Home Other Building Blocks Pseudouridine

Pseudouridine

CAS No.:
1445-07-4
Catalog Number:
AG001JNO
Molecular Formula:
C9H12N2O6
Molecular Weight:
244.2014
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥95%
1 week
United States
$166
- +
10mg
≥95%
1 week
United States
$254
- +
25mg
≥95%
1 week
United States
$496
- +
50mg
>98.0%(HPLC)
1 week
United States
$569
- +
Product Description
Catalog Number:
AG001JNO
Chemical Name:
Pseudouridine
CAS Number:
1445-07-4
Molecular Formula:
C9H12N2O6
Molecular Weight:
244.2014
MDL Number:
MFCD01861724
IUPAC Name:
5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione
InChI:
InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
InChI Key:
PTJWIQPHWPFNBW-GBNDHIKLSA-N
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)c1c[nH]c(=O)[nH]c1=O
Properties
Complexity:
382  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
244.07g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
244.203g/mol
Monoisotopic Mass:
244.07g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
128A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2.8  
Literature
Title Journal
Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports 20180101
Impact of base pair identity 5' to the spliceosomal branch site adenosine on branch site conformation. RNA (New York, N.Y.) 20121101
Identification of sense and antisense transcripts regulated by drought in sugarcane. Plant molecular biology 20120701
Role of pseudouridine in structural rearrangements of helix 69 during bacterial ribosome assembly. ACS chemical biology 20120518
Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin. Molecular therapy : the journal of the American Society of Gene Therapy 20120501
Different sensitivity of H69 modification enzymes RluD and RlmH to mutations in Escherichia coli 23S rRNA. Biochimie 20120501
Inducing nonsense suppression by targeted pseudouridylation. Nature protocols 20120329
Human tRNA(Lys3)(UUU) is pre-structured by natural modifications for cognate and wobble codon binding through keto-enol tautomerism. Journal of molecular biology 20120302
The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA. RNA (New York, N.Y.) 20120301
Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs. RNA (New York, N.Y.) 20120301
Rationalization and prediction of selective decoding of pseudouridine-modified nonsense and sense codons. RNA (New York, N.Y.) 20120301
Discovery of Pyrobaculum small RNA families with atypical pseudouridine guide RNA features. RNA (New York, N.Y.) 20120301
Effects of protein extract from head-foot tissue of Oncomelania hupensis on the growth and gene expression of mother sporocysts of Schistosoma japonicum. Parasitology research 20120201
Comparison of solution conformations and stabilities of modified helix 69 rRNA analogs from bacteria and human. Biopolymers 20120201
Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells. RNA (New York, N.Y.) 20120101
Zebrafish models for dyskeratosis congenita reveal critical roles of p53 activation contributing to hematopoietic defects through RNA processing. PloS one 20120101
Chemical approaches for structure and function of RNA in postgenomic era. Journal of nucleic acids 20120101
Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. PloS one 20120101
Pseudoscorpion mitochondria show rearranged genes and genome-wide reductions of RNA gene sizes and inferred structures, yet typical nucleotide composition bias. BMC evolutionary biology 20120101
Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes. PloS one 20120101
Altered metabolic signature in pre-diabetic NOD mice. PloS one 20120101
Regulation of ribosomal RNA production by RNA polymerase I: does elongation come first? Genetics research international 20120101
Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. PloS one 20120101
AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. PPAR research 20120101
Efficiency of purine utilization by Helicobacter pylori: roles for adenosine deaminase and a NupC homolog. PloS one 20120101
Archaeal proteins Nop10 and Gar1 increase the catalytic activity of Cbf5 in pseudouridylating tRNA. Scientific reports 20120101
Cellular dynamics of RNA modification. Accounts of chemical research 20111220
Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysis. RNA (New York, N.Y.) 20111201
Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase. Genes & development 20111115
[Muscle catabolism in patients with chronic obstructive pulmonary disease]. Revista clinica espanola 20111101
Complete modification maps for the cytosolic small and large subunit rRNAs of Euglena gracilis: functional and evolutionary implications of contrasting patterns between the two rRNA components. Journal of molecular biology 20111014
The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods. Analytical and bioanalytical chemistry 20111001
