2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-
| Title | Journal |
|---|---|
| Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells. | European journal of pharmacology 20130130 |
| Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands. | Bioorganic & medicinal chemistry 20120915 |
| Synaptic and nonsynaptic mitochondria demonstrate a different degree of calcium-induced mitochondrial dysfunction. | Life sciences 20120522 |
| Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. | Journal of medicinal chemistry 20120510 |
| The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression. | Current molecular medicine 20120501 |
| Translocator protein (TSPO) in breast cancer. | Current molecular medicine 20120501 |
| LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. | Neurochemistry international 20120501 |
| Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling. | Biochemical and biophysical research communications 20120113 |
| The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. | Biochimica et biophysica acta 20111201 |
| Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury. | Pharmaceutical research 20111101 |
| Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress. | Journal of molecular and cellular cardiology 20111101 |
| Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium. | The Journal of physiology 20111101 |
| Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. | European journal of medicinal chemistry 20110901 |
| Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum. | Blood 20110825 |
| Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. | Glia 20110201 |
| Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. | Journal of medicinal chemistry 20110113 |
| 4'-chlorodiazepam--agonist of peripheral benzodiazepine receptors as a protecting factor in IL-1 induced deregulation of collagen biosynthesis in cultured human chondrocytes. | European journal of pharmacology 20101125 |
| Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats. | European journal of pharmacology 20101010 |
| Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value. | Inflammatory bowel diseases 20100901 |
| Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells. | Molecular and cellular biochemistry 20100701 |
| Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization. | Journal of medicinal chemistry 20100527 |
| 4'-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats. | Experimental biology and medicine (Maywood, N.J.) 20100401 |
| Suppressive effect of diazepam on IFN-gamma production by human T cells. | International immunopharmacology 20100301 |
| Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. | European journal of pharmacology 20100125 |
| Reversal of propoxur-induced impairment of memory and oxidative stress by 4'-chlorodiazepam in rats. | Naunyn-Schmiedeberg's archives of pharmacology 20100101 |
| Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy. | Neuroscience 20091201 |
| Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone. | Invertebrate neuroscience : IN 20091101 |
| Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis. | Brain research 20090825 |
| The translocator protein (18 kDa): central nervous system disease and drug design. | Journal of medicinal chemistry 20090212 |
| Neuroprotective effect of Ro5-4864 following brain injury. | Experimental neurology 20081201 |
| Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons. | Neurochemistry international 20081201 |
| Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. | Journal of medicinal chemistry 20080925 |
| Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. | Cardiovascular research 20080701 |
| Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. | Bioorganic & medicinal chemistry 20080601 |
| Control of peripheral benzodiazepine receptor-mediated breast cancer in rats by soy protein. | Molecular carcinogenesis 20080401 |
| Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. | The European journal of neuroscience 20080201 |
| Steroidogenesis in BeWo cells: role of protein kinase A and benzodiazepines. | The international journal of biochemistry & cell biology 20080101 |
| Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine. | Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101 |
| The scale-free dynamics of eukaryotic cells. | PloS one 20080101 |
| The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells. | Haematologica 20071201 |
| Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization. | The Journal of pharmacology and experimental therapeutics 20071001 |
| Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands. | Neuropharmacology 20070801 |
| Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. | The Journal of biological chemistry 20070727 |
| The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. | Cell calcium 20070701 |
| Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni. | Parasitology 20070701 |
| Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines. | Bioorganic & medicinal chemistry letters 20070501 |
| Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor. | Bioorganic & medicinal chemistry letters 20070315 |
| [Peripheral benzodiazepine receptor agonist Ro5-4864 inhibits mitochondrial permeability transition in rat heart]. | Sheng li xue bao : [Acta physiologica Sinica] 20070225 |
| New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation. | Journal of medicinal chemistry 20070125 |
| A novel conjugable translocator protein ligand labeled with a fluorescence dye for in vitro imaging. | Bioconjugate chemistry 20070101 |
| Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. | Current pharmaceutical design 20070101 |
| Effects of peripheral-type benzodiazepine receptor ligands on Ehrlich tumor cell proliferation. | European journal of pharmacology 20061121 |
| Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. | Journal of medicinal chemistry 20060921 |
| The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development. | Pharmacology & therapeutics 20060601 |
| 5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors. | Die Pharmazie 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats. | Glycoconjugate journal 20060501 |
| Implication of glucocorticoid in anti-inflammatory effects of Ro5-4864 in mouse pleurisy induced by carrageenan. | Life sciences 20060313 |
| Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells. | Molecular pharmacology 20060101 |
| PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor. | Oncogene 20051117 |
| Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats. | Mechanisms of ageing and development 20051101 |
| Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. | Molecular and cellular neurosciences 20051001 |
| Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist. | Biochemical and biophysical research communications 20050722 |
| Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. | Journal of neuroscience research 20050401 |
| Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. | Biochemical pharmacology 20050301 |
| Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and alpha-keto acid profiles or immune functions. | Amino acids 20050201 |
| Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis. | Apoptosis : an international journal on programmed cell death 20050101 |
| Nootropic nefiracetam inhibits proconvulsant action of peripheral-type benzodiazepines in epileptic mutant EL mice. | Annals of the New York Academy of Sciences 20041001 |
| Monitoring drug-induced neurodegeneration by imaging of peripheral benzodiazepine receptors. | Annals of the New York Academy of Sciences 20041001 |
| Peripheral type benzodiazepine receptor in human parathyroid glands: up-regulation in adenoma. | Journal of endocrinological investigation 20041001 |
| The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets. | European journal of endocrinology 20040801 |
| Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. | Biochemical pharmacology 20040701 |
| Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands. | American journal of physiology. Gastrointestinal and liver physiology 20040601 |
| Antinociceptive effects of peripheral benzodiazepine receptors. | Pharmacology 20040401 |
| N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor. | Journal of medicinal chemistry 20040325 |
| Involvement of steroids in anti-inflammatory effects of peripheral benzodiazepine receptor ligands. | Life sciences 20040130 |
| Peripheral benzodiazepine receptors in potatoes (Solanum tuberosum). | Biochemical and biophysical research communications 20040102 |
| Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. | Journal of cellular physiology 20040101 |
| Benzodiazepine binding to mitochondrial membranes of the amoeba Acanthamoeba castellanii and the yeast Saccharomyces cerevisiae. | Acta biochimica Polonica 20040101 |
| Effects of acute and long-term diazepam administrations on neutrophil activity: a flow cytometric study. | European journal of pharmacology 20031008 |
| Structure activity studies of a novel cytotoxic benzodiazepine. | Bioorganic & medicinal chemistry letters 20031006 |
| Ligands of the peripheral benzodiazepine receptor have therapeutic effects in pneumopathies in vivo. | Immunology letters 20030908 |
| Anticholinergic and antiglutamatergic agents protect against soman-induced brain damage and cognitive dysfunction. | Toxicological sciences : an official journal of the Society of Toxicology 20030901 |
| Antidepressant-like effect of Ro5-4864, a peripheral-type benzodiazepine receptor ligand, in forced swimming test. | European journal of pharmacology 20030613 |
| Comparison of two PBR ligands with classical antiinflammatory drugs in LPS-induced arthritis in rats. | Life sciences 20030425 |
| Benzodiazepine-induced protein tyrosine nitration in rat astrocytes. | Hepatology (Baltimore, Md.) 20030201 |
| Peripheral benzodiazepine receptors: on mice and human brain imaging. | Journal of neurochemistry 20030201 |
| Mitochondrial benzodiazepine receptors regulate oxygen homeostasis in the early mouse embryo. | Reproductive toxicology (Elmsford, N.Y.) 20030101 |
| Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. | Journal of neurochemistry 20021201 |
| Identification of a peptide antagonist to the peripheral-type benzodiazepine receptor that inhibits hormone-stimulated leydig cell steroid formation. | The Journal of pharmacology and experimental therapeutics 20021101 |
| Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice. | European journal of pharmacology 20020927 |
| Modulation of tamoxifen-induced apoptosis by peripheral benzodiazepine receptor ligands in breast cancer cells. | Biochemical pharmacology 20020701 |
| Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | Journal of neuroscience research 20020701 |
| Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo. | Cancer research 20020301 |
| Binding and neuropharmacological profile of zaleplon, a novel nonbenzodiazepine sedative/hypnotic. | European journal of pharmacology 20020102 |
| Peripheral benzodiazepine binding sites/receptors (PBRs) have been localized to rat central and peripheral endocrine tissues. | Journal of andrology 20020101 |
| Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes. | European journal of pharmacology 20011207 |
| Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. | British journal of cancer 20011101 |
| Nutritional parameters modify muricidal behavior of male Wistar rats: preventive effects of amino acids and 4' Cl diazepam. | Life sciences 20011026 |
| 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands. | Bioorganic & medicinal chemistry 20011001 |
| Diazepam inhibits HIV-1 Tat-induced migration of human microglia. | Journal of neurovirology 20011001 |
| Effect of midazolam on interleukin-6 mRNA expression in human peripheral blood mononuclear cells in the absence of lipopolysaccharide. | Cytokine 20010921 |
| Structural and functional study of reconstituted peripheral benzodiazepine receptor. | Biochemical and biophysical research communications 20010608 |
| Inverse agonist binding of peripheral benzodiazepine receptors in anxiety disorder. | European archives of psychiatry and clinical neuroscience 20010601 |
| Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone. | Immunopharmacology and immunotoxicology 20010501 |
| Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells. | Gastroenterology 20010401 |
| Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue. | Biochemical pharmacology 20010315 |
| The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABAA receptor binding. | Journal of neural transmission. Supplementum 19980101 |
| Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells. | Antimicrobial agents and chemotherapy 19971101 |
| Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone. | The Journal of pharmacology and experimental therapeutics 19940701 |
| Anticonvulsant activity of delta-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs. | Brain research 19930917 |
| Toxicokinetics of Ro 5-4864, lindane and picrotoxin compared. | Pharmacology, biochemistry, and behavior 19910201 |
| Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site. | Journal of neurochemistry 19891001 |
| 'Central' and 'peripheral' benzodiazepines and kinetics of lindane-induced toxicity. | Pharmacology, biochemistry, and behavior 19890201 |
| Coincidence of seizure susceptibility to caffeine and to the benzodiazepine inverse agonist, DMCM, in SWR and CBA inbred mice. | Pharmacology, biochemistry, and behavior 19870201 |