated interferon, ribavirin and antiretroviral therapy during the first 16 weeks of pregnancy. Reproductive toxicology (Elmsford, N.Y.) 20070101
Genotypic resistance to lopinavir and fosamprenavir with or without ritonavir of clinical isolates from patients failing protease inhibitors-containing HAART regimens: prevalence and predictors. Scandinavian journal of infectious diseases 20070101
Characterization of the invariable residue 51 mutations of human immunodeficiency virus type 1 capsid protein on in vitro CA assembly and infectivity. Retrovirology 20070101
Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes. Antiviral therapy 20070101
Utilization and spending trends for antiretroviral medications in the U.S. Medicaid program from 1991 to 2005. AIDS research and therapy 20070101
Efficacy, safety, and tolerability of long-term combination antiretroviral therapy in asymptomatic treatment-naïve adults with early HIV infection. HIV clinical trials 20070101
Poor follow-up rates at a self-pay northern Indian tertiary AIDS clinic. International journal for equity in health 20070101
Medicinal importance of grapefruit juice and its interaction with various drugs. Nutrition journal 20070101
Cost-effectiveness of tipranavir versus comparator protease inhibitor regimens in HIV infected patients previously exposed to antiretroviral therapy in the Netherlands. Cost effectiveness and resource allocation : C/E 20070101
Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors. Current medicinal chemistry 20070101
Validation of high-performance liquid chromatography methods for determination of zidovudine, stavudine, lamivudine and indinavir in human plasma. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101
Factors influencing cerebrospinal fluid and plasma HIV-1 RNA detection rate in patients with and without opportunistic neurological disease during the HAART era. BMC infectious diseases 20070101
Morphological and biochemical appraisal of the liver and renal effects of indinavir on rat pregnancy. Clinical and experimental obstetrics & gynecology 20070101
Relationships between drug exposure, changes in metabolic parameters and body fat in HIV-infected patients switched to a nucleoside sparing regimen. Antiviral therapy 20070101
Clinical implications of mutations at reverse transcriptase codon 135 on response to NNRTI-based therapy. The open virology journal 20070101
Poor Efficacy and Tolerability of Stavudine, Didanosine, and Efavirenz-based Regimen in Treatment-Naive Patients in Senegal. Journal of the International AIDS Society 20070101
Maraviroc: the evidence for its potential in the management of HIV. Core evidence 20070101
Phenotypic resistance of resistant strains of HIV type-1 subtype B in China. Chinese medical journal 20061205
Antiviral activity of Arthrospira-derived spirulan-like substances. Antiviral research 20061201
Indinavir crystalluria. Kidney international 20061201
Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS medicine 20061201
Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery. Journal of leukocyte biology 20061101
Secretory aspartyl peptidase activity from mycelia of the human fungal pathogen Fonsecaea pedrosoi: effect of HIV aspartyl proteolytic inhibitors. Research in microbiology 20061101
Predictors of antiretroviral-related hepatotoxicity in the adult AIDS Clinical Trial Group (1989-1999). Journal of acquired immune deficiency syndromes (1999) 20061101
Antiretroviral drug-resistant HIV-2 infection--a new therapeutic dilemma. International journal of STD & AIDS 20061101
Acid suppressive therapy and the effects on protease inhibitors. The Annals of pharmacotherapy 20061101
Atazanavir urinary stones in an HIV-infected patient. AIDS (London, England) 20061024
Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery. Blood 20061015
Insulin sensitivity is preserved despite disrupted endothelial function. American journal of physiology. Endocrinology and metabolism 20061001
Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation. Clinical pharmacology and therapeutics 20061001
Viral and latent reservoir persistence in HIV-1-infected patients on therapy. PLoS computational biology 20061001
Evaluation of an International Pharmacopoeia method for the analysis of indinavir sulfate by liquid chromatography. Journal of pharmaceutical and biomedical analysis 20060911
Effectiveness of low-dose indinavir/ritonavir at 400/100 mg twice a day with 2 nucleoside reverse transcriptase inhibitors in nonnucleoside reverse transcriptase inhibitor-experienced HIV-infected patients in India: 1-year follow-up. Journal of acquired immune deficiency syndromes (1999) 20060901
Changes in body composition and mitochondrial nucleic acid content in patients switched from failed nucleoside analogue therapy to ritonavir-boosted indinavir and efavirenz. The Journal of infectious diseases 20060901
Nelfinavir induces liposarcoma apoptosis and cell cycle arrest by upregulating sterol regulatory element binding protein-1. Anti-cancer drugs 20060901
Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART. PLoS medicine 20060901
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. Journal of medicinal chemistry 20060824
Microarray analysis during adipogenesis identifies new genes altered by antiretroviral drugs. AIDS (London, England) 20060822
Pharmacodynamics of antiretroviral agents in HIV-1 infected patients: using viral dynamic models that incorporate drug susceptibility and adherence. Journal of pharmacokinetics and pharmacodynamics 20060801
Association of total bilirubin with indinavir and lopinavir plasma concentrations in HIV-infected patients receiving three different double-boosted dosing regimens. The Journal of antimicrobial chemotherapy 20060801
Natural polymorphisms in the protease gene modulate the replicative capacity of non-B HIV-1 variants in the absence of drug pressure. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060801
Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. Journal of acquired immune deficiency syndromes (1999) 20060801
Role of P-glycoprotein in tissue uptake of indinavir in rat. Life sciences 20060801
Antiretrovirals induce direct endothelial dysfunction in vivo. Journal of acquired immune deficiency syndromes (1999) 20060801
Feasibility of weekly HIV drug delivery to enhance drug localization in lymphoid tissues based on pharmacokinetic models of lipid-associated indinavir. Pharmaceutical research 20060801
Effect of widely used combinations of antiretroviral therapy on liver CYP3A4 activity in HIV-infected patients. British journal of clinical pharmacology 20060801
[Central nervous system HIV-associated polyarteritis nodosa: long-term outcome]. La Revue de medecine interne 20060801
Lack of in vivo correlation between indinavir and saquinavir exposure and cytochrome P450 3A phenotype as assessed with oral midazolam as a phenotype probe. Pharmacotherapy 20060801
Full validation of an analytical method for the HIV-protease inhibitor atazanavir in combination with 8 other antiretroviral agents and its applicability to therapeutic drug monitoring. Therapeutic drug monitoring 20060801
Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes. Alcoholism, clinical and experimental research 20060801
Urinary NO3 excretion and renal failure in indinavir-treated patients. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060801
High prevalence of indinavir-associated renal complications in Thai HIV-infected patients. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801
Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug metabolism and disposition: the biological fate of chemicals 20060701
Nephrotoxicity as a complication of antiretroviral therapy. Advances in chronic kidney disease 20060701
DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes. PLoS pathogens 20060701
Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells. PLoS pathogens 20060701
A randomised trial comparing genotypic and virtual phenotypic interpretation of HIV drug resistance: the CREST study. PLoS clinical trials 20060701
Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060701
Regimen-dependent variations in adherence to therapy and virological suppression in patients initiating protease inhibitor-based highly active antiretroviral therapy. HIV medicine 20060701
Pharmacokinetics and tolerability of a combination of indinavir, lopinavir and ritonavir in multiply pretreated HIV-1 infected adults. European journal of medical research 20060630
Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor. Antiviral research 20060601
Gated binding of ligands to HIV-1 protease: Brownian dynamics simulations in a coarse-grained model. Biophysical journal 20060601
The use of pharmacokinetically guided indinavir dose reductions in the management of indinavir-associated renal toxicity. The Journal of antimicrobial chemotherapy 20060601
Real-time nucleic acid sequence-based amplification assay to quantify changes in mitochondrial DNA concentrations in cell cultures and blood cells from HIV-infected patients receiving antiviral therapy. Clinical chemistry 20060601
The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: final results from a randomized clinical trial (Pulse). Journal of acquired immune deficiency syndromes (1999) 20060601
Antiretroviral drug resistance and routine therapy, Cameroon. Emerging infectious diseases 20060601
Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques. Journal of acquired immune deficiency syndromes (1999) 20060601
Recent developments in drug targets and delivery of anti-HIV drugs. Infectious disorders drug targets 20060601
High HIV type 1 subtype diversity and few drug resistance mutations among seropositive people detected during the 2005 second generation HIV surveillance in Madagascar. AIDS research and human retroviruses 20060601
Voriconazole in the management of nosocomial invasive fungal infections. Therapeutics and clinical risk management 20060601
Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation. Journal of molecular biology 20060519
HIV-associated renal diseases and highly active antiretroviral therapy-induced nephropathy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060515
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir. Biochemistry 20060502
HIV protease inhibitor therapy reverses neutrophil apoptosis in AIDS patients by direct calpain inhibition. Apoptosis : an international journal on programmed cell death 20060501
Biological characterization of human immunodeficiency virus type 1 subtype C protease carrying indinavir drug-resistance mutations. The Journal of general virology 20060501
Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Pharmacogenetics and genomics 20060501
Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: protease inhibitor-mediated neurotoxicity. Annals of neurology 20060501
Adverse effects of antiretroviral drugs on HIV-1-infected and -uninfected human monocyte-derived macrophages. Journal of acquired immune deficiency syndromes (1999) 20060501
Electrochemical methods for determination of the protease inhibitor indinavir sulfate in pharmaceuticals and human serum. Die Pharmazie 20060501