Conformation effects of base modification on the anticodon stem-loop of Bacillus subtilis tRNA(Tyr). Journal of molecular biology 20110916
Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. PLoS genetics 20110901
Pseudouridines in spliceosomal snRNAs. Protein & cell 20110901
The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another. Journal of the American Chemical Society 20110810
Mass spectrometry-based quantification of pseudouridine in RNA. Journal of the American Society for Mass Spectrometry 20110801
Single-molecule FRET reveals a cooperative effect of two methyl group modifications in the folding of human mitochondrial tRNA(Lys). Chemistry & biology 20110729
Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii. RNA (New York, N.Y.) 20110701
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 20110616
Converting nonsense codons into sense codons by targeted pseudouridylation. Nature 20110616
Protein synthesis: Stop the nonsense. Nature 20110615
Probing conformational states of modified helix 69 in 50S ribosomes. Journal of the American Chemical Society 20110608
Pseudouridylation of 23S rRNA helix 69 promotes peptide release by release factor RF2 but not by release factor RF1. Biochimie 20110501
Propiconazole induces alterations in the hepatic metabolome of mice: relevance to propiconazole-induced hepatocarcinogenesis. Toxicological sciences : an official journal of the Society of Toxicology 20110401
hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF). The Journal of biological chemistry 20110304
Molecular dynamics of ribosomal elongation factors G and Tu. European biophysics journal : EBJ 20110301
A new approach to assess and predict the functional roles of proteins across all known structures. Journal of structural and functional genomics 20110301
U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP. The EMBO journal 20110105
Pseudouridylation goes regulatory. The EMBO journal 20110105
Deletion of the RluD pseudouridine synthase promotes SsrA peptide tagging of ribosomal protein S7. Molecular microbiology 20110101
The transposon-like Correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus. PLoS genetics 20110101
Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Arthritis research & therapy 20110101
Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference. International journal of Alzheimer's disease 20110101
Use of specific chemical reagents for detection of modified nucleotides in RNA. Journal of nucleic acids 20110101
Synergistic use of plant-prokaryote comparative genomics for functional annotations. BMC genomics 20110101
Monoclonal Antibodies Bind A SNP-Sensitive Epitope that is Present Uniquely in Mycobacterium avium Subspecies Paratuberculosis. Frontiers in microbiology 20110101
GRIM-1, a novel growth suppressor, inhibits rRNA maturation by suppressing small nucleolar RNAs. PloS one 20110101
Functions and mechanisms of spliceosomal small nuclear RNA pseudouridylation. Wiley interdisciplinary reviews. RNA 20110101
tRNA Modification and Genetic Code Variations in Animal Mitochondria. Journal of nucleic acids 20110101
Comparison of RNA expression profiles on generations of Porphyra yezoensis (Rhodophyta), based on suppression subtractive hybridization (SSH). BMC research notes 20110101
SNOntology: Myriads of novel snoRNAs or just a mirage? BMC genomics 20110101
Characterization of RNase MRP RNA and novel snoRNAs from Giardia intestinalis and Trichomonas vaginalis. BMC genomics 20110101
Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites. International journal of molecular sciences 20110101
Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease. Genome biology 20110101
The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. PloS one 20110101
A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA. Scientific reports 20110101
Defining the plant peroxisomal proteome: from Arabidopsis to rice. Frontiers in plant science 20110101
Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing. The EMBO journal 20101215
Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer. The Journal of pathology 20101201
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS genetics 20101201
The nucleolus under stress. Molecular cell 20101022
HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase. The Biochemical journal 20101015
Subribosomal particle analysis reveals the stages of bacterial ribosome assembly at which rRNA nucleotides are modified. RNA (New York, N.Y.) 20101001
Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS neglected tropical diseases 20100801
Host imprints on bacterial genomes--rapid, divergent evolution in individual patients. PLoS pathogens 20100801
