Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.

Toxicology and applied pharmacology 20140301

Anti-diabetic and anti-inflammatory effect of a novel selective 11β-HSD1 inhibitor in the diet-induced obese mice.

European journal of pharmacology 20131205

18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.

Molecular and cellular biochemistry 20121101

The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan.

Cellular and molecular neurobiology 20121001

Myoendothelial coupling is unidirectional in guinea pig spiral modiolar arteries.

Microvascular research 20120901

Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption.

Journal of cellular and molecular medicine 20120801

Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex.

Stem cells and development 20120720

Enhanced transdermal delivery of 18β-glycyrrhetic acid via elastic vesicles: in vitro and in vivo evaluation.

Drug development and industrial pharmacy 20120701

TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.

American journal of physiology. Cell physiology 20120615

The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells.

European journal of pharmacology 20120615

18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.

Acta pharmacologica Sinica 20120601

18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.

Journal of cellular physiology 20120501

Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin.

Cancer letters 20120428

18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis.

Biochemical and biophysical research communications 20120420

ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts.

American journal of physiology. Cell physiology 20120401

Inhibition of gap junction channel attenuates the migration of breast cancer cells.

Molecular biology reports 20120301

Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis.

Wiener klinische Wochenschrift 20120301

Antimycobacterial and synergistic effects of 18β-glycyrrhetinic acid or glycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis.

Phytotherapy research : PTR 20120201

Characterization of a novel oral glucocorticoid system and its possible role in disease.

Journal of dental research 20120101

Endothelium-derived relaxing factor-mediated vasodilation in mouse mesenteric vascular beds.

Journal of pharmacological sciences 20120101

Pharmacokinetic analysis of alpha and beta epimers of glycyrrhetinic acid in rat plasma: differences in singly and combined administrations.

Yao xue xue bao = Acta pharmaceutica Sinica 20120101

18α-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Β1/Smad signaling pathway in human and rat hepatic stellate cells.

International journal of medical sciences 20120101

A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy.

Skin pharmacology and physiology 20120101

Gap junctions contribute to astrocytic resistance against zinc toxicity.

Brain research bulletin 20111125

Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures.

Molecular and cellular endocrinology 20110915

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.

International journal of oncology 20110901

Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats.

Urology 20110801

Inhibition of osteoblastic differentiation by warfarin and 18-α-glycyrrhetinic acid.

Archives of pharmacal research 20110801

Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.

Journal of agricultural and food chemistry 20110727

18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells.

Bioorganic & medicinal chemistry 20110715

18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis.

Ocular immunology and inflammation 20110601

18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures.

Anticancer research 20110601

Chemopreventive potential of 18beta-glycyrrhetinic acid: an active constituent of liquorice, in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.

Pakistan journal of biological sciences : PJBS 20110601

Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys.

Clinical and experimental nephrology 20110401

Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid.

Chemical biology & drug design 20110301

[Expression of 11β-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity].

Zhongguo shi yan xue ye xue za zhi 20110201

Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells.

Journal of radiation research 20110101

Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases.

PloS one 20110101

18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines.

European journal of pharmacology 20101215

Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice.

Journal of periodontal research 20101201

Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland.

British journal of pharmacology 20101201

Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture.

Experimental cell research 20100910

Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation.

Journal of agricultural and food chemistry 20100811

Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+].

Acta biochimica et biophysica Sinica 20100701

Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.

The Journal of biological chemistry 20100312

Gap junctions and memory: an investigation using a single trial discrimination avoidance task for the neonate chick.

Neurobiology of learning and memory 20100201

Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes.

European journal of pharmacology 20100125

18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha.

The Journal of biological chemistry 20100108

Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery.

Journal of pharmacological sciences 20100101

Panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica.

Veterinary journal (London, England : 1997) 20091201

Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions.

Clinical cancer research : an official journal of the American Association for Cancer Research 20090915

Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change.

Neurochemical research 20090801

Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes.

Biomaterials 20090801

A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.

Molecular cancer therapeutics 20090801

Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats.

Journal of psychopharmacology (Oxford, England) 20090701

Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats.

European journal of pharmacology 20090610

Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog.

Cellular and molecular neurobiology 20090601

In vitro effects of glycyrrhetinic acid on the growth of clinical isolates of Candida albicans.