HIV-specific cellular immune responses are stimulated by structured treatment interruption in chronically HIV-1 infected Koreans. Yonsei medical journal 20060430
Antiretroviral medications associated with elevated blood pressure among patients receiving highly active antiretroviral therapy. AIDS (London, England) 20060424
Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance. AIDS (London, England) 20060424
Maintenance of successful ritonavir-boosted indinavir and efavirenz therapy in an HIV-infected patient with tuberculosis. AIDS (London, England) 20060424
Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 20060415
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385. Bioorganic & medicinal chemistry letters 20060401
Susceptibility to protease inhibitors in HIV-2 primary isolates from patients failing antiretroviral therapy. The Journal of antimicrobial chemotherapy 20060401
High incidence of adverse reactions to initial antiretroviral therapy in Brazil. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060401
Pharmacologic optimization of protease inhibitors and nonnucleoside reverse transcriptase inhibitors (POPIN)--a randomized controlled trial of therapeutic drug monitoring and adherence support. Journal of acquired immune deficiency syndromes (1999) 20060401
[Drug-induced renal calculi]. Annales d'urologie 20060401
Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy. PLoS medicine 20060301
Antiretroviral therapy and dyslipidaemia: unlocking the code. PLoS medicine 20060301
Hyperforin in St. John's wort drug interactions. European journal of clinical pharmacology 20060301
In vitro development of resistance to human immunodeficiency virus protease inhibitor GW640385. Antimicrobial agents and chemotherapy 20060301
Indinavir-treated Cryptococcus neoformans promotes an efficient antifungal immune response in immunosuppressed hosts. Medical mycology 20060301
Simple and sensitive high-performance liquid chromatography method for the quantitation of indinavir in rat plasma and central nervous system. Journal of separation science 20060301
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. Journal of medicinal chemistry 20060223
Determination of the novel non-peptidic HIV-protease inhibitor tipranavir by HPLC-UV after solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060217
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains. Bioorganic & medicinal chemistry letters 20060215
LC-MS/MS determination of the HIV-1 protease inhibitor indinavir in brain and testis of mice. Journal of pharmaceutical and biomedical analysis 20060213
Simultaneous determination of 16 anti-HIV drugs in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
[Clinical trial comparing efficacy and safety of four highly active antiretroviral therapy (HAART) in antiretroviral-naive treatment with advanced HIV infection]. Revista clinica espanola 20060201
Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses. Arzneimittel-Forschung 20060201
High rate of proV47A selection in HIV-2 patients failing lopinavir-based HAART. AIDS (London, England) 20060102
Once-daily directly observed therapy lopinavir/ritonavir plus indinavir as a protease inhibitor-only salvage therapy in heavily pretreated HIV-1-infected patients: a pilot study. AIDS (London, England) 20060102
Simultaneous determination of six HIV protease inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir), the active metabolite of nelfinavir (M8) and non-nucleoside reverse transcriptase inhibitor (efavirenz) in human plasma by high-performance liquid chromatography. Biomedical chromatography : BMC 20060101
HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents. The Journal of pharmacology and experimental therapeutics 20060101
Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians. HIV medicine 20060101
Low urine pH is associated with reduced indinavir crystalluria in indinavir-treated HIV-infected individuals. Clinical nephrology 20060101
Effects of indinavir in a preliminary phase I study on dogs with stage III slenic hemangiosarcoma. In vivo (Athens, Greece) 20060101
Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic & clinical pharmacology & toxicology 20060101
T-cell line for HIV drug screening using EGFP as a quantitative marker of HIV-1 replication. BioTechniques 20060101
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Annals of clinical microbiology and antimicrobials 20060101
Understanding and avoiding antiretroviral adverse events. Current pharmaceutical design 20060101
Adhesive capsulitis of the shoulder in human immunodeficiency virus-positive patients during highly active antiretroviral therapy. Journal of shoulder and elbow surgery 20060101
Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma. Clinical chemistry and laboratory medicine 20060101
DR_SEQAN: a PC/Windows-based software to evaluate drug resistance using human immunodeficiency virus type 1 genotypes. BMC infectious diseases 20060101
Cerebrospinal fluid HIV-1 RNA, intrathecal immunoactivation, and drug concentrations after treatment with a combination of saquinavir, nelfinavir, and two nucleoside analogues: the M61022 study. BMC infectious diseases 20060101
Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteome science 20060101
Boosted versus unboosted indinavir with zidovudine and lamivudine in nucleoside pre-treated patients: a randomized, open-label trial with 112 weeks of follow-up (HIV-NAT 005). Antiviral therapy 20060101
Patients with ischaemic, mixed and nephrotoxic acute tubular necrosis in the intensive care unit--a homogeneous population? Critical care (London, England) 20060101
Aboriginal status is a prognostic factor for mortality among antiretroviral naïve HIV-positive individuals first initiating HAART. AIDS research and therapy 20060101
Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samples. Biology direct 20060101
Serious renal impairment occurs rarely with use of tenofovir DF. HIV clinical trials 20060101
Therapeutic drug monitoring in HIV treatment: a literature review. HIV clinical trials 20060101
Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patients. Antiviral therapy 20060101
Incidence of and risk factors for insulin resistance in treatment-naive HIV-infected patients 48 weeks after starting highly active antiretroviral therapy. Antiviral therapy 20060101
[Pneumocystis jirovecii pneumonia: an old disease with a new name]. Medicina (Kaunas, Lithuania) 20060101
Investigation of baseline susceptibility to protease inhibitors in HIV-1 subtypes C, F, G and CRF02_AG. Antiviral therapy 20060101
Normalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia--case report. BMC infectious diseases 20060101
5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals. Retrovirology 20060101
Quantitative SNP-detection method for estimating HIV-1 replicative fitness: application to protease inhibitor-resistant viruses. Microbiology and immunology 20060101
Performance of six different ritonavir-boosted protease inhibitor-based regimens in heavily antiretroviral-experienced HIV-infected patients. HIV clinical trials 20060101
Rapid propagation of low-fitness drug-resistant mutants of human immunodeficiency virus type 1 by a streptococcal metabolite sparsomycin. Antiviral chemistry & chemotherapy 20060101
Immunogenicity of a polyvalent HIV-1 candidate vaccine based on fourteen wild type gp120 proteins in golden hamsters. BMC immunology 20060101
Therapeutic challenges in hepatitis C-infected injection drug using patients. Harm reduction journal 20060101
Synthesis and in vitro biological evaluation of mannose-containing prodrugs derived from clinically used HIV-protease inhibitors with improved transepithelial transport. Bioconjugate chemistry 20060101
An immunological comparison of third companion in advanced drug-naive HIV-infected patients. HIV clinical trials 20060101
Drug-herb interactions: eliminating toxicity with hard drug design. Current pharmaceutical design 20060101
Clinical outcome of HIV-infected patients with sustained virologic response to antiretroviral therapy: long-term follow-up of a multicenter cohort. PloS one 20060101
Use of taste-masking product, FLAVORx, to assist Thai children to ingest generic antiretrovirals. AIDS research and therapy 20060101
Using cost-effectiveness analyses to inform policy: the case of antiretroviral therapy in Thailand. Cost effectiveness and resource allocation : C/E 20060101
Fosamprenavir clinical study meta-analysis in ART-naïve subjects: rare occurrence of virologic failure and selection of protease-associated mutations. HIV clinical trials 20060101
Lamivudine and indinavir/ritonavir maintenance therapy in highly pretreated HIV-infected patients (Vista ANRS 109). Antiviral therapy 20060101
Specific HIV protease inhibitors inhibit the ability of HPV16 E6 to degrade p53 and selectively kill E6-dependent cervical carcinoma cells in vitro. Antiviral therapy 20060101
Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. Bioinorganic chemistry and applications 20060101
Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture. Bioinorganic chemistry and applications 20060101
[Post-exposure prophylaxis of HIV infection in out-patient clinic of hospital for infectious diseases in Warsaw in 2001-2002]. Przeglad epidemiologiczny 20060101
Disease Management - Constructing Optimal NRTI-Based Combinations: Past, Present, and Future. Journal of the International AIDS Society 20060101
Accidental blood exposure: risk and prevention in interventional radiology. Biomedical imaging and intervention journal 20060101
Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051227
Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051215
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. Journal of molecular biology 20051209
Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy. AIDS (London, England) 20051202
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus. Bioorganic & medicinal chemistry letters 20051201
Quality of life in a clinical trial of highly active antiretroviral therapy alone or with intravenous or subcutaneous interleukin-2 administration. Journal of acquired immune deficiency syndromes (1999) 20051201
Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patients. Therapeutic drug monitoring 20051201
Possible reduction in indinavir serum concentrations by bosentan. Therapeutic drug monitoring 20051201
Tumour necrosis factor alpha in fat redistribution syndromes associated with combination antiretroviral therapy in HIV-1-infected patients: potential role in subcutaneous adipocyte apoptosis. European journal of clinical investigation 20051201
Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux. Die Pharmazie 20051201
Anti-HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. Journal of ethnopharmacology 20051114
In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug metabolism and disposition: the biological fate of chemicals 20051101
Tissue distribution of indinavir administered as solid lipid nanocapsule formulation in mdr1a (+/+) and mdr1a (-/-) CF-1 mice. Pharmaceutical research 20051101
Immunodysregulation of HIV disease at bone marrow level. Autoimmunity reviews 20051101
