Therapy with TLR7 agonists induces lymphopenia: correlating pharmacology to mechanism in a mouse model.

Journal of clinical immunology 20121001

Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN.

Biomaterials 20120601

TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen.

Journal of immunology (Baltimore, Md. : 1950) 20120515

R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts.

Cytotechnology 20120501

Bacterial immunotherapy of gastrointestinal tumors.

Langenbeck's archives of surgery 20120401

MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.

Journal of immunology (Baltimore, Md. : 1950) 20120401

Characterisation and expression analysis of the Atlantic halibut (Hippoglossus hippoglossus L.) cytokines: IL-1β, IL-6, IL-11, IL-12β and IFNγ.

Molecular biology reports 20120301

R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes.

BMC infectious diseases 20120101

Vaxjo: a web-based vaccine adjuvant database and its application for analysis of vaccine adjuvants and their uses in vaccine development.

Journal of biomedicine & biotechnology 20120101

Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system.

Frontiers in physiology 20120101

Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol.

PloS one 20120101

High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery.

PloS one 20120101

Vaccine Development Against Leishmania donovani.

Frontiers in immunology 20120101

Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms.

Frontiers in physiology 20120101

Adjuvants for Leishmania vaccines: from models to clinical application.

Frontiers in immunology 20120101

Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants.

BMC immunology 20120101

Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.

Journal of immunological methods 20111028

The innate antiviral immune system of the cat: molecular tools for the measurement of its state of activation.

Veterinary immunology and immunopathology 20111015

Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research 20110715

Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms.

European journal of immunology 20110701

Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4.

Arthritis and rheumatism 20110601

CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer.

Expert review of vaccines 20110601

Pattern recognition receptors and the innate immune response to viral infection.

Viruses 20110601

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.

Blood 20110526

Targeting the Toll-like receptor 7 pathway in asthma: a potential immunomodulatory approach?

Expert opinion on therapeutic targets 20110501

Toll-like receptor 7/8 agonist resiquimod induces late preconditioning in neonatal cardiac myocytes.

Acta pharmacologica Sinica 20110501

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.

Journal of immunology (Baltimore, Md. : 1950) 20110415

Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice.

Journal of immunology (Baltimore, Md. : 1950) 20110401

A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.

Journal of immunology (Baltimore, Md. : 1950) 20110401

Stimulation of TLR7 prior to polymicrobial sepsis improves the immune control of the inflammatory response in adult mice.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110301

The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation.

PLoS pathogens 20110301

Toll-like receptor 7 activation reduces the contractile response of airway smooth muscle.

European journal of pharmacology 20110210

Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β.

Cellular and molecular life sciences : CMLS 20110101

Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation.

Cancer immunology, immunotherapy : CII 20110101

The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma.

Journal of immunology (Baltimore, Md. : 1950) 20110101

TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs.

PloS one 20110101

Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.

Clinical & developmental immunology 20110101

Poly(I:C) enhances the susceptibility of leukemic cells to NK cell cytotoxicity and phagocytosis by DC.

PloS one 20110101

Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells.

PloS one 20110101

The transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans.

PloS one 20110101

The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation.

Cellular immunology 20110101

A common path to innate immunity to HIV-1 induced by Toll-like receptor ligands in primary human macrophages.

PloS one 20110101

Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.

Journal of translational medicine 20110101

Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis.

PloS one 20110101

Toll-like receptors and myocardial inflammation.

International journal of inflammation 20110101

Systemic administration of CpG oligodeoxynucleotide and levamisole as adjuvants for gene-gun-delivered antitumor DNA vaccines.

Clinical & developmental immunology 20110101

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

PloS one 20110101

Signatures of positive selection in Toll-like receptor (TLR) genes in mammals.

BMC evolutionary biology 20110101

The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses.

PloS one 20110101

Predicting antitumor activity of peptides by consensus of regression models trained on a small data sample.

International journal of molecular sciences 20110101

An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles.

Clinical and vaccine immunology : CVI 20101201

Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice.

European journal of applied physiology 20101101

Inhibition of the type I interferon antiviral response during arenavirus infection.

Viruses 20101101

Protective effects of Sm-p80 in the presence of resiquimod as an adjuvant against challenge infection with Schistosoma mansoni in mice.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20100901

TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.

Vaccine 20100831

2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated suppression of toll-like receptor stimulated B-lymphocyte activation and initiation of plasmacytic differentiation.

Toxicological sciences : an official journal of the Society of Toxicology 20100701

Dendritic cells in uninfected infants born to hepatitis B virus-positive mothers.

Clinical and vaccine immunology : CVI 20100701

Herpes simplex virus and human papillomavirus genital infections: new and investigational therapeutic options.

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Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.

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Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.

Blood 20100311

The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation.

Immunology and cell biology 20100201

The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells.

Cancer immunology, immunotherapy : CII 20100101

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Frontiers in bioscience (Scholar edition) 20100101

Molecular modulation of intestinal epithelial barrier: contribution of microbiota.

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Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice.

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Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists.

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Targeting Toll-like receptors for treatment of SLE.

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Do postsurgical interventions optimize ultimate scar cosmesis.

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Vaccine 20090518

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

Bioorganic & medicinal chemistry letters 20090415

Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles.

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The Journal of allergy and clinical immunology 20090101

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TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.

Immunobiology 20090101

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Respiratory research 20090101

Sequence determinants of innate immune activation by short interfering RNAs.

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Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.

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BMC cancer 20090101

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Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties.

Journal of translational medicine 20090101

Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.

Cancer immunology, immunotherapy : CII 20081101

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Experimental biology and medicine (Maywood, N.J.) 20080801

A phase II dose-ranging study of topical resiquimod to treat actinic keratosis.

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TLR7 and TLR8 as targets in cancer therapy.

Oncogene 20080107

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BMC immunology 20080101

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The open microbiology journal 20080101

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European journal of immunology 20071001

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Expert review of vaccines 20071001

Impaired CCR7 expression on plasmacytoid dendritic cells of HIV-infected children and adolescents with immunologic and virologic failure.

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070501

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Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects.

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Therapeutic use of Aldara in chronic myeloid leukemia.

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Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages.

FEMS immunology and medical microbiology 20060801

Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.

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Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers.

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Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: a pilot study.

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Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment.

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