The mitochondrial genome of the pathogenic yeast Candida subhashii: GC-rich linear DNA with a protein covalently attached to the 5' termini. Microbiology (Reading, England) 20100701
Differential effects of nucleotide analogs on scanning-dependent initiation and elongation of mammalian mRNA translation in vitro. RNA (New York, N.Y.) 20100601
Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria. Journal of the American Chemical Society 20100526
Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea. Nature chemical biology 20100401
Yeast pre-rRNA processing and modification occur cotranscriptionally. Molecular cell 20100326
Box H/ACA small ribonucleoproteins. Molecular cell 20100312
RNAsnoop: efficient target prediction for H/ACA snoRNAs. Bioinformatics (Oxford, England) 20100301
Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET. RNA (New York, N.Y.) 20100301
Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PLoS computational biology 20100301
Systematic identification and evolutionary features of rhesus monkey small nucleolar RNAs. BMC genomics 20100101
SnoPatrol: how many snoRNA genes are there? Journal of biology 20100101
Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. Biology direct 20100101
Identification of hypoxanthine as a urine marker for non-Hodgkin lymphoma by low-mass-ion profiling. BMC cancer 20100101
Spliceosomal snRNA modifications and their function. RNA biology 20100101
Characterization of the ovine ribosomal protein SA gene and its pseudogenes. BMC genomics 20100101
Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies. Journal of biomedicine & biotechnology 20100101
Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae. PloS one 20100101
Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor. BMC structural biology 20100101
Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Molecular cancer 20100101
Digital genome-wide ncRNA expression, including SnoRNAs, across 11 human tissues using polyA-neutral amplification. PloS one 20100101
Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana. BMC plant biology 20100101
Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. PloS one 20100101
A comparative genome-wide study of ncRNAs in trypanosomatids. BMC genomics 20100101
Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one 20100101
Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis. Molecular cell 20091125
Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations. Biochemistry 20091124
Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes 20091101
DKC1 overexpression associated with prostate cancer progression. British journal of cancer 20091020
Novel role of nucleostemin in the maintenance of nucleolar architecture and integrity of small nucleolar ribonucleoproteins and the telomerase complex. The Journal of biological chemistry 20090925
Anomalous electrophoretic migration of newly synthesized ribosomal RNAs and their precursors from cells with DKC1 mutations. FEBS letters 20090917
Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing. RNA (New York, N.Y.) 20090901
Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases. Archives of biochemistry and biophysics 20090901
Global analysis of extracytoplasmic stress signaling in Escherichia coli. PLoS genetics 20090901
A fast capillary electrophoresis method for separation and quantification of modified nucleosides in urinary samples. Analytical chemistry 20090801
Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome. PLoS pathogens 20090801
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science (New York, N.Y.) 20090717
The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme. Journal of molecular biology 20090710
Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. Nature structural & molecular biology 20090701
Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery. Chemical research in toxicology 20090701
Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. The Journal of biological chemistry 20090619
Predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise. Journal of proteome research 20090601
Preparation of short interfering RNA containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine. Current protocols in nucleic acid chemistry 20090601
Structural mechanism of substrate RNA recruitment in H/ACA RNA-guided pseudouridine synthase. Molecular cell 20090514
18S rRNA processing requires base pairings of snR30 H/ACA snoRNA to eukaryote-specific 18S sequences. The EMBO journal 20090506
Human U1 snRNA forms a new chromatin-associated snRNP with TAF15. EMBO reports 20090501
Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS biology 20090401
Dyskeratosis congenita, stem cells and telomeres. Biochimica et biophysica acta 20090401
Escherichia coli MazF leads to the simultaneous selective synthesis of both 'death proteins' and 'survival proteins'. PLoS genetics 20090301