Indinavir/ritonavir 800/100 mg bid and efavirenz 600 mg qd in patients failing treatment with combination nucleoside reverse transcriptase inhibitors: 96-week outcomes of HIV-NAT 009. HIV medicine 20051101
Indinavir impairs endothelial function in healthy HIV-negative men. American heart journal 20051101
Genotypic and phenotypic resistance testing of HIV-1 in routine clinical care. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20051101
A direct comparison of drug susceptibility to HIV type 1 from antiretroviral experienced subjects as assessed by the antivirogram and PhenoSense assays and by seven resistance algorithms. AIDS research and human retroviruses 20051101
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. The Journal of infectious diseases 20051015
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HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. AIDS (London, England) 20051014
MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS (London, England) 20051014
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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. The FEBS journal 20051001
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism 20051001
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters 20050915
HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo. Cancer research 20050915
Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes. Clinical cancer research : an official journal of the American Association for Cancer Research 20050915
The normalized inhibitory quotient of boosted protease inhibitors is predictive of viral load response in treatment-experienced HIV-1-infected individuals. AIDS (London, England) 20050902
Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. American journal of physiology. Endocrinology and metabolism 20050901
HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease. Molecular pharmacology 20050901
Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients. British journal of clinical pharmacology 20050901
Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. Journal of acquired immune deficiency syndromes (1999) 20050901
[HIV infection, antiretroviral therapy, and endothelium]. Herz 20050901
Hydrophobicity in the design of P2/P2' tetrahydropyrimidinone HIV protease inhibitors. Bioorganic & medicinal chemistry letters 20050815
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Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS. Laboratory investigation; a journal of technical methods and pathology 20050801
Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles. Bioorganic & medicinal chemistry letters 20050801
TDM: therapeutic drug measuring or therapeutic drug monitoring? Therapeutic drug monitoring 20050801
Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers. Clinical pharmacology and therapeutics 20050801
Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis. The Journal of investigative dermatology 20050801
Comparison of HIV type 1 protease inhibitor susceptibility results in viral samples analyzed by phenotypic drug resistance assays and by six resistance algorithms: an analysis of a subpopulation of the CHORUS cohort. AIDS research and human retroviruses 20050801
HIV associated arthritis: case report and review of the literature. European journal of medical research 20050729
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[Portal vein thrombosis in HIV-infected patients: report of four cases]. La Revue de medecine interne 20050701
Antileishmanial activity of HIV protease inhibitors. International journal of antimicrobial agents 20050701
Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapy. AIDS (London, England) 20050701
Conventional HPLC method used for simultaneous determination of the seven HIV protease inhibitors and nonnucleoside reverse transcription inhibitor efavirenz in human plasma. Biological & pharmaceutical bulletin 20050701
Effects on immunological and virological outcome of patients using one protease inhibitor or one non-nucleoside reverse transcriptase inhibitor in a triple antiretroviral therapy: normal clinical practice versus clinical trial findings. Current HIV research 20050701
Treatment response and drug resistance in patients infected with HIV type 1 group O viruses. AIDS research and human retroviruses 20050701
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[Consequences of replacing abacavir for indinavir in successful antiretroviral treatment of a patient with HIV infection]. Presse medicale (Paris, France : 1983) 20050604
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Incidence of pancreatitis in HIV-1-infected individuals enrolled in 20 adult AIDS clinical trials group studies: lessons learned. Journal of acquired immune deficiency syndromes (1999) 20050601
Simultaneous quantitative assay of atazanavir and 6 other HIV protease inhibitors by isocratic reversed-phase liquid chromatography in human plasma. Therapeutic drug monitoring 20050601
A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles. Cellular and molecular life sciences : CMLS 20050601
Population pharmacokinetic analysis of indinavir in HIV-infected patient treated with a stable antiretroviral therapy. Fundamental & clinical pharmacology 20050601
Genotypic resistance analyses in nucleoside-pretreated patients failing an indinavir containing regimen: results from a randomized comparative trial: (Novavir ANRS 073). Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050601
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Inhibitory activity of human immunodeficiency virus aspartyl protease inhibitors against Encephalitozoon intestinalis evaluated by cell culture-quantitative PCR assay. Antimicrobial agents and chemotherapy 20050601
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525
Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor. AIDS (London, England) 20050520
Antiviral drug-induced nephrotoxicity. American journal of kidney diseases : the official journal of the National Kidney Foundation 20050501
Hepatotoxicity and nelfinavir: a meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20050501
Emerging anti-HIV drugs. Expert opinion on emerging drugs 20050501
Switch from ritonavir to indinavir in combination therapy for HIV-1-infected children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050415
A pilot, double-blind, placebo-controlled trial of indinavir in patients with ALS. Neurology 20050412
Pharmacokinetic interaction between chemotherapy for non-Hodgkin's lymphoma and protease inhibitors in HIV-1-infected patients. The Journal of antimicrobial chemotherapy 20050401
The urological management of the patient with acquired immunodeficiency syndrome. BJU international 20050401
Postexposure prophylaxis after sexual assaults: a prospective cohort study. Sexually transmitted diseases 20050401
Simple and simultaneous determination of the hiv-protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir plus M8 nelfinavir metabolite and the nonnucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma by reversed-phase liquid chromatography. Therapeutic drug monitoring 20050401
Investigation of oral bioavailability and brain distribution of the Ind(8)-Val conjugate of indinavir in rodents. The Journal of pharmacy and pharmacology 20050401
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. PLoS medicine 20050401
Virtual screening of HIV-1 protease inhibitors against human cytomegalovirus protease using docking and molecular dynamics. AIDS (London, England) 20050325
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. Journal of medicinal chemistry 20050324
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[Efficacy of anti-HIV treatment and drug-resistance mutations in some parts of China]. Zhonghua yi xue za zhi 20050323
Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis. European journal of clinical pharmacology 20050301
Contribution of cellular HIV-1 DNA quantification to the efficacy analysis of antiretroviral therapy: a randomized comparison of 2 regimens, including 3 drugs from 2 or 3 classes (TRIANON, ANRS 081). Journal of acquired immune deficiency syndromes (1999) 20050301
Comparable pharmacokinetics of generic indinavir (Inhibisam) versus brand indinavir (Crixivan) when boosted with ritonavir. Journal of acquired immune deficiency syndromes (1999) 20050301
Gender differences in health-related quality of life in patients with HIV/AIDS. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20050301
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4. Therapeutics and clinical risk management 20050301
Risk of AIDS and death at given HIV-RNA and CD4 cell count, in relation to specific antiretroviral drugs in the regimen. AIDS (London, England) 20050218
Mechanism-based inactivation of CYP3A by HIV protease inhibitors. The Journal of pharmacology and experimental therapeutics 20050201
Pharmacokinetic interaction study of indinavir/ritonavir and the enteric-coated capsule formulation of didanosine in healthy volunteers. Journal of clinical pharmacology 20050201
Herb-drug interactions: an overview of the clinical evidence. Fundamental & clinical pharmacology 20050201
Indinavir plasma concentration and adherence score are codeterminant of early virologic response in HIV-infected patients of the APROCO cohort. Therapeutic drug monitoring 20050201
Dose reduction for the management of indinavir-related toxicity in human immunodeficiency virus type 1-infected patients in Taiwan: clinical and pharmacokinetic assessment. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20050201
Warning about indinavir and pregnancy. AIDS patient care and STDs 20050201
Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 20050201
The effects of HIV protease inhibitors on carbohydrate and lipid metabolism. Current HIV/AIDS reports 20050201
Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines. The Journal of biological chemistry 20050121
Influence of indinavir on virulence and growth of Cryptococcus neoformans. The Journal of infectious diseases 20050115
Antiretroviral drug pharmacokinetics in hepatitis with hepatic dysfunction. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050101
Substituting abacavir for hyperlipidemia-associated protease inhibitors in HAART regimens improves fasting lipid profiles, maintains virologic suppression, and simplifies treatment. BMC infectious diseases 20050101
No influence of the P-glycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naïve HIV-positive patients. Annals of clinical microbiology and antimicrobials 20050101
HIV type 1 protease inhibitors enhance bone marrow progenitor cell activity in normal subjects and in HIV type 1-infected patients. AIDS research and human retroviruses 20050101
Indinavir/ritonavir-based therapy in HIV-1-infected antiretroviral therapy-naive patients: comparison of 800/100 mg and 400/100 mg twice daily. HIV medicine 20050101
Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS. Lipids in health and disease 20050101
Molecular strategies to inhibit HIV-1 replication. Retrovirology 20050101
Lymphoid tissue targeting of anti-HIV drugs using liposomes. Methods in enzymology 20050101
