Home Halogens Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, sodium salt (1:2)

Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, sodium salt (1:2)

CAS No.:
149845-07-8
Catalog Number:
AG001M1S
Molecular Formula:
C7H7ClNa2O6P2S
Molecular Weight:
362.5719
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG001M1S
Chemical Name:
Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, sodium salt (1:2)
CAS Number:
149845-07-8
Molecular Formula:
C7H7ClNa2O6P2S
Molecular Weight:
362.5719
MDL Number:
MFCD16872037
IUPAC Name:
disodium;[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
InChI:
InChI=1S/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
InChI Key:
SKUHWSDHMJMHIW-UHFFFAOYSA-L
SMILES:
Clc1ccc(cc1)SC(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
UNII:
BH6M93CIA0
Properties
Complexity:
320  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
361.892g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
362.564g/mol
Monoisotopic Mass:
361.892g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
146A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Interaction between a bisphosphonate, tiludronate and nanocrystalline apatite: in vitro viability and proliferation of HOP and HBMSC cells. Biomedical materials (Bristol, England) 20121001
Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β. American journal of veterinary research 20121001
Assessment of a bone biopsy technique for measuring tiludronate in horses: a preliminary study. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20110401
Treatment with tiludronic acid helps reduce the development of experimental osteoarthritis lesions in dogs with anterior cruciate ligament transection followed by reconstructive surgery: a 1-year study with quantitative magnetic resonance imaging. The Journal of rheumatology 20110101
Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis research & therapy 20110101
Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100901
Tiludronate infusion in the treatment of bone spavin: a double blind placebo-controlled trial. Equine veterinary journal 20100701
Effect of dodecylmaltoside (DDM) on uptake of BCS III compounds, tiludronate and cromolyn, in Caco-2 cells and rat intestine model. Drug delivery 20100401
Paget's disease 2: exploring diagnosis, management and support strategies. Nursing times 20090201
Paget disease of bone: therapeutic options. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20081001
Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX-1. Journal of veterinary pharmacology and therapeutics 20080401
Pharmacological effects of tiludronate in horses after long-term immobilization. Bone 20070901
Efficacy of tiludronate in the treatment of horses with signs of pain associated with osteoarthritic lesions of the thoracolumbar vertebral column. American journal of veterinary research 20070301
Treatment with tiludronate has a similar effect to risedronate on Paget's disease activity assessed by bone markers and bone scintigraphy. Clinical and experimental rheumatology 20070101
Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. Methods and findings in experimental and clinical pharmacology 20060101
Tiludronate inhibits prostaglandin F2alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Molecular and cellular endocrinology 20050531
[Paget's disease and its therapeutic management]. Presse medicale (Paris, France : 1983) 20050423
Non-isomerized C-telopeptide fragments are highly sensitive markers for monitoring disease activity and treatment efficacy in Paget's disease of bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050401
The role of bisphosphonates in the management of advanced cancer with a focus on non-small-cell lung cancer. Part 1: Mechanisms of action, role of biomarkers and preclinical applications. Oncology 20050101
In vitro toxicity of bisphosphonates on human neuroblastoma cell lines. Anti-cancer drugs 20040901
Long-term biochemical response after bisphosphonate therapy in Paget's disease of bone. Proposed intervals for monitoring treatment. Rheumatology (Oxford, England) 20040701
Effect of bisphosphonate treatment in patients with Paget's disease of the skull. Rheumatology (Oxford, England) 20040101
Bisphosphonate resistance in Paget's disease of bone. Arthritis and rheumatism 20030801
Tiludronate as a new therapeutic agent in the treatment of navicular disease: a double-blind placebo-controlled clinical trial. Equine veterinary journal 20030601
Serum osteoprotegerin and its ligand in Paget's disease of bone: relationship to disease activity and effect of treatment with bisphosphonates. Arthritis and rheumatism 20030301
Suppression of viability and acetyl-LDL metabolism in RAW 264 macrophage-like and smooth muscle cells by bisphosphonates in vitro. Methods and findings in experimental and clinical pharmacology 20021001
Usefulness of biochemical markers of bone turnover in assessing response to the treatment of Paget's disease. Bone 20011101
Treatment of osteoporosis with bisphosphonates. Rheumatic diseases clinics of North America 20010201
Intermittent cyclic tiludronate in the treatment of osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101
Human pharmacokinetics of tiludronate. Bone 19951101
A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders. Bone 19950801
Biological and clinical assessment of a new bisphosphonate, (chloro-4 phenyl) thiomethylene bisphosphonate, in the treatment of Paget's disease of bone. Bone 19880101
Properties