Trypanosome spliced-leader-associated RNA (SLA1) localization and implications for spliced-leader RNA biogenesis. Eukaryotic cell 20090101
Functionality and substrate specificity of human box H/ACA guide RNAs. RNA (New York, N.Y.) 20090101
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC medical genomics 20090101
Genic regions of a large salamander genome contain long introns and novel genes. BMC genomics 20090101
Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs. BMC genomics 20090101
Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection. BMC cancer 20090101
Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana. BMC genomics 20090101
Families of H/ACA ncRNA molecules in trypanosomatids. RNA biology 20090101
Gain and loss of an intron in a protein-coding gene in Archaea: the case of an archaeal RNA pseudouridine synthase gene. BMC evolutionary biology 20090101
Development of new DNA triplex triads by using 5-substituted deoxycytidine. Nucleic acids symposium series (2004) 20090101
Preparation of an ochre suppressor tRNA recognizing exclusively UAA codon by using the molecular surgery technique. Nucleic acids symposium series (2004) 20090101
SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights. BMC genomics 20090101
U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis. BMC genomics 20090101
Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA). BMJ case reports 20090101
Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase. EMBO reports 20081201
Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA. RNA (New York, N.Y.) 20081201
Matrix-assisted laser desorption/ionization mass spectrometry screening for pseudouridine in mixtures of small RNAs by chemical derivatization, RNase digestion and signature products. Rapid communications in mass spectrometry : RCM 20081201
Pseudouridines in rRNA helix 69 play a role in loop stacking interactions. Organic & biomolecular chemistry 20081107
Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Molecular therapy : the journal of the American Society of Gene Therapy 20081101
YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RNA (New York, N.Y.) 20081001
Identification of pseudouridine methyltransferase in Escherichia coli. RNA (New York, N.Y.) 20081001
Ribosome performance is enhanced by a rich cluster of pseudouridines in the A-site finger region of the large subunit. The Journal of biological chemistry 20080919
Molecular identification of pseudouridine-metabolizing enzymes. The Journal of biological chemistry 20080912
Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents. Pediatric research 20080901
Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. RNA (New York, N.Y.) 20080901
The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. The EMBO journal 20080820
Mass spectrometry of the fifth nucleoside: a review of the identification of pseudouridine in nucleic acids. Analytica chimica acta 20080815
An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors. Journal of molecular biology 20080718
Mutations in SUPPRESSOR OF VARIEGATION1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis. The Plant cell 20080701
Nop10 is a conserved H/ACA snoRNP molecular adaptor. Biochemistry 20080610
Key role of Mfd in the development of fluoroquinolone resistance in Campylobacter jejuni. PLoS pathogens 20080601
X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. Biochemistry 20080520
Improving CMC-derivatization of pseudouridine in RNA for mass spectrometric detection. Analytica chimica acta 20080407
pH-dependent structural changes of helix 69 from Escherichia coli 23S ribosomal RNA. RNA (New York, N.Y.) 20080401
[Dyskeratosis congenita, a disease caused by defective telomere maintenance]. Medecine sciences : M/S 20080401
Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives. Bioorganic & medicinal chemistry 20080301
The origin and evolution of tRNA inferred from phylogenetic analysis of structure. Journal of molecular evolution 20080101
Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3. PloS one 20080101
Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins. BMC genomics 20080101
Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains. BMC microbiology 20080101
Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code. PloS one 20080101
Fisher: a program for the detection of H/ACA snoRNAs using MFE secondary structure prediction and comparative genomics - assessment and update. BMC research notes 20080101
Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer. BMC molecular biology 20080101
Evolution of the holozoan ribosome biogenesis regulon. BMC genomics 20080101
RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes. BMC genomics 20080101
Relationship between dyskerin expression and telomerase activity in human breast cancer. Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101
Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes. BMC bioinformatics 20080101
Implications of small nucleolar RNA-protein complexes discoveries. Recent patents on DNA & gene sequences 20080101
Methodology for constructing problem definitions in bioinformatics. Bioinformatics and biology insights 20080101
RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA. RNA (New York, N.Y.) 20071101
RNA analysis by MEKC with LIF detection. Electrophoresis 20071101
Substrate specificity of the pseudouridine synthase RluD in Escherichia coli. The FEBS journal 20071101
Differential roles of archaeal box H/ACA proteins in guide RNA-dependent and independent pseudouridine formation. RNA biology 20071001
Increased urinary level of oxidized nucleosides in patients with mild-to-moderate Alzheimer's disease. Clinical biochemistry 20070901
Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. RNA (New York, N.Y.) 20070801
Functional representation of enzymes by specific peptides. PLoS computational biology 20070801
Pleiotropic effects and compensation mechanisms determine tissue specificity in mitochondrial myopathy and sideroblastic anemia (MLASA). Molecular genetics and metabolism 20070601
The mechanisms of codon reassignments in mitochondrial genetic codes. Journal of molecular evolution 20070601
H/ACA guide RNAs, proteins and complexes. Current opinion in structural biology 20070601
Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans. PLoS pathogens 20070601
Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Molecular cell 20070427
Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA). Journal of medical genetics 20070301
A novel highly boron tolerant bacterium, Bacillus boroniphilus sp. nov., isolated from soil, that requires boron for its growth. Extremophiles : life under extreme conditions 20070301
Pus3p- and Pus1p-dependent pseudouridylation of steroid receptor RNA activator controls a functional switch that regulates nuclear receptor signaling. Molecular endocrinology (Baltimore, Md.) 20070301
Genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Leishmania major indicates conservation among trypanosomatids in the repertoire and in their rRNA targets. Eukaryotic cell 20070301
Cellular protein breakdown and systemic inflammation are unaffected by pulmonary rehabilitation in COPD. Thorax 20070201
Analysis of 2'-O-methylated nucleosides and pseudouridines in ribosomal RNAs using DNAzymes. Analytical biochemistry 20070201
Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo. Nucleic acids research 20070101
Specificity of phage display selected peptides for modified anticodon stem and loop domains of tRNA. The protein journal 20070101
Optimization of ribosome structure and function by rRNA base modification. PloS one 20070101
The coding/non-coding overlapping architecture of the gene encoding the Drosophila pseudouridine synthase. BMC molecular biology 20070101
On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization. Biology direct 20070101
Identification of modified residues in RNAs by reverse transcription-based methods. Methods in enzymology 20070101
Biochemical purification of box H/ACA RNPs involved in pseudouridylation. Methods in enzymology 20070101
Identifying effects of snoRNA-guided modifications on the synthesis and function of the yeast ribosome. Methods in enzymology 20070101
Reconstitution of archaeal H/ACA sRNPs and test of their activity. Methods in enzymology 20070101
Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer. Nuclear receptor signaling 20070101
Computational RNomics of drosophilids. BMC genomics 20070101
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC biochemistry 20070101
Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. The Journal of biological chemistry 20061222
Base pairing within the psi32,psi39-modified anticodon arm of Escherichia coli tRNA(Phe). Journal of the American Chemical Society 20061213
Mammalian small nucleolar RNAs are mobile genetic elements. PLoS genetics 20061201
Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure. Molecular cell 20061117
Pseudouridine synthases. Chemistry & biology 20061101
Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine. Biochemistry 20061003
Probing RNA hairpins with cobalt(III)hexammine and electrospray ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 20061001
A counterintuitive Mg2+-dependent and modification-assisted functional folding of mitochondrial tRNAs. Journal of molecular biology 20060929
Urinary pseudouridine in patients with lymphoma: comparison with other clinical parameters. Clinica chimica acta; international journal of clinical chemistry 20060901
Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8. RNA biology 20060701
Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA. Journal of molecular biology 20060616
Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. British journal of cancer 20060605
The vertebrate E1/U17 small nucleolar ribonucleoprotein particle. Journal of cellular biochemistry 20060601
Involvement of LuxR, a quorum sensing regulator in Vibrio harveyi, in the promotion of metabolic genes: argA, purM, lysE and rluA. Biochimica et biophysica acta 20060601
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science (New York, N.Y.) 20060512
Influence of phylogeny on posttranscriptional modification of rRNA in thermophilic prokaryotes: the complete modification map of 16S rRNA of Thermus thermophilus. Biochemistry 20060418
In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site. Nature structural & molecular biology 20060401
The most complex pseudouridylase. Structure (London, England : 1993) 20060201
Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. Molecular cell 20060120
Analysis of urinary nucleosides. V. Identification of urinary pyrimidine nucleosides by liquid chromatography/electrospray mass spectrometry. Rapid communications in mass spectrometry : RCM 20060101
A computational screen for mammalian pseudouridylation guide H/ACA RNAs. RNA (New York, N.Y.) 20060101
Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA. RNA (New York, N.Y.) 20060101
Phylogenetically widespread alternative splicing at unusual GYNGYN donors. Genome biology 20060101
MultiSeq: unifying sequence and structure data for evolutionary analysis. BMC bioinformatics 20060101
Non coding RNA and brain. BMC neuroscience 20060101
Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine. Bioorganic & medicinal chemistry 20051215
DEG1, encoding the tRNA:pseudouridine synthase Pus3p, impacts HOT1-stimulated recombination in Saccharomyces cerevisiae. Molecular genetics and genomics : MGG 20051201
Normal and modified urinary nucleosides represent novel biomarkers for colorectal cancer diagnosis and surgery monitoring. Journal of gastroenterology and hepatology 20051201
Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase. Biochemistry 20051129
Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051025
Elucidating the role of H/ACA-like RNAs in trans-splicing and rRNA processing via RNA interference silencing of the Trypanosoma brucei CBF5 pseudouridine synthase. The Journal of biological chemistry 20051014
Effects of nucleotide substitution and modification on the stability and structure of helix 69 from 28S rRNA. RNA (New York, N.Y.) 20050901
Detection of the common RNA nucleoside pseudouridine in mixtures of oligonucleotides by mass spectrometry. Analytical chemistry 20050801
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 20050801
Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. The EMBO journal 20050706
The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli. RNA (New York, N.Y.) 20050701
NMR spectroscopy of RNA duplexes containing pseudouridine in supercooled water. RNA (New York, N.Y.) 20050701
Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A. Biochemistry 20050607
A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS biology 20050601
Transglycosylation: a mechanism for RNA modification (and editing?). Bioorganic chemistry 20050601
The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. RNA (New York, N.Y.) 20050601
Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. The Journal of biological chemistry 20050520
RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP. Genes & development 20050515
Bacillus subtilis tRNA(Pro) with the anticodon mo5UGG can recognize the codon CCC. Biochimica et biophysica acta 20050501
[Application of urinary nucleosides in the diagnosis and surgical monitoring of colorectal cancer]. Zhonghua wai ke za zhi [Chinese journal of surgery] 20050501
Identification and functional analysis of 20 Box H/ACA small nucleolar RNAs (snoRNAs) from Schizosaccharomyces pombe. The Journal of biological chemistry 20050422
Chromatographic, capillary electrophoretic and matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of urinary modified nucleosides as tumor markers. Journal of chromatography. A 20050415
Structure of the pseudouridine synthase RsuA from Haemophilus influenzae. Acta crystallographica. Section F, Structural biology and crystallization communications 20050401
Composition and sequence-dependent binding of RNA to the nucleocapsid protein of Moloney murine leukemia virus. Biochemistry 20050315
Psi35 in the branch site recognition region of U2 small nuclear RNA is important for pre-mRNA splicing in Saccharomyces cerevisiae. The Journal of biological chemistry 20050225
Number, position, and significance of the pseudouridines in the large subunit ribosomal RNA of Haloarcula marismortui and Deinococcus radiodurans. RNA (New York, N.Y.) 20050201