[Radio-opaque lithiasis and indinavir]. Actas urologicas espanolas 20050101
Abacavir, efavirenz, didanosine, with or without hydroxyurea, in HIV-infected adults failing initial nucleoside/protease inhibitor-containing regimens. BMC infectious diseases 20050101
Capacity building for the clinical investigation of AIDS malignancy in East Africa. Cancer detection and prevention 20050101
Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. Antiviral therapy 20050101
Pharmacokinetics of reduced-dose indinavir/ritonavir 400/100 mg twice daily in HIV-1-infected Thai patients. Antiviral therapy 20050101
The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life. Health and quality of life outcomes 20050101
Herb-drug interactions: a literature review. Drugs 20050101
High frequency of Fredrickson's phenotypes IV and IIb in Brazilians infected by human immunodeficiency virus. BMC infectious diseases 20050101
Nephrotoxicity related to new therapeutic compounds. Renal failure 20050101
Incidence and risk factors for liver enzyme elevation during highly active antiretroviral therapy in HIV-HCV co-infected patients: results from the Italian EPOKA-MASTER Cohort. BMC infectious diseases 20050101
Total body composition by DXA of 241 HIV-negative men and 162 HIV-infected men: proposal of reference values for defining lipodystrophy. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20050101
Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid communications in mass spectrometry : RCM 20050101
HIV protease inhibitors prevent mitochondrial hyperpolarization and redox imbalance and decrease endogenous uncoupler protein-2 expression in gp 120-activated human T lymphocytes. Antiviral therapy 20050101
Lipid profiles for antiretroviral-naive patients starting PI- and NNRTI-based therapy in the Swiss HIV cohort study. Antiviral therapy 20050101
Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: beneficial effect of IL-2 and GM-CSF immunotherapy. Journal of immune based therapies and vaccines 20050101
Quantification of antiretroviral drugs in dried blood spot samples by means of liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20050101
Persistence of lipoatrophy after a four-year long interruption of antiretroviral therapy for HIV1 infection: case report. BMC infectious diseases 20050101
ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. Cancer cell international 20050101
HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors. AIDS research and therapy 20050101
Human immunodeficiency virus type-1 episomal cDNA in semen. AIDS research and therapy 20050101
Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection? Antiviral therapy 20050101
HIV in semen: still more to be learned. AIDS research and therapy 20050101
High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy. Clinical pharmacokinetics 20050101
Efficacy and safety of indinavir/ritonavir 400/100 mg twice daily plus two nucleoside analogues in treatment-naive HIV-1-infected patients with CD4+ T-cell counts <200 cells/mm3: 96-week outcomes. Antiviral therapy 20050101
Antiretroviral Therapy in the Real World : Population-Based Pharmacoeconomic Analysis of Administration of Anti-HIV Regimens to 990 Patients. Clinical drug investigation 20050101
Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review. Journal of the International AIDS Society 20050101
Cytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy. Journal of the International AIDS Society 20050101
Genetic barriers to resistance and impact on clinical response. Journal of the International AIDS Society 20050101
A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity. The Journal of biological chemistry 20041231
Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity? Neurology 20041228
Determination of atazanavir and other antiretroviral drugs (indinavir, amprenavir, nelfinavir and its active metabolite M8, saquinavir, ritonavir, lopinavir, nevirapine and efavirenz) plasma levels by high performance liquid chromatography with UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
Optimization of unique, uncharged thioesters as inhibitors of HIV replication. Bioorganic & medicinal chemistry 20041215
Selection of antiretroviral therapy guided by genotypic or phenotypic resistance testing: an open-label, randomized, multicenter study (PhenGen). Journal of acquired immune deficiency syndromes (1999) 20041215
A comparison of dyslipidemias associated with either lopinavir/ritonavir- or indinavir/ritonavir-based antiretroviral therapy. Journal of acquired immune deficiency syndromes (1999) 20041215
C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. AIDS (London, England) 20041203
Antiretrovirals as antimalarial agents. The Journal of infectious diseases 20041201
Effect of highly active antiretroviral therapy (HAART) on pharmacokinetics and pharmacodynamics of doxorubicin in patients with HIV-associated non-Hodgkin's lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology 20041201
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. The Journal of endocrinology 20041201
Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir. Journal of molecular modeling 20041201
Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats. Die Pharmazie 20041201
Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. Antiviral therapy 20041201
Health-related quality of life in HIV patients switching to twice-daily indinavir/ritonavir regimen or continuing with three-times-daily indinavir-based therapy. Antiviral therapy 20041201
Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in antiretroviral-naive HIV patients in Campania, Italy. Journal of chemotherapy (Florence, Italy) 20041201
Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. Clinical therapeutics 20041201
Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia. Chemico-biological interactions 20041120
Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir. AIDS (London, England) 20041119
Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data. Journal of medicinal chemistry 20041118
Potent inhibitors of the HIV-1 protease incorporating cyclic urea P1-P2 scaffold. Bioorganic & medicinal chemistry letters 20041115
Residual analysis in linear regression models with an interval-censored covariate. Statistics in medicine 20041115
CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro. AIDS (London, England) 20041105
Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes. American journal of physiology. Cell physiology 20041101
Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations. Proteins 20041101
Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20041101
Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals. Journal of acquired immune deficiency syndromes (1999) 20041101
Optimization and statistical evaluation of dissolution tests for indinavir sulfate capsules. Farmaco (Societa chimica italiana : 1989) 20041101
Persistent HIV type 1 infection in semen and blood compartments in patients after long-term potent antiretroviral therapy. AIDS research and human retroviruses 20041101
[Therapeutic strategies for HIV infection: clinical approach with boost antiproteases in adults]. Medecine et maladies infectieuses 20041101
Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041015
Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells. The Journal of infectious diseases 20041015
HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo. Cancer research 20041015
Pseudoaneurysm of the femoral artery in a HIV-infected man. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20041001
The human immunodeficiency virus (HIV) protease inhibitor indinavir directly affects the opportunistic fungal pathogen Cryptococcus neoformans. FEMS immunology and medical microbiology 20041001
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Therapeutic drug monitoring 20041001
Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation. Antimicrobial agents and chemotherapy 20041001
Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1. PLoS medicine 20041001
Prevalence of toxoplasma encephalitis in AIDS patients treated with Didanosine hospitalised in a French infectious service. Current HIV research 20041001
Antiretroviral protease inhibitors prevent l6 muscle cell fusion by reducing calpain activity. AIDS research and human retroviruses 20041001
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry 20040928
Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men. AIDS (London, England) 20040924
P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1. Bioorganic & medicinal chemistry letters 20040920
Indinavir increases glucose production in healthy HIV-negative men. AIDS (London, England) 20040903
Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20040901
The ICH guidance in practice: stress degradation studies on indinavir sulphate and development of a validated specific stability-indicating HPTLC assay method. Farmaco (Societa chimica italiana : 1989) 20040901
In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator. Journal of cellular biochemistry 20040815
HIV-1 drug resistance in subjects with advanced HIV-1 infection in whom antiretroviral combination therapy is failing: a substudy of AIDS Clinical Trials Group Protocol 388. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040815
Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases. Journal of virological methods 20040801
Lopinavir/ritonavir combined with twice-daily 400 mg indinavir: pharmacokinetics and pharmacodynamics in blood, CSF and semen. The Journal of antimicrobial chemotherapy 20040801
Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir. Infection 20040801
Impact of indinavir on the quality of life in patients with advanced HIV infection treated with zidovudine and lamivudine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040801
Resistance to HIV protease inhibitors: mechanisms and clinical consequences. Current drug metabolism 20040801
Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus. American journal of obstetrics and gynecology 20040801
ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antiviral therapy 20040801
[Drug-induced lithiasis]. Revue medicale de la Suisse romande 20040801
Nail, hair and skin hyperpigmentation associated with indinavir therapy. AIDS (London, England) 20040723
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. The Journal of clinical investigation 20040715
Incidence of and risk factors for adverse drug reactions in a prospective cohort of HIV-infected adults initiating protease inhibitor-containing therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040715
Reversed-phase liquid chromatography with ultraviolet detection for simultaneous quantitation of indinavir and propranolol from ex-vivo rat intestinal permeability studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705
HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). The Journal of pharmacology and experimental therapeutics 20040701
Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040701
Determination of indinavir and nelfinavir trough plasma concentration efficacy thresholds according to virological response in HIV-infected patients. HIV medicine 20040701
