Histamine h3 receptor: a novel therapeutic target in alcohol dependence?

Frontiers in systems neuroscience 20120101

Integrative role of the histaminergic system in feeding and taste perception.

Frontiers in systems neuroscience 20120101

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.

Journal of medicinal chemistry 20111208

The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis.

Hepatology (Baltimore, Md.) 20111101

Role of H4 receptor in histamine-mediated responses in human melanoma.

Melanoma research 20111001

Regulation of ERK2 phosphorylation by histamine in splenocytes.

Immunopharmacology and immunotoxicology 20110601

N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands.

Bioorganic & medicinal chemistry 20110501

Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins.

Molecular pharmacology 20110401

Histamine H(3) receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries.

European journal of pharmacology 20110325

Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms.

Human & experimental toxicology 20110101

Modulation of hematopoiesis through histamine receptor signaling.

Frontiers in bioscience (Scholar edition) 20110101

Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression.

BMC cancer 20110101

Histaminergic mechanisms for modulation of memory systems.

Neural plasticity 20110101

Comparison of the pharmacological properties of human and rat histamine H(3)-receptors.

Biochemical pharmacology 20101101

Investigation of 4-piperidinols as novel H3 antagonists.

Bioorganic & medicinal chemistry letters 20101101

Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection.

Journal of psychopharmacology (Oxford, England) 20100601

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.

The Journal of pharmacology and experimental therapeutics 20100601

The H3 receptor antagonist clobenpropit protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells.

Die Pharmazie 20100401

Modeling G protein-coupled receptors for structure-based drug discovery using low-frequency normal modes for refinement of homology models: application to H3 antagonists.

Proteins 20100201

R-(-)-alpha-methylhistamine, a histamine H3 receptor agonist, induces endothelium-dependent vasodilation in rat mesenteric resistance arteries.

Biological & pharmaceutical bulletin 20100101

Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.

Bioorganic & medicinal chemistry letters 20091201

[Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20091101

The histamine H receptor as a new target for treatment of canine inflammatory skin diseases.

Veterinary dermatology 20091001

Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.

Bioorganic & medicinal chemistry letters 20090801

Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.

Bioorganic & medicinal chemistry 20090601

The histamine H4 receptor is functionally expressed on T(H)2 cells.

The Journal of allergy and clinical immunology 20090301

The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster.

Behavioural pharmacology 20090301

Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.

Experimental dermatology 20090101

H4 histamine receptors mediate cell cycle arrest in growth factor-induced murine and human hematopoietic progenitor cells.

PloS one 20090101

Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine.

Allergy 20081001

Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes.

European journal of pharmacology 20080904

Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist.

Pharmacology, biochemistry, and behavior 20080901

Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice.

International immunopharmacology 20080801

Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor.

The Journal of investigative dermatology 20080701

Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.

Journal of medicinal chemistry 20080612

Zebrafish: An in vivo model for the study of neurological diseases.

Neuropsychiatric disease and treatment 20080601

4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.

Journal of medicinal chemistry 20080522

Comparison of the effect of an H(3)-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity.

Behavioural brain research 20080409

Efficient approaches to S-alkyl-N-alkylisothioureas: syntheses of histamine H3 antagonist clobenpropit and its analogues.

The Journal of organic chemistry 20080321

Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells.

Cellular and molecular neurobiology 20080201

The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

Cancer biology & therapy 20080101

Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells.

BMC pharmacology 20080101

Histamine-induced itch and its relationship with pain.

Molecular pain 20080101

Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.

The Journal of physiology 20070901

Histamine downregulates monocyte CCL2 production through the histamine H4 receptor.

The Journal of allergy and clinical immunology 20070801

The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes.

European journal of pharmacology 20070719

Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.

Immunology 20070601

The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.

European journal of pharmacology 20070601

Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated.

British journal of pharmacology 20070601

Correlation of apparent affinity values from H3-receptor binding assays with apparent affinity (pKapp) and intrinsic activity (alpha) from functional bioassays.

British journal of pharmacology 20070501

Role of histamine in ghrelin-induced gastroprotection against acute gastric lesions.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070401

Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors.

Biochemical pharmacology 20070315

[Reversing effect of histamine on neurotoxicity induced by beta-amyloid1-42].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus.

Neuropharmacology 20070201

Role of apolipoprotein E in anxiety.

Neural plasticity 20070101

STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes.

International immunopharmacology 20061001

Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway.

Neuropharmacology 20060901

Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand.

British journal of pharmacology 20060701

Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats.

Physiology & behavior 20060415

Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors.

Journal of neurophysiology 20060401

Probing the importance of N-glycosylation for [(3)H] clobenpropit binding to human H (3) receptors expressed in HEK 293 cells . 3. Molecular and chemical aspects of the histamine receptors.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060401

Role of substance P on histamine H(3) antagonist-induced scratching behavior in mice.

Journal of pharmacological sciences 20060401

N-(4-Trifluoromethylphenyl)amide group of the synthetic histamine receptor agonist inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion.

Biochemical pharmacology 20060227

Histamine increases sickle erythrocyte adherence to endothelium.

British journal of haematology 20060201

Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125

Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice.

Behavioural brain research 20060106

Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents.

Brain research 20051207

Cross state-dependent retrieval between histamine and lithium.

Physiology & behavior 20050915

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.

The Journal of pharmacology and experimental therapeutics 20050901

G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.

