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Home Other Building Blocks 1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-

1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-

CAS No.:
147025-53-4
Catalog Number:
AG001EJJ
Molecular Formula:
C10H15NO
Molecular Weight:
165.2322
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Product Description
Catalog Number:
AG001EJJ
Chemical Name:
1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-
CAS Number:
147025-53-4
Molecular Formula:
C10H15NO
Molecular Weight:
165.2322
MDL Number:
MFCD06407655
IUPAC Name:
(3R)-3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane
InChI:
InChI=1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1
InChI Key:
XVFJONKUSLSKSW-JTQLQIEISA-N
SMILES:
C#CCO[C@H]1CN2CCC1CC2
UNII:
1O8VSL798T
Properties
Complexity:
197  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
165.115g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
165.236g/mol
Monoisotopic Mass:
165.115g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
12.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8  
Literature
Title Journal
Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20060201
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling. Journal of neuroscience research 20040715
Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20030301
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy. Journal of molecular neuroscience : MN 20030101
Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine. Psychopharmacology 20020701
Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life sciences 20010427
Properties