Thrombosis and a hypercoagulable state in HIV-infected patients. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20040701
Triple nucleoside treatment with abacavir plus the lamivudine/zidovudine combination tablet (COM) compared to indinavir/COM in antiretroviral therapy-naïve adults: results of a 48-week open-label, equivalence trial (CNA3014). Current medical research and opinion 20040701
Predictors of adherence and virologic outcome in HIV-infected patients treated with abacavir- or indinavir-based triple combination HAART also containing lamivudine/zidovudine. Current medical research and opinion 20040701
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease. The Journal of biological chemistry 20040625
High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040615
Antiviral drugs in current clinical use. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040601
Direct interference of HIV protease inhibitors with pancreatic beta-cell function. Naunyn-Schmiedeberg's archives of pharmacology 20040601
The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients. Antiviral therapy 20040601
Genotypic determinants of the virological response to tenofovir disoproxil fumarate in nucleoside reverse transcriptase inhibitor-experienced patients. Antiviral therapy 20040601
Pharmacokinetic interactions of drugs with St John's wort. Journal of psychopharmacology (Oxford, England) 20040601
[Highly Active AntiRetroviral Therapy and cryptosporidiosis]. Parassitologia 20040601
HIV protease inhibitors increase adiponectin levels in HIV-negative men. Journal of acquired immune deficiency syndromes (1999) 20040501
Drug monitoring of pyrimethamine during maintenance therapy of toxoplasmic encephalitis in patients with advanced HIV infection during HAART. Medical science monitor : international medical journal of experimental and clinical research 20040501
Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines. Pharmaceutical research 20040501
Ritonavir boosted indinavir treatment as a simplified maintenance 'mono'-therapy for HIV infection. AIDS (London, England) 20040409
Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected patients: immunovirological outcome and side effects. Antiviral research 20040401
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site. European journal of biochemistry 20040401
HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2. Molecular cancer therapeutics 20040401
Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. Journal of acquired immune deficiency syndromes (1999) 20040401
Comparison of two reduced-dose regimens of indinavir (600 mg vs 400 mg twice daily) and ritonavir (100 mg twice daily) in healthy volunteers (COREDIR). Antiviral therapy 20040401
Lamivudine 300 mg in HIV infection: dose change. Once-a-day dosing. Prescrire international 20040401
Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerging infectious diseases 20040401
Updated clinical pharmacologic considerations for HIV-1 protease inhibitors. Current HIV/AIDS reports 20040401
Effect of indinavir used alone or in double or triple combination with AZT and ddC on human immune functions. Life sciences 20040319
Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles? The Journal of infectious diseases 20040315
Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine. The Journal of infectious diseases 20040315
Protease inhibitors modulate apoptosis in mesangial cells derived from a mouse model of HIVAN. Kidney international 20040301
Anticonvulsant and antiretroviral interactions. The Annals of pharmacotherapy 20040301
Indinavir and rifabutin drug interactions in healthy volunteers. Journal of clinical pharmacology 20040301
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301
Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a combination of Efavirenz and Indinavir for 48 weeks. Chinese medical journal 20040301
Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. International journal of clinical pharmacology and therapeutics 20040301
Spectrophotometric determination of indinavir in bulk and pharmaceutical formulations using bromocresol purple and bromothymol blue. Die Pharmazie 20040301
Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors. Journal of acquired immune deficiency syndromes (1999) 20040301
Buffalo hump: what the experts suggest. AIDS clinical care 20040301
Simultaneous determination of indinavir, ritonavir and saquinavir in plasma by high-performance liquid chromatography. Journal of the Formosan Medical Association = Taiwan yi zhi 20040301
Efficacy of two modalities of triple HIV therapy: probable superiority of indinavir. International journal of antimicrobial agents 20040301
Chemokine mRNA levels in mononucleated cells of HIV-infected patients before and after initiation of PI- versus NNRTI-containing HAART. Antiviral research 20040301
Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains. Bioorganic & medicinal chemistry letters 20040223
Pharmacokinetics of indinavir/ritonavir (800/100 mg twice a day) combined with efavirenz in HIV-infected patients. AIDS (London, England) 20040220
The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma. International journal of cancer 20040210
Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity. Organic & biomolecular chemistry 20040207
Capillary electrophoretic method for determination of protease inhibitor indinavir sulfate used in human immunodeficiency virus therapy. Journal of pharmaceutical and biomedical analysis 20040204
Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology 20040201
Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia. Brain : a journal of neurology 20040201
Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040201
Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir. Analytical chemistry 20040201
[Indinavir urolithiasis in HIV-positive patients. Treatment and prophylaxis]. Der Urologe. Ausg. A 20040201
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Strategies to decrease viral load rebound, and prevent loss of CD4 and onset of resistance during structured treatment interruptions. Antiviral therapy 20040201
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Relapsing blepharitis in patients under highly active antiretroviral therapy including indinavir. AIDS (London, England) 20040123
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Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure. Bioorganic & medicinal chemistry 20040102
The effect of nevirapine on the pharmacokinetics of indinavir/ritonavir 800/100 mg BID. Journal of acquired immune deficiency syndromes (1999) 20040101
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas. Cancer research 20040101
Risk factors and occurrence of rash in HIV-positive patients not receiving nonnucleoside reverse transcriptase inhibitor: data from a randomized study evaluating use of protease inhibitors in nucleoside-experienced patients with very low CD4 levels (<50 cells/microL). HIV medicine 20040101
Determinants of long-term highly active antiretroviral treatment efficacy. HIV medicine 20040101
Drug-induced renal calculi: epidemiology, prevention and management. Drugs 20040101
A randomized clinical trial comparing nelfinavir and ritonavir in patients with advanced HIV disease (CPCRA 042/CTN 102). HIV clinical trials 20040101
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors. Journal of molecular recognition : JMR 20040101
Peptidomimetic inhibitors of HIV protease. Current topics in medicinal chemistry 20040101
Pharmacokinetics of indinavir in Koreans and Caucasians. Scandinavian journal of infectious diseases 20040101
Efficacy of quality criteria to identify potentially harmful information: a cross-sectional survey of complementary and alternative medicine web sites. Journal of medical Internet research 20040101
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[Indinavir and renal lithiasis]. Actas urologicas espanolas 20040101
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Urolithiasis associated with indinavir in a patient with spinal cord injury. The journal of spinal cord medicine 20040101
Practical guidelines to interpret plasma concentrations of antiretroviral drugs. Clinical pharmacokinetics 20040101
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No clinically significant pharmacokinetic interactions between voriconazole and indinavir in healthy volunteers. British journal of clinical pharmacology 20031201
Therapeutic drug monitoring of the HIV/AIDS drugs abacavir, zidovudine, efavirenz, nevirapine, indinavir, lopinavir, and nelfinavir. Pharmacology 20031201
Clinical use of a simultaneous HPLC assay for indinavir, saquinavir, ritonavir and nelfinavir in children and adults. Therapeutic drug monitoring 20031201
Photophobia in a patient with high indinavir plasma concentrations. Therapeutic drug monitoring 20031201
Isolated intraparotid Kaposi sarcoma in human immunodeficiency virus type 1 infection. Mayo Clinic proceedings 20031201
A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir. Antiviral therapy 20031201
Efficacy and safety of ritonavir/indinavir 100/400 mg twice daily in combination with two nucleoside analogues in antiretroviral treatment-naive HIV-infected individuals. Antiviral therapy 20031201
HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma/RANKL cross-talk. The Journal of biological chemistry 20031128
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Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation. AIDS (London, England) 20031121
Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir. Bioorganic & medicinal chemistry letters 20031117
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer 20031117
Resolution of HCV infection in a HIV-infected patient under HAART after several hepatitis flare-ups. European journal of medical research 20031112
PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proceedings of the National Academy of Sciences of the United States of America 20031111
Six-year follow-up of HIV-1-infected adults in a clinical trial of antiretroviral therapy with indinavir, zidovudine, and lamivudine. AIDS (London, England) 20031107
Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases. Bioorganic & medicinal chemistry 20031103
Influence of goldenseal root on the pharmacokinetics of indinavir. Journal of clinical pharmacology 20031101
The clinical art and science of urine microscopy. Current opinion in nephrology and hypertension 20031101
Field evaluation of an improved assay using a heat-dissociated p24 antigen for adults mainly infected with HIV-1 CRF02_AG strains in Côte d'Ivoire, West Africa. Journal of acquired immune deficiency syndromes (1999) 20031101
Treating advanced HIV infection. Journal of acquired immune deficiency syndromes (1999) 20031101
The safety and efficacy of indinavir and ritonavir (400/400 mg BID) in HIV-1-infected individuals from an inner-city minority population: a pilot study. International journal of STD & AIDS 20031101
A 6-base pair insertion in the protease gene of HIV type 1 detected in a protease inhibitor-naive patient is not associated with indinavir treatment failure. AIDS research and human retroviruses 20031101
