Home Halogens Platinum, diamminedichloro-, (SP-4-1)-

Platinum, diamminedichloro-, (SP-4-1)-

CAS No.:
14913-33-8
Catalog Number:
AG001LFN
Molecular Formula:
Cl2H6N2Pt
Molecular Weight:
300.0450
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG001LFN
Chemical Name:
Platinum, diamminedichloro-, (SP-4-1)-
CAS Number:
14913-33-8
Molecular Formula:
Cl2H6N2Pt
Molecular Weight:
300.0450
MDL Number:
MFCD00011623
IUPAC Name:
azane;dichloroplatinum
InChI:
InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI Key:
LXZZYRPGZAFOLE-UHFFFAOYSA-L
SMILES:
Cl[Pt]Cl.N.N
Properties
Complexity:
2.8  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
298.956g/mol
Formal Charge:
0
Heavy Atom Count:
5  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
300.046g/mol
Monoisotopic Mass:
298.956g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Plasmodium falciparum: the potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials. Experimental parasitology 20121201
Novel role of base excision repair in mediating cisplatin cytotoxicity. The Journal of biological chemistry 20110422
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs. Breast cancer research and treatment 20110201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Transcription inhibition by platinum-DNA cross-links in live mammalian cells. Journal of the American Chemical Society 20100602
Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. Chemistry (Weinheim an der Bergstrasse, Germany) 20090914
Reaction of human metallothionein-3 with cisplatin and transplatin. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090901
The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. Toxicology in vitro : an international journal published in association with BIBRA 20090801
In silico approach to cisplatin toxicity. Quantum chemical studies on platinum(II)-cysteine systems. Journal of molecular modeling 20090601
Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes. Dalton transactions (Cambridge, England : 2003) 20090514
The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. Molecular pharmacology 20090201
Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach. Inorganic chemistry 20080107
High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA. Acta biochimica Polonica 20080101
Free radical-induced redox chemistry of platinum-containing anti-cancer drugs. Radiation research 20071001
Incorporation of two modified nucleosides allows selective platination of an oligonucleotide making it suitable for duplex cross-linking. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070801
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. Chemical communications (Cambridge, England) 20070114
Cucurbituril binding of trans-[{PtCl(NH3)2}2(micro-NH2(CH2)8NH2)]2+ and the effect on the reaction with cysteine. Dalton transactions (Cambridge, England : 2003) 20061207
Impaired cisplatin influx in an A2780 mutant cell line: evidence for a putative, cis-configuration-specific, platinum influx transporter. Cancer biology & therapy 20060801
Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells. Biochemical pharmacology 20060728
Transplatin, a cisplatin trans-isomer, may enhance the anticancer effect of 5-fluorouracil. Journal of experimental & clinical cancer research : CR 20060601
Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand. Journal of medicinal chemistry 20060420
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051101
Contrasting chemistry of cis- and trans-platinum(II) diamine anticancer compounds: hydrolysis studies of picoline complexes. Inorganic chemistry 20051017
Insights into the reaction of transplatin with DNA and proteins: methionine-mediated formation of histidine-guanine trans-Pt(NH3)2 cross-links. Chemistry (Weinheim an der Bergstrasse, Germany) 20041025
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. Biochemical pharmacology 20040315
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action. The Journal of biological chemistry 20031128
Role of the p38 MAPK pathway in cisplatin-based therapy. Oncogene 20030626
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines. Biochemistry 20030527
Synergistic inhibitory effects of transplatin and beta-hydroxyisovalerylshikon on carcinoma A431 cells involve epidermal growth factor receptor. Cancer letters 20021215
Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells. Journal of experimental & clinical cancer research : CR 20021201
Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. Journal of medicinal chemistry 20021121
Novel apoptosis-inducing trans-platinum piperidine derivatives: synthesis and biological characterization. Journal of medicinal chemistry 20021121
Formation of adenine-N3/guanine-N7 cross-link in the reaction of trans-oriented platinum substrates with dinucleotides. Journal of the American Chemical Society 20021030
Study of the modifications caused by cisplatin, transplatin, and Pd(II) and Pt(II) mepirizole derivatives on pBR322 DNA by atomic force microscopy. International journal of pharmaceutics 20021001
Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. Molecular pharmacology 20020901
Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles. Journal of inorganic biochemistry 20020725
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes. Chembiochem : a European journal of chemical biology 20020104
Metal-modified nucleobase sextet: joining four linear metal fragments (trans-a2PtII) and six model nucleobases to an exceedingly stable entity. Chemistry (Weinheim an der Bergstrasse, Germany) 20010504
Characterization of the mutational specificity of DNA cross-linking mutagens by the Lac+ reversion assay with Escherichia coli. Teratogenesis, carcinogenesis, and mutagenesis 20010101
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicological sciences : an official journal of the Society of Toxicology 20001201
Properties