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CETRORELIX

CAS No.:
145672-81-7
Catalog Number:
AG001D9O
Molecular Formula:
C72H96ClN17O16
Molecular Weight:
1491.0899
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$108
- +
5mg
≥95%
1 week
United States
$186
- +
10mg
≥95%
1 week
United States
$289
- +
25mg
99%
1 week
United States
$573
- +
50mg
99%
1 week
United States
$907
- +
Product Description
Catalog Number:
AG001D9O
Chemical Name:
CETRORELIX
CAS Number:
145672-81-7
Molecular Formula:
C72H96ClN17O16
Molecular Weight:
1491.0899
MDL Number:
MFCD08459466
IUPAC Name:
(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide;acetic acid
InChI:
InChI=1S/C70H92ClN17O14.C2H4O2/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44;1-2(3)4/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102);1H3,(H,3,4)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+;/m1./s1
InChI Key:
KFEFLCOCAHJBEA-ANRVCLKPSA-N
SMILES:
CC(=O)O.OC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)N)C)CCCNC(=N)N)CC(C)C)CCCNC(=O)N)Cc1ccc(cc1)O)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(cc1)Cl)NC(=O)[C@@H](Cc1ccc2c(c1)cccc2)NC(=O)C
UNII:
XPQ226310Q
Properties
Complexity:
2870  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0
Exact Mass:
1489.691g/mol
Formal Charge:
0
Heavy Atom Count:
106  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
17  
Isotope Atom Count:
0
Molecular Weight:
1491.113g/mol
Monoisotopic Mass:
1489.691g/mol
Rotatable Bond Count:
38  
Topological Polar Surface Area:
536A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study. Fertility and sterility 20160301
Treatment of ovarian hyperstimulation syndrome using gonadotropin releasing hormone antagonist: a pilot study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20121101
Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production. Fertility and sterility 20121101
Effect of the gonadotropin-releasing hormone antagonist cetrorelix on the prevention of chemotherapy-induced ovarian damage in women with hematological malignancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20120701
GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Human reproduction (Oxford, England) 20120601
The effects of letrozole on ovarian stimulation for fertility preservation in cancer-affected women. Reproductive biomedicine online 20120601
Mechanisms of prostate atrophy after LHRH antagonist cetrorelix injection: an experimental study in a rat model of benign prostatic hyperplasia. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120601
Peptidomimetic GnRH antagonist AEZS-115 inhibits the growth of ovarian and endometrial cancer cells. Anticancer research 20120501
Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage. The Journal of urology 20120401
Luteinizing hormone-releasing hormone receptor antagonist may reduce postmenopausal flushing. Menopause (New York, N.Y.) 20120201
Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist. Medical science monitor : international medical journal of experimental and clinical research 20120101
The effects of cetrorelix and triptorelin on the viability and steroidogenesis of cultured human granulosa luteinized cells. In vivo (Athens, Greece) 20120101
Low-dose GnRH antagonist protocol is as effective as the long GnRH agonist protocol in unselected patients undergoing in vitro fertilization and embryo transfer. Taiwanese journal of obstetrics & gynecology 20111201
[Study on the effects of gonadotropin-releasing hormone analogues in the inhibition of ovarian cancer transplanted tumors and in the protection of ovarian function after chemotherapy on nude mice]. Zhonghua fu chan ke za zhi 20111201
The dynamics of endometrial growth and the triple layer appearance in three different controlled ovarian hyperstimulation protocols and their influence on IVF outcomes. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111101
Effectiveness of a low gonadotrophin-releasing hormone antagonist dose in preventing premature luteinizing hormone rise during controlled ovarian stimulation. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111101
Evaluation of the effects of gonadotropin-releasing hormone antagonist (GnRH-ant) and agonist (GnRH-a) in the prevention of postoperative adhesion formation in a rat model with immunohistochemical analysis. Fertility and sterility 20111101
Effects of cetrorelix, a GnRH-receptor antagonist, on gonadal axis in women with functional hypothalamic amenorrhea. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111001
Testosterone and oestradiol in concert protect seminiferous tubule maturation against inhibition by GnRH-antagonist. International journal of andrology 20111001
A pilot study to assess the use of the gonadotrophin antagonist cetrorelix in preserving ovarian function during chemotherapy. The Australian & New Zealand journal of obstetrics & gynaecology 20111001
[Use of GnRH antagonist for in vitro fertilization]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110906
Administration of a gonadotropin-releasing hormone antagonist to mares at different times during the luteal phase of the estrous cycle. Animal reproduction science 20110901
Is anti-Müllerian hormone a marker of acute cyclophosphamide-induced ovarian follicular destruction in mice pretreated with cetrorelix? Fertility and sterility 20110701
Random-start gonadotropin-releasing hormone (GnRH) antagonist-treated cycles with GnRH agonist trigger for fertility preservation. Fertility and sterility 20110701
Hormone-induced delayed ovulation affects early embryonic development. Fertility and sterility 20110601
Regulation of AMH and SCF expression in human granulosa cells by GnRH agonist and antagonist. Die Pharmazie 20110601
LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. The Prostate 20110515
The heart: a novel gonadotrophin-releasing hormone target. Journal of neuroendocrinology 20110501
Possible involvement of PACAP and PACAP type 1 receptor in GnRH-induced FSH β-subunit gene expression. Regulatory peptides 20110411
Receptors for luteinizing hormone-releasing hormone (LHRH) in benign prostatic hyperplasia (BPH) as potential molecular targets for therapy with LHRH antagonist cetrorelix. The Prostate 20110401
Effects of the gonadotropin-releasing hormone antagonist cetrorelix in the early postimplantation period on rat pregnancy. European journal of obstetrics, gynecology, and reproductive biology 20110401
Fixed versus flexible gonadotropin-releasing hormone antagonist administration in in vitro fertilization: a randomized controlled trial. Fertility and sterility 20110201
