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Azilsartan

CAS No.:
147403-03-0
Catalog Number:
AG001EVU
Molecular Formula:
C25H20N4O5
Molecular Weight:
456.4501
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
98%
In Stock USA
United States
$63
- +
1g
98%
In Stock USA
United States
$125
- +
5g
98%
In Stock USA
United States
$375
- +
10g
98%(HPLC)
In Stock USA
United States
$576
- +
25g
98%
In Stock USA
United States
$1225
- +
Product Description
Catalog Number:
AG001EVU
Chemical Name:
Azilsartan
CAS Number:
147403-03-0
Molecular Formula:
C25H20N4O5
Molecular Weight:
456.4501
MDL Number:
MFCD20278186
IUPAC Name:
2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
InChI:
InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
InChI Key:
KGSXMPPBFPAXLY-UHFFFAOYSA-N
SMILES:
CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O
EC Number:
808-058-6
UNII:
F9NUX55P23
Properties
Complexity:
783  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
456.143g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
456.458g/mol
Monoisotopic Mass:
456.143g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
115A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.4  
Literature
Title Journal
Azilsartan and its Zn(II) complex. Synthesis, anticancer mechanisms of action and binding to bovine serum albumin. Toxicology in vitro : an international journal published in association with BIBRA 20180401
Efficacy and safety of 10-mg azilsartan compared with 8-mg candesartan cilexetil in Japanese patients with hypertension: a randomized crossover non-inferiority trial. Hypertension research : official journal of the Japanese Society of Hypertension 20140901
Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension. Clinical therapeutics 20140501
Assessment of the environmental fate and effects of azilsartan, a selective antagonist of angiotensin II type 1. Chemosphere 20120601
Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study. Hypertension research : official journal of the Japanese Society of Hypertension 20120501
Differential pharmacology and benefit/risk of azilsartan compared to other sartans. Vascular health and risk management 20120101
Critical evaluation of the efficacy and tolerability of azilsartan. Vascular health and risk management 20120101
Clinical utility of azilsartan-chlorthalidone fixed combination in the management of hypertension. Vascular health and risk management 20120101
Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes, obesity & metabolism 20111201
Comparison of the novel angiotensin II receptor blocker azilsartan medoxomil vs valsartan by ambulatory blood pressure monitoring. Journal of clinical hypertension (Greenwich, Conn.) 20110701
In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. The Journal of pharmacology and experimental therapeutics 20110301
Azilsartan: a newly approved angiotensin II receptor blocker. Cardiology in review 20110101
TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation. American journal of hypertension 20070501
Properties