1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-, sodium salt (1:1)
| Title | Journal |
|---|---|
| 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. | Journal of medicinal chemistry 20111208 |
| MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase. | Cancer letters 20100528 |
| Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells. | The FEBS journal 20080601 |
| Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. | Bioorganic & medicinal chemistry letters 20080315 |
| Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. | Prostaglandins & other lipid mediators 20070801 |
| Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. | Science (New York, N.Y.) 20070727 |
| Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. | The Journal of allergy and clinical immunology 20060701 |
| Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement. | Journal of leukocyte biology 20030401 |
| Role of 5-lipoxygenase products in the local accumulation of neutrophils in dermal inflammation in the rabbit. | Journal of immunology (Baltimore, Md. : 1950) 19990915 |
| Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors. | Agents and actions 19930901 |