Cetrorelix lowers premature luteinization rate in gonadotropin ovulation induction-intrauterine insemination cycles: a randomized-controlled clinical trial. Fertility and sterility 20110101
Luteinizing Hormone-Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo. Molecular cancer therapeutics 20110101
Milder is better? Advantages and disadvantages of 'mild' ovarian stimulation for human in vitro fertilization. Reproductive biology and endocrinology : RB&E 20110101
Effect of GnRH antagonist therapy on the expression of MUC-1 and heparin binding growth factor expression in the endometrium of hyperstimulated rats. Clinical and experimental obstetrics & gynecology 20110101
Cetrorelix suppresses the preovulatory LH surge and ovulation induced by ovulation-inducing factor (OIF) present in llama seminal plasma. Reproductive biology and endocrinology : RB&E 20110101
Effect of serum progesterone level on the day of human chorionic gonadotropin injection on outcome following in vitro fertilization-embryo transfer in women using gonadotropin releasing hormone antagonists. Clinical and experimental obstetrics & gynecology 20110101
Evidence that the main adverse effect of ganirelix on pregnancy and implantation rates is on the embryo rather than the endometrium. Clinical and experimental obstetrics & gynecology 20110101
Use of cetrorelix in the investigation of testosterone excess in a postmenopausal woman. BMJ case reports 20110101
Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix. BJU international 20101101
Randomized, comparative pilot study of pituitary suppression with depot leuprorelin versus cetrorelix acetate 3 mg in gonadotropin stimulation protocols for oocyte donors. Fertility and sterility 20101101
Fluorescence spectroscopic determination of the critical aggregation concentration of the GnRH antagonists Cetrorelix, Teverelix and Ozarelix. Journal of fluorescence 20101101
Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells. Fertility and sterility 20101001
Degarelix, a novel GnRH antagonist, causes minimal histamine release compared with cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples. British journal of clinical pharmacology 20101001
Alarin stimulates food intake and gonadotrophin release in male rats. British journal of pharmacology 20101001
Dose-ranging study of the luteinizing hormone-releasing hormone receptor antagonist cetrorelix pamoate in the treatment of patients with symptomatic benign prostatic hyperplasia. Urology 20101001
Comparison of GnRH antagonist with long GnRH agonist protocol after OCP pretreatment in PCOs patients. Archives of gynecology and obstetrics 20100901
Progesterone administration route in gonadotropin-releasing hormone antagonist cycles. Fertility and sterility 20100801
GnRH antagonist cetrorelix inhibits mitochondria-dependent apoptosis triggered by chemotherapy in granulosa cells of rats. Gynecologic oncology 20100701
GnRH agonist and GnRH antagonist protocols in ovarian stimulation: differential regulation pathway of aromatase expression in human granulosa cells. Reproductive biomedicine online 20100701
Safety and efficacy of mixing cetrorelix with follitropin alfa: a randomized study. Fertility and sterility 20100601
Comparison of gonadotropin-releasing hormone agonists and antagonists in assisted reproduction cycles of polycystic ovarian syndrome patients. The journal of obstetrics and gynaecology research 20100601
A circadian egg timer gates ovulation. Current biology : CB 20100323
Triggering ovulation with gonadotropin-releasing hormone agonist in in vitro fertilization patients with polycystic ovaries does not cause ovarian hyperstimulation syndrome despite very high estradiol levels. Fertility and sterility 20100301
Ovarian stimulation in women with high and low body mass index: GnRH agonist versus GnRH antagonist. Reproductive biomedicine online 20100301
Gonadotropin-releasing hormone agonist or human chorionic gonadotropin for final oocyte maturation in an oocyte donor program. Fertility and sterility 20100201
Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists. Molecular endocrinology (Baltimore, Md.) 20100201
Effects of the LHRH antagonist Cetrorelix on affective and cognitive functions in rats. Regulatory peptides 20100108
Regulation of gonadotropin-releasing hormone (GnRH) receptor-I expression in the pituitary and ovary by a GnRH agonist and antagonist. Reproductive sciences (Thousand Oaks, Calif.) 20100101
Single dose GnRH agonist administration in the luteal phase of assisted reproduction cycles: is the effect dependent on the type of GnRH analogue used for pituitary suppression? Reproductive biomedicine online 20100101
Characteristics of progesterone changes in women with subtle progesterone rise in recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonist cycle. Gynecologic and obstetric investigation 20100101
Assessment of fertility protection and ovarian reserve with GnRH antagonist in rats undergoing chemotherapy with cyclophosphamide. Reproductive biology and endocrinology : RB&E 20100101
A comparison of pregnancy rates following fresh and frozen embryo transfer according to the use of leuprolide acetate vs ganirelix vs cetrorelix. Clinical and experimental obstetrics & gynecology 20100101
Effect of controlled ovarian hyperstimulation treatment on cardiac function. The Journal of reproductive medicine 20100101
[Increased risk of early pregnancy loss and lower live birth rate with GNRH antagonist vs. long GNRH agonist protocol in PCOS women undergoing controlled ovarian hyperstimulation]. La Tunisie medicale 20091201
Dynamics of circulating concentrations of gonadotropins and ovarian hormones throughout the menstrual cycle in the bonnet monkey: role of inhibin A in the regulation of follicle-stimulating hormone secretion. American journal of primatology 20091001
Triple-negative breast cancers express receptors for luteinizing hormone-releasing hormone (LHRH) and respond to LHRH antagonist cetrorelix with growth inhibition. International journal of oncology 20091001
GnRH antagonist, cetrorelix, for pituitary suppression in modern, patient-friendly assisted reproductive technology. Expert opinion on drug metabolism & toxicology 20091001
Luteinizing hormone-releasing hormone and postmenopausal flushing. The New England journal of medicine 20090917
Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro. Human reproduction (Oxford, England) 20090901
Neurotrophic effect of gonadotropin-releasing hormone on neurite extension and neuronal migration of embryonic gonadotropin-releasing hormone neurons in chick olfactory nerve bundle culture. Journal of neuroscience research 20090801
Effects of the LHRH antagonist Cetrorelix on the brain function in mice. Neuropeptides 20090601