A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC cell biology 20050101
Creation and disruption of protein features by alternative splicing -- a novel mechanism to modulate function. Genome biology 20050101
Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis. BMC molecular biology 20050101
Study of the mass spectrometric fragmentation of pseudouridine: comparison of fragmentation data obtained by matrix-assisted laser desorption/ionisation post-source decay, electrospray ion trap multistage mass spectrometry, and by a method utilising electrospray quadrupole time-of-flight tandem mass spectrometry and in-source fragmentation. Rapid communications in mass spectrometry : RCM 20050101
Pseudouridine modification in Caenorhabditis elegans spliceosomal snRNAs: unique modifications are found in regions involved in snRNA-snRNA interactions. BMC molecular biology 20050101
Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation. RNA (New York, N.Y.) 20041201
Cellular proteolysis and systemic inflammation during exacerbation in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20041201
Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Molecular cell 20041119
The pseudouridine synthases: revisiting a mechanism that seemed settled. Journal of the American Chemical Society 20041013
Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator. Molecular cell 20040827
Molecular epidemiology of childhood mitochondrial encephalomyopathies in a Finnish population: sequence analysis of entire mtDNA of 17 children reveals heteroplasmic mutations in tRNAArg, tRNAGlu, and tRNALeu(UUR) genes. Pediatrics 20040801
Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. RNA (New York, N.Y.) 20040701
Pseudouridine-guide RNAs and other Cbf5p-associated RNAs in Euglena gracilis. RNA (New York, N.Y.) 20040701
Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathy and sideroblastic anemia (MLASA). American journal of human genetics 20040601
Detection and quantitation of RNA base modifications. RNA (New York, N.Y.) 20040601
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold. FEBS letters 20040507
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold. The Journal of biological chemistry 20040430
Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli. Biochemistry 20040420
Definition of bases in 23S rRNA essential for ribosomal subunit association. RNA (New York, N.Y.) 20040401
Pseudouridines in and near the branch site recognition region of U2 snRNA are required for snRNP biogenesis and pre-mRNA splicing in Xenopus oocytes. RNA (New York, N.Y.) 20040401
Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends in biochemical sciences 20040401
Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS biology 20040301
Not all pseudouridine synthases are potently inhibited by RNA containing 5-fluorouridine. RNA (New York, N.Y.) 20040201
Crystal structure of the catalytic domain of RluD, the only rRNA pseudouridine synthase required for normal growth of Escherichia coli. RNA (New York, N.Y.) 20040201
SmD1 is required for spliced leader RNA biogenesis. Eukaryotic cell 20040201
Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli. Journal of molecular biology 20040102
Predicting co-complexed protein pairs using genomic and proteomic data integration. BMC bioinformatics 20040101
Functional characterization of 2'-O-methylation and pseudouridylation guide RNAs. Methods in molecular biology (Clifton, N.J.) 20040101
Comprehensive analysis of pseudogenes in prokaryotes: widespread gene decay and failure of putative horizontally transferred genes. Genome biology 20040101
Structural significances of pseudouridination and methylation of uridine residues in tRNA: X-ray analyses of DNA dodecamers containing uridine and pseudouridine. Nucleic acids symposium series (2004) 20040101
Synthesis of 15N-enriched pseudouridine derivatives. Organic letters 20031030
Purification and crystallization of Escherichia coli pseudouridine synthase RluD. Acta crystallographica. Section D, Biological crystallography 20031001
Low water-soluble uremic toxins. Advances in renal replacement therapy 20031001
Purine and pyrimidine metabolites in children's urine. Clinica chimica acta; international journal of clinical chemistry 20030901
Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis. Journal of agricultural and food chemistry 20030813
The tRNA-like domains of E coli and A.aeolicus transfer-messenger RNA: structural and functional studies. Journal of molecular biology 20030808
Diurnal variation in the renal excretion of modified RNA catabolites in humans. Clinical science (London, England : 1979) 20030801
Beta-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes. Mutation research 20030708
