Home Aminos Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1)

Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1)

CAS No.:
138926-19-9
Catalog Number:
AG0019UQ
Molecular Formula:
C9H24NNaO8P2
Molecular Weight:
359.2261
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
In Stock USA
United States
$46
- +
25mg
98%
In Stock USA
United States
$72
- +
100mg
98%
In Stock USA
United States
$151
- +
1g
98%
In Stock USA
United States
$364
- +
Product Description
Catalog Number:
AG0019UQ
Chemical Name:
Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1)
CAS Number:
138926-19-9
Molecular Formula:
C9H24NNaO8P2
Molecular Weight:
359.2261
MDL Number:
MFCD00912167
IUPAC Name:
sodium;hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate;hydrate
InChI:
InChI=1S/C9H23NO7P2.Na.H2O/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);;1H2/q;+1;/p-1
InChI Key:
VBDRTGFACFYFCT-UHFFFAOYSA-M
SMILES:
CCCCCN(CCC(P(=O)(O)O)(P(=O)(O)[O-])O)C.O.[Na+]
UNII:
J12U072QL0
Properties
Complexity:
377  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
359.087g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
359.227g/mol
Monoisotopic Mass:
359.087g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
142A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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Effects of intravenous ibandronate injection on renal function in women with postmenopausal osteoporosis at high risk for renal disease--the DIVINE study. Bone 20111201
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Efficacy and safety of monthly oral ibandronate in the prevention of postmenopausal bone loss. Bone 20090301
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Ibandronate dose response is associated with increases in bone mineral density and reductions in clinical fractures: results of a meta-analysis. Bone 20090301
The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats. Biomaterials 20090301
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Plain film and CBCT findings in a case of bisphosphonate-related osteonecrosis of the jaw. Quintessence international (Berlin, Germany : 1985) 20090201
Efficacy of bisphosphonates in reducing fracture risk in postmenopausal osteoporosis. The American journal of medicine 20090201
Higher incidence of Osteonecrosis of the Jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents. Cancer investigation 20090201
Once-monthly oral ibandronate improves biomechanical determinants of bone strength in women with postmenopausal osteoporosis. The Journal of clinical endocrinology and metabolism 20090101
Oral ibandronate preserves trabecular microarchitecture: micro-computed tomography findings from the oral iBandronate Osteoporosis vertebral fracture trial in North America and Europe study. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20090101
[New development in bisphosphonate treatment. Characteristics and effectiveness of intermittent bisphophonates]. Clinical calcium 20090101
Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection. Genome biology 20090101
Gastrointestinal tolerability with ibandronate after previous weekly bisphosphonate treatment. Clinical interventions in aging 20090101
Is there a role for ibandronate in the treatment of prostate cancer patients with bony metastases? Acta oncologica (Stockholm, Sweden) 20090101
Dendritic multishell architectures for drug and dye transport. Journal of controlled release : official journal of the Controlled Release Society 20081218
Oral versus intravenous ibandronic acid: a comparison of treatment options for metastatic bone disease. Journal of cancer research and clinical oncology 20081201
Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates. Journal of surgical oncology 20081201
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[Bisphosphonates for osseus invasion caused by bronchial carcinoma]. Deutsche medizinische Wochenschrift (1946) 20081101
Ibandronate: is there an effect on nonvertebral fractures? Clinical rheumatology 20081001
An open-label pilot trial of ibandronate for complex regional pain syndrome. The Clinical journal of pain 20081001
Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20081001
[Ibandronate in the treatment of postmenopausal osteoporosis]. Lege artis medicinae : uj magyar orvosi hirmondo 20081001
Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer. Journal of pain and symptom management 20080901
Acute phase reaction with intravenous ibandronate. The American journal of medicine 20080901
Nonvertebral fracture risk reduction with nitrogen-containing bisphosphonates. Current osteoporosis reports 20080901
Therapies for treatment of osteoporosis in US women: cost-effectiveness and budget impact considerations. The American journal of managed care 20080901
[Update on treatment of postmenopausal osteoporosis]. Revue medicale de Bruxelles 20080901
Monthly oral ibandronate is effective and well tolerated after 3 years: the MOBILE long-term extension. Clinical rheumatology 20080801
[Daily practice using the guidelines for prevention and treatment of osteoporosis. Evolution of bisphosphonate therapy. Intravenous injection]. Clinical calcium 20080801
Renal safety profiles of ibandronate 6 mg infused over 15 and 60 min: a randomized, open-label study. Annals of oncology : official journal of the European Society for Medical Oncology 20080701
Identification of novel bone-specific molecular targets of binge alcohol and ibandronate by transcriptome analysis. Alcoholism, clinical and experimental research 20080701
Oral osteonecrosis associated with the use of ibandronate: report of a case and clinical implications. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20080701