Cetrorelix protocol versus gonadotropin-releasing hormone analog suppression long protocol for superovulation in intracytoplasmic sperm injection patients older than 40. Fertility and sterility 20090501
Suppression and recovery of gonadotropin and steroid secretion by a gonadotropin-releasing hormone receptor antagonist in healthy women with normal ovulation versus women with polycystic ovary syndrome in the early follicular phase. Fertility and sterility 20090501
GnRH agonist versus GnRH antagonist in controlled ovarian hyperstimulation: their role in patients with an unfavorable prognosis a priori. Fertility and sterility 20090401
Ultrashort flare GnRH agonist combined with flexible multidose GnRH antagonist for patients with repeated IVF failures and poor embryo quality. Fertility and sterility 20090401
GnRH analogue for the prevention of ovarian hyperstimulation syndrome: a pilot study. Fertility and sterility 20090401
What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization? Fertility and sterility 20090401
Predictors and implications of estradiol rise after gonadotropin-releasing hormone antagonist initiation during in vitro fertilization cycles. The Journal of reproductive medicine 20090401
[Long GnRH agonist vs. GnRH antagonist protocol in randomized controlled trial in unselected patients--hormonal and cycle characteristics--pilot study]. Ceska gynekologie 20090401
Does premature luteinization or early surge of LH impair cycle outcome? Report of two successful outcomes. Journal of assisted reproduction and genetics 20090301
In vitro fertilization cycle outcome after coasting in gonadotropin-releasing hormone (GnRH) agonist versus GnRH antagonist protocols. Fertility and sterility 20090201
Menstrual cycle synchronization, ovarian stimulation, and in vitro fertilization in olive baboons (Papio anubis): a prospective randomized study. Fertility and sterility 20090201
Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study. Fertility and sterility 20090201
Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study. Fertility and sterility 20090201
Re: Frans Debruyne, Arkadij A. Gres, Dmitrii L. Arustamov. Placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist Cetrorelix in patients with symptomatic benign prostatic hyperplasia. Eur Urol 2008;54:170-80. European urology 20090201
The GnRH antagonist reduces chemotherapy-induced ovarian damage in rats by suppressing the apoptosis. Gynecologic oncology 20090201
Dihydrotestosterone and leptin regulate gonadotropin-releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuroblasts. The journal of sexual medicine 20090201
Frozen-thawed cleavage-stage embryo transfer cycles after previous GnRH agonist or antagonist stimulation. Reproductive biomedicine online 20090101
Triggering with HCG or GnRH agonist in GnRH antagonist treated oocyte donation cycles: a randomised clinical trial. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090101
Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7. Neuroendocrinology 20090101
High doses of GnRH antagonists are efficient in the management of severe ovarian hyperstimulation syndrome. Clinical and experimental obstetrics & gynecology 20090101
The effect of cetrorelix vs. ganirelix on pregnancy outcome using minimal gonadotropin stimulation in women with elevated day 3 serum follicle stimulating hormone levels. Clinical and experimental obstetrics & gynecology 20090101
Gonadotropin releasing hormone (GnRH) enhances annexin A5 mRNA expression through mitogen activated protein kinase (MAPK) in LbetaT2 pituitary gonadotrope cells. Endocrine journal 20081201
Comparison of the effects of cetrorelix, a GnRH antagonist, and leuprolide, a GnRH agonist, on experimental endometriosis. The journal of obstetrics and gynaecology research 20081201
[Use of GnRh antagonist (Cetrorelix) in controlled ovarian hyperstimulation in women with polycystic ovary disease]. La Tunisie medicale 20081201
Comparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trial. Archives of gynecology and obstetrics 20081101
Modification of the in vitro release profile of Cetrorelix by complexation with biophilic partners. Current drug delivery 20081001
Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. Endocrinology 20080901
'Empty follicle syndrome' after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle. Fertility and sterility 20080901
A randomised controlled trial comparing GnRH antagonist cetrorelix with GnRH agonist leuprorelin for endometrial thinning prior to transcervical resection of endometrium. BJOG : an international journal of obstetrics and gynaecology 20080901
Cetrorelix suppression test in the diagnostic work-up of severe hyperandrogenism in adolescence. Journal of pediatric endocrinology & metabolism : JPEM 20080901
Effects and clinical significance of GnRH antagonist administration for IUI timing in FSH superovulated cycles: a meta-analysis. Fertility and sterility 20080801
Cumulative pregnancy rates after sequential treatment with modified natural cycle IVF followed by IVF with controlled ovarian stimulation. Human reproduction (Oxford, England) 20080801
Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial. Human reproduction (Oxford, England) 20080801
Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. American journal of physiology. Endocrinology and metabolism 20080801
Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs. Fertility and sterility 20080701
Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial. Fertility and sterility 20080701
Editorial comment on: placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist cetrorelix in patients with symptomatic benign prostatic hyperplasia. European urology 20080701
Editorial comment on: placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist cetrorelix in patients with symptomatic benign prostatic hyperplasia. European urology 20080701
Editorial comment on: placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist cetrorelix in patients with symptomatic benign prostatic hyperplasia. European urology 20080701
Placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist cetrorelix in patients with symptomatic benign prostatic hyperplasia. European urology 20080701
Increased intrafollicular androgen levels affect human granulosa cell secretion of anti-Müllerian hormone and inhibin-B. Fertility and sterility 20080601
Effect of cetrorelix dose on premature LH surge during ovarian stimulation. Reproductive biomedicine online 20080601
GnRH antagonists may affect endometrial receptivity. Fertility and sterility 20080501
Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles. Fertility and sterility 20080401
The decrease of serum luteinizing hormone level by a gonadotropin-releasing hormone antagonist following the mild IVF stimulation protocol for IVF and its clinical outcome. Journal of assisted reproduction and genetics 20080401
Multifollicular recruitment in combination with gonadotropin-releasing hormone antagonist increased pregnancy rates in intrauterine insemination cycles. Fertility and sterility 20080301
Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20080301
Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female rat. Endocrinology 20080301
Comparisons of different dosages of gonadotropin-releasing hormone (GnRH) antagonist, short-acting form and single, half-dose, long-acting form of GnRH agonist during controlled ovarian hyperstimulation and in vitro fertilization. Taiwanese journal of obstetrics & gynecology 20080301
Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists. Molecules and cells 20080227
In vivo biodistribution of an androgen receptor avid PET imaging agent 7-alpha-fluoro-17 alpha-methyl-5-alpha-dihydrotestosterone ([(18)F]FMDHT) in rats pretreated with cetrorelix, a GnRH antagonist. European journal of nuclear medicine and molecular imaging 20080201
Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines. The Journal of endocrinology 20080201
Serum cetrorelix concentrations do not affect clinical pregnancy outcome in assisted reproduction. Fertility and sterility 20080101
Molecular profiling of the human testis reveals stringent pathway-specific regulation of RNA expression following gonadotropin suppression and progestogen treatment. Journal of andrology 20080101
Ovulation induction and pregnancy in a woman with premature menopause following gonadotropin suppression with the gonadotropin releasing hormone antagonist, cetrorelix--a case report. Clinical and experimental obstetrics & gynecology 20080101
Use of GnRH antagonists in ovarian remnant syndrome experimentally induced in rats. Clinical and experimental obstetrics & gynecology 20080101
Follicular growth and development under continuous gonadotropin-releasing hormone antagonist administration. Fertility and sterility 20071201
Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist. Human reproduction (Oxford, England) 20071101
Presurgical short term treatment of uterine fibroids with different doses of cetrorelix acetate: a double-blind, placebo-controlled multicenter study. European journal of obstetrics, gynecology, and reproductive biology 20071001
GnRH agonist and antagonist protocols for stage I-II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertility and sterility 20071001
Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. American journal of physiology. Endocrinology and metabolism 20071001
The combination of antagonists of LHRH with antagonists of GHRH improves inhibition of androgen sensitive MDA-PCa-2b and LuCaP-35 prostate cancers. The Prostate 20070901
Application of GnRH antagonist in combination with clomiphene citrate and hMG for patients with exaggerated ovarian response in previous IVF/ICSI cycles. Journal of assisted reproduction and genetics 20070801
Insights into male germ cell apoptosis due to depletion of gonadotropins caused by GnRH antagonists. Apoptosis : an international journal on programmed cell death 20070601
Subtle progesterone rise in the single-dose gonadotropin-releasing hormone antagonist (cetrorelix) stimulation protocol in patients undergoing in vitro fertilization or intracytoplasmic sperm injection cycles. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070601
Protection of ovarian function and fertility using a combination of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist during cancer treatment in young females. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070501
Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. American journal of physiology. Endocrinology and metabolism 20070301
The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis. Bone 20070201
The influence of estradiol/follicle and estradiol/oocyte ratios on the outcome of controlled ovarian stimulation for in vitro fertilization. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070201
Comparisons of follicular levels of sex steroids, gonadotropins and insulin like growth factor-1 (IGF-1) and epidermal growth factor (EGF) in poor responder and normoresponder patients undergoing ovarian stimulation with GnRH antagonist. European journal of obstetrics, gynecology, and reproductive biology 20070101
GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial. Human reproduction (Oxford, England) 20070101
Vesicular phospholipid gels: a technology platform. Journal of liposome research 20070101
Impact of estradiol patterns in clomiphene citrate/human menopausal gonadotropin/cetrorelix protocol. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070101
Controlled ovarian hyperstimulation using multi-dose gonadotropin-releasing hormone (GnRH) antagonist results in less systemic inflammation than the GnRH-agonist long protocol. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070101
Preliminary report on the effect of a lower dose of gonadotropin-releasing hormone antagonist (cetrorelix) on ovarian hyperstimulation in lower-weight Asian women. Taiwanese journal of obstetrics & gynecology 20061201
GnRH-antagonist mediated down-regulation of the estrous cycle in marmosets. Journal of medical primatology 20061201
GnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis. Reproductive biomedicine online 20061101
Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols. Human reproduction (Oxford, England) 20061001
Actions of gonadotropin-releasing hormone analogues in pituitary gonadotrophs and their modulation by ovarian steroids. The Journal of steroid biochemistry and molecular biology 20061001
Precycle administration of GnRH antagonist and microdose HCG decreases clinical pregnancy rates without affecting embryo quality and blastulation. Reproductive biomedicine online 20061001
Cetrorelix in the treatment of female infertility and endometriosis. Expert opinion on pharmacotherapy 20061001
Comparison between a GnRH antagonist and a GnRH agonist flare-up protocol in oocyte donors: a randomized clinical trial. Human reproduction (Oxford, England) 20060901
Cetrorelix suppression test to assess the source of androgen overproduction in postmenopausal hirsutism. European journal of endocrinology 20060901
Comparison of follicular fluid IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A concentrations and their ratios between GnRH agonist and GnRH antagonist protocols for controlled ovarian stimulation in IVF-embryo transfer patients. Human reproduction (Oxford, England) 20060801
