Platinum, diamminedichloro-, (SP-4-1)-
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Plasmodium falciparum: the potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials. | Experimental parasitology 20121201 |
Novel role of base excision repair in mediating cisplatin cytotoxicity. | The Journal of biological chemistry 20110422 |
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs. | Breast cancer research and treatment 20110201 |
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
Transcription inhibition by platinum-DNA cross-links in live mammalian cells. | Journal of the American Chemical Society 20100602 |
Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. | Chemistry (Weinheim an der Bergstrasse, Germany) 20090914 |
Reaction of human metallothionein-3 with cisplatin and transplatin. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090901 |
The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. | Toxicology in vitro : an international journal published in association with BIBRA 20090801 |
In silico approach to cisplatin toxicity. Quantum chemical studies on platinum(II)-cysteine systems. | Journal of molecular modeling 20090601 |
Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes. | Dalton transactions (Cambridge, England : 2003) 20090514 |
The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. | Molecular pharmacology 20090201 |
Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach. | Inorganic chemistry 20080107 |
High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA. | Acta biochimica Polonica 20080101 |
Free radical-induced redox chemistry of platinum-containing anti-cancer drugs. | Radiation research 20071001 |
Incorporation of two modified nucleosides allows selective platination of an oligonucleotide making it suitable for duplex cross-linking. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070801 |
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. | Chemical communications (Cambridge, England) 20070114 |
Cucurbituril binding of trans-[{PtCl(NH3)2}2(micro-NH2(CH2)8NH2)]2+ and the effect on the reaction with cysteine. | Dalton transactions (Cambridge, England : 2003) 20061207 |
Impaired cisplatin influx in an A2780 mutant cell line: evidence for a putative, cis-configuration-specific, platinum influx transporter. | Cancer biology & therapy 20060801 |
Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells. | Biochemical pharmacology 20060728 |
Transplatin, a cisplatin trans-isomer, may enhance the anticancer effect of 5-fluorouracil. | Journal of experimental & clinical cancer research : CR 20060601 |
Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand. | Journal of medicinal chemistry 20060420 |
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051101 |
Contrasting chemistry of cis- and trans-platinum(II) diamine anticancer compounds: hydrolysis studies of picoline complexes. | Inorganic chemistry 20051017 |
Insights into the reaction of transplatin with DNA and proteins: methionine-mediated formation of histidine-guanine trans-Pt(NH3)2 cross-links. | Chemistry (Weinheim an der Bergstrasse, Germany) 20041025 |
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. | Biochemical pharmacology 20040315 |
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action. | The Journal of biological chemistry 20031128 |
Role of the p38 MAPK pathway in cisplatin-based therapy. | Oncogene 20030626 |
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines. | Biochemistry 20030527 |
Synergistic inhibitory effects of transplatin and beta-hydroxyisovalerylshikon on carcinoma A431 cells involve epidermal growth factor receptor. | Cancer letters 20021215 |
Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells. | Journal of experimental & clinical cancer research : CR 20021201 |
Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. | Journal of medicinal chemistry 20021121 |
Novel apoptosis-inducing trans-platinum piperidine derivatives: synthesis and biological characterization. | Journal of medicinal chemistry 20021121 |
Formation of adenine-N3/guanine-N7 cross-link in the reaction of trans-oriented platinum substrates with dinucleotides. | Journal of the American Chemical Society 20021030 |
Study of the modifications caused by cisplatin, transplatin, and Pd(II) and Pt(II) mepirizole derivatives on pBR322 DNA by atomic force microscopy. | International journal of pharmaceutics 20021001 |
Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. | Molecular pharmacology 20020901 |
Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles. | Journal of inorganic biochemistry 20020725 |
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes. | Chembiochem : a European journal of chemical biology 20020104 |
Metal-modified nucleobase sextet: joining four linear metal fragments (trans-a2PtII) and six model nucleobases to an exceedingly stable entity. | Chemistry (Weinheim an der Bergstrasse, Germany) 20010504 |
Characterization of the mutational specificity of DNA cross-linking mutagens by the Lac+ reversion assay with Escherichia coli. | Teratogenesis, carcinogenesis, and mutagenesis 20010101 |
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. | Toxicological sciences : an official journal of the Society of Toxicology 20001201 |