Ibandronate in profile: drug characteristics and clinical efficacy. Expert opinion on drug metabolism & toxicology 20080701
Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety. Toxicology in vitro : an international journal published in association with BIBRA 20080601
Changes in bone remodelling and antifracture efficacy of intermittent bisphosphonate therapy: implications from clinical studies with ibandronate. Postgraduate medical journal 20080601
Treatment preference for monthly oral ibandronate and weekly oral alendronate in women with postmenopausal osteoporosis: A randomized, crossover study (BALTO II). Joint, bone, spine : revue du rhumatisme 20080501
Ibandronate in benign bone disease. Reviews on recent clinical trials 20080501
Quarterly intravenous ibandronate for postmenopausal osteoporosis. Women's health (London, England) 20080501
Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain. European journal of pain (London, England) 20080401
Adherence to and gastrointestinal tolerability of monthly oral or quarterly intravenous ibandronate therapy in women with previous intolerance to oral bisphosphonates: a 12-month, open-label, prospective evaluation. Clinical therapeutics 20080401
A Phase II trial evaluating the palliative benefit of second-line oral ibandronate in breast cancer patients with either a skeletal related event (SRE) or progressive bone metastases (BM) despite standard bisphosphonate (BP) therapy. Breast cancer research and treatment 20080301
Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080301
Cost-effectiveness of a fixed dose combination of alendronate and cholecalciferol in the treatment and prevention of osteoporosis in the United Kingdom and The Netherlands. Current medical research and opinion 20080301
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Review of ibandronate in the treatment of osteoporosis. Expert opinion on pharmacotherapy 20030301
Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030201
Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys. Bone 20030101
Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-microglobulin in multiple myeloma. European journal of haematology 20030101
Effect of daily and intermittent use of ibandronate on bone mass and bone turnover in postmenopausal osteoporosis: a review of three phase II studies. Clinical therapeutics 20030101
Bisphosphonates in the management of metastatic prostate cancer. Oncology 20030101
[Effects of ibandronate on the osteopenia process in tail-suspended rats]. Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20030101
Treatment of hypercalcemia of malignancy with bisphosphonates. Seminars in oncology 20021201
Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer research 20021115
The amino bisphosphonate ibandronate prevents calciphylaxis in the rat at doses that inhibit bone resorption. Calcified tissue international 20021001
The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs. Breast cancer research and treatment 20021001
Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. The Journal of rheumatology 20021001
Effect of transplantation on bone: osteoporosis after liver and multivisceral transplantation. Transplantation proceedings 20020901
Elimination of intravenously administered ibandronate in patients on haemodialysis: a monocentre open study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020701
Novel therapeutic options for osteoporosis. Current opinion in rheumatology 20020701
Effect of bisphosphonates on cartilage turnover assessed with a newly developed assay for collagen type II degradation products. Annals of the rheumatic diseases 20020601
Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts. Journal of endocrinological investigation 20020601
Effects of long-term intravenous ibandronate therapy on skeletal-related events, survival, and bone resorption markers in patients with advanced multiple myeloma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020501
Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats. The Journal of rheumatology 20020501
Bisphosphonates for prevention of postmenopausal osteoporosis. Danish medical bulletin 20020201
Ibandronate treatment decreases the effects of tumor-associated lesions on bone density and strength in the rat. Bone 20020101
Association between pharmacokinetics of oral ibandronate and clinical response in bone mass and bone turnover in women with postmenopausal osteoporosis. Bone 20020101
Safety and efficacy of the new bisphosphonate ibandronate in the management of bone metastasis following rapid infusion. In vivo (Athens, Greece) 20020101
Ibandronate in the treatment of prostate cancer associated painful osseous metastases. Prostate cancer and prostatic diseases 20020101
Ibandronate: a comparison of oral daily dosing versus intermittent dosing in postmenopausal osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20011001
[Radiotherapy and bisphosphonate therapy in bone metastases of prostate carcinoma]. Praxis 20010920
Effect of ibandronate on bone loss and renal function after kidney transplantation. Journal of the American Society of Nephrology : JASN 20010701
The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases. Cancer research 20010601
Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arteriosclerosis, thrombosis, and vascular biology 20010501
Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma. Experimental hematology 20010401
Bisphosphonates induce breast cancer cell death in vitro. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20001101
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401
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