[A randomized clinical trial to compare the effectiveness of indinavir, ritonavir and saquinavir]. Medicina clinica 20031025
Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals. AIDS (London, England) 20031017
Differential effect of HIV protease inhibitors on adipogenesis: intracellular ritonavir is not sufficient to inhibit differentiation. AIDS (London, England) 20031017
Long-term efficacy, safety, and tolerability of indinavir-based therapy in protease inhibitor-naive adults with advanced HIV infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031015
Anti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain. Biochemical pharmacology 20031015
HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent. Bioorganic & medicinal chemistry letters 20031006
[Interaction between methadone and antiretrovirals (stavudine, indinavir, ritonavir, nevirapine)]. Medicina clinica 20031004
Modulation of the LDL receptor and LRP levels by HIV protease inhibitors. Journal of lipid research 20031001
Changes in indinavir exposure over time: a case study in six HIV-1-infected children. The Journal of antimicrobial chemotherapy 20031001
Analysis of the protease sequences of HIV-1 infected individuals after Indinavir monotherapy. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20031001
Clinical use of a simultaneous HPLC assay for indinavir, saquinavir, ritonavir, and nelfinavir in children and adults. Therapeutic drug monitoring 20031001
Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells. HIV medicine 20031001
Pharmacokinetics of indinavir/ritonavir (800/100 mg) in combination with efavirenz (600 mg) in HIV-1-infected subjects. Journal of acquired immune deficiency syndromes (1999) 20031001
Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes. Antiviral therapy 20031001
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Atazanavir (Reyataz). Project Inform perspective 20031001
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Efficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failures. AIDS (London, England) 20030905
Stavudine or indinavir-containing regimens are associated with an increased risk of diabetes mellitus in HIV-infected individuals. AIDS (London, England) 20030905
Effect of antiretroviral protease inhibitors alone, and in combination with paromomycin, on the excystation, invasion and in vitro development of Cryptosporidium parvum. The Journal of antimicrobial chemotherapy 20030901
Effect of protease inhibitor-containing regimens on lymphocyte multidrug resistance transporter expression. The Journal of antimicrobial chemotherapy 20030901
Lipodystrophy in HIV-infected pediatric patients receiving protease inhibitors. The Annals of pharmacotherapy 20030901
A randomized trial of 2 different 4-drug antiretroviral regimens versus a 3-drug regimen, in advanced human immunodeficiency virus disease. The Journal of infectious diseases 20030901
Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 Trial. The Journal of infectious diseases 20030901
In vitro hypersusceptibility of human immunodeficiency virus type 1 subtype C protease to lopinavir. Antimicrobial agents and chemotherapy 20030901
The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration. European journal of immunology 20030901
Factors associated with maintenance of long-term plasma human immunodeficiency virus RNA suppression. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030901
Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20030901
Use of HIV protease inhibitors to block Kaposi's sarcoma and tumour growth. The Lancet. Oncology 20030901
The long-term effects of anti-retroviral protease inhibitors on sugar transport in L6 cells. The Journal of endocrinology 20030901
The binding of HIV-1 protease inhibitors to human serum proteins. Biophysical chemistry 20030901
Overdose reports--an underutilized resource. Pharmacoepidemiology and drug safety 20030901
A five-year evaluation of reports of overdose with indinavir sulfate. Pharmacoepidemiology and drug safety 20030901
Outcomes of dual-protease inhibitor salvage therapy in human immunodeficiency virus-infected patients referred to a telephone consultation service. Pharmacotherapy 20030901
Efficacy and durability of nevirapine in antiretroviral drug näive patients. Journal of acquired immune deficiency syndromes (1999) 20030901
Protein binding in antiretroviral therapies. AIDS research and human retroviruses 20030901
Boosted PIs: competition hots up. The AIDS reader 20030901
Characterizing classes of antiretroviral drugs by genotype. Statistics in medicine 20030830
Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. Annals of internal medicine 20030819
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Virological rebound after suppression on highly active antiretroviral therapy. AIDS (London, England) 20030815
The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro. Journal of acquired immune deficiency syndromes (1999) 20030815
Viral dynamics and their relations to baseline factors and longer term virologic responses in treatment-naive HIV-1-infected patients receiving abacavir in combination with HIV-1 protease inhibitors. Journal of acquired immune deficiency syndromes (1999) 20030815
HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent. Bioorganic & medicinal chemistry letters 20030804
The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains. Bioorganic & medicinal chemistry letters 20030804
Push/pull mechanisms of GLUT4 traffic in muscle cells. Acta physiologica Scandinavica 20030801
HIV-1 phenotypic susceptibility to lopinavir (LPV) and genotypic analysis in LPV/r-naive subjects with prior protease inhibitor experience. Journal of acquired immune deficiency syndromes (1999) 20030801
Quantitation of blood lymphocyte mitochondrial DNA for the monitoring of antiretroviral drug-induced mitochondrial DNA depletion. Journal of acquired immune deficiency syndromes (1999) 20030801
Rapid assessment of P-glycoprotein inhibition and induction in vitro. Pharmaceutical research 20030801
HIV protease inhibitors as new treatment options for Kaposi's sarcoma. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20030801
Vasodilator agents protect against indinavir nephrotoxicity. Antiviral therapy 20030801
Administration of indinavir and low-dose ritonavir (800/100 mg twice daily) with food reduces nephrotoxic peak plasma levels of indinavir. Antiviral therapy 20030801
Sequential cutaneous drug reactions to protease inhibitors in the context of occupational post-exposure prophylaxis. AIDS (London, England) 20030725
Joint models for efficient estimation in proportional hazards regression models. Statistics in medicine 20030715
Indinavir reduces Cryptosporidium parvum infection in both in vitro and in vivo models. International journal for parasitology 20030701
HIV protease inhibitors acutely impair glucose-stimulated insulin release. Diabetes 20030701
Low-dose indinavir in combination with low-dose ritonavir: steady-state pharmacokinetics and long-term clinical outcome follow-up. HIV medicine 20030701
Coadministration of milk thistle and indinavir in healthy subjects. Pharmacotherapy 20030701
Rapid enzymatic test for phenotypic HIV protease drug resistance. Biological chemistry 20030701
Prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients who have rebound in viral load while receiving antiretroviral therapy in the UNAIDS-Drug Access Initiative in Abidjan, Côte d'Ivoire. AIDS (London, England) 20030701
Low rate of genotypic HIV-1 drug-resistant strains in the Senegalese government initiative of access to antiretroviral therapy. AIDS (London, England) 20030701
Antiretroviral therapy in HIV-2-infected patients: changes in plasma viral load, CD4+ cell counts, and drug resistance profiles of patients treated in Abidjan, Côte d'Ivoire. AIDS (London, England) 20030701
Clinical, immunological and virological response to different antiretroviral regimens in a cohort of HIV-2-infected patients. AIDS (London, England) 20030701
Variable prediction of antiretroviral treatment outcome by different systems for interpreting genotypic human immunodeficiency virus type 1 drug resistance. The Journal of infectious diseases 20030615
Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: homeostatic mechanisms of HIV protease inhibitors. Journal of immunology (Baltimore, Md. : 1950) 20030615
A review of low-dose ritonavir in protease inhibitor combination therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030615
Latrogenic nephrogenic diabetes insipidus. AIDS (London, England) 20030613
Reverse phase high-performance liquid chromatography method for the analysis of amprenavir, efavirenz, indinavir, lopinavir, nelfinavir and its active metabolite (M8), ritonavir, and saquinavir in heparinized human plasma. Therapeutic drug monitoring 20030601
Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography. Therapeutic drug monitoring 20030601
Cholelithiasis possibly induced by protease inhibitors in 3 patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030601
Assessment of adherence to triple antiretroviral treatment including indinavir: role of the determination of plasma levels of indinavir. Journal of acquired immune deficiency syndromes (1999) 20030601
Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity. The American journal of the medical sciences 20030601
Interaction with indinavir to enhance systemic exposure of an investigational HIV protease inhibitor in rats, dogs and monkeys. Xenobiotica; the fate of foreign compounds in biological systems 20030601
Indinavir plasma concentrations and resistance mutations in patients experiencing early virological failure. AIDS research and human retroviruses 20030601
Nucleoside-free regimen tested. AIDS patient care and STDs 20030601
Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics. Antiviral therapy 20030601
Comparison of nine resistance interpretation systems for HIV-1 genotyping. Antiviral therapy 20030601
Lack of mutations in LMNA, its promoter region, and the cellular retinoic acid binding protein II (CRABP II) in HIV associated lipodystrophy. European journal of medical research 20030530
Sensitive and specific determination of eight antiretroviral agents in plasma by high-performance liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525
Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected individuals. AIDS (London, England) 20030523
Suppression of cerebrospinal fluid HIV burden in antiretroviral naive patients on a potent four-drug antiretroviral regimen. AIDS (London, England) 20030523
Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant women. AIDS (London, England) 20030523
Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus. Bioorganic & medicinal chemistry letters 20030519
[HIV-infection, HAART (highly-active antiretroviral therapy) and hyperlipidemia]. Deutsche medizinische Wochenschrift (1946) 20030509
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. Journal of medicinal chemistry 20030508
A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients. AIDS (London, England) 20030502