Direct effect of progestogen on gene expression in the testis during gonadotropin withdrawal and early suppression of spermatogenesis. The Journal of clinical endocrinology and metabolism 20060701
Recombinant gonadotrophins associated with GnRH antagonist (cetrorelix) in ovarian stimulation for ICSI: comparison of r-FSH alone and in combination with r-LH. European journal of obstetrics, gynecology, and reproductive biology 20060601
Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study. Human reproduction (Oxford, England) 20060601
Gonadotropin-releasing hormone antagonists increase follicular fluid insulin-like growth factor-I and vascular endothelial growth factor during ovarian stimulation cycles. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060601
Comparison of outcome of clomiphene citrate/human menopausal gonadotropin/cetrorelix protocol and buserelin long protocol--a randomized study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060601
Outcome of frozen-thawed blastocysts derived from gonadotropin releasing hormone agonist or antagonist cycles. Journal of assisted reproduction and genetics 20060601
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Impact of coasting in patients undergoing controlled ovarian stimulation with the gonadotropin-releasing hormone antagonist cetrorelix. Fertility and sterility 20060501
Efficacy of low-dose human chorionic gonadotropin (hCG) in a GnRH antagonist protocol. Journal of assisted reproduction and genetics 20060501
IGF-I and epidermal growth factor levels in follicular fluid of women undergoing controlled ovarian hyperstimulation using the multidose GnRH-antagonist protocol or the long GnRH-agonist protocol. Journal of endocrinological investigation 20060501
Dynamic changes in mitogen-activated protein kinase (MAPK) activities in the corpus luteum of the bonnet monkey (Macaca radiata) during development, induced luteolysis, and simulated early pregnancy: a role for p38 MAPK in the regulation of luteal function. Endocrinology 20060401
[Endometriosis]. Nihon rinsho. Japanese journal of clinical medicine 20060401
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Serum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cycles. European journal of obstetrics, gynecology, and reproductive biology 20060301
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Use of gonadotropin-releasing hormone antagonists to overcome the drawbacks of intrauterine insemination on weekends. Fertility and sterility 20060301
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Emerging drug therapies for benign prostatic hyperplasia. Expert opinion on emerging drugs 20060301
GnRH agonists and antagonists decrease the metastatic progression of human prostate cancer cell lines by inhibiting the plasminogen activator system. Oncology reports 20060201
Levels of apoptosis in human granulosa cells seem to be comparable after therapy with a gonadotropin-releasing hormone agonist or antagonist. Fertility and sterility 20060201
Effect of gonadotropin-releasing hormone agonist and antagonist on steroidogenesis of low responders undergoing in vitro fertilization. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060201
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Effect of GnRH analogs on the expression of TrkA and p75 neurotrophin receptors in primary cell cultures from human prostate adenocarcinoma. The Prostate 20051101
No effect of short-term testosterone manipulation on exercise substrate metabolism in men. Journal of applied physiology (Bethesda, Md. : 1985) 20051101
Effect of cetrorelix acetate on apoptosis and apoptosis regulatory factors in cultured uterine leiomyoma cells. Fertility and sterility 20051101
Coordination of antral follicle growth: basis for innovative concepts of controlled ovarian hyperstimulation. Seminars in reproductive medicine 20051101
Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cells. Molecular and cellular endocrinology 20051020
GnRH-I and GnRH-II have differential modulatory effects on human peripheral blood mononuclear cell proliferation and interleukin-2 receptor gamma-chain mRNA expression in healthy males. Clinical and experimental immunology 20051001
Comparison of embryo implantation in Wistar rats that underwent ovarian stimulation using exogenous gonadotropins associated with cetrorelix acetate or leuprolide acetate. Fertility and sterility 20051001
[GnRH antagonists and benign prostatic hyperplasia]. Annales d'urologie 20051001
Comparison of GnRH agonists and antagonists in assisted reproduction cycles of patients at high risk of ovarian hyperstimulation syndrome. Human reproduction (Oxford, England) 20050901
Different effects of agonistic vs. antagonistic gnrh-analogues (triptorelin vs. cetrorelix) on bone modeling and remodeling in peripubertal female rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050901
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Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor. Biochemical and biophysical research communications 20050729
Prospective, randomized trial comparing cetrorelix acetate and ganirelix acetate in a programmed, flexible protocol for premature luteinizing hormone surge prevention in assisted reproductive technologies. Fertility and sterility 20050701
Clinical suppression of precocious puberty with cetrorelix after failed treatment with GnRH agonist in a girl with gonadotrophin-independent precocious puberty. Reproductive biomedicine online 20050701
A randomised study of GnRH antagonist (cetrorelix) versus agonist (busereline) for controlled ovarian stimulation: effect on safety and efficacy. European journal of obstetrics, gynecology, and reproductive biology 20050601
Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration. Fertility and sterility 20050601
Hormonal manipulations in the luteal phase to coordinate subsequent antral follicle growth during ovarian stimulation. Reproductive biomedicine online 20050601
Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol. Human reproduction (Oxford, England) 20050501
A prospective randomized study comparing gonadotropin-releasing hormone agonists or gonadotropin-releasing hormone antagonists in couples with unexplained infertility and/or mild oligozoospermia. Fertility and sterility 20050501
Development and in vitro evaluation of a liposome based implant formulation for the decapeptide cetrorelix. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050401