A snoRNA that guides the two most conserved pseudouridine modifications within rRNA confers a growth advantage in yeast. RNA (New York, N.Y.) 20030701
Caenorhabditis elegans pseudouridine synthase 1 activity in vivo: tRNA is a substrate, but not U2 small nuclear RNA. The Biochemical journal 20030601
A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya. RNA (New York, N.Y.) 20030601
Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030205
RNA-modifying enzymes. Current opinion in structural biology 20030201
Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center. Molecular cell 20030201
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science (New York, N.Y.) 20030110
Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model. Bioorganic & medicinal chemistry letters 20030106
Preliminary X-ray crystallographic analysis of tRNA pseudouridine 55 synthase from the thermophilic eubacterium Thermotoga maritima. Acta crystallographica. Section D, Biological crystallography 20030101
Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level. Genome biology 20030101
Characterization of the cofactor-binding site in the SPOUT-fold methyltransferases by computational docking of S-adenosylmethionine to three crystal structures. BMC bioinformatics 20030101
Synthesis of helix 69 of Escherichia coli 23S rRNA containing its natural modified nucleosides, m(3)Psi and Psi. The Journal of organic chemistry 20021213
Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine. Nature structural biology 20021201
Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency. The Journal of biological chemistry 20020823
Pseudouridine, an antimutagenic substance in beer towards N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks. Clinica chimica acta; international journal of clinical chemistry 20020801
The expanding snoRNA world. Biochimie 20020801
Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP. Nature structural biology 20020501
Chips off the old block. Nature structural biology 20020501
Pseudouridylation of U(35) in the anticodon of Arabidopsis thaliana pre-tRNA(Tyr) depends on length rather than structure of an intron. Biochimica et biophysica acta 20020319
Ribosomal RNA pseudouridines and pseudouridine synthases. FEBS letters 20020306
Role of editing in plant mitochondrial transfer RNAs. Gene 20020306
MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. The EMBO journal 20020301
Pulmonary function, body composition, and protein catabolism in adults with cystic fibrosis. American journal of respiratory and critical care medicine 20020215
Structural features of tRNALys favored by anticodon nuclease as inferred from reactivities of anticodon stem and loop substrate analogs. The Journal of biological chemistry 20020208
Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. Bioorganic & medicinal chemistry 20020201
Cytosines do it, thymines do it, even pseudouridines do it--base flipping by an enzyme that acts on RNA. Structure (London, England : 1993) 20020201
The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA. RNA (New York, N.Y.) 20020201
Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin. Gene expression 20020101
Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast. The Journal of biological chemistry 20011207
Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. RNA (New York, N.Y.) 20011101
The brome mosaic virus RNA3 intergenic replication enhancer folds to mimic a tRNA TpsiC-stem loop and is modified in vivo. RNA (New York, N.Y.) 20011101
Mapping pseudouridines in RNA molecules. Methods (San Diego, Calif.) 20011101
Identification of the first trypanosome H/ACA RNA that guides pseudouridine formation on rRNA. The Journal of biological chemistry 20011026
Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae. The Journal of biological chemistry 20010914
A second function for pseudouridine synthases: A point mutant of RluD unable to form pseudouridines 1911, 1915, and 1917 in Escherichia coli 23S ribosomal RNA restores normal growth to an RluD-minus strain. RNA (New York, N.Y.) 20010701
A conserved pseudouridine modification in eukaryotic U2 snRNA induces a change in branch-site architecture. RNA (New York, N.Y.) 20010601
Phosphorescence and optically detected magnetic resonance of HIV-1 nucleocapsid protein complexes with stem-loop sequences of the genomic Psi-recognition element. Biochemistry 20010206
Novel nucleoside triphosphate analogs for the enzymatic labeling of nucleic acids. Nucleosides, nucleotides & nucleic acids 20010101
[Pseudouridine synthases--enzymes introducing the most abundant modified nucleoside in nucleic acids--pseudouridine]. Postepy biochemii 20010101
Pseudouridines and pseudouridine synthases of the ribosome. Cold Spring Harbor symposia on quantitative biology 20010101
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