High indinavir plasma concentrations in HIV-positive patients co-infected with hepatitis B or C virus treated with low doses of indinavir and ritonavir (400/100 mg twice a day) plus two nucleoside reverse transcriptase inhibitors. AIDS (London, England) 20030502
Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients. The Journal of antimicrobial chemotherapy 20030501
APHS can act synergically with clinically available HIV-1 reverse transcriptase and protease inhibitors and is active against several drug-resistant HIV-1 strains in vitro. The Journal of antimicrobial chemotherapy 20030501
Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues. Diabetologia 20030501
Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4+ T lymphoblastoid CEM cell line. Chemotherapy 20030501
Once-a-day highly active antiretroviral therapy: a systematic review. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030501
Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants. Antiviral research 20030501
Hepatotoxicity associated with antiretroviral therapy containing HIV-1 protease inhibitors. Seminars in liver disease 20030501
Factors associated with accelerated atherosclerosis in HIV-1-infected persons treated with protease inhibitors. AIDS patient care and STDs 20030501
[Observational study on the efficacy of the application of two classical regimens of triple antiretroviral therapy]. Anales de medicina interna (Madrid, Spain : 1984) 20030501
In-vitro crystallization of indinavir in the presence of ritonavir and as a function of pH. The Journal of pharmacy and pharmacology 20030501
[Managing side effects. Individualized dosage makes indinavir more tolerable]. MMW Fortschritte der Medizin 20030428
Determination of protease inhibitors using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030425
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains. Journal of medicinal chemistry 20030424
Changes in CSF and plasma HIV-1 RNA and cognition after starting potent antiretroviral therapy. Neurology 20030422
Brief report: efficacy and treatment-limiting toxicity with the concurrent use of lopinavir/ritonavir and a third protease inhibitor in treatment-experienced HIV-infected patients. Journal of acquired immune deficiency syndromes (1999) 20030415
Continued indinavir versus switching to indinavir/ritonavir in HIV-infected patients with suppressed viral load. AIDS (London, England) 20030411
Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication. Antimicrobial agents and chemotherapy 20030401
Sildenafil does not alter nelfinavir pharmacokinetics. Therapeutic drug monitoring 20030401
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. The Journal of infectious diseases 20030401
[Measuring the HIV viral load with LCx (Abbott): importance for the therapeutic follow-up of 3 patients infected by type O HIV]. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 20030401
Diffuse ulcerations due to disseminated histoplasmosis in a patient with HIV. Journal of drugs in dermatology : JDD 20030401
HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin D. AIDS (London, England) 20030307
Steady-state pharmacokinetic interaction of modified-dose indinavir and rifabutin. Clinical pharmacology and therapeutics 20030301
Indinavir-induced thrombocytopenia. AIDS patient care and STDs 20030301
Superior virological efficacy of ritonavir-boosted protease inhibitor regimens compared to single protease inhibitor therapy. European journal of medical research 20030221
Measurement of strain-dependent toxicity in the indene bioconversion using multiparameter flow cytometry. Biotechnology and bioengineering 20030220
Inference for a linear regression model with an interval-censored covariate. Statistics in medicine 20030215
Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030205
Toward the development of a virus-cell-based assay for the discovery of novel compounds against human immunodeficiency virus type 1. Antimicrobial agents and chemotherapy 20030201
The etiology of urolithiasis in HIV infected patients. The Journal of urology 20030201
Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction. The Annals of pharmacotherapy 20030201
Persistent leukocyturia and loss of renal function in a prospectively monitored cohort of HIV-infected patients treated with indinavir. Journal of acquired immune deficiency syndromes (1999) 20030201
Effect of indinavir on the intestinal exsorption of amprenavir, saquinavir and nelfinavir after intravenous administration in rats. Biological & pharmaceutical bulletin 20030201
Rapid quantification of HIV protease inhibitors in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Journal of mass spectrometry : JMS 20030201
Synthesis and anti-HIV activity of new C2 symmetric derivatives designed as HIV-1 protease inhibitors. Farmaco (Societa chimica italiana : 1989) 20030201
The HIV protease inhibitor indinavir impairs glycogen synthesis in HepG2 hepatoma cells. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201
Performance analysis of a rapid HPLC determination with the solvent demixing extraction of HIV antiproteases and efavirenz in plasma. Journal of chromatographic science 20030201
Protease inhibitor drug levels in the management of human immunodeficiency virus-1 antiretroviral therapy. International journal of STD & AIDS 20030201
[Antiretrovirals]. Nihon rinsho. Japanese journal of clinical medicine 20030201
Anti-retroviral protease inhibitors--'a two edged sword?'. IUBMB life 20030201
Diagnosis, antiretroviral therapy, and emergence of resistance to antiretroviral agents in HIV-2 infection: a review. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20030201
[HIV protease inhibitors for the treatment of Kaposi's sarcoma]. Recenti progressi in medicina 20030201
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance. Biochemistry 20030128
Inhibition of TNF-alpha mediated cell death by HIV-1 specific protease inhibitors. European journal of medical research 20030128
Efficacy of a twice-daily antiretroviral regimen containing 100 mg ritonavir/400 mg indinavir in HIV-infected patients. AIDS (London, England) 20030124
[Fatty liver and increased serum lactate in a woman with HIV]. Deutsche medizinische Wochenschrift (1946) 20030117
Simultaneous quantitative determination of the HIV protease inhibitors indinavir, amprenavir, ritonavir, lopinavir, saquinavir, nelfinavir and the nelfinavir active metabolite M8 in plasma by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030115
Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors. AIDS (London, England) 20030103
Drug-induced nail abnormalities. American journal of clinical dermatology 20030101
Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. The Journal of pharmacology and experimental therapeutics 20030101
Predicting HIV drug resistance with neural networks. Bioinformatics (Oxford, England) 20030101
The effects of protease inhibitors on basal and insulin-stimulated lipid metabolism, insulin binding, and signaling. Journal of lipid research 20030101
'Multi-component reactions : emerging chemistry in drug discovery' 'from xylocain to crixivan'. Current medicinal chemistry 20030101
Overcoming resistance: virologic response to a salvage regimen with the combination of ritonavir plus indinavir. HIV clinical trials 20030101
Lipid changes in patients initiating efavirenz- and indinavir-based antiretroviral regimens. HIV clinical trials 20030101
In vitro activity of potential anti-poxvirus agents. Antiviral research 20030101
Severe cutaneous reactions associated with the use of human immunodeficiency virus medications. Acta dermato-venereologica 20030101
Methadone maintenance treatment and St. John's Wort - a case report. Pharmacopsychiatry 20030101
Therapeutic drug monitoring: an aid to optimising response to antiretroviral drugs? Drugs 20030101
Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs 20030101
[Study of interactions between anti-retroviral agents and concomitant drugs]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20030101
Lamivudine/zidovudine/abacavir: triple combination tablet. Drugs 20030101
Saquinavir: a review of its use in boosted regimens for treating HIV infection. Drugs 20030101
An in vivo pharmacokinetic/pharmacodynamic model for antiretroviral combination. HIV clinical trials 20030101
Pharmacokinetic interactions with rifampicin : clinical relevance. Clinical pharmacokinetics 20030101
Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors. Journal of molecular recognition : JMR 20030101
Indinavir did not further increase mean triglyceride levels in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors: an analysis of three randomized clinical trials. Pharmacoepidemiology and drug safety 20030101
Combined analysis of two-year follow-up from two open-label randomized trials comparing efficacy of three nucleoside reverse transcriptase inhibitor backbones for previously untreated HIV-1 infection: OzCombo 1 and 2. HIV clinical trials 20030101
Inhibition of cytochrome P450 3A: relevant drug interactions in gastroenterology. Digestion 20030101
Dietary effects on drug metabolism and transport. Clinical pharmacokinetics 20030101
[Decrease of HIV-1 replicative capacity after serial passage in MT-4 cells under conditions of the combined antiretroviral therapy]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20030101
The effect of human immunodeficiency virus-1 protease inhibitors on the toxicity of a variety of cells. In vitro cellular & developmental biology. Animal 20030101
Three- or four- versus two-drug antiretroviral maintenance regimens for HIV infection. The Cochrane database of systematic reviews 20030101
Differences in durability of treatment with initial PI-based regimens. HIV clinical trials 20030101
Efficacy of a twice-daily antiretroviral regimen containing 100 mg ritonavir/400 mg indinavir in HIV-infected patients, by Ghosn et al. AIDS (London, England) 20030101
Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug metabolism and pharmacokinetics 20030101
Drug-induced urinary calculi. Reviews in urology 20030101
Report from the 4th International Workshop on Clinical Pharmacology of HIV Therapy. Drinking lots of water still necessary with new indinavir regimens. TreatmentUpdate 20030101
Onychodystrophy and its management. German medical science : GMS e-journal 20030101
Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine or stavudine, each in combination with lamivudine and indinavir. Journal of acquired immune deficiency syndromes (1999) 20021215
Open-label study of a twice-daily indinavir 800-mg/ritonavir 100-mg regimen in protease inhibitor-naive HIV-infected adults. Journal of acquired immune deficiency syndromes (1999) 20021215
Open-label study of a twice-daily indinavir 800-mg/ritonavir 200-mg regimen in HIV-infected adults failing a protease inhibitor regimen. Journal of acquired immune deficiency syndromes (1999) 20021215
Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains. Journal of molecular biology 20021206
Increased risk of lipoatrophy under stavudine in HIV-1-infected patients: results of a substudy from a comparative trial. AIDS (London, England) 20021206