Minimal stimulation IVF with late follicular phase administration of the GnRH antagonist cetrorelix and concomitant substitution with recombinant FSH: a pilot study. Human reproduction (Oxford, England) 20050301
GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial. Human reproduction (Oxford, England) 20050301
Use of antagonists in ovarian stimulation protocols. Reproductive biomedicine online 20050301
Gonadotropin-releasing hormone antagonist cetrorelix down-regulates proliferating cell nuclear antigen and epidermal growth factor expression and up-regulates apoptosis in association with enhanced poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human leiomyoma cells. The Journal of clinical endocrinology and metabolism 20050201
Agonist 'flare-up' versus antagonist in the management of poor responders undergoing in vitro fertilization treatment. Fertility and sterility 20050201
Use of a GnRH antagonist in controlled ovarian hyperstimulation for assisted conception in women with polycystic ovary disease: a randomized, prospective, pilot study. The Journal of reproductive medicine 20050201
GnRH antagonist-induced down-regulation of the mRNA expression of pituitary receptors: comparisons with GnRH agonist effects. Endocrine journal 20050201
Use of GNRH antagonists in reproductive medicine. Minerva ginecologica 20050201
Extrapituitary effects of GnRH antagonists in assisted reproduction: a review. Reproductive biomedicine online 20050201
Modified natural cycle using GnRH antagonist can be an optional treatment in poor responders undergoing IVF. Journal of assisted reproduction and genetics 20050201
Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline. British journal of cancer 20050131
Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure. Journal of andrology 20050101
Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine. Hormone research 20050101
[Optimisation of possible success in an IVF program]. Zentralblatt fur Gynakologie 20041201
A modified gonadotropin-releasing hormone (GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol. Fertility and sterility 20041101
Comparative efficacy and safety of cetrorelix with or without mid-cycle recombinant LH and leuprolide acetate for inhibition of premature LH surges in assisted reproduction. Reproductive biomedicine online 20041101
The role of particle engineering in relation to formulation and de-agglomeration principle in the development of a dry powder formulation for inhalation of cetrorelix. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041001
[The programming of IVF cycles with antagonists]. Journal de gynecologie, obstetrique et biologie de la reproduction 20041001
[Antagonist protocols: residual LH levels and the value of exogenous LH supplementation]. Journal de gynecologie, obstetrique et biologie de la reproduction 20041001
[Introduction of the antagonist: on a determined day or depending on follicular growth?]. Journal de gynecologie, obstetrique et biologie de la reproduction 20041001
Gonadotropin releasing hormone antagonists and cryopreservation outcome: a review. Archives of gynecology and obstetrics 20040901
Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study. Human reproduction (Oxford, England) 20040901
Identification of novel genes regulated by LH in the primate corpus luteum: insight into their regulation during the late luteal phase. Molecular human reproduction 20040901
Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study. Human reproduction (Oxford, England) 20040901
Hormone therapy in prostate cancer: LHRH antagonists versus LHRH analogues. European urology 20040901
GnRH antagonist improved blastocyst quality and pregnancy outcome after multiple failures of IVF/ICSI-ET with a GnRH agonist protocol. Journal of assisted reproduction and genetics 20040901
Evidence for different gonadotropin-releasing hormone response sites in rat ovarian and pituitary cells. Biology of reproduction 20040801
Luteinizing hormone supplementation increases pregnancy rates in gonadotropin-releasing hormone antagonist donor cycles. Fertility and sterility 20040801
Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor. European journal of endocrinology 20040701
FSH time-concentration profiles before and after administration of 0.25 mg cetrorelix in the gnRH-antagonist multiple-dose protocol for ovarian hyperstimulation. Journal of assisted reproduction and genetics 20040701
The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Human reproduction (Oxford, England) 20040601
Premenstrual administration of gonadotropin-releasing hormone antagonist coordinates early antral follicle sizes and sets up the basis for an innovative concept of controlled ovarian hyperstimulation. Fertility and sterility 20040601
Hormonal regulation of human trophoblast differentiation: a possible role for 17beta-estradiol and GnRH. Molecular and cellular endocrinology 20040415
Minimal stimulation using recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist in women of advanced age. Fertility and sterility 20040401
Development and validation of a HPLC method for routine quantification of the decapeptide Cetrorelix in liposome dispersions. Journal of pharmaceutical and biomedical analysis 20040310
Luteinizing hormone-releasing hormone antagonist Cetrorelix regulates the expression of Galphas and Galphai protein subunits and adenylate cyclase activity in rat ovary, breast and pituitary. International journal of oncology 20040301
Triptorelin versus cetrorelix in intracytoplasmic sperm injection cycles in women with a single ovary. European journal of obstetrics, gynecology, and reproductive biology 20040210
Gonadotropin-releasing hormone receptor gene expression during pubertal development of female rats. Biology of reproduction 20040201
Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201
[Comparison of GnRH agonists and antagonists in an ovular donation program]. Ginecologia y obstetricia de Mexico 20040201
Expression and function of gonadotropin-releasing hormone (GnRH) receptor in human olfactory GnRH-secreting neurons: an autocrine GnRH loop underlies neuronal migration. The Journal of biological chemistry 20040102
Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models. Pediatric research 20040101
Gonadotropin-releasing hormone antagonists for assisted reproductive techniques: are there clinical differences between agents? Drugs 20040101
Protocol combining GnRH agonists and GnRH antagonists for rapid suppression and prevention of gonadal damage during cytotoxic therapy. European journal of gynaecological oncology 20040101
Luteinizing hormone-releasing hormone (LHRH) inhibits apoptosis induced by cytotoxic agent and UV-light but not apoptosis mediated through CD95 in human ovarian and endometrial cancer cells. Anticancer research 20040101
Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertility and sterility 20031201
Gonadal protection from radiation by GnRH antagonist or recombinant human FSH: a controlled trial in a male nonhuman primate (Macaca fascicularis). The Journal of endocrinology 20031101
[Revisiting the clomifene-gonadotropin protocol in IVF with the use of a GnRH antagonist]. Gynecologie, obstetrique & fertilite 20031101
Gonadotropin-releasing hormone (GnRH)-antagonist versus GnRH-agonist in ovarian stimulation of poor responders undergoing IVF. Journal of assisted reproduction and genetics 20031101
GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors. Molecules and cells 20031031
Regulatory effects of gonadotropin-releasing hormone (GnRH) I and GnRH II on the levels of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinases-1 in primary cultures of human extravillous cytotrophoblasts. The Journal of clinical endocrinology and metabolism 20031001
Comparable effectiveness using flexible single-dose GnRH antagonist (cetrorelix) and single-dose long GnRH agonist (goserelin) protocol for IVF cycles--a prospective, randomized study. Reproductive biomedicine online 20031001
Phase II study of cetrorelix, a luteinizing hormone-releasing hormone antagonist in patients with platinum-resistant ovarian cancer. Gynecologic oncology 20030901
Depot GnRH agonist versus the single dose GnRH antagonist regimen (cetrorelix, 3 mg) in patients undergoing assisted reproduction treatment. Reproductive biomedicine online 20030901
[Protocol of GNRH antagonist in poor responders in IVF-ET cycles]. Ginekologia polska 20030901
Prolactin inhibits annexin 5 expression and apoptosis in the corpus luteum of pseudopregnant rats: involvement of local gonadotropin-releasing hormone. Endocrinology 20030801
Differential effects of gonadotropin-releasing hormone I and II on the urokinase-type plasminogen activator/plasminogen activator inhibitor system in human decidual stromal cells in vitro. The Journal of clinical endocrinology and metabolism 20030801
The use of gonadotropin-releasing hormone antagonist in a flexible protocol: a pilot study. American journal of obstetrics and gynecology 20030801
Actions of GnRH antagonists on IGF-II, IGF-binding protein-2 and pregnancy-associated plasma protein-A in human granulosa-lutein cells. European journal of endocrinology 20030701
An overview of GnRH antagonists in infertility treatments. Introduction. Fertility and sterility 20030701
The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase. The Journal of clinical endocrinology and metabolism 20030701
The administration of the GnRH antagonist, cetrorelix, to ooctye donors simplifies oocyte donation. Human reproduction (Oxford, England) 20030601
Impact of the gonadotropin-releasing hormone antagonist in oocyte donation cycles. Fertility and sterility 20030601
The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate/gonadotrophin/0.25 mg cetrorelix. Reproductive biomedicine online 20030601
Safety and efficacy of a 3 mg dose of the GnRH antagonist cetrorelix in preventing premature LH surges: report of two large multicentre, multinational, phase IIIb clinical experiences. Reproductive biomedicine online 20030601
Single dose application of cetrorelix in combination with clomiphene for friendly IVF: results of a feasibility study. Reproductive biomedicine online 20030601
No influence of body weight on pregnancy rate in patients treated with cetrorelix according to the single- and multiple-dose protocols. Reproductive biomedicine online 20030601
Gonadotropin-releasing hormone receptor gene expression during pubertal development of male rats. Biology of reproduction 20030501
Stimulation of luteinizing hormone secretion by N-methyl-D,L-aspartic acid in the adult male guinea-pig: incomplete blockade by gonadotropin-releasing hormone receptor antagonism. Journal of neuroendocrinology 20030501
Sperm to zona pellucida binding depends on the use of a gonadotropin-releasing hormone agonist or a gonadotropin-releasing hormone antagonist. Fertility and sterility 20030301
Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women. Journal of clinical pharmacology 20030301
Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles. Human reproduction (Oxford, England) 20030101
The use of clomiphene citrate/human menopausal gonadotrophins in conjunction with GnRH antagonist in an IVF/ICSI program is not a cost effective protocol. Acta obstetricia et gynecologica Scandinavica 20030101
An evaluation of the multiple dose protocol of cetrorelix in single ovary women. In vivo (Athens, Greece) 20030101
Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reproductive biology and endocrinology : RB&E 20030101
The effects of gonadotropin-releasing hormone (GnRH) I and GnRH II on the urokinase-type plasminogen activator/plasminogen activator inhibitor system in human extravillous cytotrophoblasts in vitro. The Journal of clinical endocrinology and metabolism 20021201
Tailoring the GnRH antagonist cetrorelix acetate to individual patients' needs in ovarian stimulation for IVF: results of a prospective, randomized study. Human reproduction (Oxford, England) 20021101
Effectiveness of an antagonist to gonadotrophin releasing hormone on the FSH and LH response to GnRH in perifused equine pituitary cells, and in seasonally acyclic mares. Animal reproduction science 20020916
Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig. Endocrinology 20020901
Inhibition of recovery of spermatogenesis in irradiated rats by different androgens. Endocrinology 20020901
Novel formulations of cetrorelix acetate in healthy men: pharmacodynamic effects and noncompartmental pharmacokinetics. Journal of clinical pharmacology 20020901
[Use of GnRH antagonists (cetrorelix) in assisted reproduction: first report in Mexican literature]. Ginecologia y obstetricia de Mexico 20020901
Use of cetrorelix in combination with clomiphene citrate and gonadotrophins: a suitable approach to 'friendly IVF'? Human reproduction (Oxford, England) 20020801
Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasing hormone antagonist Cetrorelix. The Journal of clinical endocrinology and metabolism 20020801
An unusual steroid-producing ovarian tumour: case report. Human reproduction (Oxford, England) 20020601
Comparison of GnRH agonists and antagonists in unselected IVF/ICSI patients treated with different controlled ovarian hyperstimulation protocols: a matched study. European journal of obstetrics, gynecology, and reproductive biology 20020510
