Dammar-24-ene-3,6,12,20-tetrol, (3β,6α,12β,20R)-
| Title | Journal |
|---|---|
| Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. | Plant & cell physiology 20120901 |
| Fungal sensitivity to and enzymatic deglycosylation of ginsenosides. | Phytochemistry 20120601 |
| Co-transformation of Panax major ginsenosides Rb₁ and Rg₁ to minor ginsenosides C-K and F₁ by Cladosporium cladosporioides. | Journal of industrial microbiology & biotechnology 20120401 |
| Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-d-aspartic Acid receptor-mediated ion currents. | The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120401 |
| Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806. | World journal of microbiology & biotechnology 20120401 |
| Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the Akt-dependent phosphorylation of endothelial nitric oxide synthase. | Journal of agricultural and food chemistry 20120328 |
| Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20120205 |
| Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. | Chinese medicine 20120101 |
| Antioxidant and hepatoprotective effects of the red ginseng essential oil in H(2)O(2)-treated hepG2 cells and CCl(4)-treated mice. | International journal of molecular sciences 20120101 |
| Inhibitory Effect of Ginsenoside Rg1 on Vascular Smooth Muscle Cell Proliferation Induced by PDGF-BB Is Involved in Nitric Oxide Formation. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Application of Monoclonal Antibodies against Bioactive Natural Products: Eastern Blotting and Preparation of Knockout Extract. | International journal of analytical chemistry 20120101 |
| Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen Activator. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives. | Molecules (Basel, Switzerland) 20111219 |
| Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. | Journal of ethnopharmacology 20111011 |
| Simultaneous determination of ginsenoside (G-Re, G-Rg1, G-Rg2, G-F1, G-Rh1) and protopanaxatriol in human plasma and urine by LC-MS/MS and its application in a pharmacokinetics study of G-Re in volunteers. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715 |
| Development of a rapid and convenient method to separate eight ginsenosides from Panax ginseng by high-speed counter-current chromatography coupled with evaporative light scattering detection. | Journal of separation science 20110501 |
| Development of new staining technology 'eastern blotting' using monoclonal antibody. | Current drug discovery technologies 20110301 |
| Protopanaxatriol-type ginsenosides from the root of Panax ginseng. | Journal of agricultural and food chemistry 20110112 |
| Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) Root Extract Combinations Increase Hepatocarcinoma Cell (Hep-G2) Viability. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. | Planta medica 20110101 |
| Effect of 20(S)-protopanaxatriol and its epimeric derivatives on myocardial injury induced by isoproterenol. | Arzneimittel-Forschung 20110101 |
| Neuroprotective effects of ginsenosides Rh1 and Rg2 on neuronal cells. | Chinese medicine 20110101 |
| Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. | Chinese medicine 20110101 |
| Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | BMC genomics 20110101 |
| Ginseng for cognition. | The Cochrane database of systematic reviews 20101208 |
| Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet. | Fitoterapia 20101201 |
| Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship. | Drug metabolism and disposition: the biological fate of chemicals 20101001 |
| Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. | Psychopharmacology 20101001 |
| Antihepatocarcinoma activity of lactic acid bacteria fermented Panax notoginseng. | Journal of agricultural and food chemistry 20100811 |
| Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng. | Journal of agricultural and food chemistry 20100512 |
| [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100501 |
| Validated quantification for selective cellular uptake of ginsenosides on MCF-7 human breast cancer cells by liquid chromatography-mass spectrometry. | Analytical and bioanalytical chemistry 20100401 |
| Protopanaxatriol metabolites identified by LC-MS/MS after oral administration in mice. | International journal of clinical pharmacology and therapeutics 20100401 |
| The ginsenoside protopanaxatriol protects endothelial cells from hydrogen peroxide-induced cell injury and cell death by modulating intracellular redox status. | Free radical biology & medicine 20100201 |
| Isolation, synthesis and structures of ginsenoside derivatives and their anti-tumor bioactivity. | Molecules (Basel, Switzerland) 20100119 |
| Microbial conversion of rare ginsenoside Rf to 20(S)-protopanaxatriol by Aspergillus niger. | Bioscience, biotechnology, and biochemistry 20100101 |
| De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. | BMC genomics 20100101 |
| Pharmacology of ginsenosides: a literature review. | Chinese medicine 20100101 |
| Ginseng on hyperglycemia: effects and mechanisms. | Evidence-based complementary and alternative medicine : eCAM 20091201 |
| New achievements in ginseng research and its future prospects. | Chinese journal of integrative medicine 20091201 |
| Induction of chemoprotective phase 2 enzymes by ginseng and its components. | Planta medica 20090801 |
| Antioxidant and apoptotic effects of korean white ginseng extracted with the same ratio of protopanaxadiol and protopanaxatriol saponins in human hepatoma HepG2 cells. | Annals of the New York Academy of Sciences 20090801 |
| Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. | Journal of pharmacological sciences 20090401 |
| Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. | British journal of pharmacology 20090201 |
| Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng. | Phytotherapy research : PTR 20090101 |
| Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study. | European journal of mass spectrometry (Chichester, England) 20090101 |
| [Clinical value of protoparaxotril saporlirs combined with aspirin in the secondary prevention of cerebral infarction]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080901 |
| Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells. | Biotechnology and bioengineering 20080801 |
| Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra. | Journal of natural products 20080301 |
| Manipulation of ginsenoside heterogeneity of Panax notoginseng cells in flask and bioreactor cultivations with addition of phenobarbital. | Bioprocess and biosystems engineering 20080201 |
| Effects of ginsenosides Re and Rg3 on intracellular redox state and cell proliferation in C6 glioma cells. | Chinese medicine 20080101 |
| Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes. | PloS one 20080101 |
| Two new dammarane triterpene glycosides from the rhizomes of Panax notoginseng. | Journal of Asian natural products research 20080101 |
| Potential role of ginseng in the treatment of colorectal cancer. | The American journal of Chinese medicine 20080101 |
| Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products. | Phytochemistry 20071001 |
| Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. | Journal of natural products 20070701 |
| Eastern blotting and immunoaffinity concentration using monoclonal antibody for ginseng saponins in the field of traditional chinese medicines. | Journal of agricultural and food chemistry 20070516 |
| Purification and characterization of new special ginsenosidase hydrolyzing multi-glycisides of protopanaxadiol ginsenosides, ginsenosidase type I. | Chemical & pharmaceutical bulletin 20070201 |
| Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. | Vaccine 20070122 |
| Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle. | BMC complementary and alternative medicine 20070101 |
| Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. | FEBS letters 20061002 |
| Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD. | Journal of pharmaceutical and biomedical analysis 20060828 |
| Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations. | Phytochemistry 20060701 |
| [Analysis of ginsenosides in Sheng-Mai-Yin decoction by high performance liquid chromatography-diode array detection-electrospray mass spectrometry]. | Se pu = Chinese journal of chromatography 20060701 |
| Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect. | Chemistry & biodiversity 20060701 |
| Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. | Toxicological sciences : an official journal of the Society of Toxicology 20060601 |
| Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain. | European journal of pharmacology 20060113 |
| Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng. | International immunopharmacology 20060101 |
| Effect of ginseng saponins on a rat visceral hypersensitivity model. | Biological & pharmaceutical bulletin 20051101 |
| Induction and characterization of adventitious roots directly from the explants of Panax notoginseng. | Biotechnology letters 20051101 |
| Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. | Biological & pharmaceutical bulletin 20051001 |
| [Alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium]. | Yao xue xue bao = Acta pharmaceutica Sinica 20051001 |
| Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography-mass spectrometry after solid-phase extraction. | Journal of pharmaceutical and biomedical analysis 20050601 |
| Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus. | Journal of natural products 20050501 |
| Immunological-adjuvant saponins from the roots of Panax notoginseng. | Chemistry & biodiversity 20050401 |
| Protopanaxatriol-type ginsenosides differentially modulate type 1 and type 2 cytokines production from murine splenocytes. | Planta medica 20050301 |
| Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells. | Acta pharmacologica Sinica 20041201 |
| The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity. | Biological & pharmaceutical bulletin 20041001 |
| Selection of high ginsenoside producing ginseng hairy root lines using targeted metabolic analysis. | Phytochemistry 20041001 |
| Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography. | Chemical & pharmaceutical bulletin 20040801 |
| 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide. | Cancer letters 20040308 |
| Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2. | Canadian journal of physiology and pharmacology 20040301 |
| Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. | Molecules and cells 20040227 |
| In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins. | Biochemical pharmacology 20031201 |
| Modulating effects of Korean ginseng saponins on ovarian function in immature rats. | Biological & pharmaceutical bulletin 20031101 |
| Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes. | Archives of pharmacal research 20031001 |
| In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. | Journal of agricultural and food chemistry 20030423 |
| Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng. | Planta medica 20030301 |
| Ginsenosides inhibit EGF-induced proliferation of renal proximal tubule cells via decrease of c-fos and c-jun gene expression in vitro. | Planta medica 20021101 |
| Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells. | Japanese journal of pharmacology 20021101 |
| Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. | Archives of biochemistry and biophysics 20021001 |
| Can ginsenosides protect human erythrocytes against free-radical-induced hemolysis? | Biochimica et biophysica acta 20020815 |
| Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. | Biological & pharmaceutical bulletin 20020701 |
| [Comparative study of cytotoxic and hemolytic effects of triterpenoids isolated from Ginseng and Sea cucumber]. | Izvestiia Akademii nauk. Seriia biologicheskaia 20020101 |
| Ginsenosides protect apical transporters of cultured proximal tubule cells from dysfunctions induced by h(2)o(2). | Kidney & blood pressure research 20020101 |
| Double staining of ginsenosides by Western blotting using anti-ginsenoside Rb1 and Rg1 monoclonal antibodies. | Biological & pharmaceutical bulletin 20011001 |
| In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng. | Archives of pharmacal research 20010801 |
| Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. | Planta medica 20010701 |
| Regioselective enzymatic glycosylation of natural polyhydroxylated compounds: galactosylation and glucosylation of protopanaxatriol ginsenosides. | The Journal of organic chemistry 20010112 |
| Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice. | Journal of ethnopharmacology 19990801 |