Relationships between structure and interaction kinetics for HIV-1 protease inhibitors. Journal of medicinal chemistry 20021205
Persistence of earlier HIV-1 drug resistance mutations at new treatment failure. Journal of medical virology 20021201
Incidence of adipose tissue alterations in first-line antiretroviral therapy: the LipoICoNa Study. Archives of internal medicine 20021201
Comparison of the efficacy, safety and predictive value of HIV genotyping using distinct ritonavir-boosted protease inhibitors. International journal of antimicrobial agents 20021201
Post-exposure prophylaxis. International journal of STD & AIDS 20021201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20021201
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS (London, England) 20021122
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Underpowered clinical trials of antiretroviral treatment. JAMA 20021106
Application of multi-parameter flow cytometry using fluorescent probes to study substrate toxicity in the indene bioconversion. Biotechnology and bioengineering 20021105
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New anti-HIV agents and targets. Medicinal research reviews 20021101
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Human infection with Cryptosporidium felis: case report and literature review. Emerging infectious diseases 20020101
Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection. The Journal of infectious diseases 20020101
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Viral and immunologic follow up of 4 to 9 years of AIDS treatments by quadruple combinations of virostatics including integrase inhibitors applied in short sequences differing by drug rotation. Acta pharmacologica Sinica 20020101
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Interaction between levothyroxine and indinavir in a patient with HIV infection. Infection 20020101
HIV postexposure prophylaxis in the remote prehospital environment. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors 20020101
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The role of pharmacokinetics in drug discovery: finding drug candidates with the greatest potential for success. Ernst Schering Research Foundation workshop 20020101
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Successful simplification of HAART in patients with acute primary HIV infection. Journal of biological regulators and homeostatic agents 20020101
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A critical evaluation of the therapeutic range of indinavir. The Annals of pharmacotherapy 20020101
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Evaluation of the origins of the selectivity of polymers imprinted with a HIV protease inhibitor using infrared spectroscopy and high performance liquid chromatography. Enantiomer 20020101
Clinical implications of CNS penetration of antiretroviral drugs. CNS drugs 20020101
Hepatic and intestinal contributions to pharmacokinetic interaction of indinavir with amprenavir, nelfinavir and saquinavir in rats. Antiviral chemistry & chemotherapy 20020101
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Immune reconstitution during intensive chemotherapy in patients with human immunodeficiency virus related non-Hodgkin lymphoma. The hematology journal : the official journal of the European Haematology Association 20020101
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Reversible coma caused by risperidone-ritonavir interaction. Clinical neuropharmacology 20020101
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[Drug-induced acute pancreatitis: a personal contribution]. Chirurgia italiana 20020101
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[Acute severe pancreatitis caused by anti-HIV drugs]. Annali italiani di chirurgia 20020101
[Renal lithiasis due to indinavir]. Revista de medicina de la Universidad de Navarra 20020101
Modulation of the multidrug resistance (MDR) phenotype in CEM MDR cells simultaneously exposed to anti HIV-1 protease inhibitors (PI's) and cytotoxic drugs. Annali dell'Istituto superiore di sanita 20020101
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Management of protease inhibitor-associated hyperlipidemia. American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101
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Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320. Annals of internal medicine 20011204
Summaries for patients. Predictors of outcomes in patients with HIV infection treated with indinavir, zidovudine, and lamivudine. Annals of internal medicine 20011204
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The chemotherapeutic agent bleomycin in a two-drug combination with zidovudine, ritonavir or indinavir synergistically inhibits HIV Type-1 replication in peripheral blood lymphocytes. International journal of antimicrobial agents 20011201
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. British journal of pharmacology 20011201
Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease. Chemistry & biology 20011201
Reduction of signal suppression effects in ESI-MS using a nanosplitting device. Analytical chemistry 20011201
Has there been a decrease in the prevalence of mood disorders in HIV-seropositive individuals since the introduction of combination therapy? European psychiatry : the journal of the Association of European Psychiatrists 20011201
Therapeutic drug monitoring of HIV protease inhibitors using high-performance liquid chromatography with ultraviolet or photodiode array detection. Therapeutic drug monitoring 20011201
[Urinary lithiasis secondary to indinavir in an HIV-positive patient]. Archivos espanoles de urologia 20011201
Combination of protease inhibitors for the treatment of HIV-1-infected patients: a review of pharmacokinetics and clinical experience. Antiviral therapy 20011201
Genotypic correlates of resistance to HIV-1 protease inhibitors on longitudinal data: the role of secondary mutations. Antiviral therapy 20011201
Ritonavir/saquinavir plus one nucleoside reverse transcriptase inhibitor (NRTI) versus indinavir plus two NRTIs in protease inhibitor-naive HIV-1-infected adults (IRIS study). Antiviral therapy 20011201
[Tuberculosis among HIV-infected persons in Norway]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20011130
Correlation between reduction in plasma HIV-1 RNA concentration 1 week after start of antiretroviral treatment and longer-term efficacy. Lancet (London, England) 20011124
Protease inhibitors and erectile dysfunction. AIDS (London, England) 20011123
HIV protease inhibitors reduce IL-2 release from normal human phytohaemagglutinin-activated T cells. AIDS (London, England) 20011123
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors. Journal of medicinal chemistry 20011122
Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir. Carbohydrate research 20011121
Synergistic antiadipogenic effects of HIV type 1 protease inhibitors with tumor necrosis factor alpha: suppression of extracellular insulin action mediated by extracellular matrix-degrading proteases. AIDS research and human retroviruses 20011120
[Rate and risk factors of liver toxicity in patients receiving antiretroviral therapy]. Medicina clinica 20011117
Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo. The Journal of infectious diseases 20011115
New developments in anti-HIV chemotherapy. Current medicinal chemistry 20011101
Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy. The Journal of infectious diseases 20011101
DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrobial agents and chemotherapy 20011101
Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte cultures. Drug and alcohol dependence 20011101
Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy. Metabolism: clinical and experimental 20011101
Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice. Laboratory investigation; a journal of technical methods and pathology 20011101
Symptomatic hyperbilirubinemia with indinavir/ritonavir-containing regimen. The Annals of pharmacotherapy 20011101
Prevalence of adverse events associated with potent antiretroviral treatment: Swiss HIV Cohort Study. Lancet (London, England) 20011020
HIV-protease inhibitors alter retinoic acid synthesis. AIDS (London, England) 20011019
Synthesis of potent C(2)-symmetric, diol-based hiv-1 protease inhibitors. Investigation of thioalkyl and thioaryl P1/P1' substituents. Journal of medicinal chemistry 20011011
Functional expression of P-glycoprotein in rat brain microglia. The Journal of pharmacology and experimental therapeutics 20011001
Indinavir nephropathy revisited: a pattern of insidious renal failure with identifiable risk factors. American journal of kidney diseases : the official journal of the National Kidney Foundation 20011001
[Skin manifestations of immune restoration syndrome in treated tuberculosis]. Annales de dermatologie et de venereologie 20011001
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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. The Journal of biological chemistry 20010907
Drug resistance in patients experiencing early virological failure under a triple combination including indinavir. AIDS (London, England) 20010907
Indinavir-associated asymptomatic nephrolithiasis and renal cortex atrophy in two HIV-1 infected children. AIDS (London, England) 20010907
Mismatched double-stranded RNA (polyI-polyC(12)U) is synergistic with multiple anti-HIV drugs and is active against drug-sensitive and drug-resistant HIV-1 in vitro. Antiviral research 20010901
Antiretroviral drug concentrations in semen of HIV-infected men: differential penetration of indinavir, ritonavir and saquinavir. The Journal of antimicrobial chemotherapy 20010901
Incidence and risk factors for the development of indinavir-associated renal complications. The Journal of antimicrobial chemotherapy 20010901
Application of radiolabeled tracers to biocatalytic flux analysis. European journal of biochemistry 20010901
Indinavir crystallization around the loop of Henle: experimental evidence. Journal of acquired immune deficiency syndromes (1999) 20010901
Different combinations of ritonavir-indinavir. TreatmentUpdate 20010901
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A case of flare syndrome. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20010901
Indinavir did not increase the short-term risk of adverse cardiovascular events relative to nucleoside reverse transcriptase inhibitor therapy in four phase III clinical trials. AIDS (London, England) 20010817
Antiviral drugs: current state of the art. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20010801
HIV-protease inhibitors contribute to P-glycoprotein efflux function defect in peripheral blood lymphocytes from HIV-positive patients receiving HAART. Journal of acquired immune deficiency syndromes (1999) 20010801
Comparison of virologic, immunologic, and clinical response to five different initial protease inhibitor-containing and nevirapine-containing regimens. Journal of acquired immune deficiency syndromes (1999) 20010801
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