Phytotherapy research : PTR 20090401

Locomotor rhythm maintenance: electrical coupling among premotor excitatory interneurons in the brainstem and spinal cord of young Xenopus tadpoles.

The Journal of physiology 20090401

Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats.

European journal of pharmacology 20090315

Possible participation of chloride ion channels in ATP release from cancer cells in suspension.

Clinical and experimental pharmacology & physiology 20090301

ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide.

European journal of pharmacology 20090301

Pharmacological 'cross-inhibition' of connexin hemichannels and swelling activated anion channels.

Glia 20090201

Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins.

European journal of cell biology 20090201

Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid.

The Journal of steroid biochemistry and molecular biology 20090201

Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway.

Journal of agricultural and food chemistry 20090128

The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation.

Bone 20090101

Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics.

Biomedical chromatography : BMC 20090101

Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats.

Shock (Augusta, Ga.) 20090101

Microbial transformation of 18beta-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products.

Natural product research 20090101

18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity.

Life sciences 20080926

Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.

Cell calcium 20080801

Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.

Hepatology (Baltimore, Md.) 20080601

Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells.

Circulation research 20080328

Role of gap junctions and protein kinase A during the development of oocyte maturational competence in Ayu (Plecoglossus altivelis).

General and comparative endocrinology 20080201

Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites.

American journal of physiology. Regulatory, integrative and comparative physiology 20080201

Role of gap junctions in spontaneous activity of the rat bladder.

American journal of physiology. Renal physiology 20071001

Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis.

The Journal of physiology 20070915

Blockade of gap junction coupling by glycyrrhetinic acids in guinea pig cochlear artery: a whole-cell voltage- and current-clamp study.

British journal of pharmacology 20070801

Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions.

Experimental eye research 20070701

Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 20070401

18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

The function of connexin 43 on the differentiation of rat bone marrow cells in culture.

Biomedical research (Tokyo, Japan) 20061201

A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction.

Biomedical research (Tokyo, Japan) 20061001

The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor.

Experimental brain research 20060401

Protective effect of gap junction uncouplers given during hypoxia against reoxygenation injury in isolated rat hearts.

American journal of physiology. Heart and circulatory physiology 20060201

Role of gap junctional coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress and hippocampal damage.

The European journal of neuroscience 20060101

Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia.

Journal of neurochemistry 20051001

Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes.

The Journal of biological chemistry 20050318

Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis.

Biochemical and biophysical research communications 20040709

Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor.

Biochemical and biophysical research communications 20040514

Global, synchronous oscillations in cytosolic calcium and adherence in bradykinin-stimulated Madin-Darby canine kidney cells.

Acta physiologica Scandinavica 20040401

Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells.

Mutagenesis 20040101

Human primary endothelial cells stimulate human osteoprogenitor cell differentiation.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

[Involvement of gap junctions in stimulation of in vitro maturation of the common frog oocytes by low progesterone concentrations].

Ontogenez 20040101

ECM-induced gap junctional communication enhances mammary epithelial cell differentiation.

Journal of cell science 20030901

Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells.

Experimental cell research 20030715

Functional hemichannels in astrocytes: a novel mechanism of glutamate release.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501

Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors.

Biochemical and biophysical research communications 20030418

Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat.

Journal of neurophysiology 20030101

Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries.

American journal of physiology. Heart and circulatory physiology 20021201

Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication.

Journal of cellular physiology 20021101

The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women.

British journal of pharmacology 20020801

Critical role of gap junctions in endothelium-dependent hyperpolarization in rat mesenteric arteries.

Clinical and experimental pharmacology & physiology 20020701

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.

Biochemical and biophysical research communications 20020125

Bimodal inhibition of connexin 43 gap junctions decreases ACTH-induced steroidogenesis and increases bovine adrenal cell population growth.

The Journal of endocrinology 20011001

An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide.

Hypertension (Dallas, Tex. : 1979) 20011001

Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010801

Persistence of gap junction communication during myocardial ischemia.

American journal of physiology. Heart and circulatory physiology 20010601

Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats.

British journal of pharmacology 20010401

Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5.

Molecular and cellular endocrinology 20010122

Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium.

British journal of pharmacology 20010101