The Journal of pharmacology and experimental therapeutics 20050701

Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates.

The Journal of pharmacy and pharmacology 20050601

Generation of cell lines for drug discovery through random activation of gene expression: application to the human histamine H3 receptor.

Assay and drug development technologies 20050601

Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) 20050501

Influence of intracerebroventricular administration of histaminergic drugs on morphine state-dependent memory in the step-down passive avoidance test.

Pharmacology 20050501

Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80.

Life sciences 20050304

Inhibition of tryptase release from human colon mast cells by histamine receptor antagonists.

Asian Pacific journal of allergy and immunology 20050301

2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.

Journal of medicinal chemistry 20050113

Histamine H3 receptors modulate reactive hyperemia in rat gut.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901

Histamine H3 receptor activation inhibits dopamine D1 receptor-induced cAMP accumulation in rat striatal slices.

Neuroscience letters 20040708

Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.

British journal of pharmacology 20040601

Ligand identification for G-protein-coupled receptors: a lead generation perspective.

Current opinion in chemical biology 20040601

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.

Journal of medicinal chemistry 20040520

Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats.

Behavioural brain research 20040505

Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice.

British journal of pharmacology 20040501

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.

British journal of pharmacology 20040501

[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040501

Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia.

Methods and findings in experimental and clinical pharmacology 20040501

Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040401

Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures.

Brain research bulletin 20040315

Involvement of central and peripheral histamine H(3) receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction.

European journal of pharmacology 20040119

Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats.

European journal of pharmacology 20031215

Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor.

British journal of pharmacology 20031101

Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice.

International immunopharmacology 20031101

Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats.

Pharmacology 20030901

Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice.

The British journal of dermatology 20030701

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.

The Journal of pharmacology and experimental therapeutics 20030601

An in vitro study of histamine on the pulmonary artery of the Wistar-Kyoto and spontaneously hypertensive rats.

European journal of pharmacology 20030530

Molecular and pharmacological characterization of the mouse histamine H3 receptor.

European journal of pharmacology 20030425

Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.

Journal of medicinal chemistry 20030410

Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists.

Naunyn-Schmiedeberg's archives of pharmacology 20030101

Increased brain histamine H3 receptor expression during hibernation in golden-mantled ground squirrels.

BMC neuroscience 20030101

Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes.

Pharmacology 20021101

Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.

British journal of pharmacology 20021101

Characteristics of recombinantly expressed rat and human histamine H3 receptors.

European journal of pharmacology 20021018

Histamine H3 receptor activation inhibits neurogenic sympathetic vasoconstriction in porcine nasal mucosa.

European journal of pharmacology 20021011

Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.

The Journal of pharmacology and experimental therapeutics 20021001

Ligands for histamine H(3) receptors modulate cell proliferation and migration in rat oxyntic mucosa.

British journal of pharmacology 20020901

Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model.

Pharmacology, biochemistry, and behavior 20020601

Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway.

Molecular pharmacology 20020101

Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis.

Journal of receptor and signal transduction research 20020101

Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.

The Journal of pharmacology and experimental therapeutics 20011201

Dynamics of histamine H(3) receptor antagonists on brain histamine metabolism: do all histamine H(3) receptor antagonists act at a single site?

European journal of pharmacology 20011116

Histamine H3 receptor-mediated impairment of contextual fear conditioning and in-vivo inhibition of cholinergic transmission in the rat basolateral amygdala.

The European journal of neuroscience 20011101

Involvement of central histamine in amygdaloid kindled seizures in rats.

Behavioural brain research 20011015

Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation.

The Journal of pharmacology and experimental therapeutics 20011001

Histaminergic modulation of GABAergic transmission in rat ventromedial hypothalamic neurones.

The Journal of physiology 20010801

[Identification and characterization of histamine H4 receptor].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010701

Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010601

Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.

Journal of medicinal chemistry 20010524

Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats.

European journal of pharmacology 20010504

Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices.

British journal of pharmacology 20010501

[Role of central histamine in amygdaloid kindled seizures].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010501

Genomic organization and characterization of splice variants of the human histamine H3 receptor.

The Biochemical journal 20010415

Different antagonist binding properties of human and rat histamine H3 receptors.

Bioorganic & medicinal chemistry letters 20010409

Novel histamine H(3)-receptor antagonists and partial agonists with a non-aminergic structure.

British journal of pharmacology 20010401

Effect of clobenpropit on regional cerebral blood flow in rat hippocampus.

Acta pharmacologica Sinica 20010401

Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.

Molecular pharmacology 20010301

Cloning and characterization of a novel human histamine receptor.

The Journal of pharmacology and experimental therapeutics 20010301

H3 receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways.

Naunyn-Schmiedeberg's archives of pharmacology 20010201

The rat H3 receptor: gene organization and multiple isoforms.

Biochemical and biophysical research communications 20010112

Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat.

The European journal of neuroscience 20010101

Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.

British journal of pharmacology 20001201

Identification of a histamine H(3)-like receptor in the zebrafish (Danio rerio) brain.

Journal of neurochemistry 20000801

Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.

The Journal of pharmacology and experimental therapeutics 20000601

Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia.

Behavioural brain research 19991001

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

The Journal of clinical investigation 19981115

Effect of interleukin-1beta on the ascending and descending reflex in rat small intestine.

European journal of pharmacology 19981023

Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats.

Naunyn-Schmiedeberg's archives of pharmacology 19970201

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian hamster.

Endocrinology