Effect of clomiphene citrate on follicular and luteal phase luteinizing hormone concentrations in in vitro fertilization cycles stimulated with gonadotropins and gonadotropin-releasing hormone antagonist. Fertility and sterility 20020401
[LH and GnRH antagonists]. Journal de gynecologie, obstetrique et biologie de la reproduction 20020401
Comparison of cryopreservation outcome with gonadotropin-releasing hormone agonists or antagonists in the collecting cycle. Fertility and sterility 20020301
Optimizing gonadotrophin-releasing hormone antagonist protocols. Human fertility (Cambridge, England) 20020201
[GnRH antagonists]. Gynecologie, obstetrique & fertilite 20020101
Plasma and follicular fluid concentrations of LHRH antagonist cetrorelix (Cetrotide) in controlled ovarian stimulation for IVF. Archives of gynecology and obstetrics 20020101
New drugs 2002, part 1. Nursing 20020101
Comparison of the effects of two GnRH antagonists on LH and FSH secretion, follicular growth and ovulation in the mare. Reproduction, nutrition, development 20020101
[Reproductive health--new hormonal agents to treat infertility]. Akusherstvo i ginekologiia 20020101
Clomiphene-induced LH surges and cetrorelix. Reproductive biomedicine online 20020101
Use of GnRH antagonists in the treatment of endometriosis. Reproductive biomedicine online 20020101
The place of gonadotrophin-releasing hormone antagonists in reproductive medicine. Reproductive biomedicine online 20020101
Structure-function studies of linear and cyclized peptide antagonists of the GnRH receptor. Biochemical and biophysical research communications 20011207
Human ovarian steroid secretion in vivo: effects of GnRH agonist versus antagonist (cetrorelix). Human reproduction (Oxford, England) 20011201
Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this non-aromatizable androgen alone. Human reproduction (Oxford, England) 20011201
Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit. Endocrinology 20011101
Comparison of luteal phase profile in gonadotrophin stimulated cycles with or without a gonadotrophin-releasing hormone antagonist. Human reproduction (Oxford, England) 20011101
LHRH antagonist decreases LH and progesterone secretion but does not alter length of estrous cycle in heifers. Journal of animal science 20011101
Use of GnRH antagonists in ovarian stimulation for assisted reproductive technologies compared to the long protocol. Meta-analysis. Archives of gynecology and obstetrics 20011101
[GnRH antagonists in IVF]. Journal de gynecologie, obstetrique et biologie de la reproduction 20011101
Use of gonadotrophin releasing hormone (GnRH) antagonist (cetrotide) during ovarian stimulation for in-vitro fertilization treatment: multiple doses and single dose. The journal of obstetrics and gynaecology research 20011001
Histological effects of androgen deprivation on the adult chimpanzee epididymis. Tissue & cell 20011001
Inhibition of growth of ES-2 human ovarian cancers by bombesin antagonist RC-3095, and luteinizing hormone-releasing hormone antagonist Cetrorelix. Cancer letters 20010928
Use of third generation gonadotropin-releasing hormone antagonists in in vitro fertilization-embryo transfer: a review. Obstetrical & gynecological survey 20010901
The role of gonadotropin-releasing hormone antagonists in in vitro fertilization. Seminars in reproductive medicine 20010901
Gonadotropin-releasing hormone antagonist protocol: a novel method of ovarian stimulation in poor responders. European journal of obstetrics, gynecology, and reproductive biology 20010801
Stimulation effect of galanin-like peptide (GALP) on luteinizing hormone-releasing hormone-mediated luteinizing hormone (LH) secretion in male rats. Endocrinology 20010801
A prospective, randomized comparison of two starting doses of recombinant FSH in combination with cetrorelix in women undergoing ovarian stimulation for IVF/ICSI. Human reproduction (Oxford, England) 20010801
Applications for GnRH antagonists. Trends in endocrinology and metabolism: TEM 20010801
Luteinizing hormone-releasing hormone antagonists in prostate cancer. Urology 20010801
Low-temperature micronization of a peptide drug in fluid propellant: case study cetrorelix. AAPS PharmSciTech 20010712
Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice. Endocrinology 20010701
Actions of gonadotropin-releasing hormone antagonists on steroidogenesis in human granulosa lutein cells. European journal of endocrinology 20010601
Systemic delivery of cetrorelix to rats by a new aerosol delivery system. Pharmaceutical research 20010601
Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. The Journal of endocrinology 20010501
Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial. Human reproduction (Oxford, England) 20010501
Comparison of LH concentrations in the early and mid-luteal phase in IVF cycles after treatment with HMG alone or in association with the GnRH antagonist Cetrorelix. Human reproduction (Oxford, England) 20010401
Pharmacodynamic effects and plasma pharmacokinetics of single doses of cetrorelix acetate in healthy premenopausal women. Fertility and sterility 20010201
Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010201
Health of 227 children born after controlled ovarian stimulation for in vitro fertilization using the luteinizing hormone-releasing hormone antagonist cetrorelix. Fertility and sterility 20010101
Stability of several LHRH antagonists against proteolytic enzymes and identification of degradation products by mass spectrometry. Die Pharmazie 20010101
[GnRH antagonist]. Nihon rinsho. Japanese journal of clinical medicine 20010101
GnRH agonists and antagonists stimulate recovery of fertility in irradiated LBNF1 rats. Journal of andrology 20010101
Gonadotrophin-releasing hormone antagonists for assisted conception. The Cochrane database of systematic reviews 20010101
Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding. Molecular endocrinology (Baltimore, Md.) 20000701
Pharmacokinetics of new testosterone transdermal therapeutic systems in gonadotropin-releasing hormone antagonist-suppressed normal men. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 19990101
Sustained release formulations of luteinizing hormone-releasing hormone antagonist SB-75 inhibit proliferation and enhance apoptotic cell death of human prostate carcinoma (PC-82) in male nude mice. Cancer research 19920501
Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analog RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model. The Prostate 19920101
Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters. International journal of cancer 19910909
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